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All Journal Indonesian Journal of Pharmaceutical Science and Technology MEDISAINS Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Acta Pharmaciae Indonesia : Acta Pharm Indo Majalah Farmaseutik Jurnal Penelitian Farmasi Indonesia Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia HERBAPHARMA : Journal of Herb Farmacological BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmagazine journal of Basic Medical Veterinary Journal of Fundamental and Applied Pharmaceutical Science JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Clavia: Journal of Law Jurnal Farmasi Sains dan Praktis Mandala of Health : A Scientific Journal Jurnal Global Ilmiah Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Hamzah, Hasyrul
Fakultas Farmasi, Universitas Muhammadiyah Kalimantan Timur
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Effectiveness of Oxalis corniculata L. Ethanol Extract against Mono-Species of Biofilm Staphylococcus aureus Hasyrul Hamzah; Khalish Arsy Al Khairy Siregar; Ari Nurwijayanto; Retno Wahyuningrum; Seftika Sari
Borneo Journal of Pharmacy Vol. 4 No. 3 (2021): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v4i3.2418

Abstract

Inappropriate administration of antibiotics can cause resistance to bacteria. Staphylococcus aureus is one of the strong biofilm-forming bacteria that cause antibiotic resistance. Calincing (Oxalis corniculata L.) leaves have excellent antibacterial activity, but their antibiofilm activity against S. aureus has not been reported until now. Currently, the discovery of new antibiofilm against S. aureus biofilms is significant to prevent the impact of infections caused by biofilms. This study was intended to determine the effectiveness of the ethanol extract of O. corniculata leaves in inhibiting and eradicating S. aureus biofilm formation. Planktonic testing, inhibition, and biofilm eradication activity were carried out using the microtiter broth method. Antibiofilm activity of O. corniculata leaves against S. aureus biofilm was analyzed by calculating the minimum concentration of biofilm inhibitor (MBIC50) and minimum biofilm eradication concentration (MBEC50). Data were analyzed using the Statistical Package for the Social Sciences (SPSS) with a 95% confidence level. Oxalis corniculata leaves showed inhibitory activity on the formation of the tested S. aureus biofilm. The ethanol extract of 1% O. corniculata leaves gave 76.23±0.01% antibacterial activity of S. aureus and 71.32±0.01% of mid-phase antibiofilm activity, and 69.33±0.01% maturation phase. The results also prove that the ethanolic extract of O. corniculata leaves can eradicate S. aureus biofilm formation. Therefore, the ethanol extract of O. corniculata leaves can be developed as a new antibiofilm against S. aureus.
Characterization of Onchidiid Slug (Onchidium typhae) West Kalimantan Waters as Antibacterials and Antifungal Bambang Wijianto; Hasyrul Hamzah; Annisa Larasati Nurhidayah; Guci Intan Kemuning; Riyadh Aqilsya Amaryl Dyas
Borneo Journal of Pharmacy Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i1.2936

Abstract

Onchidiid slug (Onchidium typhae) is a nudibranch that coastal communities in West Kalimantan have widely used as wounds. The study aims to characterize the West Kalimantan water O. typhae as antibacterial and antifungal. The study of O. typhae was carried out in several stages: preparation and optimization, extraction by Quinn method, characterization and identification of bioactive compounds, and antibacterial and antifungal assay using the microdilution method. The result of the proximate test showed that O. typhae powder contains high protein, namely 67.68%. Phytochemical screening results from methanol, ethyl acetate, and chloroform extracts contain alkaloids and amino acids. Methanol, chloroform, and ethyl acetate extract 1% of O. typhae showed inhibitory activity against Staphylococcus aureus, Escherichia coli, and Candida albicans. The most significant inhibition value was indicated by chloroform extract 1%, where the inhibition value against S. aureus, E. coli, and C. albicans was 82±0.01%; 85.8±0.01%; 85±0.01%, respectively. From these results, O. typhae powder can be developed as a wound medicine through its antibacterial and antifungal activity.
Pembuatan Kue Dengan Olahan Dasar Ikan Teri Sebagai Makanan Pengontrol Glukosa Darah Pasien Diabetes Tipe 2 di Desa Maratua Kalimantan Timur Muh Irham Bakhtiar; Hasyrul Hamzah; Chaerul Fadly Mocthar Luthfi; Dwi Lestari; Sinta Ratna Dewi; Wirnawati Wirnawati; Hendra Wahyudi; Virgiawan Yoga Pratama; Anugrah Riska Pradana; Risna Aris; Tomi Perdani; Aulan Syahala
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 4 (2023)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v4i4.6462

Abstract

Penyakit Diabetes Melitus adalah penyakit dengan berbagai gangguan metabolisme yang berdampak pada meningkatnya glukosa darah secara kronis.  Diabetes Mellitus (DM) memiliki jenis 2 jenis yaitu DM tipe 1 dan DM tipe 2.  Berdasarkan penelitian sebelumnya pasien Diabetes Mellitus tipe 2 ditemukan tidak terkontrol dengan melihat profil glukosa karena hal ini disebabkan karena antara lain tidak termonitoring atau dievaluasi secara berkala. Dalam monitoring pengobatan pada pasien diabetes mellitus tipe 2 sangat penting untuk menilai efektivitas pengobatan.  Diabetes mellitus tipe 2 di Indonesia terkhususnya di desa maratua dengan adanya inovatif olahan kue berbasis sumber daya alam perikanan (ikan teri) masyarakat setempat.
In-Vivo Anti-Inflammatory Activity of Kelubut Leaf Ethyl Acetate Extract (Passiflora foetida L.) from Samarinda City Mochtar, Chaerul Fadly; Devi, Reni Selviana; Hamzah, Hasyrul; Faradillah, Ayu; Hafidzah, Elva; Varizza, Fathiah Putri; Aisyiyah, Novia Misnawati; Husna, Qur'anni Akhwatun
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.18287

Abstract

Kelubut (Passiflora foetida L.), as an anti-inflammatory, is widely found in various regions in Indonesia, including in Central Kalimantan. Its main chemical compounds include alkaloids, phenols, glycosides, flavonoids, and cyanogenic compounds. Flavonoids show more than a hundred kinds of bioactivity, including antipyretic, analgesic, and anti-inflammatory. This study aims to determine the anti-inflammatory activity of kelubut leaf extract (Passiflora foetda L.) against mice (Mus musculus). This research went through a Pretest and Posttest Control Group Design with 5 treatment groups, negative control, positive control, and ethyl acetate extract of kelubut leaves with 3 doses of 250 mg/KgBW, 125mg/KgBW and 62.5 mg/KgBB. Before being given treatment, each treatment group was induced by carrageenin by sub-planar injection into the sole of the left leg of the mouse. Then, the edema developed rapidly and persisted for 6 hours. After being induced by carrageenin, the researchers waited for 30 minutes and measured the volume of edema every 30 minutes to 120 minutes. The inhibition of all groups of ethyl acetate extract of kelubut leaves showed anti-inflammatory activity, but the resulting abilities were different. Inflammation inhibition by ethyl acetate extract at a dose of 250 mg/KgBW was 92.78%, at a dose of  125 mg/KgBW, was 91.76%, and at a dose of 62.5 mg/KgBW was 84.61%. From the results obtained, the ethyl acetate extract group of kelubut leaves at a dose of 250 mg/KgBW had the greatest inflammatory inhibition activity compared to a dose of 125 mg/KgBW and 62.5 mg/KgBW.
Formulation and Physical Quality Testing of Solid Soap From a Combination of Citronella Oil with Patchouli Leaf Oil Againts Staphylococcus aureus Bacteria Pradana, Anugrah Riska; Hamzah, Hasyrul; Dewi, Sinta Ratna; Wirnawati, Wirnawati
Journal of Islamic Pharmacy Vol 9, No 1 (2024): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v9i1.26885

Abstract

Bacteria on the skin can cause infections ranging from mild to quite serious. Bacteria that are commonly found on human skin are the pathogenic bacteria Staphylococcus aureus. The choice for making antibacterial solid soap based on active ingredients from patchouli oil and citronella oil is that this oil has inhibitory power in the growth of bacteria on the skin, one of which is Staphylococcus aureus. The aim of this research is to determine how large the inhibition zone is produced by the antibacterial solid soap formulation and to determine the characteristics and physical quality tests of the solid soap preparation combining citronella oil with patchouli leaf oil so that it is safe to use. The method used is a pure experimental method. Data collection was carried out for 4 weeks according to the testing time and then analyzed using the Graphad application. The results of the research on the inhibition zone test used 2 concentrations, namely 50% and 100%, each formulation had different average results, namely at F2 50% the average was 21 mm with a very strong category, at F2 100% the average was 19.5 mm with the strong category, at F3 50% we get an average of 16 mm in the strong category and at F3 100% we get an average of 18.6 mm in the strong category. In the tests that have been carried out, it was concluded that citronella oil and patchouli leaf oil can be made into antiseptic solid soap and can inhibit the growth of Staphylococcus aureus bacteria. The results of testing physical quality characteristics for 4 weeks have met the standard requirements for solid soap.
ANALISIS DRPs STATIN DAN ESTIMASI RISIKO ATHEROSCLEROTIC CARDIOVASCULAR DISEASE (ASCVD) PASIEN DIABETES MELITUS TIPE 2 RAWAT JALAN DI RS “X” SAMARINDA Irham Bakhtiar, Muh.; Novy Yudhistirawati; Hamzah, Hasyrul
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 6 No. 2 (2023): Vol. 6 No. 2, Maret Tahun 2023
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v6i2.1268

Abstract

Atherosclerotic Cardiovascular Disease (ASCVD) is the main cause of death in patients with diabetes mellitus with a cardiovascular risk that will increase 2-4 times higher than non-diabetic patients. The statin group is a class of drugs recommended by ACC/AHA 2018 in reducing cardiovascular risk in patients with type 2 diabetes mellitus. This study aims to analyze Drug Related Problems (DRPs) of statin drugs in patients with type 2 diabetes mellitus and calculate the estimated risk for the next 10 years. The research was conducted using a non-experimental descriptive analytic method. Data collection was carried out retrospectively through a population of 194 type 2 diabetes mellitus patients at "X" Samarinda Hospital for the period January-September 2022, 11 patient medical record data were obtained through the Total Sampling technique whose sampling complied with the inclusion and exclusion criteria. The results showed that the most commonly prescribed statins were simvastatin 20 mg in 9 patients (82%), and atorvastatin 20 mg in 2 patients (18%). The results of the DRPs analysis showed that there were 4 cases of DRPs consisting of 1 case of underdose (25%), and 3 cases of drugs not being indicated for the existing medical profile (75%). The total risk level of ASCVD based on the calculation of the ASCVD calculator found that 3 patients (27%) had low risk, 4 patients (36%) medium risk, and 4 patients (36%) high risk.
TRACING THE ANTIBACTERIAL, ANTIFUNGAL AND ANTI-BIOFILM ACTIVITIES OF ROOT EXTRACT BAJAKAH TAMPALA (SPATHOLOBUS LITTORALIS HASSK) Setyowati, Endang; Irzani, Elza Fadia; Mochtar Luthfi, Chaerul Fadly; Hamzah, Hasyrul
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.8804

Abstract

Biofilm is a common causative factor for urinary tract infections due to catheter usage with a percentage of infection around 70-80%. The Bajakah tampala (Spatholobus littoralis Hassk) is one of native plants of Kalimantan which contains phenolic compounds, flavonoids and tannins which are proven to accelerate wound healing, have antibacterial activity, and have very high and strong antioxidant activity. This study aims to determine the antibacterial and anti-biofilm activity of bajakah root extract (Spatholobus littoralis Hassk) on catheter colonies of Staphylococcus aureus, Escherichia coli and Candida albicans and to determine their mechanism of action in vitro. This research is carried out with an in vitro experimental study design using a microplate reader. Extraction was carried out by maceration method using 96% ethanol solvent. The results showed that the ethanol extract of Bajakah tampala (Spatholobus littoralis Hassk) had antibacterial activity against S. aureus with a concentration of 1% w/v of 88.33% ± 0.01 and anti-biofilm activity of 82.21% ± 0.01. E. Coli bacteria had an antibacterial activity of 84.83% and an anti-biofilm activity of 80.11 at a concentration of 1% w/v. C. albicans had an antifungal activity at a concentration of 1% w/v of 82.31% ± 0.01 and anti-biofilm activity of 77.00% ± 0.01. From these results it can be concluded that the ethanol extract of Bajakah tampala (Spatholobus littoralis Hassk) has antibacterial and antifungal activities and the potential as a new anti-biofilm agent against S.aureus, E. coli and C. albicans
OPTIMIZATION OF pH VALUE AND GEL VISCOSITY IN PORANG TUBER CAPSULE SHELL FORMULATION Maulana, Riza; Muhtadi; Suhendi, Andi; Prasetya, Farid Adi; Harimurti, Sabtanti; Hamzah, Hasyrul
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1212

Abstract

The porang tuber contains glucomannan compounds that can expand into a gel so that it has the potential to be used as the main ingredient of capsule shells. This research aims to optimize the pH and viscosity values that can affect the consistency of the capsule shell produced. The method used in the manufacture of capsule shells is the dipping pen method, while the optimization method carried out is trial and error by making 3 formulas by combining glycerin and PEG 400. The results obtained by the gel mass formed by the glycerin-PEG 400 gelling agent have a viscosity value of 586.67 dPas and a pH value of 6.02 can provide a gel mass that is easy to mold capsule shells and obtain capsule shells with elastic characters.  The results indicate optimal viscosity and pH values to obtain a gel mass that is easy to mold capsule shells with good organoleptic characteristics. Keywords:  Glucomannan, pH, viscosity, capsule shell.
Innovative insight: ChatGPT's contribution to advanced health research articles Muslim, M. Rifqi Fadillah; Chabib, Lutfi; Hamzah, Hasyrul; Santosa, Agus
MEDISAINS Vol 21, No 3 (2023)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v21i3.20211

Abstract

The current technological advancement follows a pattern of both disruptive and gradual changes. The field of communication is currently the most extensively utilized technology. The rapid development of AI has enabled those without a background in computer coding or specialized health knowledge to utilize this technology, which gives rise to numerous issues. This phenomenon elicits curiosity and engenders debate among the general public, scholars, healthcare providers, and researchers in the health industry. Utilizing AI in the composition of scientific publications necessitates explicit norms and regulations, a robust validation procedure, and effective collaboration between AI systems and human expertise. Ensuring transparency and acknowledgment of AI usage is crucial to maintaining human researchers' accountability for the ultimate outcomes of their research.
Pemberdayaan Masyarakat Melalui Inovasi Pembuatan Sabun Padat Bajakah Tampala (Spatholobus littoralis Hassk) pada Masyarakat Kampung Ketupat Samarinda: Community Empowerment Through Innovation in Making Bajakah Tampala Solid Soap (Patholobus littoralis Hassk) in the Community of Ketupat Village, Samarinda Hasyrul Hamzah; Chaerul Fadly Mochtar Luthfi M; Faldi Faldi; Anugrah Riska Pradana; Riska Febriani; Risna Aris; Suci Mardatilah; Frederika Erwina Rani
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 6 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i6.6323

Abstract

Bajakah tampala is a plant native to Kalimantan that can be found in forests in the interior of Kalimantan. The use of Bajakah Tampala wood is not widely known by most people. One of the uses of Bajakah Tampala wood is that it can be used as an economically valuable product. This community service takes the form of an empowerment program for PKK and Dasawisma women to provide training in making bajakah solid soap. However, before that, education or outreach was carried out regarding solid soap. Of all participants, 22.2% answered that they knew the process of making solid soap, 44.4% knew about solid soap which has a steel composition, and 20% had an understanding of making solid soap. The results of community service activities showed an increase in the total understanding of participants to 100% answered that they knew the process of making solid soap, 100% answered that they knew about solid soap which has a steel composition, and 100% answered that they understood the process of making solid soap. This activity concludes that all participants can better understand the process of making solid soap products and can feel the benefits of Bajakah solid soap.
Co-Authors A. Nurfitriani Abdul Rozak Agus Santosa Ahmad Faqih Aisyiyah, Novia Misnawati Aji Firda Lia F Alfin Syahrian Dwi Nugraha Amelia Wandini Amrina Rossada Septilapani Andi Suhendi Annisa Larasati Nurhidayah Anshari, Rahman Anugrah Riska Pradana Anugrah Riska Pradana Ari Nurwijayanto Arifin Nur Fahdianto Astriani, Nur Atika Aulan Syahala Ayu Faradillah Azizah, Aryantinur Badrani Abbas Al Fajri Bafadal, Mentarry Bakhtiar, Muh. Irham Bakti, Muhammad Tursina Bambang Setiaji Bambang Setiaji Bambang WIJIANTO Besan, Emma Jayanti Cahyaningrum, Putri Khaerani Chaerul Fadly Mochtar Dedi Setiawan Devi, Reni Selviana Diana Indri Sulistia Dwi Lestari Elva Hafidzah Endang Setyowati Erika Nandini Erika Nandini Erlisa Maharani Putri Fadlillah, Synta Haqqul Faldi Faldi Faldi Faradillah, Ayu Farid Adi Prasetya Farida, Norma Feti Fathiah Putri Varizza Fathur Rahman Fendy Prasetyawan Fhirda Azhari Frederika Erwina Rani Fredy Dian Kurniawan Guci Intan Kemuning Gunawan, Dede Reza Hafidzah, Elva Hendra Wahyudi Hendra Wahyudi Husna, Qur'anni Akhwatun Indra Yudhawan Indra Yudhawan Irzani, Elza Fadia Jamiatur Rasyidah Jati Pratiwi Junianda Haris Dwiagam Kamilah, Lila Zulfa Khalish Arsy Al Khairy Siregar Lila Zulfa Kamila Lutfi Chabib, Lutfi Luthfi M, Mochtar Lysa Oktaviani Saleh Lysa Oktaviani Saleh MAULANA, RIZA Muh Irham Bakhtiar Muhammad Nurul Fadel Muhammad Rusli Muhammad Subhan Muhtadi Mundzir, Chaerul Muslim, M. Rifqi Fadillah Neni Frimayanti Nila Fajrianti Nita Magfirah Ilyas Noor Aida Norma Feti Farida Novia Misnawati Aisyiyah Novy Yudhistirawati Nur Atika Astriani Nur Halimah Nur Lutfiah Damis Nur Rasdianah Perdana Priya Haresmita, Perdana Priya Phebe Hendra Pradana, Anugrah Riska Pratama, Virgiawan Yoga Putri, Erlisa Maharani Qur’anni Akhwatun Husna Rabiatul Adawiyah Rahmah, Widya Reni Selviana Devi Ressandy, Sylvan Septian Retno Wahyuningrum Rini Dwiastuti Riska Febriani Risna Aris Risna Aris Riyadh Aqilsya Amaryl Dyas Riza Maulana Rizky Kurniawan Rizky Kurniawan Syamat Rusdeni, Sofia Sabtanti Harimurti, Sabtanti Salsabila Azzahra Sari, Mely Anita Sari, Seftika Sekar Ayu Kumara Shella Carlina Tasya Sinta Ratna Dewi Sinta Ratna Dewi Siti Hajar Siti Hajar Suci Cahya Ningsih Suci Mardatilah Suhartomo, Dalri Muhammad Suriati Suriati Suwoko Suwoko Syayid Al Manar Sylvan Septian Ressandy Sylvan Septian Ressandy Sylvia Utami Tunjung Pratiwi Tasya Amanda, Putri Titik Nuryastuti Tomi Perdani Triana Hertiani Varizza, Fathiah Putri Virgiawan Yoga Pratama Virgiawan Yoga Pratama Wicaksari, Sifa Aulia Widya Rahmah Widya Rahmah Widya Rahmah Wirnawati Wirnawati Wirnawati, Wirnawati Yudhawan, Indra