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All Journal HAYATI Journal of Biosciences Health Science Journal of Indonesia Indonesian Journal of Tropical and Infectious Disease Medula JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) The Indonesian Biomedical Journal BIOMA : Jurnal Biologi Makassar Nusantara Medical Science Journal Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Paediatrica Indonesiana Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Indonesian Contemporary Nursing Journal (ICON Journal) Jurnal Ilmu Alam dan Lingkungan Biosaintifika: Journal of Biology & Biology Education Alami Journal (Alauddin Islamic Medical) Journal Nurse and Health: Jurnal Keperawatan JKM (Jurnal Kebidanan Malahayati) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Biomedika Jurnal Riset Kesehatan Poltekkes Depkes Bandung Poltekita : Jurnal Ilmu Kesehatan Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal ABDINUS : Jurnal Pengabdian Nusantara Journal of Telenursing (JOTING) Indian Journal of Forensic Medicine & Toxicology Jurnal Midwifery Narra J Sasambo Journal of Pharmacy Jurnal Medika: Media Ilmiah Analis Kesehatan
Muh. Nasrum Massi
Microbiology Department, Faculty Of Medicine, Universitas Hasanuddin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Single-nucleotide polymorphism of interleukin-10 promoter (IL-10 -819C/T) in leprosy patients with and without erythema nodosum leprosum, and household contacts Arif, Sitti M.; Massi, Nasrum
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.276

Abstract

Leprosy, caused by Mycobacterium leprae, is a chronic infectious disease that impacts the skin and peripheral nerves, causing long-term disability. The invasion of M. leprae into the body triggers immunologic responses and single single-nucleotide polymorphisms in cytokine-encoding genes may influence predisposition and susceptibility, possibly predicting the incidence of leprosy reactions. The aim of this study was to assess the gene polymorphism of interleukin-10 promoter IL-10 −819C/T in leprosy patients, leprosy patients with erythema nodosum leprosum (ENL) reaction, and household contacts. A total of 54 individuals were included, with 18 in each group. Skin smear and histopathologic examinations were used to confirm the diagnosis of leprosy and ENL. The polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) technique was used to determine the polymorphism. The results confirmed the presence of polymorphism of which all TT, CT, and CC genotypes presented. The TT genotype was most prevalent in household contacts (94.4%) followed by ENL (50%), and leprosy patients (44.4%). The CT genotype was most frequently detected in leprosy patients (50%), followed by ENL cases (44.4%), and household contacts (5.56%). In contrast, CC was mostly presented in ENL cases (5.56%), only 1% in leprosy patients, and absent among household contacts. Although the most prevalent allele in all three groups was the T allele, the C allele presented in 27% and 30% of ENL and leprosy patients, respectively and only 5% in household contact individuals. This study suggests that the polymorphism variations of IL-10 −819C/T are higher in leprosy and ENL patients compared to household contacts. Since this data is preliminary, larger studies are needed.
Co-Authors Adyatma Muhammad Nur Agus Sangka Pratama Ahmad, Mardiana Ahyar Ahmad Alwi A Mappiasse Amiruddin Laompo Anas, Lukman Andi Alfian Zainuddin Andi Ariyandi Andi Asadul Islam Andi M Ichsan Andi Nilawati Usman Andi Nur Asrinawaty Andi Rofian Sultan Andi Zulkifli AS Anita Anita Ari Yuniastuti Arif, Sitti M. Arsyad, Andi Fatimah Asaad Maidin Asty Amalia Nurhadi Azhar, Muh. Aprizal Baedah Madjid Bahrul Fikri Budu - Budu Budu Bukhari, Agussalim Chalid, Maisuri Tadjuddin Conny Tanjung Dasril Daud DAVID HANDOJO MULJONO Dewi Mutisari Dian Amelia Abdi Diana Muchsin Dwi Kesuma Sari Eddyman W Ferial Faisal Attamimi Faradillah Suhar Febriani, Dwi Bahagia Ferra Indrawati Fikri, Bahrul Firdaus Hamid Firdaus Kasim Furqan Zakiyabarsi Gemini Alam Gemini Alam Habibah S Muhiddin Hendra Wibawa Herlina Rante Hidayah, Najdah Hursepuny, Valentine Ibrahim Labeda Idham Jaya Ganda Ilhamjaya Patellongi Ilhamjaya Pattelongi Irawan Yusuf Irawati Djaharuddin Irma Andriani Irma Andrianys Kasmiati Kasmiati Khairuddin Djawad Khairuddin Djawad Kusrini S. Kadar Latief, Nikmatia Linda Runtuwene Lisa Tenriesa Lokita Purnamasari Luthfi, Muhammad M Natsir Djide Marcellus Simadibrata Mardiana Ahamad Mardiana Ahmad Mardiana Ahmad Meutiah Ilhamjaya Mochammad Hatta Mochammad Hatta Mochammad Hatta Muflihanah Muhammad Akmal A. Sukara Mustika Hutabarat Sari Mustika Sari Nadirah Rasyid Ridha, Nadirah Rasyid Nadyah Nasir Djide Nilawati Usman Nilawati, Andi Norma Tiku Kambuno Nur Fajri Nurfadillah S Nurmadilla, Nesyana Nurpajri, Nurpajri Palantei, Elyas Palulun, Prajayanti Pattelongi, Ilhamjaya Prihantono Prihantono Putri, Sri Hardiyanti Raden Tina Dewi Judistiani Rahmawaty Rahimi Rahmi Rahmi Rajia Rasita, Yoeke Dewi Ratna Ridha Wahyuni, Ridha Rina Masadah Rinda Nariswati Ritha Pratiwi Riza Linda Rizalinda Sjahril Rizalinda Sjahril Rosana Agus Rosdiana Natzir Rusdianto Rusdianto Safruddin Amin Saidah Syamsuddin Samara, Yulianti Sari Handayani Sartini Sartini Sharvianty Arifuddin Sharvianty Arifuddin Shelly Salmah Sjafaraenan Sjafaraenan, Sjafaraenan Solly Aryza Sri Vitayani Suanti Sudirman Katu Sudirman Katu, Sudirman Suhuyanly, Nella Supri Suryani As'ad Syahril, Rizalinda Syakib Bakri Tjahjadi Robert Tedjasaputra Turyadi Turyadi, Turyadi UPIK ANDERIANI MISKAD, UPIK ANDERIANI Veni Hadju Wardihan Sinrang Yenti Purnamasari Yoeke Dewi Rasita Zakiani Sakka