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All Journal MEDIA MEDIKA INDONESIANA Jurnal Kedokteran Brawijaya International Journal of Integrated Health Sciences Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Sari Pediatri Universa Medicina Paediatrica Indonesiana Jurnal Penelitian Kesehatan Suara Forikes Indonesian Journal of Medicine ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Indian Journal of Forensic Medicine & Toxicology KESANS : International Journal of Health and Science Health & Medical Sciences Prosiding International Conference on Sustainable Innovation (ICoSI) Folia Medica Indonesiana
Anang Endaryanto
Allergy Immunology Division, Department Of Child Health, Faculty Of Medicine, Airlangga University-Dr. Soetomo General Hospital
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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THE ZINC STATUS IN CHILDREN WITH ALLERGIES: A SYSTEMATIC REVIEW AND META-ANALYSIS Ningsih, Rusdian; Hikmah, Zahrah; Endaryanto, Anang
Media Gizi Indonesia Vol. 20 No. 3 (2025): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v20i3.234-244

Abstract

Allergies pose significant health concerns, particularly in children, where they can adversely affect growth and quality of life. Recent studies have suggested that zinc deficiency may play a critical role in the immune dysregulation associated with allergies. The method used in This systematic review followed the PRISMA guidelines and analyzed studies on the relationship between zinc levels and allergies in children, using data from PubMed, Science Direct, EBSCO, and Cochrane Library, and a meta-analysis was conducted to evaluate the effect size and risk of bias assessed using the Newcastle-Ottawa Scale to examine the relationship between zinc levels and allergies in children. Our findings indicate that children with allergies may exhibit different zinc levels compared to healthy controls, with a pooled effect size of -0.56 (95% CI: [-0.99, -0.13]). The analysis revealed significant heterogeneity (Tau² = 0.39; Chi² = 79.41, df = 8, p < 0.00001; I² = 90%), highlighting the variability across studies and the necessity for further research to standardize the methodologies. These results were statistically significant (Z = 2.54, p = 0.01), suggesting a potential association between zinc levels and allergies in children. Further investigations are needed to explore whether zinc supplementation can support immune function and alleviate allergic symptoms.
Lactiplantibacillus plantarum IS-10506 Enhances Tight Junction Integrity in Bronchial Epithelium: An Experimental Study Fetarayani, Deasy; Soegiarto, Gatot; Surono, Ingrid Suryanti; Endaryanto, Anang; Athiyyah, Alpha Fardah; Hernaningsih, Yetti; Fauziah, Dyah; Sudiana, I Ketut; Utomo, Budi; Prakoeswa, Cita Rosita Sigit
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2995

Abstract

BACKGROUND: Airway epithelium constitutes the initial structural defense against inhaled allergens, with its integrity primarily maintained through the formation of tight junctions (TJ) consisting of claudins, occludins, and zonula occludens (ZO). Currently, the effects of probiotics on airway TJ remain unclear. Therefore, this study was conducted to explore the impact of Lactiplantibacillus plantarum IS-10506, a native probiotic from Indonesia, on bronchial epithelial TJ in a mouse model of allergic airway inflammation.METHODS: Twenty-four BALB/c mice were randomly assigned to three groups: negative control, positive control subjected to Dermatophagoides pteryonissinus (Der p) sensitization and challenge, and treatment group exposed to Der p and administered L. plantarum IS-10506 since one week before sensitization up to three weeks after. The expression levels of claudin-18, occludin, and ZO-1 were investigated through immunohistochemistry analysis and quantified based on the immunoreactive score (IRS). RESULTS: The results of this study demonstrated that L. plantarum IS-10506 significantly enhanced the expressions of claudin-18, occludin, and ZO-1 (p<0.05).CONCLUSION: These findings underscore the probiotic's role in fortifying the integrity of airway TJ.KEYWORDS: allergic inflammation, probiotic Lactiplantibacillus plantarum, immunology, respiratory system, tight junction, occludin, claudin, zonula occludens
Lactiplantibacillus plantarum IS-10506 Supplementation Improves Clinical Outcome and Immunology Markers in Psoriasis Vulgaris Patients: A Randomized Controlled Trial Umborowati, Menul Ayu; Hasna, Iffa Halimah; Endaryanto, Anang; Surono, Ingrid Suryanti; Prakoeswa, Cita Rosita Sigit
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3155

Abstract

BACKGROUND: Probiotics may modify the gut microbiome and have been proven to improve psoriasis vulgaris. Lactiplantibacillus plantarum IS-10506 is a probiotic strain of Indonesian origin. It offers a safe and effective probiotic for psoriasis patients in Indonesia. This study was conducted to evaluate the effect of L. plantarum IS-10506 on clinical and immunology markers in psoriasis vulgaris.METHODS: This randomized, placebo-controlled, and double-blind trial compared L. plantarum IS-10506 (2×1010 CFU/day) and placebo in 49 patients mild-moderate psoriasis vulgaris, which were divided into intervention (n=24) and control groups (n=25). The interventions were given twice daily for 12 weeks. Both groups received topical corticosteroid and emollient as standard treatment. Psoriasis area and severity index (PASI), dermatology life quality index (DLQI), interleukin (IL)-10, IL-17, and forkhead box protein (Foxp3) were then assessed.RESULTS: Mean PASI score for the the subjects in probiotic group was significantly reduced compared to placebo at week-6 (p=0.024), and was sustained until week-12 (p=0.049). At week-12, DLQI scores in the probiotic group were lower than placebo (7.57±5.77 vs. 7.79±5.48). IL-17 level was significantly decreased (p=0.013), while the IL-10 and Foxp3 were significantly increased (p≤0.001 and p=0.048, respectively) in probiotic group. Six months after the completion of study, subjects in probiotic group had a lower probability of flares (52.2%) compared to placebo (79.2%). Two subjects receiving probiotics and one receiving placebo noticed changes in defecation frequency, while another subject in the placebo group complained of mild nausea.CONCLUSION: L. plantarum IS-10506 might effectively improve clinical outcomes and immune biomarkers in psoriasis vulgaris patients, potentially acting as an adjuvant therapy.KEYWORDS: psoriasis, probiotic, clinical severity, immune marker, human and health
Preliminary Investigation of Risk Factors for Food Allergies in the Pediatric Population: Observations from a Survey Utilizing a Simplified Questionnaire in Gresik, East Java, Indonesia Jahja, Natalia Erica; Hikmah, Zahrah; Putera, Azwin Mengindra; Endaryanto, Anang
Folia Medica Indonesiana Vol. 60, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. A questionnaire, comprising various risk factors associated with food allergies, is anticipated to provide reliable indications for determining the necessity of restrictive diets for patients within primary healthcare settings. 2. Over time, the findings of this study can facilitate the development of a streamlined and cost-effective diagnostic tool, which will be particularly beneficial in remote regions due to its practical and efficient means of identifying food allergies. Abstract In Gresik, Indonesia, limited resources have led to challenges in accurately diagnosing food allergies. This study aimed to identify risk factors for food allergies among children in Gresik using a questionnaire-based approach. The study's ultimate goal was to develop a simple diagnostic tool in primary healthcare settings. Conducted at Petrokimia Gresik Hospital, this cross-sectional study enrolled children aged ≥6 months experiencing respiratory symptoms or atopic dermatitis for ≥1 week. The subjects (n = 247) underwent a two- to four-week restrictive diet for diagnostic purposes. The questionnaire demonstrated validity and reliability. Bivariate statistical analyses were performed to examine the correlations between risk factors and the incidence of food allergies (p < 0.05). A receiver operating characteristic (ROC) curve analysis was used to establish the cut-off values for the number of food allergies and atopic family members. The majority of the 247 children enrolled in this study were 6 to 12 years old. Respiratory symptoms (56.3%) were more common than atopic dermatitis (38.1%). The significant risk factors for food allergies included atopic dermatitis (p = 0.001; R = 0.203), previous history of suspected food allergies (p < 0.001; R = 0.747), and atopy in the family (p = 0.013; R = 0.157). The ROC curve analysis established the cut-off values for the number of atopic family members at 1.5 (p = 0.005; 95% CI 0.53-0.67) and the number of food allergies at 0.5 (p = 0.000; 95% CI 0.85-0.94). In conclusion, children are considered at risk of food allergies if they display persistent respiratory symptoms or atopic dermatitis, considering the history of suspected food allergies even to only one specific type of food.
Enhanced Efficacy of Sublingual Immunotherapy in Childhood Allergic Asthma by Probiotics Endaryanto, Anang; Irmawati, Mira
Folia Medica Indonesiana Vol. 54, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

It is expected that probiotics may act synergistically to improve the clinical efficacy of sublingual immunotherapy (SLIT). The aim of this study was to investigate the role of probiotics in enhancing efficacy of sublingual immunotherapy in childhood allergic asthma. This was a randomized single blind clinical trial conducted on 6-17 year-old asthmatic children sensitive to house dust mite allergens. Subjects were allocated to Group A receiving SLIT, Group B receiving probiotics and SLIT, Group C receiving probiotics only. Clinical parameters (FEV1 reversibility, medication score, and symptom score) and immunological parameters (total IgE, eosinophil count, IFN-γ, IL-2, IL-4, IL5, IL10, and TGF-b were evaluated in week 0 until 14. Statistical analysis revealed that the difference of clinical parameters (FEV1 reversibility, medication score, and symptom score) between groups were not significant. The difference of the immunological parameters of total IgE, IFN-γ, IL-2, IL-4, IL5, IL10, and TGF-íŸ were also not significant. Eosinophil count decreased in subjects who received combination SLIT with probiotics. In conclusion, probiotics enhanced the efficacy of sublingual immunotherapy in childhood allergic asthma by decreasing the eosinophil count.
Prokalsitonin dan Sel Darah Putih sebagai Penanda Infeksi pada Anak dengan Ketoasidosis Diabetikum Nur Rochmah; Muhammad Faizi; Yudhi Kurniawan; Latifatu Choirunisa; Anang Endaryanto; Soetjipto Soetjipto
Majalah Kedokteran Indonesia Vol 70 No 12 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.12-2020-291

Abstract

Introduction: Diabetic ketoacidosis (DKA), an acute complication of type 1 (insulin dependent) diabetes mellitus (T1DM), can be precipitated by infection. Procalcitonin (PCT) is an accurate marker of bacteremia, sepsis, and inflammation, however white blood cells (WBC) are still often used by clinicians. We aimed to analyze PCT levels and WBC counts in children with DKA.Methods: A cross-sectional study was conducted in Dr. Soetomo General Hospital, Surabaya, Indonesia, between 2015 and 2019. T1DM and DKA diagnosis was based on the International Society for Pediatric and Adolescent Diabetes. PCT levels and WBC counts were measured in samples from patients with and without DKA, and were compared using the Mann-Whitney test.Results: A total of 41 samples were included, with 15 samples (36.6%) from children with DKA, and 26 (63.4%) from children without DKA. PCT levels and WBC counts were significantly higher in those with DKA (p less than 0.001). The receiver operating characteristic curve analysis of WBC was lower than PCT (0.849 vs. 0.982). PCT had a higher sensitivity and spesificity as an infection marker than WBC (93.3 vs. 86.7; 92.3 vs. 88.5, respectively).Conclusion: PCT is a better infection marker in children with DKA than WBC
The Association between the Covid-19 Pandemic and the Number of Visits, Clinical Profile, and Treatment Costs on Pediatric Patients with Acute Gastroenteritis at dr. Soetomo General Hospital Carisa Auralia Ramadhani; Anang Endaryanto; Ummi Maimunah
Health & Medical Sciences Vol. 3 No. 4 (2026): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/phms.v3i4.769

Abstract

The COVID-19 pandemic disrupted healthcare utilization and may have influenced the clinical characteristics and treatment costs of pediatric acute gastroenteritis (AGE). This study aimed to evaluate changes in the number of visits, clinical profiles, and treatment costs of pediatric AGE patients pre-, during, and post- the COVID-19 pandemic at Dr. Soetomo General Academic Hospital, Surabaya. Methods: A retrospective observational comparative study was conducted using medical records of pediatric AGE patients (≤18 years old) treated at Dr. Soetomo General Hospital. A total of 3,721 patients who met the inclusion and exclusion criteria were included. Data were compared across the pre-pandemic, pandemic, and post-pandemic periods using the Kruskal–Wallis test, followed by the Mann–Whitney U test. Results: Among the 3,721 patients, the mean monthly visits decreased from 91.8 patients pre-pandemic to 59.2 patients during the pandemic (p < 0.05). The mean number of comorbidities increased from 3.91 to 4.68 during pandemic, particularly among hospitalized patients (p < 0.05). The mean total treatment costs increased from IDR 3,74 million to IDR 7,56 million during the pandemic. Discussion: The COVID-19 pandemic significantly affected healthcare utilization, clinical characteristics, and treatment costs among pediatric AGE patients. These findings may help guide healthcare planning, resource allocation, and the development of strategies during future public health emergencies.
Co-Authors Afif Nurul Hidayati Ahmad Suryawan Aida Fahira Rachma Albarok, Muhammad Abdir Rahman Alpha Fardah Athiyyah Andy Darma Anggraeni, Sylvia Anindya Paramita Anisa Ayu Maharani Annisa Fitriana Ariani Setiawati Arijanto Harsono Arini Setiawati Ariyanto Harsono Ariyanto Harsono Ariyanto Harsono Ariyanto Harsono, Ariyanto Aryanto Harsono Aryono Harsono Azwin Lubis Azwin Mengindra Putera Badriul Hegar Bagus Bagus Bella Ayu Paramitha Budi Prasetyo Budi Setiabudiawan Budi Utomo Budiono Budiono Carisa Auralia Ramadhani Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Deasy Fetarayani desy wulandari Dewanto, Naomi Esthernita Fauzia Dina Muktiarti, Dina Dinda Anes Tunjungsari Dominicus Husada DYAH FAUZIAH, DYAH Dyahris Kuntartiwi Ergia Latifolia Evy Ervianti Far-Far, Imanuel Ferry Sandra Flora Ramona Sigit Prakoeswa Florentina Sustini Garindra Wicaksono Gatot Soegiarto Hardyanto Soebono Hari Basuki Notobroto Haryono Utomo Hasna, Iffa Halimah Hidajat, Boerhan I Dewa Gede Ugrasena I Gusti Ayu Agung Elis Indira I Gusti Made Reza Gunadi Ranuh I Gusti Nyoman Darmaputra Ida Bagus Ramajaya Sutawan, Ida Bagus Ramajaya Ike Wahyu Triastuti Imelda Fabiola Ingrid Suryanti Surono Johannes Hudyono Ketut Dewi Kumara Wati Latifatu Choirunisa Linda Astari, Linda Linda Dewanti Lutvia Hidayati M. Yulianto Listiawan Marcos, Imella Maya Weka Santi Melva Louisa Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Mira Irmawati Mira lrmawati Muhammad Faizi Muhammad Faris, Muhammad Natalia Erica Jahja Natalia Erica Jahja, Natalia Erica Ningsih, Rusdian Nur Rochmah Nur Rochmah Nur Rochmah, Nur Nyoman Suryawati Pambudi, Wiyarni Pudji Lestari Retno Asih Setyoningrum Retno Asih, Retno Retno Asti Werdhani Retno Indrawati Roestamadji Reza Ranuh S.Pd. M Kes I Ketut Sudiana . Santi Martini SITI NURUL HIDAYATI Sitisalma Amirah Dzakiyyah Soetjipto SOETJIPTO . Subijanto MS Sudarmo, Subijanto Marto Sumadiono Sumadiono Thinni Nurul Rochmah Umi Fahmida Ummi Maimunah Widodo, Naufallutfi Wisnu Barlianto Wisnu Triadi Nugroho Wiweka Merbawani Yetti Hernaningsih Yohanes Aditya Adhi Satria Yudhi Kurniawan Yuni Hisbiyah Yusra, Yusra Zahrah Hikmah, Zahrah Zakiudin Munasir