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All Journal HAYATI Journal of Biosciences Torani Journal of Fisheries and Marine Science Media Penelitian dan Pengembangan Kesehatan Jurnal Fitofarmaka Indonesia Indonesian Journal of Chemistry ANNALES BOGORIENSES Dinamisia: Jurnal Pengabdian Kepada Masyarakat Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Riset Kesehatan Poltekkes Depkes Bandung Sainstech Farma: Jurnal Ilmu Kefarmasian Narra J Jurnal Ilmiah Kesehatan (JIKA) Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Journal of Pharmaceuticals and Natural Sciences Jurnal Kefarmasian Indonesia Annales Bogorienses
Berna Elya
Fakultas Farmasi Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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ISOLASI DAN KARAKTERISASI SENYAWA KIMIA DARI EKSTRAK n-HEKSAN KULIT BATANG Garcinia rigida Elya, Berna
Makara Journal of Science Vol. 7, No. 2
Publisher : UI Scholars Hub

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Garcinia rigida, stogmasterol, triterpen, oleanolic acid.
UJI PENDAHULUAN EFEK KOMBINASI ANTIJAMUR INFUS DAUN SIRIH (Piper betle L.), KULIT BUAH DELIMA (Punica granatum L.), DAN RIMPANG KUNYIT (Curcuma domestica Val.) TERHADAP JAMUR CANDIDA ALBICANS Soemiati, Atiek; Elya, Berna
Makara Journal of Science Vol. 6, No. 3
Publisher : UI Scholars Hub

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The investigation for antifungal effect of medicinal plants, combination infusion of Piper bettle leaves, Punica granatum Fructus Cortec, Curcuma domestica Rhizome. The tested demartophyta used Candida albicans. This research using dilution method to determine of minimum inhibitory concentration (MIC) and difusion method to determine zone inhibition around of disc. The results of determination of MIC showed that combination infusion Piper bettle leaves with Punica granatum Fructus Cortex against C. albicans respectively, 31,2 mg/ml : 7,8 mg/ml; 15,6 mg/ml : 15,6 mg/ml and 7,8 mg/ml : 31,2 mg/ml. The determination for zone inhibition from 3 concentration of infusion of Piper bettle leaves with 3 concentration of Punica granatum Fructus Cortex with 9 combination against C. albicans showed that combination of two infusion is the larger than the single infusion.
ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMA Basah, Katrin; Elya, Berna; Amin, Juheini; Julian, Muhamad Iqbal
Makara Journal of Science Vol. 15, No. 1
Publisher : UI Scholars Hub

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The effect of Justicia gendarussa leaves extract has been investigated using oxonate-induced hyperuricemic male albino rats. In this experiment thirty five male albino rats were divided randomly into seven groups. There were three group doses variations of J. gendarussa extract that were 1.3 g/kg bw, 2.6 g/kg bw and 5.2 g/kg bw; two comparison groups that were allopurinol 0.68 g/kg bw and herbal “X” 0.85 g/kg bw; and two control groups that were induced control potassium oxonate 0.25 mg/kg bw and normal control CMC 0,5 %. Intraperitoneal administration of potassium oxonate 0.25 mg/kg bw was given one hour before administration of test drugs in eight day and plasma uric acid was measured in rats after two hours. Plasma uric acid was measured by spectrophotometric on 520 nm with enzymatic method. The results showed that all extracts could reduced uric acid level of rats. The decreasing potency of uric acid level was equal to doses increase, so the best result that can reduce uric acid level was J. gandarussa extract at a dose 5.2 g/ kg bw. This results indicated that J. gendarussa leaves extract may be effective for the prevention and the treatment of hyperuricemia.
TOKSISITAS AKUT DAUN Justicia gendarussa Burm Elya, Berna; Amin, Juheini; Emiyanah, Emiyanah
Makara Journal of Science Vol. 14, No. 2
Publisher : UI Scholars Hub

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Acute Toxicity of Justicia gendarussa Burm. Leaves. Preminelary experiment showed that ethanolic extract of gandarusa leaves (Justicia gendarussa Burm.) could decreased uric acid blood level on rats. The aim of this experiment was to determine of the value LD50 and liver function based on activities of aminotransferase. Animals test which were used in this experiment were 50 males and 50 females white mice. They were divided into 5 groups. Group 1 as control group was given aquadest. Group 2-5 were treated by ethanolic extract of gandarusa leaves with dosage 4, 8, 16, and 32 g/kg bw. The LD50 value was determined by the amount of death in group during 24 hours after giving a single dose of test substance. The result showed that the highest dose was practically non toxic with LD50 value of 31.99 g/kg bw (male groups) and 27.85 g/kg bw (female groups). Measurement of aminotransferase activity was done by using colorimetric method. The result of ANOVA analysis for liver function showed that the giving test substance 4 g/kg bw –16 g/kg bw was not significantly different between treated groups and control group.
KUALITAS SPERMATOZOA DARI TANAMAN Polyscias guilfoylei Elya, Berna; Kusmana, Dadang; Krinalawaty, Nevy
Makara Journal of Science Vol. 14, No. 1
Publisher : UI Scholars Hub

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Spermatozoa Quality from Polyscias guilfoylei. In our study, we investigated the effect of extract Polyscias guilfoylei L.H. Bailey leaves on spermatozoa quality in rabbits. The experiment used 18 male rabbits from New Zealand white strain which were devided randomly into three groups. Group I was normal control group, Group II and III were given the extract of Polyscias guilfoylei leaves in these following doses: 327.56 mg/1.5 kg body weight and 655.2 mg/1.5 kg bw. The extract was given orally once a day, continuously for 8 weeks. Semens from the rabbit was taken every two weeks and were observed over the quality and consentration of spermatozoa. The result of the research showed that the extract of Polyscias guilfoylei leaves with dosage of 327.56 mg/1.5 kg bw and 655.2 mg/1.5 kg bw could decrease the consentration and the quality of spermatozoa of the male rabbits
Aktivitas Anti-elastase dan Antioksidan dari Ekstrak Etanol Kayu Bangkal (Nauclea subdita) Korth. Steud. dengan Variasi Metode Ekstraksi Sintiami Ramadhani; Berna Elya; Roshamur Cahyan Forestrania
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 2 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i2.347

Abstract

Kayu Bangkal (Nauclea subdita) (Korth.) Steud. telah digunakan secara tradisional oleh penduduk asli Kalimantan Selatan, sebagai produk perawatan kulit berupa masker wajah, yang diyakini dapat melindungi kulit dari pengaruh buruk sinar matahari. Penelitian ini bertujuan untuk membandingkan rendemen, aktivitas anti-elastase, efek proliferasi sel, total polifenol, dan total flavonoid dan aktivitas antioksidan dari berbagai metode ekstraksi. Ekstraksi dilakukan dengan metode UAE (Ultrasound Assisted Extraction), MAE (Microwave Assisted Extraction), dan Soxhlet. Aktivitas anti-elastase dilakukan secara enzimatis menggunakan Porcine Pancreatic Elastase (PPE). Ekstrak teraktif dilanjutkan dengan pengujian proliferasi sel menggunakan HDFa. Pengujian kadar total polifenol dan flavonoid dilakukan dengan metode kolorimetri dan aktivitas antioksidan dengan metode DPPH, ABTS, dan FRAP. Hasil penelitian menunjukkan bahwa rendemen metode ekstraksi UAE (Ultrasound Assisted Extraction) kayu bangkal menghasilkan rendemen tertinggi, dengan nilai 7,12% lebih tinggi dibandingkan metode MAE (Microwave Assisted Extraction) dan Soxhlet, aktivitas anti-elastase tertinggi diperoleh pada ekstrak metode UAE (361,22 ?g/mL). Ekstrak teraktif memiliki efek proliferasi terhadap sel HDFa dependent dose, total fenol dan flavonoid tertinggi pada metode MAE dengan kadar berturut-turut 124.96±0.42 mg EAG/g ekstrak dan 16.62±0.23 mg EK/g ekstrak. Pengujian antioksidan dari masing-masing ekstrak umumnya menunjukkan aktivitas yang kuat dalam meredam radikal ABTS, DPPH dan reduksi besi. Hasil penelitian ini menunjukkan bahwa metode ekstraksi UAE dalam menarik senyawa aktif N. subdita berpotensi sebagai anti elastase, antiaging, dan antioksidan dibandingkan dengan metode ekstraksi lainnya. Penelitian ini diharapkan dapat memberikan informasi kepada masyarakat untuk dapat dikembangkan pada penelitian lebih lanjut.
Potential of Malang Robusta Coffee Beans as Anti-breast Cancer In-Vitro Utami, Novi Fajar; Elya, Berna; Hayun, Hayun; Kusmardi, Kusmardi; Nur, Syamsu; Fajriati, Annisa
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.8922

Abstract

Robusta coffee from Malang Regency, East Java is one of the superior products of the largest coffee-producing region in Indonesia. The coffee has high antioxidants. The component that acts as an antioxidant is the tannin content, and these tannins are also anti-cancer. Using the UV-Vis spectrophotometry method the tannin content in Malang Robusta coffee beans is known and then to measure its ability as an anticancer in-vitro against breast cancer cells using MCF-7.  The results showed that the tannin contained in Malang Robusta coffee bean extract was 2.81 % and inhibited MCF-7 at 400 µg/mL, it has potential as an anticancer with an inhibition value of 68.88 %. Therefore, the use of Robusta coffee from Malang at this concentration can be used as an anti-breast cancer agent.
Pharmacognostic Evaluation and Antioxidant Activities of Tetracera indica (Christm. and Panz.) Merr Ladeska, Vera; Elya, Berna; Hanafi, Muhammad; Kusmardi; Rohmat, Siti Saudah
HAYATI Journal of Biosciences Vol. 31 No. 5 (2024): September 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.5.836-853

Abstract

The community uses Tetracera indica (Christm. and Panz.) Merr extensively as a traditional medicine. This plant was the main source of raw materials for herbal medicinal products, so identification was needed to ensure its authenticity through pharmacognosy evaluation. The present study evaluated macros- and microscopic characteristics, performed phytochemical analysis, and performed total phenolic (TPC) and flavonoid content (TFC) analysis. The organoleptic and macroscopic studies were carried out through sensory organs. The microscopic characteristics of leaf powder and twigs identification using chloral hydrate and distilled water. Numerous chemical reagents, TLC methods and LC-MS/MS analysis were employed in the phytochemical study. Research employed DPPH and FRAP tests to assess the antioxidant activity. Furthermore, quercetin was used as a marker of antioxidant activity. The morphological marker of the leaf T. indica showed the surface of the leaves is rough bristles, shape elliptic-oblong, margin serratus and phyllotaxy alternate. The stem is lignosus, and the rough stem surface is slightly peeling. The lower leaf surface had paracytic stomata and uniseriate trichomes with tapering ends. Raphide crystals and cork cells were detected in the powder analysis of the twigs. The ethyl acetate extract's twig had the highest TPC and TFC values. Ethyl acetate extract from Tetracera indica twigs has potent antioxidant activity with IC50 = 99.84±0.011 µg/ml (DPPH) and 4296.67±0.024 mol/g (FRAP). The study showed that Tetracera indica contains possible active components that could be developed as novel antioxidants. The result of this study might provide early verification and identification to obtain quality medicinal raw materials.
Identifikasi Kandungan Saponin dalam Ekstrak Kamboja Merah (Plumeria rubra L.) dan Daya Surfaktan dalam Sediaan Kosmetik Nurzaman, Fulka; Djajadisastra, Joshita; Elya, Berna
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i2.325

Abstract

Saponin is a group of compounds contained in natural materials that have amphiphilic properties and can reduce surface tension. The reduction of surface tension caused by a soap compound (Latin = sapo) that can disrupt hydrogen bonds in water. Red frangipani plant (Plumeria rubra) is known to have saponin content. The research objectives were to identify the saponin content of red frangipani plant extract (Plumeria rubra) which could reduce the surface tension. Part of red frangipani plant (flowers, leaves and stems) was extracted using five kinds of solvents. Each of the extracts obtained was then tested for saponin content qualitatively. Extract from each part of the plant (flower, leaf, and stem) which has the highest foam was selected then tested surface tension using surface tensionmat equipment. The result of qualitative saponin test showed that flower, stem and flower extract of red frangipani with aqua demineralisata solvent had the highest saponin content compared to extract with other solvent. The content of saponins in plumeria rubra extract either from the leaves, stems or flowers could decrease the surface tension with the best results obtained from the flower extract with 8,61% of Critical Micelle Concentration (CMC).
Uji Aktivitas Antioksidan dan Penghambatan Tirosinase serta Uji Manfaat Gel Ekstrak Kulit Batang Taya (Nauclea subdita) terhadap Kulit Charissa, Meiliana; Djajadisastra, Joshita; Elya, Berna
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2924

Abstract

Dayak women in Borneo treat their skin with natural ingredients, one of which is taya cortex (Nauclea subdita). Flavonoids that can be found in natural ingredients have antioxidant effect and can inhibit the activity of tyrosinase in melanogenesis process. The research objectives were to measure the antioxidant activity and the inhibition of tyrosinase of taya cortex extract, to obtain a stable formulation of taya cortex extract gel, and to determine the safety and efficacy on human skin. The method used for antioxidant activity test was DPPH method. The inhibition of tyrosinase was conducted with kojic acid as control. The safety and efficacy test were conducted to healthy women ages 35-50 with healthy and normal skin. The results show IC50 value of 568.58 µg/mL in L-tyrosine and 1374.69 µg/mL in L-DOPA for inhibiton of tyrosinase. Antioxidant activity assay of the extract shows IC50 value of 48.78 µg/mL and can be categorized as a powerful antioxidant (
Co-Authors . Azizahwati . Azizahwati . Farida . Frengki . Katrin . Katrin . Nofiantini Ali Muhammad Shodiq Amarila Malik Anastasia Bangun Anastasia Bangun, Anastasia Ariestanti, Donna Maretta Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifianti, Ayun Erwina Aryo Tedjo Atiek Soemiati Atiek Soemiati Atiek Soemiati Atriyon Julzarika Atriyon Julzarika Azizah, Norma N. Azizahwati Azizahwati Azminah Azminah Basah, Katrin Chairunissa, Ananda Hanny Charissa, Meiliana Daan Khambri Dadang Kusmana Dadang Kusmana Deddi Prima Donna Maretta Ariestanti Effionora Anwar Elis Apriyanti Elis Apriyanti, Elis Emiyanah . Emiyanah, Emiyanah Fadlina Chany Saputri Fajriati, Annisa Fajrin, Ajeng M. Farida Farida Farida Ibrahim Fasya Hadaina Maharani Fatma Sri Wahyuni Febriani, Amelia Febrina Amelia Saputri Forestrania, Roshamur Cahya Forestrania, Roshamur Cahyan Frengki Frengki Fulka Nurzaman Hanita Omar Hashim, Najihah BM. Hayun Hayun, Hayun Henny Vanda Herman Suryadi Hessy Novita Hindun Wilda Risni Iis Irawatty Dewi Ika Maruya Kusuma Ika Mustika Imam Syafi'i Irianti, Marina Ika Islamudin Ahmad Jamilah Abbas Jamilah Abbas Jantan, Ibrahim Joshita Djajadisastra Joshita Djajadisastra Joshita Djajadisastra, Joshita Juheini Amin Juheini Amin Juheini Amin Julian, Muhamad Iqbal Kamaruzzaman, Mohd Amir Kartika Citra Dewi Permata Sari Katrin Basah Katrin Katrin Krinalawaty, Nevy Kusmardi Kusmardi Ladeska, Vera Liza Ariantina Maharani Maharani, Maharani Maharani, Fasya Hadaina Mahdi Jufri Mahmuda, Nur Amalia Makau, Juliann Nzembi Marcha Putri, Nada MARIA BINTANG Martha, Septiani Media Fitri Isma Nugraha Meiliana Charissa Mia Permawati Mihardja, Laurentia K. Muh Alias L Rajamuddin Muhamad Iqbal Julian Muhammad Hanafi MUHAMMAD HANAFI Muhammad Hanafi Muhammad Hanafi Muhammad Muhammad Nanang Yunarto Nanang Yunarto Neneng Siti Silfi Ambarwati Nevy Krinalawaty Nisa Maria Nofiantini Nofiantini Nofiantini Nofiantini, Nofiantini Noni Zakiah Novi Fajar Utami Novi Sulistyaningrum Novita, Hessy Nugraha, Media Fitri Isma Nurzaman, Fulka Prasetio, Nisrina Putri Puspitasari, Rara Merinda Rahmadi, Agus Rahmasari, Ratika Rajamuddin, Muh Alias Rajamuddin, Muh Alias L Ramadanti, Nur A. Rani Sauriasari, Rani Ratu Ayu Dewi Sartika Reflinur Reflinur REFLINUR REFLINUR Regita Putri, Jasmine Retnosari Andrajati Rieka Widihasputri Rieka Widihasputri, Rieka Robiatul Adawiyah Rohmat, Siti Saudah Roshamur Cahyan Forestrania Roshamur Cahyan Forestrania Rosmalena, Rosmalena Rossa Yunita ROSSA YUNITA Santy Rahmawati Sari, Atika Mutiara Sari, Rifta Sintiami Ramadhani Siti Khadijah Soleh Kosela Soleh Kosela Syafi'i, Imam Syamsu Nur, Syamsu Taufiq Indra Rukmana Veryanti, Putu Rika Wening Enggarini Wening Enggarini Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yesi Desmiaty, Yesi Yuditya Artha