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Dahlan
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Journal : Journal of Stem Cell Research and Tissue Engineering

 1 
UTILIZATION OF STEM CELL RESEARCH IN MICROGRAVITY FOR INNOVATION IN CELLULAR THERAPY ON EARTH Hendrizal; Dahlan; Gower
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67764

Abstract

Recent advancements in stem cell biology, coupled with developments in space exploration, have opened new avenues for regenerative medicine. Microgravity environments in space induce significant physiological changes in the human body, such as muscle atrophy, decreased bone density, and immune system impairments, mimicking accelerated aging and chronic disease progression. These conditions offer a unique opportunity to study stem cell behavior, proliferation, and differentiation, which occur at a faster pace in space compared to Earth. The three-dimensional (3D) microgravity environment provides a more accurate representation of the human body’s natural state than traditional two-dimensional culture systems, fostering enhanced stem cell development. Among the various stem cells studied in space, mesenchymal stem cells (MSCs) have shown promise for therapeutic applications, including the treatment of stroke, cancer, and neurodegenerative diseases. Research aboard the International Space Station (ISS) has demonstrated that MSCs maintain their properties, proliferate, and differentiate under microgravity conditions, offering potential for future therapies. Additionally, MSCs exhibit resistance to space radiation, protecting astronauts from its harmful effects by promoting tissue repair and releasing regenerative factors. This radiation resistance, coupled with cryopreservation techniques, enables MSCs to be used in long-duration space missions. The ongoing research on MSCs in space not only supports astronaut health but also holds the potential to revolutionize regenerative medicine on Earth. By understanding how microgravity influences stem cell behavior, scientists are uncovering critical insights into tissue repair and cell function, paving the way for innovative treatments for aging-related diseases and other medical conditions. These findings highlight the broader implications of space-based stem cell research for advancing human health both in space and on Earth.
Co-Authors Abdul Kadir Ahmad Ahmad Muzammil Alfiana Anas Laode andi mirza Andry Syafrizal Tnjung Asia Habby, Fihanas Permada AZHAR ANSI, AZHAR Azis H, Abd Aziz Sakti Nugroho Bachtiar Simatupang Bambang Fitrianto Desy Radhiyah Dini Rohmayani Djamil Hasim Eliana Etty Sri Wahyuni Etty Uyun Fachry Abda El Rahman Fadhil Rifgi Pratama fahrudin Fajar Fitriani , Andi Alya Fransiscus S. Rembon Gaffar, Syamsul Bakhri Gower Hargo Basuki Hasnur Ferya Khomaini Hasriyodan Hendrizal Henry Aspan Herdian, Freddy Hermanu Iriawan Idham Kholid Intan Chairun Nisa Irfan Harmain Irma Novianti Irwin Iwan Sahat Maruli Simanjuntak Jalal , Novita Maulidya kahar, kaharuddin Kaloko, Ilhamda Fattah La Harimu La Ode Ahmad Nur Ramadhan Laksana, Mohammad Alfi Nanda Laode Muhammad Harjoni Kilowasid Laode Sabaruddin Lestari Lamindo Limbong Listiana Sri Mulatsih M. Anas M. Jafar Mahyuddin, Reza Masykur Rauf, Masykur MAYANG SARI Muh. Edihar Muh. Said Hasan Muhammad Andi Muhammad Farhan Pratama Muhammad Juang Rambe MUHAMMAD RIZAL Mulyati Mulyati Muslim Nasrum Ninik Ayuhandika Parapa, Imelia Putra, Rian Rusmana Rachman, Muhammad Aimar Ramlan Randy Asmoro Dwi Purnomo Regina D. Krobo Rivai, Iskandar Riza Firdaus Robert Molenaar Ruland Rantung Rustam Musta Saida Rasnovi Saipan Sarah Fadilah Sulaeman Siti Nurhayati Sri Handayani Sri Sartini Muniaha Sukartono Sukmana, Uza Sumardi, Lalu Sumarno Susmihara Susmihara Syahruni Junaid, Syahruni Syaiful Dinata Syam, Rahmawati Tamara, Adrian Kristanto Tamaulina Br. Sembiring Taruna Prakarsa Tati Ernawati TAYIB, ADE SOPYAN HADI Teuku Muttaqin Mansur TRESJIA CORINA RAKIAN, TRESJIA CORINA Unsha, Fuji Attariq Veni Sofia Wa Ode Mulyana Wibisono, Gendoet Indarto Yopa Emalia Fajarini Yuliansyah, Riski Yusra Yusuf, Putri Zulfikar