Claim Missing Document
Check
Articles

Potensi Antioksidan Kombinasi Ekstrak Daun Cocor Bebek (Kalanchoe pinnata L.) Dan Ekstrak Daun Kratom (Mitragyna speciosa Korth.) Dengan Metode DPPH Meisa, Devina; Rohama, Rohama; Rahmadani, Rahmadani; Nastiti, Kunti
Jurnal Pelayanan Kefarmasian dan Sains Vol 6 No 1 (2025): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v6i1.816

Abstract

Background: Indonesia is a country that has plants that are widely used by the public as traditional medicine, including bebek cocor leaves (Kalanchoe pinnata L.) and kratom leaves (Mitragyna speciosa Korth.) which have been proven to contain antioxidants and are empirically proven to be a pain reliever. Objective: To determine the IC50 of the combined extract of cocor bebek leaves (Kalanchoe pinnata L.) and kratom leaves (Mitragyna speciosa Korth.). Methods: In this study, simplicia leaves of cocor bebek (Kalanchoe pinnata L.) and kratom leaves (Mitragyna speciosa Korth.) were extracted by maceration. Phytochemical screening and antioxidant activity tests were carried out on each extract. Antioxidant activity testing was carried out using the DDPH (2,2-diphenyl-1-picrylhydrazyl) method. Antioxidant activity was tested quantitatively using Uv-Vis spectrophotometry at a wavelength of 528 nm with the comparison standard used being Vitamin C. Results: The results show that the ethanol extract of Cocor Bebek leaves and Kratom leaves alone has very strong antioxidant activity with IC50 values ​​of 17,96 ppm and 14.43 ppm. The combination with a ratio of 2:1 obtained the lowest IC50 value, namely, 10.60 ppm compared to 1:1 with an IC50 of 15.14 ppm and 1:2 with an IC50 of 12.72 ppm Conclusion: The highest antioxidant activity is found in a combination of ethanol extract of Cocor Bebek leaves and Kratom leaves in a ratio of 2:1 with a lower IC50 than either alone.
Co-Authors Abdul Latif Ali Rakhman Hakim Amalia, Ghina Rezki Amalia, Putri Rizky Ananda, Hesti Aulia Andriani, Ine Anggraini, Livani Aryzki, Saftia Aulia, Devina Caroline, Putricia Chicade, Anabaena Dagau, Lelie Dari, Kristina Wulan Dede Mahdiyah, Dede Deviani, Norma Dewi Susanti Atmaja Elieser, Michael Fauzah Fauzah, Fauzah Fawwaz, Muhammad Taufiq Febriani, Agnesia Febriani, Carolina Fitriani, Dyah Fuaddah, Munawarah Gunawan, Prayogo Aldi Gusnianti, Elva Hastika, Febby Yulika Husna, Hafizatul Husnul Khatimah Ida Ayu Putu Sri Widnyani Indah Purnamasari Intan Intan Irawan, Angga Ismiadi, Rahmad Jannah, Ghina Raudhatul Khairunnisa Khairunnisa Khairunnisa, Aisya F. Khuluqia, Munirah Kristiana, Isha Desty Kristina, Isha Desty Kurniawati, Darini Kusnia, Risha I. K. Kusuma D, Muhammad Chandra Hadi Mahmudah Mahmudah Mardlatillah, Mardlatillah Martha, Dhea Yolanda Mawarid, M.T.F. Meisa, Devina Melviani, Melviani Mia Audina, Mia Nabila, Putri Nabila, Yasmin Nastiti, Kunti Ningsih, Gusria Surya Ningtias, Radita Dia Ayu Noor Latifah Nor Erpiana, Indah Noval Noval Nugraha, Dyan Fitri Nurhidayah, Dea Octavia, Mutia Oktavia, Helda Oktavia, Rissa Pawestri, Hasna Priadi, Ota Puspita, Melinda Dian Pusvita, Shela Putra, Dedy Karmadi Putri Vidiasari Darsono, Putri Vidiasari Putri, Mela Julia Rahayu, Desi Dwi Rahmadani Rahmadani Rahmawati, Rahmawati Rahmawati, Sinta Raihanah Raihanah Rianti, Nur Addina Rina Amelia Rina Safitri Rina Saputri Romadhina, Rodhiatul Sadlia, Fitri Setia Budi Shinta, Laili Shinta Ayu Siti Aisyiyah, Siti Syahfitri, Laili Shinta Ayu Syifha, Nor Tazkiyah, Aulia Tumanggor, Agustina Hotma Uli Tuti Alawiyah Uljanati, Khairi Witin, Rafelita Septania B. Yanti, Novita Yuniar, Nabila Yuwindry, Iwan Zainul Abidin