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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Pharmacon Pharmascience Berkala Kedokteran Jurnal Surya Medika Jurnal Ilmiah Manuntung JURNAL PENDIDIKAN TAMBUSAI Jurnal Mandala Pharmacon Indonesia Bubungan Tinggi: Jurnal Pengabdian Masyarakat Indonesia Berdaya Community Empowerment Jurnal Kesehatan Tambusai Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Pharmaceutical Care and Sciences SENTRI: Jurnal Riset Ilmiah Sains Medisina Majalah Cendekia Mengabdi Jurnal Farmasi SYIFA Benzena Pharmaceutical Scientific Journal Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Pengabdian Masyarakat Wadah Publikasi Cendekia
Aryzki, Saftia
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Journal : Pharmacon

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Acute Toxicity Test Oral Effervecent Tablet Ethanol Extract of Ramania Leaves (Bouea macrophylla Griffith.) from South Kalimantan Aryzki, Saftia; Budi, Setia; Yanti, Yanti
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23472

Abstract

Ramania (Bouea macrophylla Griffith.) is a herbal plant that has antioxidant properties and inhibits free radicals. This research aims to evaluate the safety of effervescent tablets of the ethanol extract of ramania leaves with acute toxicity test. The experimental animals used in this research were female Wistar white rats. The acute toxicity test was carried out orally using the fixed dose method in 4 groups of animals with dose groups of 50 (I), 300 (II), 2000 (III) and 5000 mg/kgBW (IV) respectively. Observations were made on the LD50, clinical condition, body weight and pathological condition of the test animals. The results of this study were that there were no animal deaths in all groups of test animals during observation. In clinical conditions, the 4 groups experienced discoloration and hair loss, while in groups III and IV the animals were inactive (weak). Based on the body weight of the test animals from the 4 observation groups, the sig value 0.05 means there is no significant change in the weight of the test group, on day 7 the values are 0.921 and 0.314, meaning there is no significant change in the weight of the test group. However, in the weight group 14 day with a value of 0.031, it means there is a significant difference to the weight of the test group. It can be concluded that the effervescent tablets of the ethanol extract of ramania leaves have an LD50 5000 mg/kg BW with a classification of non-toxic to animals.
Co-Authors Abdi, Muhammad Mahendra Adhea Martin, Muhammad Agustina, Ani Aisyah, Noor Ali Rakhman Hakim Amanda, Era Dea Andriani, Dwi Ika Anggoro Mukti, Yusuf Anna Khumaira Sari Anugrahni, Chindy Monica Ariani, Malisa Astuti, Puspita Aulia, Yunita Ayuchecaria, Noverda Darman, Aprilino Saputra Donaretsi, Olga Nathania Eka Kumalasari Elisa, Audiya Febriani, Carolina Febrianti, Dwi Rizki Fitriyadi Frambudi, M. Noval Gaghauna, Eirene E. M. Gamah, Gamah Gunawan, Zellin Eldina Henno, Mei Humaira, Muhammad Nurridho Alfian Husna, Hafizatul Hutami, Hesti Ida Ayu Putu Sri Widnyani Intan Intan Karelius, Karelius Khadijah, Maulida Komaliya, Risyda Kristiani, Windilla Kurniawati, Darini Kusuma, Citra Agustiani Laili, Rofiatul Lilis Rosmainar Limah, Siti Sali Maharatini, Mei Eklesia Malahayati, Siti Mara, Ignatius Ronaldy Marliani, Siti Mawarid, Muhammad Taufiq Fawwaz Melviani, Melviani Mia Audina, Mia Monica, Chindy Mubarak, Jaki Mukti, Yusuf Anggoro Mursidah, Diana Aulia Mustaqimah Mustaqimah Nabila, Regina Syifa Nastiti, Kunti Nata Asi, Seva Bela Niah, Rakhmadhan Norliani, Rahma Norlita, Devi Noval Noval Nur Hidayah Octaviani, Via Okvianingsih, Arum Dwi Permatasari, Dhea Indah Pramadiyani, Naurinnissa Pratiwi, Sinta Putri Vidiasari Darsono, Putri Vidiasari Putri, Mela Julia Qibtiyah, Mariatul Rabiatul Adawiyah Rahayu, Eria Wienty Rahmadani Rahmadani Rahmadhania, Eka Rahmawati, Shinta Ramadhan, Novalina Rossa Ramadhani, Alya Ramadina, Najwa Rina Safitri Rina Saputri Rini, Ilma Widya Riza Alfian Rohama, Rohama Rubina, Miranda Rustiana Rustiana Sadlia, Fitri Saftia Aryzki Salsabila, Shofa Tsuraya Salwati, Salwati Septianto, Gemilang Setia Budi Sien, Lim Lie Sindi Kornelia Siti Rahmawati Sudarya, Maharani Fitria Syamsu, Erlina Syamu, Erlina Trisia, Trisia Uljanati, Khairi Utomo, Yudha Wahyuni, Amaliah Wahyusari, Besty Yanti Yanti Yesika, Yesika Yuwindry, Iwan Zhafirah, Nurul