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All Journal HAYATI Journal of Biosciences Media Veteriner Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Veteriner Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) Journal of Indonesian Tourism and Development Studies Biotropika Wacana, Jurnal Sosial dan Humaniora Journal of Degraded and Mining Lands Management Journal of Innovation and Applied Technology Jurnal Pembangunan dan Alam Lestari Natural B AGRIVITA, Journal of Agricultural Science UNEJ e-Proceeding Berkala Kedokteran Jurnal Triton Berkala Penelitian Hayati Jurnal Kedokteran Hewan

Moch Sasmito Djati

Biology Department, Faculty Of Mathematics And Natural Science, Brawijaya University, Malang

Author-ID : 254853

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary Other

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The Immunomodulatory Effect of Elephantopus scaber and Sauropus androgynus Extract to Cellular Immune Response in Pregnant Mus muscullus Infected by Salmonella typhimurium Jannah, Nur; Djati, Moch. Sasmito; Widyarti, Sri
The Journal of Experimental Life Science Vol. 6 No. 1 (2016)
Publisher : Graduate School, Universitas Brawijaya

Pregnancy has a high risk and is more susceptible to infectious diseases. E. scaber and S. androgynus contains saponins and flavonoids as an immunomodulatory that can increase the body's immunity. The purpose of this study is to determine the immunomodulatory effects of E. scaber and S. androgynus leaf extract against cellular immune response in pregnant mice infected S. typhimurium. This research used seven treatment groups including negative control (K-) mice without injected S. typhimurium, positive control (K+) mice were injected S. typhimurium and extract treatment with 5 variant doses and dissected on the 12th and 18th days. Lymphocytes was isolated from the blood, then relative number of CD4+ and CD8+ were analyzed with flow cytometry and data continued with ANOVA. Statistical analysis showed that different extract dose and duration of treatment had a significant effect on the number of CD4+ and CD8+ T cells. E. scaber and S. androgynus act as immunomudulatory effect and treatment with combination of extracts E. scaber and S. androgynus 50 mg.kg-1 BW + 112.5 mg.kg-1 BW respectively and treatment with extract of S. androgynus 150 mg.kg-1 BW are the optimum treatment which can restore immune system conditions such as normal pregnancy without infection.Keywords: Cellular Immune, E. scaber, Immunomodulatory, S. androgynus, S. typhimurium.

Tapak liman (Elephantopus scaber L) Extract Induced CD4+ and CD8+ Differentiation from Hematopoietic Stem Cell/Progenitor Cell Proliferation of Mice (Mus musculus) Djati, M. Sasmito; Habibu, Hindun; Jatiatmaja, Nabilah A; Rifai, Muhaimin
The Journal of Experimental Life Science Vol. 5 No. 2 (2015)
Publisher : Graduate School, Universitas Brawijaya

Tapak liman (Elephantopus scaber L) is one of the traditional medicinal plants, which are containing several active compounds that potentially affecting hematopoietic. The aims of this study are to elucidate the effect of leaf extract of Tapak Liman on hematopoietic in mice BALB/c, by observation on relative number of cells expressing CD4/CD8, CD4/CD62L, and TER119/B220 in the spleen; TER119/B220, TER119/VLA-4 and TER119/CD34 in bone marrow, after given the leaf extract for 2 weeks. This experiment was used 12 female mice, which is divided on 3group treated with leaf extract of Tapak Liman (P1= 0.5 g. g bw-1.day-1, P2= 1.0 g. g bw-1.day-1 and P3 = 2.0 g. g bw-1.day-1) and control. The relative numbers of cells expressing surface molecules were analyzed by flowcytometry and quantitative data were tested using one way ANOVA. The result showed the leaf extract of Tapak Liman has no significant effect on erythrocyte proliferation, on the other hand it have significant effect on both proliferation and differentiation of B lymphocytes (B220+) in the bone marrow (p=0.044) and increase the expression of CD4+, CD8+molecule in B cells (p=0.026) and erytroid (TER119+VLA-4+) in spleen and bone marrow. The administration of 1 g. g bw-1.day-1 of the extract (P2) stimulate proliferation of lymphocytes and erythrocytes lineage (TER119+VLA-4+), in spleen and bone marrow.Keywords: CD4+, CD8+, Elephantopus scaber, erythrocyte, hematopoiesis.

Modified Risk Factors for Coronary Heart Disease (CHD) in Minahasa Ethnic Group From Manado City Indonesia Nelwan, Ester Jeini; Widjajanto, Edi; Andarini, Sri; Djati, M. Sasmito
The Journal of Experimental Life Science Vol. 6 No. 2 (2016)
Publisher : Graduate School, Universitas Brawijaya

Coronary heart disease (CHD) is a non-transmitted disease which is particular concern at the global, national, and local level. CHD has become a concern because it has caused a lot of deaths. Risk factors linked with CHD consist of permanent risk factors and variable risk factors. The purpose of the research is to analyze the correlation between variable risk factors and CHD in the Minahasa ethnic society in Manado City. This research was an observational case-control study conducted by Prof. dr. R. D. Kandou Hospital, Manado, from August to October 2016. In total, there were 220 patients included. The sampling used a simple random sampling method and the data obtained were analyzed by chi-squared test. According to the results, hypertension, smoking, and behavioral type were connected to cases of CHD. The correlation degree showed that the respondents suffering hypertension were 5.70 times more likely to suffer CHD, the smoking respondents were 2.25 times more likely to experience, and behavior type A respondents were 2.96 times more likely to suffer CHD. Hypertension, smoking, and behavioral type are linked with CHD, so there should be some promotion and preventive actions from the health governmental institution to society, especially aimed at adults, about the quality of life enhancement by healthy behavior and avoiding CHD risk factors. Keywords: behavioral type, Case-control study, hypertension, smoking behavior.

The Effect of E. scaber Extract to TNF-α and TGF-β on Mice under Carcinogen Treatment Amalia, Rizki; Widyarti, Sri; Djati, Moch. Sasmito
The Journal of Experimental Life Science Vol. 8 No. 2 (2018)
Publisher : Graduate School, Universitas Brawijaya

Carcinogen compounds are the compounds that cause DNA damage and trigger cancer. TNF-α and TGF-β are cytokines produced by immune cells and serve to maintain body homeostasis. Elephantopus scaber is a plant that prevents the cancer progression, and improve the body's immune system, so this study was conducted to determine the effect of E. scaber extract on TNF-α and TGF-β after the administration of carcinogen compounds. The study was conducted by administering the carcinogen compound DMBA with a dosage of 0.56 mg kg-1 BW and estradiol with a dose of 0.0504 mg kg-1 BW which was given alternately for 8 weeks to the Mus musculus test animals. The study was conducted in 3 groups: K- (the normal group of mice), K + (a carcinogen-induced group of mice), and P (a group of carcinogen-induced mice and E. scaber extract). The treatment was done in 1 week, 2 weeks, and 3 weeks. Immune cells were isolated from splenocytes and performed immunostaining for flow cytometry analysis. The computed relative amount is TNF-α produced by macrophages CD11b and TGF-β produced by Treg CD4CD25. The relative number of cells was analyzed by two-way ANOVA and advanced Tukey test with 95% confidence level (α = 0.05). The results showed no significant differences in the number of cytokines TNF-α and TGF-β in both the carcinogen-induced mice group and the mice group was given the extract of Elephantopus scaber for 1 week, 2 weeks and 3 weeks. Keywords: Carcinogen, Elephantopus scaber, TNF-α, TGF-β

Effects of Monosodium Glutamate Oral Administration on LH and Testosterone Levels in Serum of Adult Male Rats (Rattus norvegicus) Annisa, Riska; Djati, Moch. Sasmito; Rahayu, Sri
The Journal of Experimental Life Science Vol. 9 No. 2 (2019)
Publisher : Graduate School, Universitas Brawijaya

This study aims to determine the effect of monosodium glutamate on LH and testosterone levels in serum of adult male rats (Rattus norvegicus). A total of 12 male Wistar-strained rats divided into three groups with 4 rats per group. Control group was given distilled water, while M1 was given MSG at a dose of 4mg g-1 BW for 15 days and M2 was given MSG at a dose of 4 mg g-1BW for 45 days. All substances were given orally. At the end of the study, rats were sacrificed with a dislocation to draw blood from the heart. Then, the blood was incubated at room temperature to obtain serum. Serum was used to analyze LH and testosterone levels using the ELISA kit. Data were analyzed using one way ANOVA (p ≤ 0.05) with SPPS 16.0 for windows. The results showed that serum LH levels after MSG treatments for 45 days was significantly decreased compared with the control. The serum testosterone levels M2 was significantly difference with the control group (p ≤ 0.01). This study predicts that monosodium glutamate have a direct and indirect effect on male reproductive organs. Keywords: Luteinizing hormone, Monosodium glutamate, testosterone.

Assessment of Water Quality Using Benthic Macroinvertebrate Along Sumber Maron River, District of Gondanglegi Kulon, East Java-Malang, Indonesia Tawati, Faiza; Risjani, Yenny; Djati, M Sasmito; Yanuwiadi, Bagyo
The Journal of Experimental Life Science Vol. 10 No. 1 (2020)
Publisher : Graduate School, Universitas Brawijaya

Human activities such as agriculture, swimming, livestock, public washing, and the use of latrines around the river are considered as major causes of damage to the river ecosystem, affecting the growth of Macroinvertebrate, and thus assessing the condition of the river. This study aimed to study the composition of Macroinvertebrate and the quality of water health in Sumber Maron River, in the village of Gondanglegi. This research was conducted from March to April 2018. The method used in this research was the quantitative method using primary data. Research stations were identified by considering land-use in nine regions. The sampling technique of total macroinvertebrates was the kicking technique using the manual mesh with a 500 µm applied to the submerged solid substrates. The data were analyzed using a BMWP Index and interpreted by calculating the Average Scores Per Taxon (ASPT). The result of this research represented that there were 20 taxa of macroinvertebrates, which consisted of It belongs to 8 orders (Trichoptera, Coleoptera, Diptera, Tricladida, Decapoda, Odonata, Ephemeroptera, Plecoptera) and four class (Oligochaeta, Hirudinea, Gastropoda, Crustacea). Generally, the lowest taxa groups found in the station A1 (3 taxa), which were the agriculture and toilet (recreation area). Meanwhile, the highest taxa groups were found in station B3, which was the recreation area, by a total of 14 taxa. Macroinvertebrate with the lowest abundance was Gerridae at station A3, which respectively had the number of 1 ind.5m-2. Macroinvertebrate with the highest abundance was Baetidae at the station B3, which is the recreation area, by the number of 549 ind.5m-2. The result of modified BMWP - ASPT analysis showed a value of 3.3 - 5.75, which indicated that the condition of Sumber Maron River was ranging from bad to excellent category. The bad water condition was found in the agriculture and toilet (recreation area), whereas the excellent water condition was found in the swimming pool (recreation area). Canonical Correspondence Analysis (CCA) revealed that environmental variables were significant for an explanation of the variance in the family. Keywords: BMWP-ASPT, Macroinvertebrate, River.

In Silico Study to Predict the Potential of Beta Asarone, Methyl Piperonylketone, Coumaric Acid in Piper Crocatum as Anticancer Agents Abkar, Ahmed Hasan; Djati, Moch. Sasmito; Widodo, Widodo
The Journal of Experimental Life Science Vol. 11 No. 3 (2021)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2021.011.03.04

Piper Crocatum Ruiz & Pav leaves often be used to treat various diseases, including cancer, empirically. This study aimed to analyze the anticancer activities of Piper Crocatum bioactive compounds via In Silico analysis. The methods were biological activity analysis, cell line cytotoxicity activity, SwissADME, STITCH, molecular docking, and molecular dynamics simulation. The investigated bioactive compounds were Î²-asarone, methyl piperonylketone, and coumaric acid. The results showed the biological activities of the compounds related to anticancer were anti-mutagenic, TNF expression inhibitive, and MMP9 expression inhibitive. The prediction of cytotoxicity analysis results showed that investigated bioactive compounds were toxic on various tumor cell lines. Based on swissADME results, almost all compounds have good pharmacological properties, except coumaric acid. Docking analysis demonstrated the presence of bioactive compounds inhibited TNFa, HER2, and MMP9 as the target protein. The molecular dynamic result was confirmed using molecular dynamic and it shows that β-asarone interaction was stable against MMP9 and TNF protein showed by the low RMSD value. The study found the investigated bioactive compounds of Piper crocatum have the activity of anti-cancer via the inhibition of TNFa and MMP9 protein. However, further research still needs to be done to confirm the prediction results of this In Silico study. Keywords: anticancer, In Silico, molecular docking, Piper crocatum.

Sustainable groundwater management policy strategy in confined aquifers: A SWOT analysis approach Saves, Faradlillah; Bisri, Mohammad; Siswoyo, Hari; Djati, Moch Sasmito
Journal of Degraded and Mining Lands Management Vol. 13 No. 2 (2026)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15243/jdmlm.2026.132.9943

Groundwater management in confined aquifers in Probolinggo Regency is currently under significant pressure due to industrial growth and the impacts of climate change. This study aimed to formulate adaptive policy strategies by synergizing internal technological strengths and the latest regulatory dynamics. The scope of the experiment included identifying internal and external strategic factors through structured interviews and literature reviews validated by technical stakeholders. The method used was the Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis, using the internal factor analysis strategy and external factor analysis strategy matrices to determine the organization's position on the Cartesian diagram. The results of the study showed that internal strengths recorded a total score of 2.4498, while external opportunities recorded a total score of 0.7199. The position analysis places groundwater management in Quadrant I (aggressive) with coordinates (2.3170; 0.5929). The main findings indicated that the organization has a significant competitive advantage through the integration of geospatial data and cutting-edge sensor technology. The formulated strategy includes a transformation towards digital-based management, strengthening science-based conservation through injection technology, and diversifying external funding. This study concludes that implementing aggressive strategies that integrate technological innovation and law enforcement is essential to ensure aquifer sustainability and mitigate the risk of seawater intrusion. The use of this policy roadmap is expected to serve as a guide for local authorities in realizing sustainable groundwater management amid the threat of overexploitation.

Co-Authors Abkar, Ahmed Hasan Achfas Zacoeb Agatha Maria Dian Kusumawati Ahmad Imron Rozuli Ahmad Rudijanto Ahmad Shobrun Jamil Ahmad Soni Ahmad Soni Amin Setyo Leksono Amin Setyo Leksono Aminullah, Lela - Anak Agung Gede Sugianthara Andi Rizki A, Pradana Andi Rizki Adi Pradana Andi Rizki Adi Pradana, Andi Rizki Andi Rizki Adi Pradana, Andi Rizki Adi Anis Artiyani Annisa, Riska Annisa, Yuslinda Aris Soewondo Asfi, Nida Asyhari, Firda Nuri Aya shofiyah Azerlyn, Defiona Rensia Naomi Bagyo Yanuwiadi Chomsa Dintasari Umi Baszary Chomsa Dintasari Umi Baszary Dewi Liesnoor Setyowati Dewi Mustikaningtyas Dinia Rizqi Dwijayanti Dliyauddin, Moh Edi Widjajanto Edi Widjajanto Eko Ganis Sukoharsono Eko Puji Astuti El Baroroh, Alif Rosyidah Erin Kurnianingtyas Erly Nur Aisyah Fatchiyah Fatchiyah Gato Gato Grahadi, Rahmat Habibu, Hindun Hafil Kusuma, Kavana Handono Kalim hari siswoyo Hendra Susanto Henny Johanna Kambey Herminah Febrianty Herminah Febrianty, Herminah HUSNUL KHOTIMAH Ida Idewa Agung Willy Pramana Ika Christina, Yuyun Indriati Dwi Rahayu Izzah, Fathiyah Nurul Jamhari Jamhari Jatiatmaja, Nabilah A Kambey, Henny Johanna Kamila, Fairuz Sarah Khodijah, Riska Amalia Kliwon Hidayat Kusuma, Kavana Hafil Kuswati Kuswati Lulut Dwi Nurmamulyosari Lulut Dwi Nurmamulyosari, Lulut Dwi M Aris Widodo Mansur Ibrahim Marlita Marlita, Marlita Miasih, Dewi Sekar Minang, Bony Zulkarnaen Mohammad Bisri Mohammad Rasjad Indra Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin RifaÃ¢Â€Â™i Muhaimin Rifa’i Muhaimin Rifa’i Muhaimin Rifa’i Muhammad Basyaruddin, Muhammad Muhammad Basyarudin Muhammad Halim Natsir Mutya Farsely Nabilah, Sarah Nahdah Nafisah, Wirdatun Nashi Widodo Nelwan, Ester Jeini Nida Asif Noer Hasanah Nur Hidayat Nur Jannah Nur Jannah Nurul Faizah NURUL FAIZAH Oktavia Fitri Santika Petrus Sadsoeitoeboen Pramana, Ida Idewa Agung Willy Prima, Alex Putri, Nenis Try Melani Rachmawati , Hidajah Retno Anggraini Retty Ratnawati Rifa'i, Muhaimin Rifa'i, Muhaimin Rifa'i, Muhaimin - Rifai, Muhaimin Rifa`i, Muhaimin Rifa’i, Muhaimin Rini Dwi Wahyuni Ririn Rochmawati Rizki Amalia Rizqi Dwijayanti, Dinia Rochmatika, Lailiyavina Roffico Roffico Rohmah, Ilmiana Nurur Rony Irawanto Rooije R.H. Rumende Rosyadah, Nuraini Satuman Satuman Saves, Faradlillah septi utami dewi Shofiyah, Aya Siti Aisah SITI AISAH SN Nurul Makiyah soehartojo Hardjopranjoto Soemarno Soemarno Soemarno Soni, Ahmad Sri Andarini SRI RAHAYU Sri Rahayu Sri Rahayu Lestari Sri Wahjuningsih Sri Widyarti Sunaryono Sunaryono, Sunaryono Susanti, Winda Karina Susilo Sutiman B. Sumitro Sutiman Bambang Sumitro Swastika Pinca Pinca Swastika Pinca Pinca Syabril Ulum, Akhdiyat Syamsul Arifin Tawati, Faiza Tri Eko Susilorini Turniningtyas Ayu Rachmawati Warsito Warsito Widodo Widodo Widya Ayu Prasdini Widyananda, Muhammad Hermawan Wike andre Septian Yayu Fuadah Yayu Tsamrotul Fuadah, Yayu Tsamrotul Yenny Risjani Yuli Prayitno Yuyun Ika Christina Zulfatim, Heni Sukma

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