Article Per Year (5 Year)
p-Index From 2021 - 2026
2.619
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences Torani Journal of Fisheries and Marine Science Media Penelitian dan Pengembangan Kesehatan Jurnal Fitofarmaka Indonesia Indonesian Journal of Chemistry ANNALES BOGORIENSES Dinamisia: Jurnal Pengabdian Kepada Masyarakat Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Riset Kesehatan Poltekkes Depkes Bandung Sainstech Farma: Jurnal Ilmu Kefarmasian Narra J Jurnal Ilmiah Kesehatan (JIKA) Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Journal of Pharmaceuticals and Natural Sciences Jurnal Kefarmasian Indonesia Annales Bogorienses
Berna Elya
Fakultas Farmasi Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 44 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 44 Documents
Search

 1   2   3   4   5 
Antibakteri Ekstrak Kulit Batang Manggis Hutan (Garcinia rigida miq.) Elya, Berna; Soemiati, Atiek; Farida, Farida
Majalah Ilmu Kefarmasian Vol. 6, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A research on the antibacterial activity of n-hexane extract and the ethyl acetate Garcinia rigida Miq. Bark against Salmonella typhosa ATCC 14028, Staphylo-coccus aureus ATCC 29213 dan Bacillus subtilis ATCC 6633 has been carried out. The research was included the determination of the growth inhibition zona with the cylinder diffusion method and the minimum inhibitory concentration with the petri dish dilution method. The result of this study showed that the n-hexane extract of Garcinia rigida Miq.bark did not give the growth inhibition zona to Salmonella typhosa ATCC 14028, Staphylococcus aureus ATCC 29213 and Bacillus subtilis ATCC 6633, but gave the minimum inhibitory concentration at 500 mg/ml for Sal-monella typhosa ATCC 14028, 250 mg/ml for Staphylococcus aureus ATCC 29213 and 125 mg/ml for Bacillus subtilis ATCC 6633. Whereas the ethyl acetate extract of Garcinia rigida Miq. bark gave the growth inhibition zona of concentra-tion 500, 250 and 125 mg/ml with average diameter to Salmonella typhosa ATCC 14028 were about 11.15, 9.05, 7.55 mm, to Staphylococcus aureus ATCC 29213 were about 14.25, 11.10, 8.95 mm and to Bacillus subtilis ATCC 6633 were about 20.97, 15.00, 10.07 mm. The minimum inhibitory concentration to ethyl acetate extract to Salmonella typhosa ATCC 14028, Staphylococcus aureus ATCC 29213 and Bacillus subtilis ATCC 6633 were about 250, 62,5 and 31,25 mg/ml respec-tively. As a conclusion, the ethyl acetate extract of Garcinia rigida Miq. bark had more better antibacterial activity than the n-hexane extract of Garcinia rigida Miq. Bark.
Uji Aktivitas Penghambatan Enzim Alfaglukosidase Pada Beberapa Tanaman Suku Euphorbiaceae Elya, Berna; Katrin, Katrin; Bangun, Anastasia
Majalah Ilmu Kefarmasian Vol. 9, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus (types 1 and 2) is recognized as a serious global health problem that characterized by hyperglycemia. Type 2 diabetes is more common in diabetic populations. In type 2 diabetes mellitus, inhibition of α-glucosidase is a useful treatment to delay the absorption of glucose after meals. Avoiding the adverse effects of current agents, it is still necessary to search alternative for better options. Plants have been a rich source of α-glucosidase inhibitors. In this research, screenings based on chemotaxonomic approach to determine the class of chemical constituents and to know α-glucosidase inhibiting activity of some plants from Euphorbiaceae. The simplisia powder was extracted using ethanol 80% by reflux. Measurement of inhibitory activity of α-glucosidase performed using a spectrophotometer UV-VIS. In vitro assays of α-glucosidase activity showed 14 extracts had IC50 values of between 2.34 µg/mL and 64.78 µg/mL, which were lower than that of acarbose (117.20 µg/mL). Leaves extract from Antidesma celebicum had the highest α-glucosidase inhibiting activity with an IC50 of 2.34 µg/mL. The results of phytochemical screening in 15 extracts generally contain glycosides, terpenoids/ sterols, tannins, saponins and alkaloids.
Uji Stabilitas Fisik Losio Yang Mengandung Fraksi Diklorometana Ekstrak Metanol Kulit Buah Manggis (Garcinia mangostana L.) Apriyanti, Elis; Jufri, Mahdi; Elya, Berna
Majalah Ilmu Kefarmasian Vol. 9, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Mangosteen pericarp (Garcinia mangostana L.) contains some of xanthones derivates which have antioxidant activity.Those compounds prevent formation of free radicals that cause premature aging. Dichloromethane fraction from methanol extract of mangosteen pericarp has very strong antioxidant activity. Dicholomethane fraction of mangosteen pericarp was formulated into lotion dosage form with different concentration 0.01; 0.05; and 0.25%.. Physical stability of lotion was evaluated by cycling test, centrifugal test, and stored the lotions at low temperature (4±2˚C), room temperature (27±2˚C), dan high temperature (40±2˚C). The result showed that the lotions stable at each strorage condition and cycling test. However, the result of centrifugal test showed separation phase of lotions.
Uji Penghambatan Aktivitas alfa-glukosidase Ekstrak dan Fraksi Daun Antidesma neurocarpum Miq. Widihasputri, Rieka; Elya, Berna; Azizahwati, Azizahwati
Majalah Ilmu Kefarmasian Vol. 9, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a metabolic dysfunction disease showed by hyperglicemia and abnormality of carbohydrates, fats, and proteins metabolism. It is known can be cured with a-glucosidase inhibitor. Previous experiment reported that methanol extract from leaves of Antidesma neurocarpum Miq. has a strong inhibitory activity of a-glucosidase (IC50 = 2,18 mikrogram/mL). The aim of this experiment was to know about the most active extract and fraction of inhibitory activity of a-glycosidase and also the chemical compounds from those most active extract and fraction. Extraction is done by using multilevel maceration (n-hexane, ethyl acetate and methanol). Inhibitory activity of a-glucosidase tested with microplate reader at 405 nm wavelength. As standard, we used carbose (IC50=38.37 gg/mL). Methanol extract has the strongest inhibitory activity of a-glucosidase as shown the highest inhibitor percentage (89.53%). It is identified the chemical compounds and fracinationed by flash column chromatography. Fractination produced 15 combined fractions. Combined fractions which more than 200 mg tested to know their inhibitory activity of a-glucosidase. Result showed that the most active fraction is the 8th (IC50=40.77 gg/mL) with a competitive inhibitor mechanism to a-glycosidase. Chemical compounds that is found in the methanol extract and 8th fraction of Antidesma neurocarpum Miq. leaves are flavonoids, tannins, glycosides, fenol and alkaloids.
Uji Penghambatan Aktivitas alfa-glukosidase Ekstrak dan Fraksi Daun Antidesma montanum Blume Nofiantini, Nofiantini; Elya, Berna; Azizahwati, Azizahwati
Majalah Ilmu Kefarmasian Vol. 9, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

alpha-Glucosidase inhibitor has known to be a therapeutic agent for diabetes mellitus (DM) treatment, especially type 2 DM. Based on previous studies. There are various plants that have the effect of inhibiting the activity of a-glucosidase, one of which is garu leaves (Antidesma montanum Blume). This research aimed to get the fraction which had the highest Il-glucosidase inhibiting activity from ethanol extract of garu leaves and identify the chemical compounds from the most active fraction. Simplisia powder was extracted by maseration using 80% ethanol then fractionated using n-hexane, ethyl acetate, and methanol. Inhibitory activity test was performed by measuring absorbance of p-nitrophenol, which produced by reaction between Il-glucosidase and p-nitrophenyl-u-l)-glucopyranoside, using microplate reader at 405 nm. The result showed that ethyl acetate fraction have the best Il-glucosidase inhibitory activity with IC50 values 138.38 ppm. The test of enzyme kinetics showed that ethyl acetate fraction inhibited competitively. The phytochemical screening showed that ethyl acetate fraction of garu leaves contained glycosides, tannins, and terpenes.
Antifungal Activity of Polyscias scutellaria Fosberg Leaves Against Candida albicans Marcha Putri, Nada; Regita Putri, Jasmine; Elya, Berna; Adawiyah, Robiatul
Pharmaceutical Sciences and Research Vol. 7, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Polyscias scutellaria Fosberg is one of the indigenous plants from Indonesia that widely used as folk medicines for several illnesses. The leaves of P. scutellaria were previously studied as an antimicrobial agent. Nonetheless, this theory of antifungal activity has never been scientifically verified. This study aimed to evaluate the antifungal activity of P. scutellaria against Candida albicans. The leaves of P. scutellaria were macerated using an ethanol solvent. Then, the extract was evaporated and dissolved by 1% DMSO into different concentrations (100 μg/mL, 200 μg/mL, 400 μg/mL, 800 μg/mL, 1600 μg/mL, 3200 μg/mL, and 6400 μg/mL). Fluconazole, as a common antifungal treatment, was used as the positive control. The antifungal activity of P. sculletaria against Candida albicans was tested using well dilution and diffusion disc methods. Ethanol extract of P. scutellaria leaves showed antifungal activities against Candida albicans. It showed the minimum inhibitory concentration of above 6400 μg/mL and formed the inhibitory zone against Candida albicans. As a conclusion, ethanol extract of P. scutellaria has the potential to be used as an antifungal agent against Candida albicans.
Inhibitory and Anti-Biofilm Effects of Orthoshipon aristatus Against Candida albicans Rahmasari, Ratika; Chairunissa, Ananda Hanny; Irianti, Marina Ika; Forestrania, Roshamur Cahyan; Arifianti, Ayun Erwina; Suryadi, Herman; Makau, Juliann Nzembi; Jantan, Ibrahim; Elya, Berna
Pharmaceutical Sciences and Research Vol. 7, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

There are increasing number of reports on Candida albicans developing resistance to available anti-fungal drugs. Thus, there is an urgent need to discover new agents for treatment of candidiasis. The alcoholic extracts of Orthoshipon aristatus have been shown to exhibit antifungal activity against C. albicans by using the agar diffusion and broth microdilution methods. However, the underlying mechanisms of anti-C. albicans effect of O. aristatus have not been well understood. This study was aimed to evaluate the cytotoxic and anti-biofilm effects of the n-hexane and ethanol extracts of purple and white varieties of O. aristatus leaves and branches against C. albicans. The effect of n-hexane and ethanol extract against C. albicans growth was carried out by crystal violet viability assay. IC50 values of the most active extract, and nystatin and fluconazole as positive controls were also determined by the crystal violet assay. Evaluation of the anti-biofilm effect was performed by treating C. albicans with the extracts at adhesion, development, and biofilm maturation stages using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The n-hexane extract of the purple variety of O. aristatus leaves demonstrated the strongest cytotoxic activity against C. albicans amongst the tested extracts, with an IC50 value of 0.67 µg/mL. The extract also showed strong anti-biofilm effect as fluconazole, with pronounced inhibition at the adhesion stage and less activity at the biofilm development and maturation stages. These results suggested that the n-hexane extract of the purple variety of O. aristatus leaves could be explored for discovery and development of anti-C. albicans agent.
Dexamethasone and 5% NaCl Solution Induce Hypertension in Sparangue dawly Male Rats Imam Syafi'i; Fadlina Chany Saputri; Berna Elya
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.5975

Abstract

High blood pressure can be caused by excess salt intake Dexamethasone is a potent anti-inflammatory drug, but the long-term administration can cause hypertension. This study aims to determine the accurate time and dose that cause hypertension in rat models by administration of a combination of dexamethasone and 5% NaCl solution. The control group was administrated with aquadest orally, 3 test groups were administrated with dexamethasone at a doses of 0.02mg/kg BW, 0.03mg/kg BW, and 0.5mg/kg BW intraperitonially (i.p) for 28 days. A 5% NaCl solution were administrated instead of drinking water to the test group. Blood pressure and body weight were measured weekly for 28 days. Results of the study show that Dexamethasone at a dose of 0.02mg/kg BW caused hypertension on day-28 where the rats blood pressure increase to 148mmHg/103mmHg (±1.9/±3.1) (P0.05) compared to control rats and the weight decline by 90 grams. Dexamethasone 0.03mg/kg BW caused hypertension on day-21, with the increase of rats blood pressure at144mmHg/101mmHg (±2,6/±3.2) (P0.05) compared to control and the weight decrease by 83 grams.  Dexamethasone 0.5mg/kg BW caused hypertension on day-7, the rats blood pressure rise to 146mmHg/103mmHg (±1.6/1.9) (P0.05) compared to control and the weight decrease by 69 grams. As conclusion, Dexamethasone at dose of 0.5mg/kg BW and NaCl 5% cause hypertension faster on day 14 compared to dexamethasone at dose of 0.02mg/kg BW and NaCl 5% which cause hypertension slower after 28 days of administration.
Hanjeli, Rosela and Stevia Cultivation Training in Sasak Panjang Village, Bogor Regency: Pelatihan Budidaya Hanjeli, Rosela dan Stevia di Desa Sasak Panjang Kabupaten Bogor Roshamur Cahyan Forestrania; Febrina Amelia Saputri; Kartika Citra Dewi Permata Sari; Nisa Maria; Taufiq Indra Rukmana; Hindun Wilda Risni; Donna Maretta Ariestanti; Berna Elya
Dinamisia : Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 1 (2023): Dinamisia: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/dinamisia.v7i1.12947

Abstract

The community service program in Sasak Panjang Village, Bogor Regency, started with an assessment of the problems and potency of the village. These problems are the lack of close access to health care services and the failure to cultivate Family Medicinal Plants (FMP). According to The Ministry of Education and Culture program focus in 2022, it is necessary to carry out community service activities to increase the independence of public health efforts. Therefore, a community service program was performed through education, training, and mentoring for FMP cultivation to solve these problems. The success indicator of this activity was that the communities in Sasak Panjang were trained to cultivate the FMP (adlay, roselle, and stevia), and all crops could grow well. The outcome of this program is likely to encourage the independence of local community health initiatives in Sasak Panjang Village, Bogor Regency.
SENYAWA TRITERPENOID DARI EKSTRAK N-HEKSANA KULIT BATANG TANAMAN Garcinia benthami Elya1, Berna; Kosela, Soleh; Muhammad, Muhammad
Makara Journal of Science Vol. 13, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Triterpenoids compounds from N-hexane extract of the stem bark of Garcinia benthami. Two triperpenoids compounds, i.e. friedelin (1) and 3β-hydroxy-lanosta-9(11),24-dien-26-oic acid (2) were isolated from the n-hexane extract of the stem bark of Garcinia benthami. The structures of these compounds were elucidated by IR, MS,1 H-NMR and 13C-NMR spectroscopy and by comparison of their spectroscopic data with those reported data from the literature.
Co-Authors . Azizahwati . Azizahwati . Farida . Frengki . Katrin . Katrin . Nofiantini Ali Muhammad Shodiq Amarila Malik Anastasia Bangun Anastasia Bangun, Anastasia Ariestanti, Donna Maretta Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifianti, Ayun Erwina Aryo Tedjo Atiek Soemiati Atiek Soemiati Atiek Soemiati Atriyon Julzarika Atriyon Julzarika Azizah, Norma N. Azizahwati Azizahwati Azminah Azminah Basah, Katrin Chairunissa, Ananda Hanny Charissa, Meiliana Daan Khambri Dadang Kusmana Dadang Kusmana Deddi Prima Donna Maretta Ariestanti Effionora Anwar Elis Apriyanti Elis Apriyanti, Elis Emiyanah . Emiyanah, Emiyanah Fadlina Chany Saputri Fajriati, Annisa Fajrin, Ajeng M. Farida Farida Farida Ibrahim Fasya Hadaina Maharani Fatma Sri Wahyuni Febriani, Amelia Febrina Amelia Saputri Forestrania, Roshamur Cahya Forestrania, Roshamur Cahyan Frengki Frengki Fulka Nurzaman Hanita Omar Hashim, Najihah BM. Hayun Hayun, Hayun Henny Vanda Herman Suryadi Hessy Novita Hindun Wilda Risni Iis Irawatty Dewi Ika Maruya Kusuma Ika Mustika Imam Syafi'i Irianti, Marina Ika Islamudin Ahmad Jamilah Abbas Jamilah Abbas Jantan, Ibrahim Joshita Djajadisastra Joshita Djajadisastra Joshita Djajadisastra, Joshita Juheini Amin Juheini Amin Juheini Amin Julian, Muhamad Iqbal Kamaruzzaman, Mohd Amir Kartika Citra Dewi Permata Sari Katrin Basah Katrin Katrin Krinalawaty, Nevy Kusmardi Kusmardi Ladeska, Vera Liza Ariantina Maharani Maharani, Maharani Maharani, Fasya Hadaina Mahdi Jufri Mahmuda, Nur Amalia Makau, Juliann Nzembi Marcha Putri, Nada MARIA BINTANG Martha, Septiani Media Fitri Isma Nugraha Meiliana Charissa Mia Permawati Mihardja, Laurentia K. Muh Alias L Rajamuddin Muhamad Iqbal Julian Muhammad Hanafi Muhammad Hanafi Muhammad Hanafi MUHAMMAD HANAFI Muhammad Muhammad Nanang Yunarto Nanang Yunarto Neneng Siti Silfi Ambarwati Nevy Krinalawaty Nisa Maria Nofiantini Nofiantini Nofiantini Nofiantini, Nofiantini Noni Zakiah Novi Fajar Utami Novi Sulistyaningrum Novita, Hessy Nugraha, Media Fitri Isma Nurzaman, Fulka Prasetio, Nisrina Putri Puspitasari, Rara Merinda Rahmadi, Agus Rahmasari, Ratika Rajamuddin, Muh Alias Rajamuddin, Muh Alias L Ramadanti, Nur A. Rani Sauriasari, Rani Ratu Ayu Dewi Sartika Reflinur Reflinur REFLINUR REFLINUR Regita Putri, Jasmine Retnosari Andrajati Rieka Widihasputri Rieka Widihasputri, Rieka Robiatul Adawiyah Rohmat, Siti Saudah Roshamur Cahyan Forestrania Roshamur Cahyan Forestrania Rosmalena, Rosmalena Rossa Yunita ROSSA YUNITA Santy Rahmawati Sari, Atika Mutiara Sari, Rifta Sintiami Ramadhani Siti Khadijah Soleh Kosela Soleh Kosela Syafi'i, Imam Syamsu Nur, Syamsu Taufiq Indra Rukmana Veryanti, Putu Rika Wening Enggarini Wening Enggarini Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yesi Desmiaty, Yesi Yuditya Artha