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All Journal Jurnal Ilmu Pertanian Indonesia FORUM STATISTIKA DAN KOMPUTASI Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kimia (Journal of Chemistry) International Journal of Renewable Energy Development SAINS DAN MATEMATIKA JURNAL KIMIA SAINS DAN APLIKASI Jurnal Ilmu Lingkungan The Journal of Pure and Applied Chemistry Research agriTECH INDONESIAN JOURNAL OF PHARMACY Indonesian Journal of Chemical Science Indonesian Journal of Chemistry Jurnal Agroqua: Media Informasi Agronomi dan Budidaya Perairan Jurnal Ilmiah Pesantren Jurnal Ilmu dan Teknologi Kayu Tropis Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Media Agribisnis RESEARCH AND DEVELOPMENT JOURNAL OF EDUCATION (RDJE) Jurnal Pengabdian Polinema Kepada Masyarakat Prosiding Seminar Nasional Sasindo Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan
Mohamad Rafi
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Bogor
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
OPTIMIZATION OF EXTRACTION CONDITIONS FOR ANDROGRAPHOLIDE USING FRACTIONAL FACTORIAL DESIGN Mohamad Rafi
Indonesian Journal of Pharmacy Vol 25 No 3, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (674.243 KB) | DOI: 10.14499/indonesianjpharm25iss3pp145

Abstract

Andrographolide is a major bioctive compound found in king of bitter (Andrographis paniculata). In this study, the extraction method and its condition were investigated in order to get an extract with maximum amount of andrographolide by comparing three other extraction methods, i.e. maceration, soxhletation and ultrasonication and also determination for the optimum condition of the selected extraction method. The highest andrographolide amount was found by maceration, so this method was choosen for further optimization of extraction condition. The optimum condition based on the prediction amount from 27 factor combinations was obtained in 360 times of extraction time, 2g/100mL of sample to solvent ratio, and 3fold of extraction frequency with prediction of andrographolide amount was 3.50%. While by using prediction profile, the optimum condition was obtained in 360min of extraction time, 2 g/100mL of sample and solvent ratio, and 4 times of extraction frequency with the amount was 3.47-3.74%.
Co-Authors A. Wahyuningrum Abdul Rohman Abdul Rohman Abdul Waris Adi Novriansyah Agus Jatnika Effendi Agus Mohamad Soleh Alfi Hudatul Karomah Ali Miftahudin Allen Kurniawan Amalia Yunita Amrullah Amrullah Antonio Kautsar Aryo Tedjo Asefin Nurul Ikhtiarini Atang Sutandi Auliatifani, Reza Auliya Ilmiawati Baba Barus Bambang - Riyanto Bambang Prajogo Eko Wardoyo Cahya Septyanti Cecep Abdurohman Putra Derry Permana Dewi Anggraeni Septaningsih Dewi Pusparani Sinambela Dien Atin Boritnaban Djoko Santosa Dyan Fitri Nugraha E. Rohaeti Edy Djauhari Purwakusumah Edy Djauhari Purwakusumah Edy Djauhari Purwakusumah Esti Mumpuni Eti Rohaeti Fadila Karunina Fifi Gus Dwiyanti Hanifullah Habibie Henny Purwaningsih Herdiyanto Herdiyanto Heriyanto Syafutra Ikrar M. Saleh Indah Mutiara Ningtyas Razaad Irma Herawati Suparto Irmanida Batubara Irnawati Irnawati ISKANDAR ZULKARNAEN SIREGAR Khaydanur, Khaydanur Khoirotul Muzayanah L. K. Darusman Latifah K Darusman Latifah K Darusman Latifah K. Darusman Latifah K. Darusman Latifah Kosim Darusman Latifah Kosim Darusman Latifah Kosim Darusman Latifah Kosim Darusman Lee Wah Lim Liliek Nurhidayati Lisa Aprilia Indriyani Lusi Royani M. Agung Zaim Adzkiya Maeda Wahyuningrum Makmum Syafi’i Maya Melati Muhamad Insanu Muhamad Noor Azizu, Muhamad Noor Muhammad Bachri Amran Muhammad Fuad Zaini Muhammad Majiidu Nancy Dewi Yuliana Nanik Siti Aminah Neliwati Nengsih, Nunuk Kurniati Nita Hestiyana Nurameylia Rasaidi Nurhajawarsi Nurhajawarsi Nurmaida Nurmaida Nursifa Mawadah Partomuan Simanjuntak Parwito Purnomo, Tsania Firqin Putra Astaman Putri Vidiasari Darsono R. Heryanto Rifki Husnul Khuluk Rita K Sari Rizka Wildani Rizky Kurniawan Murtiyanto Rizna Azrianiningsari Roza Linda Roza Linda Roza Yusfiandayani Rudi Heryanto Sandra Arifin Aziz Septaningsih, Dewi Anggraini Setyaningsih, Widiastuti Shinta Maharani Trivena Sifa Awalul Fikriah Siti Norazian Ismail Slamet Ari Dwi Ratnanto SUMINAR SETIATI ACHMADI Suyanti Natalia Syamsudin Abdillah Syamsudin Abdillah Syifa Muflihah Taopik Ridwan Tatik Raisawati Toyohide Takeuchi Tun Tedja Irawadi Umi Khabibah Usman Ahmad Utami Dyah Safitri Utami Dyah Syafitri Waras Nurcholis Widia Citra Anggundari, Widia Citra Wina Yulianti Wisnu Ananta Kusuma Wulan Tri Wahyuni Wulansari, Laela Yanuar Chandra Wirasembada Yashinta Fitriani Yulita Suyatmika Zulhan Arief Zulhelmi Aziz Zulliati Zulliati