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Sosialisasi cara penanganan kulit manggis dan buahnya untuk kebutuhan industri obat herbal Muchtaridi, Muchtaridi; Setyawati, Luthfi Utami; Nursuhud; Hartono, Sugianto Ayudha; Nahariyah, St. Rohmani; Budiman, Arif; Hadiwijaya, Nathannael Adrya; Liawardi, Petra Pahlawanda Chrisanto; Jhoni, I Made; Pratomo, Muhammad Fadhil; Aulifa, Diah Lia; Mardianingrum, Richa
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 6 No 3 (2023)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v6i3.19528

Abstract

Desa Parakanmanggu merupakan wilayah yang memproduksi buah manggis paling besar di Kabupaten Pangandaran dengan potensi manggis yang berkualitas. Selain daging buahnya yang dapat dikonsumsi, kulit manggis juga memiliki berbagai manfaat yang sangat berharga sebagai obat herbal yang telah dimanfaatkan sejak zaman dulu. Tujuan kegiatan ini yaitu untuk mengetahui pemahaman petani manggis Desa Parakanmanggu sebelum dan sesudah dilakukannya penyuluhan mengenai Teknologi Tepat Guna (TTG) terkait ekstraksi manggis dari limbah kulit manggis sebagai bahan baku obat herbal. Metode yang digunakan dalam kegiatan ini yaitu melalui Participatory Action Research (PAR) dengan metode wawancara mendalam (in-depth interview) diintegrasikan dengan survei dan diskusi kelompok terfokus (FGD), serta pre-test dan post-test dengan pendekatan kuantitatif untuk analisis data. Hasil dari kegiatan ini menunjukkan bahwa sebelum penyuluhan, sebanyak 64% dari populasi memiliki pengetahuan yang rendah mengenai manfaat dan cara pengolahan limbah kulit manggis. Namun, setelah penyuluhan dilakukan, terjadi peningkatan pengetahuan para responden, yaitu sebesar 64% dari populasi memiliki pengetahuan yang sedang dan 20% memiliki pengetahuan yang tinggi mengenai TTG pengolahan limbah kulit manggis dan manfaatnya.
Molecular Docking Study of Mangosteen (Garcinia mangostana L.) Xanthone-Derived Isolates as Anti Androgen Suhandi, Cecep; Fadhilah, Ersa; Silvia, Nurfianti; Atusholihah, Annisa; Prayoga, Randy Rassi; Megantara, Sandra; Muchtaridi, Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 12, No 1 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss1pp11-20

Abstract

Androgen receptor (AR) is the member of steroid hormone receptor involved in the progression of prostate cancer growth due to receptor over-activation. On the other hand, mangosteen (Garcinia mangostana L.) as a medicinal plant contains xanthone-derived compounds which were known to have cytotoxic activity towards any types of human cancer cells. This research aims to determine xanthone-derived isolates potency from mangosteen as AR antagonists. The study was carried out through molecular docking assay utilizing AutoDock 4.2.6 using androgen receptor obtained from PDB ID 2AM9, testosterone as native ligand, and bicalutamide, flutamide, and nilutamide as reference. The results indicated that three isolates (1,3,7-trihydroxy-2,8-di-(3-methylbut-2-enyl)xanthone, mangostinone, and trapezifolixanthone) have the highest potency to be AR antagonist seen from the lower bond-free energy value than all of reference ligand. The lowest bond-free energy was provided by mangostinone with a ΔG value of -10.05 kcal/mol. However, the highest difference of residual amino acids interaction with testosterone and similar interaction with bicalutamide was provided by 1,3,7-trihydroxy-2,8-di-(3-methylbut-2-enyl)xanthone, with five different amino acids with testosterone and nine similar amino acids with bicalutamide, respectively. Interestingly, 1,3,7-trihydroxy-2,8-di-(3-methylbut-2-enyl)xanthone has similar hydrogen bond with the key residue amino acids of AR (705-Asn and 711-Gln) which indicates probably partial agonist activity while mangostinone has the highest amount of hydrogen bond in the absence of hydrogen bond towards key residual amino acids of AR. The results concluded that three specific derived-xanthone compounds were predicted to have activity as AR antagonists.Keywords: Prostate cancer, Androgen receptor, Mangosteen, Xanthone, Molecular docking.
Co-Authors A. A. Putri A. Diantini - A. Khalilah A. L. Triadenda A. Mutalib - Abdul Mutalib Abdul Mutalib Abednego K. Gwiharto Abednego Kristande Abun Abun Abun Ade Rizqi Ridwan Firdaus Ade Zuhrotun Adhinagoro, Bagus Aeni, Wida Nur Ahmadi, Nurish Farisha Ahsanul Haq, Fahmi AJENG DIANTINI Al Faruq, Muhammad Ariq Aliya Nur Hasanah Ami Tjiraresmi Anas Subarnas Andini, Nasywa Putri Andri Kusmayadi Angga Geganaputra Anggi, Joseph Fide Anggraeni, Diyani Sovia Annisa Rafashafly Anton Apriyantono Aprilio, Kevin Ardiansyah, Fahriza Arief Cahyanto Arif Budiman Arif Budiman Asep Kuswandi Asep Nurrahman Yulianto ASMAN SADINO, ASMAN Athaya, Salsabila Atusholihah, Annisa Aziz, Calista Sasikirana Finola Banowati, Nadya Dwi Basuki Hidayat C. Suhandi Cecep Suhandi Christine Christine Christy, Alicia CINDY APRILLIANIE WIJAYA Cindy Aprillianie Wijaya Cleopatra D. Semesta Desra Widdy Syafra Destia, Melsa Devani Olivia Winardi Dewi Permatasari Dewi, Humaira Praswatika Diah Lia Aulifa Diantini, A. - Dilal Adlin Fadil Dini Rochdiani Dipadharma, Ratu Hanifa Fayza Djamaluddin, Muhammad Ilham Dolih Gozali - E. Laelasari E. Novianti Eli Halimah ELI HALIMAH Eli Halimah Ellen N. Yunita Elsa N. Sitinjak Elvan Kamal Elvian, Elvian F. Ardiansyah Fadhilah, Ersa Fadil, Dilal Adlin Fadil, Dilal Adlin Faizal Hermanto Fakhirah, Maitsa Alya Fatharan, Rahma Haniyyah FATHIA NABILA AULANI Fatiya, Nadia Ulil Fernanda, Frisca Florencia, Carla Ganendra Akbar Hadiyanto Gazzali, Amirah Mohd Gia A. Faradiba Gin Gin Ginanjar, Gin Gin Gofarana Wilar Gramita, Widya Siva Hadiwijaya, Nathannael Adrya Hafidh Beta Arif Putra Hartono, Sugianto Ayudha Hasna Chaerunisa Herlina Herlina I Made Joni I. R. Hartanti Ichsani, Luthfia Nur Ida Ayumiati Ida Musfiroh Ida Musfiroh Ida Musfiroh - Ikram, NKK Imam Adi Wicaksono Iyan Sopyan Jessica Tristi Jessyca Sirait Jhoni, I Made Jutti Levita Karyadi Karyadi Karyn Elizabeth Keiichi Motoyama Kevin Reinard Lie Khairul Ikram, Emmy Hainida Khairul Ikram, Nur Kusaira Kusnadi, Ivanna Fauziyah L. Pangestu Lestyawan, Samuel Levita, J. - Liawardi, Petra Pahlawanda Chrisanto Lovita Adriani Luthfi Ihsan Sulaeman Luthfi U Setyawati Luthfi U. Setyawati Luthfi Utami Setyawati Mardisanutol, Harsoning Tyas Mardisanutomo, Harsoning Tyas Marhaendra, Laurentius Ivan Ageng Martalena Ramli Megantara, Sandra MEGANTARA, SANDRA Meilinda setya praceka MELISSA MELISSA Mentari Luthfika Dewi Mohamad Taufik Ismullah Monica Richelle Herdady Muhammad Ryan Radix Rahardhian Muhammad Syahid Abdillah Muhammad Yusuf Muhammad Yusuf Muhammad, Rosmaliza Mulyana - - Musfiroh, I. - Mustarichie, R. - Mutakin Mutakin N. Elly Rosilawati N. N. Auliya AS Nabila Alivia Yasmin Nabilah Muhamad NAELI FARHATY Nahariyah, St. Rohmani Napitupulu, Gloria Nasrul Wathoni Nazwa N. Mikdar Neli Neli Nia Yuniarsih Norisca A. Putriana Norisca Aliza Putri Norisca Aliza Putri Nurhanifah Puspitadewi Nurjanah, Yuni Nursuhud Nursuhud Nursuhud Nurulaini, Siti Nunung NUZAHA BAQIYATUS SHOLIHAH AZIMAH Oktariani, Anisa Pebriani, Fathia Pratomo, Muhammad Fadhil Prayoga, Randy Rassi Ramdani, Aura Radiatia Sesiani Refitha N. Putri Renggana, Hesti Richa Mardianingrum Rina Fajri Nuwarda Risda R Islamiyati Risda Rahmi Islamiaty Riska Febriyanti Riska Prasetiawati, Riska Riyaldi, Muhammad Raihan Ronny Lesmana Rusdin, Agus S. Hidayat Salsa Sagitasa Salsabila, Salma Salsabila, Shela SANDRA MEGANTARA Savira Silma Aulia Setyawati, Luthfi Utami Setyowati, Lulu Alya Shafa Nurul Fadilah Siagian, Virginia Heaven Mariboto Silvia, Nurfianti Sitti Faza Karima Slamet Budijanto Sri Adi Sumiwi Sri Aguswarini Sri Gustini Husein Stepanus Massora Sugianto, Nada Sekar Martani Suhandi, Cecep Suhendi, Cece Suryanto, Rajwa Dwifauza Susy Tjahjani Susyati Susyati Suwandi, Deden Winda Syahla Afaaf Alliyah Syahrul Hidayat T. N. Apriliya Taofik Rusdiana TIANA MILANDA TIARA SALSABILA MAJID Tina Rostinawati Udin. L.Z - Ujang Hidayat Tanuwiria W. Oktavelia Wa Ode Ida Fitriah WARID ALI QOSIM Wirantono, Sebastian Nathanoel Wiwit Nurhidayah Yasmiwar Susilawati Yudi Rosandi Yulianto, Asep Nurrahman Yunita Al-Azzahra Yustiandini, Benedicta Andrea Zahra, Citra Aulia Zelika Mega Ramadhania