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PENGARUH KOMPLEKSASI INKLUSI ATORVASTATIN DENGAN β-SIKLODEKSTRIN TERHADAP FORMULASI DAN EVALUASI FAST DISINTEGRATING TABLETS (FDT) ATORVASTATIN Fadil, Dilal Adlin; Rusdiana, Taofik; Muchtaridi, Muchtaridi
Media Farmasi: Jurnal Ilmu Farmasi Vol. 13 No. 2: September 2016
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v13i2.7768

Abstract

Atorvastatin merupakan salah satu zat aktif penurun kolesterol darah golongan statin atau inhibitor HMG-CoA reductase. Atorvastatin memiliki karaktersitik biofarmasetik kelarutan dalam air yang buruk tetapi  permeabilitas dalam membran usus yang tinggi (BCS kelas II), sehingga untuk memperbaiki bioavailabilitasnya dapat diupayakan dengan cara memperbaiki tingkat kelarutannya dalam air. Penelitian ini bertujuan untuk mengetahui pengaruh kompleksasi inklusi atorvastatin dengan β-siklodekstrin terhadap kelarutan dan disolusinya serta terhadap proses formulasi sediaan Fast Disintegrating Tablets (FDT). Kompleks inklusi dibuat dengan cara kneading method dengan perbandingan molar atorvastatin dengan β-siklodkestrin; 1:1, 1:2, dan 1:3. Studi ketetapan kesetimbangan kompleks didapat 502,087 M-1. Hasil uji disolusi dalam medium buffer fosfat pH 6,8 menunjukkan peningkatan laju disolusi atorvastatin dalam kompleks inklusi atorvastatin-β-siklodkestrin (KIAS) masing-masing sekitar 5,76% (1:1); 8,89% (1:2); dan 7,73% (1:3). Hasil karakterisasi KIAS dengan metode X-ray difraction (X-RD), spektroskopi inframerah, dan differential scaning calorimetry (DSC) menunjukkan adanya pembentukan kompleks inklusi. Formulasi FDT dibuat dengan menggunakan metode kempa langsung terhadap 6 formula (3 formula menggunakan KIAS dan 3 formula tanpa KIAS), superdisintegrat yang digunakan adalah Kyron T 314 dengan variasi penggunaannya masing-masing sebanyak 2, 4, dan 6% dan variasi kekerasan tablet sebesar 4 dan 6 N. Hasil evaluasi FDT menunjukan bahwa FDT dengan KIAS lebih baik dibandingkan dengan FDT tanpa KIAS. Hasil uji disolusi FDT dalam medium buffer fosfat pH 6,8 diketahui terjadi peningkatan laju disolusi atorvastatin dalam FDT KIAS. Dengan demikian, dapat disimpulkan bahwa kompleksasi inklusi atorvastatin dengan β-siklodkestrin dapat meningkatkan laju disolusi atorvastatin secara signifikan.
Studi In Silico Daun Kemangi (Ocimum basilicum Folium) sebagai Antikanker Payudara terhadap ESRα Ichsani, Luthfia Nur; Elvian, Elvian; Zahra, Citra Aulia; Ramdani, Aura Radiatia Sesiani; Aprilio, Kevin; Rusdin, Agus; Mardisanutomo, Harsoning Tyas; Muchtaridi, Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.47530

Abstract

Kanker payudara merupakan penyebab utama kedua kematian akibat kanker pada wanita. Berdasarkan data Global Cancer Observatory tahun 2022, terdapat penambahan 66.271 (16,2%) kasus baru kanker payudara di Indonesia dengan jumlah kematian mencapai 22.598 kasus.  Daun kemangi (Ocimum basilicum Folium) diketahui memiliki berbagai efek farmakologis contohnya antiproliferatif. Namun, hingga saat ini belum diketahui komponen spesifik dalam daun kemangi yang berkontribusi terhadap efek tersebut. Penelitian ini bertujuan untuk mencari senyawa daun kemangi yang berpotensi sebagai pengobatan untuk kanker payudara melalui metode penambatan molekuler. Berdasarkan aturan Lipinski, didapatkan hasil bahwa senyawa apigenin, luteolin, eugenol, cirsimaritin, cirsilineol, carvacrol, spathulenol, asam ursolat, linalool, dan asam rosmarinat memenuhi kriteria sebagai senyawa obat. Melalui studi penambatan molekuler didapatkan hasil cirsimaritin sebagai lead compound dengan energi ikatan sebesar -8.19 kcal/mol yang mendekati afinitas ikatan tamoxifen. Terdapat lima interaksi asam amino pada cirsimaritin yang mirip dengan tamoxifen, yaitu tiga ikatan hidrogen pada GLY A : 521; HIS A : 524; GLU A : 353 serta dua ikatan alkil berupa LEU A : 387 dan ILE A : 424. Hasil penelitian menunjukkan bahwa cirsimaritin memiliki potensi sebagai antikanker payudara melalui penghambatan pada ESR. Penelitian ini diharapkan dapat memberikan informasi dasar untuk pertimbangan modifikasi lanjutan cirsimaritin sebagai kandidat obat yang potensial.
Sosialisasi cara penanganan kulit manggis dan buahnya untuk kebutuhan industri obat herbal Muchtaridi, Muchtaridi; Setyawati, Luthfi Utami; Nursuhud; Hartono, Sugianto Ayudha; Nahariyah, St. Rohmani; Budiman, Arif; Hadiwijaya, Nathannael Adrya; Liawardi, Petra Pahlawanda Chrisanto; Jhoni, I Made; Pratomo, Muhammad Fadhil; Aulifa, Diah Lia; Mardianingrum, Richa
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 6 No 3 (2023)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v6i3.19528

Abstract

Desa Parakanmanggu merupakan wilayah yang memproduksi buah manggis paling besar di Kabupaten Pangandaran dengan potensi manggis yang berkualitas. Selain daging buahnya yang dapat dikonsumsi, kulit manggis juga memiliki berbagai manfaat yang sangat berharga sebagai obat herbal yang telah dimanfaatkan sejak zaman dulu. Tujuan kegiatan ini yaitu untuk mengetahui pemahaman petani manggis Desa Parakanmanggu sebelum dan sesudah dilakukannya penyuluhan mengenai Teknologi Tepat Guna (TTG) terkait ekstraksi manggis dari limbah kulit manggis sebagai bahan baku obat herbal. Metode yang digunakan dalam kegiatan ini yaitu melalui Participatory Action Research (PAR) dengan metode wawancara mendalam (in-depth interview) diintegrasikan dengan survei dan diskusi kelompok terfokus (FGD), serta pre-test dan post-test dengan pendekatan kuantitatif untuk analisis data. Hasil dari kegiatan ini menunjukkan bahwa sebelum penyuluhan, sebanyak 64% dari populasi memiliki pengetahuan yang rendah mengenai manfaat dan cara pengolahan limbah kulit manggis. Namun, setelah penyuluhan dilakukan, terjadi peningkatan pengetahuan para responden, yaitu sebesar 64% dari populasi memiliki pengetahuan yang sedang dan 20% memiliki pengetahuan yang tinggi mengenai TTG pengolahan limbah kulit manggis dan manfaatnya.
Molecular Docking Study of Mangosteen (Garcinia mangostana L.) Xanthone-Derived Isolates as Anti Androgen Suhandi, Cecep; Fadhilah, Ersa; Silvia, Nurfianti; Atusholihah, Annisa; Prayoga, Randy Rassi; Megantara, Sandra; Muchtaridi, Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 12, No 1 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss1pp11-20

Abstract

Androgen receptor (AR) is the member of steroid hormone receptor involved in the progression of prostate cancer growth due to receptor over-activation. On the other hand, mangosteen (Garcinia mangostana L.) as a medicinal plant contains xanthone-derived compounds which were known to have cytotoxic activity towards any types of human cancer cells. This research aims to determine xanthone-derived isolates potency from mangosteen as AR antagonists. The study was carried out through molecular docking assay utilizing AutoDock 4.2.6 using androgen receptor obtained from PDB ID 2AM9, testosterone as native ligand, and bicalutamide, flutamide, and nilutamide as reference. The results indicated that three isolates (1,3,7-trihydroxy-2,8-di-(3-methylbut-2-enyl)xanthone, mangostinone, and trapezifolixanthone) have the highest potency to be AR antagonist seen from the lower bond-free energy value than all of reference ligand. The lowest bond-free energy was provided by mangostinone with a ΔG value of -10.05 kcal/mol. However, the highest difference of residual amino acids interaction with testosterone and similar interaction with bicalutamide was provided by 1,3,7-trihydroxy-2,8-di-(3-methylbut-2-enyl)xanthone, with five different amino acids with testosterone and nine similar amino acids with bicalutamide, respectively. Interestingly, 1,3,7-trihydroxy-2,8-di-(3-methylbut-2-enyl)xanthone has similar hydrogen bond with the key residue amino acids of AR (705-Asn and 711-Gln) which indicates probably partial agonist activity while mangostinone has the highest amount of hydrogen bond in the absence of hydrogen bond towards key residual amino acids of AR. The results concluded that three specific derived-xanthone compounds were predicted to have activity as AR antagonists.Keywords: Prostate cancer, Androgen receptor, Mangosteen, Xanthone, Molecular docking.
In Silico Study of Bioactive Compounds from Cinchona Bark as Potential Antimalarial Against Human Glucokinase Receptor Kezia Stella Carmencinta Salvi; Alifa Dhia Shalima; Alya Novia Hanifa; Johnessa Cung; Bagus Adhinagoro; Shela Salsabila; Muchtaridi
Indonesian Journal of Chemical Science Vol. 14 No. 1 (2025): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v14i1.16502

Abstract

Malaria remains a significant health concern in Indonesia, with endemic regions reporting persistent transmission of Plasmodium parasites. This study explores the potential of compounds derived from Cinchona succirubra, traditionally known for its antimalarial properties, using a comprehensive in silico approach. Utilizing Lipinski’s prediction, ADME-Tox, pharmacophore screening, and molecular docking techniques, we assessed the pharmacological potential of its compounds against glucokinase enzymes. Through 10 alkaloid compounds taken from the bark of the cinchona tree, among which the one that gives the best results in its role on the receptor is mefloquine. The result showed that mefloquine had a BE of -3.95 kcal/mol, an inhibition constant of 1.27 μM, but no interactions with any important amino acid residues. The HIA and CaCo-2 values were 93.737% and 22.686 nm/sec, respectively, whereas the PPB and BBB values were 74.270% and 74.270%. Neither is this substance carcinogenic or mutagenic. Low binding energy and the most favored interaction with the receptor were observed for mefloquine. Thus, mefloquine exhibits potential as a prospective glucokinase inhibitor.
Immunomodulatory and Acute Toxicity Studies of Peronema canescens Jack Leaves: in vivo Hematological Analysis and in vitro IL-6 Gene Expression Inhibition Muhammad Ryan Radix Rahardhian; Fahriza Ardiansyah; Yasmiwar Susilawati; Gofarana Wilar; Sri Adi Sumiwi; Jutti Levita; Muchtaridi Muchtaridi
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3577

Abstract

BACKGROUND: Peronema canescens Jack is traditionally employed in the treatment of inflammation, malaria, and immune-related disorders. Despite its traditional use, scientific evidence on its immunomodulatory effects, interleukin (IL)-6 modulation, hematological impact, as well as its related acute toxicity data remains limited. Therefore, this study was conducted to investigate the immunostimulatory potential of P. canescens leaf extract through in vitro and in vivo assessments and evaluate its acute toxicity profile.METHODS: The in vitro immunomodulatory activity of P. canescens ethanolic extract, n-hexane fraction (NHF), ethyl acetate fraction (EAF), and water fraction (WF) were assessed by measuring IL-6 inhibition in lipopolysaccharide-stimulated RAW 264.7 macrophages. For in vivo analysis, Balb/C mice were divided into six groups: a normal control (Na-CMC), a positive control (50 mg/kg BW/day Stimuno Phyllanthus niruri extract), a negative control (80 mg/kg BW/day cyclophosphamide as immunosuppressant), and 3 treatment groups receiving P. canescens extract at doses of 100, 200, and 400 mg/kg BW/day. Hematological parameters, including white blood cell (WBC) counts, lymphocyte percentages, and neutrophil percentages, were analyzed. Acute toxicity studies were performed by administering P. canescens extract at doses of 300, 2000, and 5000 mg/kg BW over observation period.RESULTS: EAF exhibited the most pronounced IL-6 inhibition in vitro. In vivo, the administration of P. canescens extract at 200 and 400 mg/kg BW significantly elevated WBC and lymphocyte levels while concurrently reducing neutrophil counts. No mortality or neurotoxic manifestations were observed, confirming the P. canescens extract’s safety profile up to 5000 mg/kg BW.CONCLUSION: P. canescens leaf extract, particularly EAF, demonstrates robust immunomodulatory activity with a favorable safety margin. These findings underscore its potential therapeutic application in immune modulation.KEYWORDS: Peronema canescens Jack, immunomodulatory, IL-6 inhibition, acute toxicity, hematology, cytokines
Rapid and Non-Destructive Analysis of Plant Material Using FTIR and Chemometric Methods Salsabilla, Bunga Indra; Muchtaridi, Muchtaridi; Megantara, Sandra; Novitasari, Dhania; Musfiroh, Ida
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.63950

Abstract

Plant material analysis requires efficient, reliable, and sustainable methods for characterization, authentication, and quality control. Fourier Transform Infrared Spectroscopy (FTIR), combined with chemometrics, has emerged as a non-destructive approach that requires minimal sample preparation. This review summarizes developments and applications of FTIR chemometrics in plant analysis from 2015 to 2025, based on more than 32 published studies. The evolution of data analysis is described from classical techniques, including Principal Component Analysis and Partial Least Squares, to machine learning methods such as Support Vector Machines and Random Forests. Various FTIR modes, namely ATR FTIR, DRIFTS, and FTIR PAS, are discussed for analyses of leaves, roots, rhizomes, flowers, fruits, and fossilized plant materials. Reported applications include species identification with accuracies approaching 100%, geographic origin authentication with 77-94% accuracy, detection of adulteration in high-value commodities such as saffron, quantification of bioactive constituents with determination coefficients of 0.96-0.99, and assessment of environmental or agronomic influences on plant composition. Although challenges remain, particularly matrix complexity and calibration transfer, FTIR chemometrics represents a sustainable, rapid, and cost-effective tool for research and industrial quality control. Future directions emphasize the global integration of artificial intelligence and instrument miniaturization.
In Silico Study of Bioactive Compounds from Syzygium malaccense Targeting HER2 and Progesterone Receptors in Breast Cancer Nawadhir Fauzan; Riska Prasetiawati; Meilia Suherman; Dhania Novitasari; Muchtaridi Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp1-14

Abstract

Breast cancer remains one of the most common causes of cancer-related deaths among women, with progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) being key molecular targets in its progression. This study aimed to explore the potential of bioactive compounds from Syzygium malaccense that have exhibited anticancer activities, as targeted inhibitors for PR and HER2, using computational approaches. A total of 155 compounds were initially screened for anticancer potential using the Prediction of Activity Spectra for Substances (PASS), identifying 80 compounds for further analysis. Drug-likeness and pharmacokinetic predictions indicated that several compounds complied with the Rule of Five (RO5) and had favorable absorption and distribution profiles, suggesting their suitability as oral drug candidates. Molecular docking revealed that quercetin exhibited favorable interactions with PR, particularly involving the ARG 766 residue, while myricetin demonstrated strong binding affinity to HER2, surpassing trastuzumab, and interacting with key residues Asp 863, Lys 753, Ala 751, and Leu 796. Molecular dynamics simulations confirmed the stability of the Myricetin-HER2 complex under physiological conditions over 15 ns, supporting its potential as a HER2 inhibitor. These findings highlight myricetin and quercetin as promising natural compounds for breast cancer therapy targeting HER2 and PR, respectively. However, further experimental validation, including in vitro and in vivo studies, is necessary to confirm their therapeutic efficacy and safety. Overall, this study supports Syzygium malaccense as a valuable source of natural bioactive compounds for breast cancer drug discovery.Keywords: in silico screening, Syzygium malaccense, breast cancer, progesterone receptor, HER2.
In Silico Study of Torch Ginger Flower (Etlingera elatior (Jack) R.M.Sm. flos) Bioactive Compounds Targeting TGF-β Receptor Type I (TGF-βR1) as Potential Tumor Suppressor Agents Yohana Faustine Yuarsa; Garneta Izzati Herdy Putri; Valeri Belliana Sanjaya; Akmal Taufiqur Rahman; Shela Salsabila; Nawadhir Fauzan; Muchtaridi Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp15-28

Abstract

Cancer remains one of the leading causes of death worldwide, with an estimated 16.3 million cancer-related deaths projected by 2040. Current cancer therapies still face various challenges such as resistance, toxicity, and high costs, highlighting the need for more targeted approaches in the discovery of new therapies. Torch ginger flower (Etlingera elatior (Jack) R.M.Sm. flos) has been reported to contain bioactive compounds with potential tumor-suppressive activities through modulation of cancer-related pathways. However, in silico evidence evaluating its active compounds as potential inhibitors of transforming growth factor-beta receptor type I (TGF-βR1), a protein involved in tumor proliferation and metastasis remains limited. This study aimed to predict and evaluate the potential of Etlingera elatior compounds as tumor-suppressing agents targeting TGF-βR1 using computational approaches. Lipinski’s Rule of Five and ADME-Tox predictions were performed to assess drug-likeness and pharmacokinetic properties, while pharmacophore screening and molecular docking were conducted to identify hit compounds and predict their binding affinities. Among the tested compounds, kaempferol and quercetin showed the highest pharmacophore fit scores (47.21% and 47.07%, respectively) and the best binding affinities to TGF-βR1 (-7.98 kcal/mol; Ki 1.42 μM for kaempferol and -7.87 kcal/mol; Ki 1.72 μM for quercetin), and although their binding poses were not the most similar to the reference inhibitor LY3200882 (-8.39 kcal/ mol; Ki 0.71 μM), the consistent alignment of favorable pharmacophore fit and binding energy still reinforces their potential. These findings indicate that kaempferol and quercetin have promising potential as candidate natural tumor-suppressive agents targeting TGF-βR1.Keywords: Cancer, TGF-βR1, Torch Ginger Flower, Molecular Docking.
In Silico Study of Moringa Leaf (Moringa oleifera L.) Compounds as an Antiproliferative in Hepatocellular Carcinoma against TGF-β Receptor Arnees Angzora; Athena Lilavya Putri; Johanna Felicia Susanto; Kathlia Putri Alyanisa; Debian Mydea Erliputeri; Nawadhir Fauzan; Shela Salsabila; Muchtaridi Muchtaridi
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.105514.74-87

Abstract

Liver cancer is a condition in which liver cells grow uncontrollably. Liver cancer, also known as hepatoma, occurs when cells proliferate and acquire malignant properties. Liver cancer is among the types of cancer with a high contribution to global mortality rates each year. This study aims to predict and identify the activity of compounds isolated from Moringa leaves (Moringa oleifera L.) against liver cancer by targeting the TGF-β receptor using molecular docking. The research was conducted using software tools including LigandScout, ADMETlab 2.0, BIOVIA Discovery Studio Visualizer, and AutoDock Tools. The results showed that ten out of eleven test compounds from Moringa oleifera L. leaves met Lipinski's Rule of Five, indicating their potential as good oral drug candidates. Pharmacophore screening yielded an AUC100 value of 0.94 with three hit compounds: rutin, kaempferol, and isorhamnetin. In the molecular docking stage, the compound with the lowest binding energy was Isorhamnetin, with a binding energy of -8.18 kcal/mol against the TGF-β receptor, and it also demonstrated a favorable ADMET profile.
Co-Authors A. A. Putri A. Diantini - A. Khalilah A. L. Triadenda A. Mutalib - Abdul Mutalib Abdul Mutalib Abednego K. Gwiharto Abednego Kristande Abun Abun Abun Ade Rizqi Ridwan Firdaus Ade Zuhrotun Adhinagoro, Bagus Aeni, Wida Nur Ahmadi, Nurish Farisha Ajeng Diantini, Ajeng Akmal Taufiqur Rahman Al Faruq, Muhammad Ariq Alifa Dhia Shalima Aliya Nur Hasanah Alya Novia Hanifa Ami Tjiraresmi Anas Subarnas Anas Subarnas Andini, Nasywa Putri Andri Kusmayadi Andri Nugraha Nugraha Sutomo Angga Geganaputra Anggi, Joseph Fide Anggraeni, Diyani Sovia Annisa Rafashafly Anton Apriyantono Aprilio, Kevin Arief Cahyanto Arif Budiman Arif Budiman Arnees Angzora Asep Kuswandi Asep Nurrahman Yulianto ASMAN SADINO, ASMAN Athaya, Salsabila Athena Lilavya Putri Atusholihah, Annisa Ayu Nursiti Fatimah Aziz, Calista Sasikirana Finola Bagus Adhinagoro Bagus Adhinagoro Banowati, Nadya Dwi Basuki Hidayat C. Suhandi Cecep Suhandi Chindiana Khutami Christine Christine Christy, Alicia CINDY APRILLIANIE WIJAYA Cindy Aprillianie Wijaya Cleopatra D. Semesta Debian Mydea Erliputeri Desra Widdy Syafra Destia, Melsa Devani Olivia Winardi Dewi Permatasari Dewi, Humaira Praswatika Dhania Novitasari Dhania Novitasari Diah Lia Aulifa Diah Lia Aulifa Diantini, A. - Difla 'Afina Ghifari Suhendar Dilal Adlin Fadil Dini Rochdiani Dipadharma, Ratu Hanifa Fayza Djamaluddin, Muhammad Ilham Dolih Gozali E. Laelasari E. Novianti Eli Halimah, Eli Ellen N. Yunita Elsa N. Sitinjak Elvan Kamal Elvian, Elvian F. Ardiansyah Fadhilah, Ersa Fadil, Dilal Adlin Fadil, Dilal Adlin Fahmi Ahsanul Haq Fahriza Ardiansyah Faizal Hermanto Fakhirah, Maitsa Alya Fatharan, Rahma Haniyyah FATHIA NABILA AULANI Fatiya, Nadia Ulil Fernanda, Frisca Florencia, Carla Ganendra Akbar Hadiyanto Garneta Izzati Herdy Putri Gazzali, Amirah Mohd Gia A. Faradiba Gin Gin Ginanjar, Gin Gin Gofarana Wilar Gramita, Widya Siva Hadiwijaya, Nathannael Adrya Hafidh Beta Arif Putra Hanifahzin Khatami Hartono, Sugianto Ayudha Hasna Chaerunisa Herlina Herlina I Made Joni I. R. Hartanti Ichsani, Luthfia Nur Ida Ayumiati Ida Musfiroh Ida Musfiroh Ida Musfiroh -, Ida Musfiroh Ikram, NKK Imam Adi Wicaksono Iyan Sopyan Jessica Tristi Jessyca Sirait Jhoni, I Made Johanna Felicia Susanto Johnessa Cung Jutti Levita Karyadi Karyadi Karyn Elizabeth Kathlia Putri Alyanisa Keiichi Motoyama Kevin Reinard Lie Kezia Stella Carmencinta Salvi Khairul Ikram, Emmy Hainida Khairul Ikram, Nur Kusaira Kusnadi, Ivanna Fauziyah L. Pangestu Lestyawan, Samuel Levita, J. - Liawardi, Petra Pahlawanda Chrisanto Lovita Adriani Luthfi Ihsan Sulaeman Luthfi U Setyawati Luthfi U. Setyawati Luthfi Utami Setyawati Mardisanutol, Harsoning Tyas Mardisanutomo, Harsoning Tyas Marhaendra, Laurentius Ivan Ageng Martalena Ramli MEGANTARA, SANDRA Meilia Suherman Meilinda setya praceka MELISSA MELISSA Mentari Luthfika Dewi Mohamad Taufik Ismullah Monica Richelle Herdady Muhamad Ali Daffa Muhammad Ryan Radix Rahardhian Muhammad Syahid Abdillah Muhammad Yusuf Muhammad Yusuf Muhammad, Rosmaliza Mulyana - - Musfiroh, I. - Mustarichie, R. - Mutakin Mutakin N. Elly Rosilawati N. N. Auliya AS Nabila Alivia Yasmin Nabilah Muhamad Nabillah Fauziyyah NAELI FARHATY Nahariyah, St. Rohmani Nalia El-Huda Ismail Napitupulu, Gloria Nasrul Wathoni Nawadhir Fauzan Nawadhir Fauzan Nawadhir Fauzan Nazma Mumtaz Sidik Nazwa N. Mikdar Neli Neli Nia Yuniarsih Nisriinaa Ayu Dewanto Nissa Andjani Kusmawidiyanti Norisca A. Putriana Norisca Aliza Putri Norisca Aliza Putri Nurhanifah Puspitadewi Nurhidayah, Wiwit Nurjanah, Yuni Nursuhud Nursuhud Nursuhud Nurulaini, Siti Nunung NUZAHA BAQIYATUS SHOLIHAH AZIMAH Oktariani, Anisa Pebriani, Fathia Pratomo, Muhammad Fadhil Prayoga, Randy Rassi Ramdani, Aura Radiatia Sesiani Refitha N. Putri Renggana, Hesti Richa Mardianingrum Rina Fajri Nuwarda Risda R Islamiyati Risda Rahmi Islamiaty Riska Febriyanti Riska Prasetiawati Riska Prasetiawati, Riska Riyaldi, Muhammad Raihan Ronny Lesmana Rusdin, Agus S. Hidayat Salsa Sagitasa Salsabila, Salma Salsabila, Shela Salsabilla, Bunga Indra Sandya Amelia Febriliani Savira Silma Aulia Setyawati, Luthfi Utami Setyowati, Lulu Alya Shafa Nurul Fadilah Shela Salsabila Shela Salsabila Shela Salsabila Shela Salsabila Siagian, Virginia Heaven Mariboto Silvia, Nurfianti Sitti Faza Karima Slamet Budijanto Sri Adi Sumiwi Sri Aguswarini Sri Gustini Husein Stepanus Massora Sugianto, Nada Sekar Martani Suhandi, Cecep Suhendi, Cece Suryanto, Rajwa Dwifauza Susy Tjahjani Susyati Susyati Suwandi, Deden Winda Syahla Afaaf Alliyah Syahrul Hidayat T. N. Apriliya Taofik Rusdiana TIANA MILANDA TIARA SALSABILA MAJID Tina Rostinawati Udin. L.Z - Ujang Hidayat Tanuwiria Valeri Belliana Sanjaya Vannisa Artasya W. Oktavelia Wa Ode Ida Fitriah Warid Ali Qosim Wirantono, Sebastian Nathanoel Yasmiwar Susilawati Yohana Faustine Yuarsa Yudi Rosandi Yulianto, Asep Nurrahman Yunita Al-Azzahra Yustiandini, Benedicta Andrea Zahra, Citra Aulia Zelika Mega Ramadhania