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Strategi Penguatan Pendidikan Akhlak melalui Pembelajaran Tahfizh di Madrasah Ibtidaiyah Aziz, Nur; Subando, Joko
TSAQOFAH Vol 5 No 5 (2025): SEPTEMBER
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/tsaqofah.v5i5.6933

Abstract

Moral education is a fundamental aspect of character formation at the primary level, particularly in Madrasah Ibtidaiyah. This article aims to analyze the role of tahfidz al-Qur’an instruction as a strategy for strengthening moral education within the madrasah environment. Using a descriptive qualitative approach through literature review, the study finds that tahfidz functions not only as a process of memorizing the sacred text but also as a medium for the internalization of moral values contained in the Qur’an. The implementation of tahfidz integrated with character development has been shown to foster religious, disciplined, honest, and responsible behavior in students. The success of this internalization process is significantly influenced by the teacher’s role as a moral exemplar, the creation of a supportive school environment, and the application of contextual learning methods relevant to students' daily lives. Therefore, tahfidz al-Qur’an serves as an effective instrument for cultivating noble character from an early age in Islamic primary education.
METTL25 EXPRESSION PROFILING ACROSS HUMAN TISSUES AND CANCERS Aziz, Nur; Rahmawati, Laily; Qomaladewi, Nurinanda Prisky
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.53300

Abstract

Background: Although recent studies have established the critical roles of methyltransferases in epigenetic regulation and cellular homeostasis, the biological function of METTL25, a member of this enzyme family, is not well known. Current clinical research has identified various methyltransferases as key regulators of gene expression, yet METTL25 remains functionally uncharacterized, representing a significant knowledge gap in our understanding of methyltransferase biology. Objective: This study examines the expression patterns of METTL25 across normal human tissues and cancer contexts to identify its potential physiological and pathological roles and to understand its regulatory mechanisms in health and disease. Methods: We conducted a systematic computational analysis using large-scale publicly available transcriptomic and proteomic datasets. Expression patterns were analyzed across normal human tissues and cancer cell lines. Correlation analysis between mRNA and protein levels was performed, followed by differential gene expression analysis comparing thyroid carcinoma to normal thyroid tissue. Functional enrichment analysis was applied to identify biological pathways associated with METTL25 expression. Results: METTL25 exhibited tissue-specific expression patterns with highest expression observed in endocrine organs (thyroid, adrenal glands) and immune compartments (lymphoid tissues). Moderate correlation between mRNA and protein levels was identified (r=0.404 ; p=0.001), indicating transcriptional control of protein abundance. METTL25 expression was significantly downregulated in thyroid carcinoma compared to normal thyroid tissue (p<0.01). Higher METTL25 expression in tumors was statistically significant and positively correlated with gene signatures related to wound healing, coagulation, and hemostasis pathways. Conclusion: METTL25 functions as a tissue-restricted methyltransferase with tumor suppressor characteristics in thyroid cancer. The positive correlation between METTL25 expression and wound healing pathways was statistically significant, suggesting its involvement in tissue repair mechanisms. These findings provide the foundation for future mechanistic studies investigating METTL25's role in cancer biology and its potential as a therapeutic target.
Enhancing Professionalism in Zakat Management Through Islamic Competency-Based Human Resource Management: A Literature Review of Key Competencies for Amil Zakat Aziz, Nur
International Journal of Zakat Vol. 10 (2025): Special Issue 2
Publisher : Center of Strategic Studies (PUSKAS) BAZNAS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37706/ijaz.v10i4.685

Abstract

Adequate competencies of zakat officers (amil) significantly impact the overall effectiveness of zakat programs. This study aims to examine the implementation of Islamic Competency-Based Human Resource Management (ICBHRM) in zakat institutions, focusing on identifying key competency dimensions of zakat officers that support professionalism in zakat management. The method employed is a literature review through a systematic analysis of relevant studies from journals, books, and conference papers. Data were collected from academic sources such as Google Scholar and ScienceDirect. The findings suggest that technical, personal, and social competencies serve as the core pillars supporting the professional performance of zakat officers. These competencies play a crucial role in ensuring effective and accountable zakat management. Technical competencies include a deep understanding of zakat jurisprudence, management, and sharia accounting. Meanwhile, personal and social competencies encompass integrity, trustworthiness, and strong interpersonal skills. Zakat officer certification is also considered vital in enhancing the quality of zakat officer performance and the accountability of zakat institutions.This study concludes that implementing ICBHRM in zakat institutions can significantly improve the professionalism and efficiency of zakat management, mainly through applying the core competencies outlined in the Indonesian National Work Competency Standards (SKKNI) and leadership competencies, such as the ability to influence others, develop talent, and provide clear guidance. The discussion of these findings suggests the importance of continuous development through training and certification to ensure zakat officers can compete and adapt to modern management standards without compromising Sharia principles.