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All Journal Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Jurnal Sain Veteriner Buletin Peternakan Jurnal Veteriner Jurnal MIPA JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) PROSIDING SEMINAR KIMIA Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Bioma : Jurnal Biologi Indonesia ARSHI Veterinary Letters Jambura Physics Journal JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Fisika dan Terapannya Jurnal Abdimas ADPI Sains dan Teknologi Jurnal Pusat Inovasi Masyarakat Jurnal Kedokteran Hewan Jurnal Veteriner Nusantara Current Biomedicine
koekoeh santoso
IPB University
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Energy Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Journal : PROSIDING SEMINAR KIMIA

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LITERATUR REVIEW: PENGARUH INJEKSI INTRACEREBROVENTRIKULAR STREPTOZOTOCIN PADA OTAK MENCIT SEBAGAI KANDIDAT HEWAN MODEL ALZHEIMER Daryanti, Edhita Putri; Anggadiredja, Kusnandar; Wibowo, Agung Eru; Santoso, Koekoeh
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Background: Animal models of Alzheimer's have now been developed in various studies to become potential animal models suitable for clinical conditions. Alzheimer's in clinical conditions is characterized by Amyloid βeta (Aβ) plaques and intracellular tangles of neurofibrillary tangles as well as disorders of the acetylcholinesterase enzyme in the hippocampus. Rodents used include rats and mice. Mice are used because they are efficient and parts of the brain can be penetrated with a needle without requiring surgery. Objectives: Appropriate toxicant induction is needed so that the process of developing Alzheimer's pathology is known, namely the use of Streptozotocin. Intracerebroventricular induction of strepzotocin in mice needs to be further understood. Material and Methods: The research method uses literature review with identification, screening, evaluation and interpretation of all research results collected through online search engines such as; Sciencedirect, Pubmed, GoogleScholar with keywords and meet the inclusion criteria Results: The results of the synthesis obtained selected data from 8 articles. ICV-STZ has been proven from various studies to induce Alzheimer's pathology in both young and old male mice through neuroinflammatory pathways, oxidative stress, increasing Aβ expression and hyperphosphorylation of Tau as Alzheimer's markers which are similar to clinical patients. Keywords : Alzheimer, Hewan model, Literatur review, Mencit, Streptozotocin.
Co-Authors A.S. Satyaningtijas Abdul Zahid Abidah, Puri Adzrok ACHMAD FARAJALLAH Afiff , Usamah Afrilia Bagus Putri Hapsari Agik Suprayogi Agung Eru Wibowo Agus Wijaya Ainul Khadija Saleema Akhiruddin Maddu Aldo Febriano Tarigan Alfarisi, Hamzah Amalia Khairina Amrozi Andayani, Prawita Lintang Anindita Sista Widyadhari Anindita Sista Widyadhari Annisa Madyanti Geminastiti Parampasi Ardilasunu Wicaksono Asah Hilaliah Athirah Rerana Fitrianthy Aziz, Sandra Dalia Sukmawati Damhuri Damhuri Damiana Rita Ekastuti Daryanti, Edhita Putri David Anwar Denny Widaya Lukman Denny Widya Hikman Desrayni Hanadhita Dhani S. Wibawa Dwi Nurhidayah Zubaidah Edi Sukmawinata Edi Sukmawinata Elok Budi Retnani Etih Sudarnika Farida Cintiyah Gandasari, Ira Agustina Dewi Gilang Kala Maulana, Gilang Kala Hadri Latif heny Nitbani HERA MAHESHWARI Herwin Pisestyani Huda Shalahudin Darusman I wayan Teguh Wibawan Ika Mayasari, Ni Luh Putu Ikhwan Wirahadikesuma ikhwan wirahadikesuma Imelda Yanti Lumongga Simanjuntak Irfan Nurhidayat, Irfan Irwan Oktoni Isdoni Bustaman Isnaeni Isnaeni Isnaeni Jefri Naldi Jumadin, La Jumardin jumardin jumardin Kholidah Fauziah Komariah komariah komariah Kudang Boro Seminar Kusnandar Anggadiredja La Jumadin La Jumadin La Jumadin La Jumadin Lili Darlian Lili Darlian M. Ichwan Mutaqqin MADE ASTAWAN Made Darawati Maharani Salsabila Mahendra, Arindina Maneewong, Sattabongkoch Maria, Joanita Maryce Agusthinus Walukou Mawali, Maharja Mokhamad Fakhrul Ulum, Mokhamad MUHAMMAD AGIL Muhammad Primadevan Pascaharchana Noor Nadhear Nadadyanha Dannar NASTITI KUSUMORINI Nenis Rahma Wulandari Niken Ulupi Nugraha, Arifin Budiman Nuri Ardiani Nurul Masyita, Nurul Okta Irviana Muminin Okti Nadia Poetri Ong Huey, Lynette Pudji Achmadi Putri, Anisya Saeila Putri, Fatimatus Sa’diyah Putri, Maritrana Rahmadhani, Elsi Rani Audona Rasyida Ulfa Ratasha Zahwanda Rachmani Ridi Arif Ridzky Pratama Risqika Akla Velayati Rivangga Yuda Hendika Ronald Tarigan Rotinsulu, Dordia Anindita Sadiah, Siti Santoso, Hera Sasmita, Annissa Nuridfi Satvika, Fadhila Saut Renato Rahmat Simanjuntak sri murtini . Supiyani, Atin Tarigan, Ronald Tutik Wresdiyati Ulfatin Khoiriyah Herowati Umi Cahyaningsih Warysatul Ummah Wasmen Manalu Wijaya, Yanuar Restu Yulvian Sani Yusuf Ridwan Zora, Nelda Fliza Zulvia Maika