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Biomolecular Mechanism of Herbal Medicine on Muscle Atrophy in Type 2 Diabetes Mellitus Rats: Systematic Review Kuswandi, Asep; Ikram, NKK; Muchtaridi, Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.50895

Abstract

Musculoskeletal atrophy causes an increase in advanced glycation end products, a proinflammatory phenotype, and oxidative stress, which can lead to micro- and macrovascular complications.This can cause loss of skeletal muscle mass, strength, and function, potentially leading to sarcopenia. Herbal medicines have been proven to be able to treat various diseases in humans, herbal medicines have the potential to increase skeletal muscle mass. There are various genes that have been induced by herbal medicines to prevent muscle atrophy in chronic diseases. It is necessary to explain the molecular mechanisms of the role of herbal medicines in preventing muscle atrophy due to chronic diseases. This study explores the biomolecular mechanisms of each herbal medicine based on the pathways of inflammation, protein synthesis, apoptosis, autophagy, and glucose uptake in T2DM mice. The research results show that herbal medicine can potentially activate 81 gene expressions that can prevent muscle atrophy in T2DM mouse models. Keywords: biomolecular, herbal medicine, musculoskeletal atrophy, type 2 diabetes 
Antiviral Activity of Various Glycoside Compounds Al Azzahra, Yunita; Muchtaridi, Muchtaridi; Yusuf, muhammad
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.44496

Abstract

Glycoside compounds consist of several groups of important compounds, such as flavonoids and alkaloids. Sometimes the glycosidic residues in glycoside compounds have an important role in their activity, but some can only increase their pharmacokinetic parameters. However, recent developments in molecular glycobiology have gained a greater understanding of the activity of aglycones vs. glycosides. Several glycoside compounds, such as flavonoid glycosides and Cardiac glycosides, have been known to have antiviral activity, including against Herpes Simplex Virus, Influenza, and Human Immunodeficiency Virus. Still, until now, the potential for various Glycoside compounds as antivirals have not been widely studied, although many biologically active compounds are in the form of glycosides. Further studies regarding the antiviral activity of this glycoside compound are needed to determine the possibility of this compound as an alternative for treating diseases caused by viruses.Keyword : flavonoid glikosida, cardiac glikosida, HSV, Influenza, HIV
Effects of Mangosteen Peel Extract Microcapsules Supplemented in Diets on Intestinal Characteristics and Malondialdehyde of Cihateup Duck Kusmayadi, Andri; Adriani, Lovita; Abun, Abun; Muchtaridi, Muchtaridi; Tanuwiria, Ujang Hidayat
Jurnal Ilmu dan Teknologi Peternakan Tropis Vol 10, No 1 (2023): JITRO, January
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/jitro.v10i1.27371

Abstract

The aim of this study was to examine the effect of supplementation of mangosteen peel extract microcapsule which was encapsulated using maltodextrin from sugar palm starch (MPEM) on intestinal characteristics, and malondialdehyde of Cihateup duck. This study used 140 male Cihateup ducks, which were divided randomly into 7 groups of cages with different feed treatments. The T1 treatment consisted of only basal rations. The T2 treatment contained basal rations added with 50 ppm bacitracin. The treatment of T3 to T7 consisted of basal rations added by MPEM at the doses of 0.5, 1.0, 1.5, 2.0, and 2.5%, respectively. Data on intestinal characteristics, and malondialdehyde level were analyzed using a completely randomized design and if there were significant differences, further testing using DMRT method was performed. The results showed that MPEM treatment had a significant effect (P
Knowledge, Attitude, and Practices of Traditional Herbs and Spices Consumption among Adults in Malaysia Khairul Ikram, Emmy Hainida; Ahmadi, Nurish Farisha; Khairul Ikram, Nur Kusaira; Muchtaridi, Muchtaridi; Muhammad, Rosmaliza
Jurnal Gizi dan Pangan Vol. 19 No. Supp.2 (2024)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2024.19.Supp.2.173-182

Abstract

This research aimed to assess knowledge, attitude, and practices regarding traditional herbs and spices consumption among Malaysian adults aged 18 to 60 years. A- 5-parts close-ended questionnaire was partially adapted and modified from articles and validated by 11 experts. Data collection was performed by using an online questionnaire (n=281). Most participants are female (75.4%) and Malay (85.1%), followed by Chinese (10.0%), Indian (2.1%), and other ethnicities (2.8%) such as Sabah natives, Iban, Dusun, and Javanese. Most respondents consumed traditional herbs and spices. Centella asiatica ('pegaga'), ginseng, Labisia pumila ('kacip fatimah'), and longjack ('tongkat ali') were the most consumed herbs whereas lemongrass, garlic, ginger, turmeric, and star anise were the most consumed spices. The study found good knowledge, fair attitude, and poor practice regarding traditional herbs and spices consumption. Knowledge was significantly associated with ethnicity, while consumption status was associated with attitude and practice levels. A moderate and positive correlation was observed between attitudes and practices. Enhancing public knowledge and promoting positive attitudes towards these traditional ingredients is essential for preserving cultural heritage and incorporating them into modern diets.
PEMAHAMAN PETANI DALAM BUDIDAYA BUAH MANGGIS DI DESA PARAKANMANGGU PANGANDARAN UNTUK PENINGKATAN KUALITAS HASIL PANEN Nursuhud, Nursuhud; Oktariani, Anisa; Jhoni, I Made; Mardianingrum, Richa; Napitupulu, Gloria; Wirantono, Sebastian Nathanoel; Gramita, Widya Siva; Muchtaridi, Muchtaridi
Kumawula: Jurnal Pengabdian Kepada Masyarakat Vol 7, No 3 (2024): Kumawula: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/kumawula.v7i3.56424

Abstract

Pangandaran Regency has not optimally produced mangosteen, therefore it is not in the top 10 regencies producing mangosteen in West Java. Parakanmanggu Village is the largest mangosteen producer in Pangandaran Regency and has the potential to increase its production and has promising potential. This is due to the suitable agro climatic conditions in the area. The aim of this survey is to identify the conditions and issues in mangosteen cultivation and other commodities. The method used in this survey will be direct interviews, with the measurement of community understanding evaluated through assessments by farmers regarding their satisfaction with harvest results and the selling price of their harvest products. Based on this study, the results concluded that the majority of mangosteen farmers already know or understand how to plant and care for the mangosteen trees they grow themselves. However, there are some farmers who do not know how to control pests properly thus it carried out outreach regarding pest control procedures.Kabupaten Pangandaran belum optimal memproduksi manggis sehingga berada di atas 10 besar di Jawa Barat. Desa Parakanmanggu merupakan penghasil manggis terbesar di Kabupaten Pangandaran, sehingga memiliki potensi yang menjanjikan untuk meningkatkan produksinya. Hal ini disebabkan oleh cocoknya kondisi agroklimatik di daerah tersebut. Tujuan dari kajian ini adalah untuk mengidentifikasi kondisi dan permasalahan yang terjadi dalam budidaya manggis dan komoditas lainnya. Metode yang digunakan dalam survei ini adalah survei langsung, dengan pengukuran tingkat pemahaman masyarakat yang di evaluasi melalui penilaian dari para petani mengenai tingkat kepuasan mereka terhadap hasil panen dan nilai jual produk panen mereka. Berdasarkan studi ini, hasilnya menyimpulkan bahwa mayoritas petani manggis sudah mengetahui atau memahami cara menanam dan merawat pohon manggis yang mereka tanam sendiri. Namun, terdapat beberapa petani yang belum mengetahui cara mengendalikan hama dengan benar, sehingga dilakukan penyuluhan mengenai prosedur pengendalian hama.
In Silico Study of Compounds in Noni (Morinda citrifolia L.) against Main-Protease in SARS-CoV-2 Lestyawan, Samuel; Fakhirah, Maitsa Alya; Prasetiawati, Riska; Anggraeni, Diyani Sovia; Muchtaridi, Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.58058

Abstract

Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a contagious illness transmitted from person to person. The main protease (Mpro) of SARS-CoV-2 is a promising target for therapeutic intervention. Noni (Morinda citrifolia L.), a plant commonly used in traditional medicine in Indonesia for treating COVID-19, has been investigated for its potential anti-SARS-CoV-2 compounds. However, the specific bioactive compounds targeting SARS-CoV-2 remain unidentified. This study aimed to identify and predict the activity of compounds in Noni against Mpro through pharmacophore modeling, molecular docking, drug-likeness, and pharmacokinetic analysis using LigandScout®, Discovery Studio Visualizer®, AutoDock®, SwissADME, Pre-ADMET, and Toxtree®. Among the 40 compounds analyzed, quercetin emerged as the most promising candidate, with a pharmacophore fit score of 41.05, a binding energy (ΔG) of -7.79 kcal/mol, and interactions with amino acid residues GLY143A and MET165A, similar to the native ligand. These findings suggest that quercetin from M. citrifolia has the potential to be developed as a novel anti-SARS-CoV-2 therapeutic agent.
In-Silico Study of N-Hydroxysuccinimide Folate and GAPDH as Targeting Agents for Tuberculosis Treatment Marhaendra, Laurentius Ivan Ageng; Muchtaridi, Muchtaridi; Rosandi, Yudi; Gazzali, Amirah Mohd
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.59597

Abstract

Tuberculosis remains a major public health concern due to emerging cases of drug resistance. To overcome this issue, the effectiveness of antitubercular medications must be reinforced. One of the methods that can be used is using active targeting, which involves small molecules that bind to a specific receptor. In this research, we study the potential of N-hydroxysuccinimide (NHS) folate to be used as the targeting agent against the GAPDH (glyceraldehyde-3-phosphate dehydrogenase) cell-surface receptor, a common virulence factor found on many pathogenic bacteria, including Mycobacterium tuberculosis. We conducted this research using computational methods, specifically molecular docking and molecular dynamics simulation. Based on the evaluation of molecular docking and molecular dynamics simulation results, NHS-folate is predicted to have a huge potential to be an active targeting agent against the GAPDH receptor of Mycobacterium tuberculosis.
Prediction of Secondary Metabolite Compounds in Lotus (Nelumbo nucifera Gaertn.) Targeting Androgen-α Receptors for Breast Cancer Treatment Using Molecular Docking Siagian, Virginia Heaven Mariboto; Destia, Melsa; Andini, Nasywa Putri; Yustiandini, Benedicta Andrea; Adhinagoro, Bagus; Salsabila, Shela; Muchtaridi, Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 15, No 2 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss2pp137-149

Abstract

Breast cancer (BC) is a malignant tumor that grows in the breast tissue and can spread to other organs. BC is often found at an advanced stage and therefore has a poor prognosis. With 68,858 cases, BC is the most common type of cancer in Indonesia. The development of breast carcinoma is strongly influenced by steroid hormones and their receptors, such as estrogen, progesterone, and androgen. Androgen receptors (AR) are found more (70-90%) compared to estrogen receptors (60-80%) and progesterone receptors (50-70%). Therefore, research on natural compounds that inhibit cancer cell proliferation influenced by AR needs to be increased. The lotus plant (Nelumbo nucifera Gaertn.) has been used as a traditional herbal medicine and food in Asia. Bioactive compounds in lotus have therapeutic potential against BC. In the pharmacophore screening results, five hit compounds were found: isorhamnetin, luteolin, catechin, kaempferol, and apigenin. The compound with the best pharmacophore fit score value is isorhamnetin with a value of 41.31, while the compound with the best binding affinity to AR is kaempferol with a binding affinity of -9.44 and an inhibitor constant of 121.12 nM.Keywords: breast-cancer, androgen-α receptor, lotus, molecular docking.
STUDI IN-SILICO SENYAWA PADA BAWANG PUTIH (Allium sativum L.) SEBAGAI INHIBITOR NEURAMINIDASE PADA INFLUENZA Fatiya, Nadia Ulil; Kusnadi, Ivanna Fauziyah; Riyaldi, Muhammad Raihan; Dipadharma, Ratu Hanifa Fayza; Suhandi, Cecep; Hidayat, Syahrul; Muchtaridi, Muchtaridi
Farmaka Vol 20, No 3 (2022): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i3.37598

Abstract

Influenza merupakan penyakit pernapasan menular yang disebabkan oleh virus influenza. Salah satu glikoprotein permukaan utama virus influenza adalah Neuraminidase. Pencegahan dan pengobatan influenza dapat dilakukan dengan menghambat Neuraminidase untuk mengganggu proses pelepasan virus influenza turunan dari sel inang yang terinfeksi. Ekstrak dari Bawang putih (Allium sativum L.) dilaporkan dapat menginhibisi virus influenza A (H1N1) pdm09 dengan cara menghambat sintesis nukleoprotein dan aktivitas polimerase virus. Penelitian ini dilakukan untuk karakterisasi lebih lanjut dan mekanisme spesifik bawang putih terhadap penghambatan virus influenza. Penelitian dilakukan dalam dua langkah yaitu penambatan molekuler dan pemodelan farmakofor. Berdasarkan penelitian yang telah dilakukan, senyawa S-allylmercapto-cysteine memiliki afinitas terbaik dengan nilai ∆G dan Ki terendah, yaitu -6.46 kkal/mol dan 18.41 uM.Kata Kunci: Influenza, Bawang putih, Penambatan molekuler, Pemodelan farmakofor
Immunomodulatory and Acute Toxicity Studies of Peronema canescens Jack Leaves: in vivo Hematological Analysis and in vitro IL-6 Gene Expression Inhibition Rahardhian, Muhammad Ryan Radix; Ardiansyah, Fahriza; Susilawati, Yasmiwar; Wilar, Gofarana; Sumiwi, Sri Adi; Levita, Jutti; Muchtaridi, Muchtaridi
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3577

Abstract

BACKGROUND: Peronema canescens Jack is traditionally employed in the treatment of inflammation, malaria, and immune-related disorders. Despite its traditional use, scientific evidence on its immunomodulatory effects, interleukin (IL)-6 modulation, hematological impact, as well as its related acute toxicity data remains limited. Therefore, this study was conducted to investigate the immunostimulatory potential of P. canescens leaf extract through in vitro and in vivo assessments and evaluate its acute toxicity profile.METHODS: The in vitro immunomodulatory activity of P. canescens ethanolic extract, n-hexane fraction (NHF), ethyl acetate fraction (EAF), and water fraction (WF) were assessed by measuring IL-6 inhibition in lipopolysaccharide-stimulated RAW 264.7 macrophages. For in vivo analysis, Balb/C mice were divided into six groups: a normal control (Na-CMC), a positive control (50 mg/kg BW/day Stimuno Phyllanthus niruri extract), a negative control (80 mg/kg BW/day cyclophosphamide as immunosuppressant), and 3 treatment groups receiving P. canescens extract at doses of 100, 200, and 400 mg/kg BW/day. Hematological parameters, including white blood cell (WBC) counts, lymphocyte percentages, and neutrophil percentages, were analyzed. Acute toxicity studies were performed by administering P. canescens extract at doses of 300, 2000, and 5000 mg/kg BW over observation period.RESULTS: EAF exhibited the most pronounced IL-6 inhibition in vitro. In vivo, the administration of P. canescens extract at 200 and 400 mg/kg BW significantly elevated WBC and lymphocyte levels while concurrently reducing neutrophil counts. No mortality or neurotoxic manifestations were observed, confirming the P. canescens extract’s safety profile up to 5000 mg/kg BW.CONCLUSION: P. canescens leaf extract, particularly EAF, demonstrates robust immunomodulatory activity with a favorable safety margin. These findings underscore its potential therapeutic application in immune modulation.KEYWORDS: Peronema canescens Jack, immunomodulatory, IL-6 inhibition, acute toxicity, hematology, cytokines
Co-Authors A. A. Putri A. Diantini - A. Khalilah A. L. Triadenda A. Mutalib - Abdul Mutalib Abdul Mutalib Abednego K. Gwiharto Abednego Kristande Abun Abun Abun Ade Rizqi Ridwan Firdaus Ade Zuhrotun Adhinagoro, Bagus Aeni, Wida Nur Ahmadi, Nurish Farisha Ahsanul Haq, Fahmi AJENG DIANTINI Al Faruq, Muhammad Ariq Alifa Dhia Shalima Aliya Nur Hasanah Alya Novia Hanifa Ami Tjiraresmi Anas Subarnas Anas Subarnas Andini, Nasywa Putri Andri Kusmayadi Andri Nugraha Nugraha Sutomo Angga Geganaputra Anggi, Joseph Fide Anggraeni, Diyani Sovia Annisa Rafashafly Anton Apriyantono Aprilio, Kevin Ardiansyah, Fahriza Arief Cahyanto Arif Budiman Arif Budiman Asep Kuswandi Asep Nurrahman Yulianto ASMAN SADINO, ASMAN Athaya, Salsabila Atusholihah, Annisa Ayu Nursiti Fatimah Aziz, Calista Sasikirana Finola Bagus Adhinagoro Banowati, Nadya Dwi Basuki Hidayat C. Suhandi Cecep Suhandi Chindiana Khutami Christine Christine Christy, Alicia CINDY APRILLIANIE WIJAYA Cindy Aprillianie Wijaya Cleopatra D. Semesta Desra Widdy Syafra Destia, Melsa Devani Olivia Winardi Dewi Permatasari Dewi, Humaira Praswatika Diah Lia Aulifa Diantini, A. - Dilal Adlin Fadil Dini Rochdiani Dipadharma, Ratu Hanifa Fayza Djamaluddin, Muhammad Ilham Dolih Gozali - E. Laelasari E. Novianti Eli Halimah Eli Halimah ELI HALIMAH Ellen N. Yunita Elsa N. Sitinjak Elvan Kamal Elvian, Elvian F. Ardiansyah Fadhilah, Ersa Fadil, Dilal Adlin Fadil, Dilal Adlin Faizal Hermanto Fakhirah, Maitsa Alya Fatharan, Rahma Haniyyah FATHIA NABILA AULANI Fatiya, Nadia Ulil Fernanda, Frisca Florencia, Carla Ganendra Akbar Hadiyanto Gazzali, Amirah Mohd Gia A. Faradiba Gin Gin Ginanjar, Gin Gin Gofarana Wilar Gramita, Widya Siva Hadiwijaya, Nathannael Adrya Hafidh Beta Arif Putra Hanifahzin Khatami Hartono, Sugianto Ayudha Hasna Chaerunisa Herlina Herlina I Made Joni I. R. Hartanti Ichsani, Luthfia Nur Ida Ayumiati Ida Musfiroh Ida Musfiroh Ida Musfiroh - Ikram, NKK Imam Adi Wicaksono Iyan Sopyan Jessica Tristi Jessyca Sirait Jhoni, I Made Johnessa Cung Jutti Levita Karyadi Karyadi Karyn Elizabeth Keiichi Motoyama Kevin Reinard Lie Kezia Stella Carmencinta Salvi Khairul Ikram, Emmy Hainida Khairul Ikram, Nur Kusaira Kusnadi, Ivanna Fauziyah L. Pangestu Lestyawan, Samuel Levita, J. - Liawardi, Petra Pahlawanda Chrisanto Lovita Adriani Luthfi Ihsan Sulaeman Luthfi U Setyawati Luthfi U. Setyawati Luthfi Utami Setyawati Mardisanutol, Harsoning Tyas Mardisanutomo, Harsoning Tyas Marhaendra, Laurentius Ivan Ageng Martalena Ramli MEGANTARA, SANDRA Megantara, Sandra Meilinda setya praceka MELISSA MELISSA Mentari Luthfika Dewi Mohamad Taufik Ismullah Monica Richelle Herdady Muhammad Ryan Radix Rahardhian Muhammad Syahid Abdillah Muhammad Yusuf Muhammad Yusuf Muhammad, Rosmaliza Mulyana - - Musfiroh, I. - Mustarichie, R. - Mutakin Mutakin N. Elly Rosilawati N. N. Auliya AS Nabila Alivia Yasmin Nabilah Muhamad NAELI FARHATY Nahariyah, St. Rohmani Nalia El-Huda Ismail Napitupulu, Gloria Nasrul Wathoni Nazwa N. Mikdar Neli Neli Nia Yuniarsih Norisca A. Putriana Norisca Aliza Putri Norisca Aliza Putri Nurhanifah Puspitadewi Nurjanah, Yuni Nursuhud Nursuhud Nursuhud Nurulaini, Siti Nunung NUZAHA BAQIYATUS SHOLIHAH AZIMAH Oktariani, Anisa Pebriani, Fathia Pratomo, Muhammad Fadhil Prayoga, Randy Rassi Ramdani, Aura Radiatia Sesiani Refitha N. Putri Renggana, Hesti Richa Mardianingrum Rina Fajri Nuwarda Risda R Islamiyati Risda Rahmi Islamiaty Riska Febriyanti Riska Prasetiawati, Riska Riyaldi, Muhammad Raihan Ronny Lesmana Rusdin, Agus S. Hidayat Salsa Sagitasa Salsabila, Salma Salsabila, Shela SANDRA MEGANTARA Savira Silma Aulia Setyawati, Luthfi Utami Setyowati, Lulu Alya Shafa Nurul Fadilah Shela Salsabila Siagian, Virginia Heaven Mariboto Silvia, Nurfianti Sitti Faza Karima Slamet Budijanto Sri Adi Sumiwi Sri Aguswarini Sri Gustini Husein Stepanus Massora Sugianto, Nada Sekar Martani Suhandi, Cecep Suhendi, Cece Suryanto, Rajwa Dwifauza Susy Tjahjani Susyati Susyati Suwandi, Deden Winda Syahla Afaaf Alliyah Syahrul Hidayat T. N. Apriliya Taofik Rusdiana TIANA MILANDA TIARA SALSABILA MAJID Tina Rostinawati Tina Rostinawati Udin. L.Z - Ujang Hidayat Tanuwiria W. Oktavelia Wa Ode Ida Fitriah WARID ALI QOSIM Wirantono, Sebastian Nathanoel Wiwit Nurhidayah Yasmiwar Susilawati Yudi Rosandi Yulianto, Asep Nurrahman Yunita Al-Azzahra Yustiandini, Benedicta Andrea Zahra, Citra Aulia Zelika Mega Ramadhania