Ida Bagus Komang Ardana
Laboratorium Patologi Klinik, Fakultas Kedokteran Hewan, Univesitas Udayana, Jl. Raya Sesetan, Gg. Markisa No. 6. Denpasar Bali

Published : 51 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Pathogenesis studies of African swine fever virus isolates from Bali and East Nusa Tenggara as a basis for inactivated vaccine development Tenaya, I Wayan Masa; Agustina, Kadek Karang; Suada, Ketut; Sukada, Made; Mufa, Romy Muhammad Dary; Apsari, Ida Ayu Pasti; Dwinata, I Made; Ardana, Ida Bagus Komang; Damriyasa, Made; Sari, Tri Komala; Astawa, Nyoman Mantik; Supartika, Ketut Eli; Wirata, Ketut; Suarsana, Nyoman; Suartha, Nyoman
Jurnal Medik Veteriner Vol. 9 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol9.iss1.2026.150-160

Abstract

African swine fever (ASF) is a highly contagious and lethal disease of pigs for which no effective vaccine is currently available. This study evaluated the pathogenicity of field African swine fever virus (ASFV) isolates from Bali and East Nusa Tenggara and assessed their potential for inactivated vaccine development using spleen-derived antigens. Based on the qPCR results, among all ASFV isolates tested, only the Bali isolate, designated B1, exhibited the highest DNA concentration, suggesting that this sample contained the highest ASFV titer. Consequently, the B1 isolate was selected and processed into chemically treated (CT-ASFV) and non-treated (NCT-ASFV) formulations. In the pathogenesis trials, pigs inoculated with NCT-ASFV developed acute ASF and died within 12 days, whereas those receiving CT-ASFV exhibited no clinical signs of ASF and showed no evidence of viral replication. In the vaccination trial, pigs immunized with CT-ASFV emulsified in Montanideā„¢ ISA 50 V2 demonstrated survival in two out of three animals (67%) following challenge with a virulent strain, while all control animals succumbed to infection. Despite the absence of detectable humoral responses as determined by ELISA, the observed protection suggests a potential role for cell-mediated immunity. These findings indicate that the B1 isolate was highly virulent and represents a promising candidate for the development of an inactivated ASF vaccine. Further evaluation in larger-scale field trials is warranted.
Co-Authors . Suriansyah Achoiro Wati Rasid Adiari, Komang Sri Akbar, Saiful Anak Agung Ayu Mirah Adi Anak Agung Gde Oka Darmayudha Anak Agung Gde Oka Dharmayudha Anak Agung Ngurah Subawa Anak Agung Sagung Kendran Andi Azhary Azmy, Andi Azhary Anjuman Zukhri Apsari, Ni Wayan Diah Aryitahlia, Ninis Astawa, I Ketut Astuti, Komang Regi Kusuma Astuti, Komang Tri Cahyanti, Putu Yunika Damara, Doni Djara, Devita Vanessa Sukmawati Domingas Pereira Dr. Iyus Akhmad Haris,M.Pd . DWI SURYANTO Gede Ari Krisna Gunawan, I Wayan Nico Fajar Gusti Ayu Yuniati Kencana Handayani, Ida Ayu Lidya HILDA PRASETYO I Dewa Ketut Harya Putra I Gede Gilang Ikra Raditya I Gede Made Sunu Satwika Nur Agung I Gede Soma I Gusti Agung Gede Putra Pemayun I Gusti Made Krisna Erawan I Gusti Ngurah Kade Mahardika I Gusti Ngurah Sudisma I Ketut Berata I Ketut Suada I Made Bakta I Made Damriyasa I Made Dwinata I Made Kerta Pratama I Made Merdana I Made Sukada I NYOMAN MANTIK ASTAWA I Nyoman Suarsana I Nyoman Suartha I Nyoman Sulabda I Putu Cahyadi Putra, I Putu Cahyadi I Putu Sampurna I Wayan Masa Tenaya, I Wayan Masa I Wayan Sudira Ida Ayu Pasti Apsari Ida Bagus Dimas Kusumadarma Ida Bagus Kade Suardana Ida Bagus Oka Winaya Irmawan, Adi Ita Octarina Purba Iwan Harjono Utama Jamhari Jamhari Jayanata, I Made Jayantara, I Kadek Eka K. K. Agustina Kadek Karang Agustina Ketut Budiasa Ketut ELI Supartika KETUT SUADA Ketut Tono Pasek Gelgel Kiki Lulu Maduma Simanungkalit Kusamadarma, Ida Bagus Agung Dimas Lubis, Barata Sultan Luh Dewi Anggreni Luh Made Sudimartini LULUK WULANDARI Made Damriyasa, Made MADE KOTA BUDIASA Made Suma Anthara Made Suma Anthara Mahendra, I Putu Gede Marshanindya, Andra Meidianthi, Kadek Putri Mufa, Romy Muhammad Dary Muhammad Ainun Najib Ni Ketut Suwiti Ni Luh Eka Setiasih Ni Luh Kartini Ni Made Dwi Adnyana Pertiwi NUR KOMALASARI Nyoman Suartha Pio, Paulus Oktavianus Pradnyani, Gusti Ayu Putu Indira PRATIWI DEVI GM Pratiwi, Ni Made Diah Kusuma Putu Diah Puspa Adhi Putu Suastika Qutrotu'ain, Salsabila Robby Deddy Septianto Roby Rohmandhani Rosni Lumban Gaol S Siswanto Santoso, Sri Wahyuningsih Heri SARI PUTRIANI Septiyan, Fayyadh Syafiq Sidabutar, Febyana Sri Kayati Widyastuti Sri Rezeki Tampubolon Suharsono, Hamong Sukada, Made Sunusi, Sulham TRI KOMALA SARI Tyas Pandieka Yoga Wibawa, I Gede Pratama Candra WIDHI YANUNGRAH Widihantoro Gunawan Putra Wirata, Ketut Yoga Pratama Nuradi Yustika, I Made Aris