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All Journal HAYATI Journal of Biosciences Jurnal Teknologi Dan Industri Pangan ACTA VETERINARIA INDONESIANA Jurnal Pengolahan Hasil Perikanan Indonesia Media Veteriner Jurnal Veteriner ILMU KELAUTAN: Indonesian Journal of Marine Sciences Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Mikologi Indonesia Jurnal Medik Veteriner JURNAL KAJIAN VETERINER Jurnal Kedokteran Hewan
Ketut Adnyane Mudite
Departemen Anatomi, Fisiologi Dan Farmakologi, Fakultas Kedokteran Hewan, Institut Pertanian Bogor, Kampus IPB Darmaga, Jalan Agatis, Bogor 16680 Jawa Barat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Veterinary

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Pengujian Toksisitas Akut Lethal Dose 50 (LD50) Infusa Ikan Nomei (Harpodon nehereus) dengan Menggunakan Mencit (Mus musculus) sebagai Hewan Uji Adnyane, I Ketut Mudite; yuri, Nurasmi yuri; I Ketut Mudite; Andriyanto; Wasmen Manalu
Acta VETERINARIA Indonesiana Vol. 12 No. 3 (2024): November 2024
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.12.3.187-193

Abstract

Ikan Nomei (Harpodon nehereus) merupakan jenis ikan yang lembek dan memiliki nilai ekonomis yang cukup tinggi untuk dapat dimanfaatkan secara luas. Penelitian bertujuan menguji toksisitas akut ekstrak infusa daging ikan nomei Harpodon nehereus pada mencit betina dengan menentukan nilai lethal dose 50 (LD50), mengamati pengaruhnya pada organ tubuh mencit, dan menghitung konsentrasi ekstrak yang paling efektif. Hewan uji yang digunakan adalah mencit galur DDY sebanyak 25 ekor dibagi secara acak ke dalam 5 kelompok perlakuan, yaitu kelompok kontrol (pemberian akuades) dan kelompok perlakuan pemberian infusa nomei masing-masing dengan dosis 5, 10, 15, dan 20 g/kg BB secara per oral. Parameter yang diamati meliputi mortalitas, respons fisiologis, gejala klinis, bobot badan, bobot absolut organ, dan bobot relatif organ. Nilai LD50 menunjukkan pemberian infusa ikan nomei pada mencit betina bersifat tidak toksik. Pemberian infusa nomei sampai dengan dosis 20 g/kg BB tidak menimbulkan gejala klinis yang bersifat patologis, perubahan makroanatomi organ, atau kematian. Pemberian infusa tidak menunjukkan efek yang signifikan pada peningkatan atau penurunan bobot badan. Berdasarkan penelitian, pemberian infusa ikan nomei sampai dengan dosis 20 g/kg BB bersifat tidak menimbulkan kelainan baik secara klinis atau kelainan pada organ mencit. Kesimpulan dari penelitian ini adalah infusa ikan nomei termasuk dalam golongan bahan yang diklasifikasikan dalam sediaan praktis tidak toksik (aman).
Effects of Physalis angulata Leaf Extract on Female Reproductive Organs Following Busulfan Injection in Rats Satyaningtijas, Aryani; Ekastuti, Damiana Rita; Tarigan, Ronald; Prasetyaningtyas, Wahono Esthi; Adnyane, I Ketut Mudite; Mohamad, Kusdiantoro; Rahmadhani, Elsi; Sulistyana, Yanti; Mahendra, Arindina
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.490-498

Abstract

Physalis angulata L. (ciplukan) is traditionally used as an herbal remedy with anticancer and antioxidant properties. At the same time, busulfan, a chemotherapy alkylating agent, causes gonadotoxicity and oxidative stress that impair female reproduction. This study aimed to evaluate the effect of P. angulata on reproductive function after busulfan administration in female rats. Twenty-five 6-week-old female rats were randomly divided into: Group I (control), Group II (busulfan only), Group III (P. angulata only), Group IV (busulfan followed by P. angulata after 14 days), and Group V (busulfan and P. angulata administered for 28 days). FSHR and LHR expression in the ovaries and MDA levels in the ovaries and uterus were measured to assess reproductive changes. Busulfan showed no significant effect on FSHR and LHR, whereas P. angulata induced downregulation, suggesting a potential negative feedback mechanism on ovarian receptors. Ovarian MDA showed a decreasing trend with combined treatments, while uterine MDA peaked after busulfan but declined markedly with P. angulata, indicating its role in alleviating oxidative stress. In conclusion, P. angulata may modulate hormonal balance in rat ovaries and decrease oxidative stress in the uterus after busulfan treatment.
Short-term treatment of osteoarthritis-induced sheep with human umbilical cord–derived mesenchymal stem cells: A morphological and proteomic analysis Mohamad, Kusdiantoro; Situmeang, Adrian; Rakhmawati, Handina; Adnyane, I Ketut Mudite; Fahrudin, Mokhamad; Nurhidayat, Nurhidayat; Murti, Harry; Lubis, Andri Maruli Tua; Boediono, Arief
Jurnal Medik Veteriner Vol. 9 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol9.iss1.2026.106-123

Abstract

Knee joints are the primary sites affected by osteoarthritis (OA) in humans and animals. Although intra-articular human umbilical cord–derived mesenchymal stem cells (hUC-MSCs) show therapeutic promise, their combined use with hyaluronic acid (HA) remains underexplored in large animals. This study evaluated morphological and proteomic changes in a sheep osteoarthritis model treated with both agents. A total of twelve sheep were divided into four groups (n = 3 per group): control (normal and OA) and three treatment groups receiving hUC-MSCs, HA, or a combination of HA and hUC-MSCs (HA + hUC-MSCs). OA was induced by meniscectomy, and intra-articular injections were administered four weeks post-surgery. Macroscopic scoring was conducted according to the Osteoarthritis Research Society International system, while histological evaluation was performed using hematoxylin–eosin, Safranin O, and Masson’s trichrome staining. Proteomic analysis of synovial fluid was carried out using liquid chromatography–tandem mass spectrometry. The macroscopic OA score in the HA + hUC-MSC group was lower than in the other treatment groups and was not significantly different from the normal group (p > 0.05). Microscopic observations indicated that hUC-MSCs supported joint cartilage regeneration by preserving proteoglycan and collagen content. Proteomic profiling revealed that treatment with HA + hUC-MSCs modulated proteins associated with complement activation and coagulation pathways. The combination of HA and hUC-MSCs provided synergistic benefits for cartilage regeneration in a sheep OA model during a short treatment period. These findings suggest that this approach represents a promising regenerative therapy for OA in large animals within veterinary medicine and has translational relevance for human regenerative medicine.
Co-Authors . Zuchri A.S. Satyaningtijas Adi Winarto Adisti Dwijayanti Adkhilni Utami Alastair A Macdonald Aldina Safitri Alif Iman Fitrianto Ana Rufaidah Andriyanto Arief Boediono Bibiana W Lay Damiana Rita Ekastuti Diini Fithriani Dwi Kesuma Sari Dwinna Aliza Eka Prasetiawan Eka Prasetiawan Eka Prasetiawan Elmanaviean, Muhammad Elpita Tarigan Fadli A. Gani Fayca Rudhatin Swartidyana Fithriani, Diini Frans Dhyanagiri Suyatna Frans Dhyanagiri Suyatna Gani, Fadli A. Gholib Gholib Gholib Gholib, Gholib Gusdinar, Rizal Hafizuddin Hafizuddin Hamny Sofyan Harry Murti Henny Nuraini Hidayati, Mustika I Ketut Mudite I Ketut Suatha I Wayan Batan Indra Bachtiar Irwandi Jaswir Ita Djuwita Joko Hermanianto Kartika, I Wayan Darya Kelvin Yaprianto Kusdiantoro Mohamad Lidya Elizabeth M. Manik Lisa Dwi Fannessia Lubis, Andri Maruli Tua M Agus Setiadi MADE ASTAWAN Maha, Inggrid Trinidad Mahendra, Arindina Masturi Muhajir Md Zuki Abu Bakar Mokhamad Fahrudin MUHAMMAD AGIL Muhammad Jalaluddin Muhammad Jalaluddin, Muhammad Muhammad Syukur Hamdan Mulyadi Adam Mulyadi Adam, Mulyadi Muslim Akmal Mustika Hidayati Nancy Dewi Yuliana Ni Wayan Kurniani Karja Nining Handhayani Noordin Mohamed Mustapha Novi Susanty Nugraha, Arifin Budiman Nurhidayat Nurhidayat Prabandari, Silvia Arin Prasetyawati, Renny Candra R. Iis Arifiantini Rahmadhani, Elsi Rahmaniyah, Wiwit Ridhani Rakhmawati, Handina Renny Candra Prasetyawati Rudy Priyanto Sandy Qlintang Savitri Novelina Sevy Tiara Ilham Silvia Arin Prabandari Situmeang, Adrian Sofiawati Sofiawati Sofiawati, Sofiawati Sri Wahyuni Sri Wahyuni Srihadi Agungpriyono Sulistyana, Yanti Supar - Supratikno . Tarigan, Ronald Tongku Nizwan Siregar Tutik Wresdiyati Tuty Laswardi Yusuf Tuty Laswardi Yusuf Wahono Esthi Prasetyaningtyas Wahono Esti Prasetyaningtyas Wahyuni, Sri Wasmen Manalu Wini - Trilaksani Wining Astini Wiwit Ridhani Rahmaniyah Yohana Paula Prihatmi Pamungkasari yuri, Nurasmi yuri