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FACTORS INFLUENCING THE DEVELOPMENT OF MULTI DRUG-RESISTANT TUBERCULOSIS: LITERATURE REVIEW Azzahra, Ilya Nur Aulia; Adi, Mateus Sakundarno; Hadisaputro, Suharyo
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 2 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i2.2902

Abstract

Multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge in global TB control, caused by Mycobacterium tuberculosis strains resistant to first-line antibiotics isoniazid and rifampicin. According to WHO, an estimated 400,000 MDR-TB cases were reported worldwide in 2024. This literature review aims to analyze socio-demographic, comorbidity, lifestyle, and policy factors influencing MDR-TB occurrence by reviewing 20 studies conducted in Africa, Asia, Europe, Australia, and America. Employing a meta-analysis approach, the study identifies key risk factors, including medication non-adherence, history of diabetes mellitus (DM) and HIV comorbidities, and productive age. Findings highlight the importance of targeted community interventions, improved treatment adherence, and strengthened TB control programs. Evidence-based policies for early screening and integrated management, as well as adaptive intervention models, are necessary. Further research is recommended to evaluate community-based approaches and digital innovations in enhancing treatment success.
GLOBAL EVIDENCE ON RISK FACTORS FOR CHILDHOOD TUBERCULOSIS: A SCOPING REVIEW Safira, Rahma; Setyawan, Henry; Hadisaputro, Suharyo
Jambura Journal of Health Sciences and Research Vol 7, No 4 (2025): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v7i4.34181

Abstract

Childhood tuberculosis (TB) remains a major global public health concern, particularly in developing countries, due to children’s immature immune systems and frequent exposure to infectious adults within households. This scoping review aimed to identify and synthesize global evidence on risk factors associated with TB among children aged 0–19 years, following the Joanna Briggs Institute (JBI) methodology and PRISMA-ScR guidelines. Unlike previous systematic reviews that focused on specific regions or populations, this study comprehensively mapped risk factors using evidence from PubMed, Scopus, and Garuda databases up to March 2025. Eleven primary studies meeting the inclusion criteria were analyzed thematically. The most frequently reported risk factors included close contact with adult TB patients, lack of Bacillus Calmette–Guérin (BCG) vaccination, malnutrition, overcrowded housing, and poor ventilation. Additional factors such as HIV infection, exposure to cigarette smoke, low parental education, and poor household income further increased susceptibility. The findings indicate that childhood TB arises from a complex interplay of biological, social, and environmental determinants. Therefore, effective prevention strategies should integrate immunization, active contact tracing, family health education, and improvement of living conditions. This review provides valuable insights for strengthening community-based TB control programs, highlights the need to prioritize children as a vulnerable population, and identifies research gaps to guide future policy and interventions toward TB elimination.
Effectiveness of Transdermal Patch Compressed Red Ginger Ekstract (Zingiber Officinale Var.Rubrum) as Therapy Alternative to Flowness Breast Milk in Postpartum Mothers Ladyvia, Fiyola; Hadisaputro, Suharyo; Suwondo, Ari
Indonesian Journal of Global Health Research Vol 6 No 3 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i3.3186

Abstract

Breast milk smoothness occurs because the blockage of venous and lymphatic flow increases, causing breast swelling, inhibiting milk flow, and pain in the breast and increasing body temperature, if not treated immediately there can be breast milk dams, mastitis and even breast infections. This causes pain, to reduce breast swelling non-pharmacologically can be done with the development of transdermal patch compress red ginger extract. The research purposes is a resulted in the development of a viable red ginger extract transdermal patch compress and proved its effectiveness as an alternative therapy for smooth breastfeeding in postpartum mothers. Produce and analyze its effectiveness as an alternative therapy for smooth breast milk in postpartum mothers. Method: This type of research is R&D, and quasi-experimental Pre-Posttest With Control Group Design. The sample amounted to 30 postpartum mothers divided into 2 intervention groups with the development of transdermal patches of red ginger extract and breastcare and a control group with breasrcare. The variables measured were breast milk volume, decreased swelling and breast tenderness. Consecutive sampling technique. Data collection using questionnaires and observations. Data analysis using univariate and bivariate using Wilcoxon and Mann Whitney. The development of transdermal red ginger extract patches is validated and feasible to be applied as an alternative therapy to smooth breast milk of puerperal mothers. Test results of effectiveness of increasing breast milk volume from 2,47 to 71,07 (p = 0.000), decreasing breast swelling from 3,45 to 1,32 (p = 0.000), breast pain from 2,91 to 0,14 (p = 0.001). The application of the development of Transdermal Extract Red Ginger Patch is feasible and effective as an alternative therapy against the smooth breastfeeding of puerperal mothers.
HUBUNGAN FREKUENSI PENYELAMAN, LAMA MENYELAM, PILEK, DAN MEROKOK, TERHADAP KEJADIAN BAROTRAUMA TELINGA TENGAH PENYELAM TRADISIONAL Martinus, Ishak; Hadisaputro, Suharyo; Munasik, Munasik
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 8, No 1 (2020): EDITION MARCH 2020
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.354 KB) | DOI: 10.33366/jc.v8i1.1175

Abstract

Inability to equate middle ear space pressure with the surrounding environment can cause tissue damage or barotrauma. Factors influencing the incidence of middle ear barotrauma in traditional divers are colds, smoking, frequency of diving and length of diving. The purpose of explaining the factors related to the occurrence of barotrauma in the middle ear of traditional breath-resistant divers. The analytic observational research design with cross sectional approach is supported by in-depth interviews, by conducting interviews using questionnaires and otoscopy examinations of respondents to determine the events of middle ear barotrauma. The study population was traditional divers, totaling 78 respondents. The dependent variable is the occurrence of barotrauma in the middle ear of traditional divers, the independent variable with colds, smoking habits, frequency of diving and length of diving, data analysis using bivariate and multivariate. Results as many as 32 people (41.0%) of 78 respondents experienced middle ear barotrauma. Bivariate analysis showed a correlation between the frequency of diving with the events of the middle ear barotrauama p = 0.012. Logistic regression test showed the significance value of the frequency of diving ≥ 4 days / week (p = 0.0106; PR = 5.310; 95% CI = 1.619-17.413). Conclusion of factors related to the incidence of middle ear barotrauma in traditional divers is the frequency of diving hari 4 days / week, with a probability of 38.13%.
EVALUASI PROGRAM PENGENDALIAN TUBERCULOSIS DI WILAYAH KERJA PUSKESMAS (Studi di Kota Ambon) Parera, Lodri; Hadisaputro, Suharyo; Lukmono, Djoko Tri Hadi
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 8, No 3 (2020): EDITION NOVEMBER 2020
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v8i3.1266

Abstract

The TB control program has been carried out at each publich health centers in Ambon city. But the decrease in the number of new and old cases is not sufficiently accelerated according to the target, there are still high TB cases and there are also differences or disparities in the number of case detection rates between puskesmas and case detection The highest rate is among the puskesmas with the lowest CDR. This study aims to control tuberculosis in the working area of the health center. The type of research used in this research is descriptive analytic research using an observational approach supported by qualitative research. The sample is the program and also the TB laboratory staff at the Ambon City publich health centers, the holder of 44 respondents. Descriptive data analysis with the results described in narrative form then compared the level of case data. The results showed that the case finding program and treatment of TB patients as well as health promotion were carried out by 100% of the respondents. The TB sputum examination program was well implemented by 18 (81.8%) TB laboratory staff respondents. This is related to suspects that do not return the sputum pot. Program TB officers or laboratory workers have multiple jobs, as well as demographic conditions that are far away and difficult to reach by vehicle. Selection of places for TB promotion activities and health centers that are far from where the community lives. Laboratory conditions that should be separate and small for TB. Laboratory staff receive poor quality sputum provided by program holders. The TB control program is carried out and has been running well, but there are several conveniences that the sputum pot cannot return, demographics, treatment at other health facilities, inadequate space and not good enough sputum quality.
Assessing Interventions for Declining Childhood Immunization Dropout - A Systematic Review Jaleha, Jaleha; Widjarnarko, Bagoes; Susanto, Henry Setyawan; Margawati, Ani; Hadisaputro, Suharyo; Hikmah, Kholisotul
JURNAL INFO KESEHATAN Vol 21 No 3 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss3.1271

Abstract

Childhood routine immunization is a critical stage to ensure the health of infants and protect against serious diseases. Therefore, adequate strategies are urgently needed to increase childhood immunization coverage to prevent global disease and death. This review has identified the effect of interventions to increase immunization coverage among children in developing countries. A review included published studies from 2013 to 2023 on randomized controlled trials (RCT) and pre-post intervention that met eligible criteria. All included studies had been conducted in English-published articles on Pub Med and Google Scholar, without being limited to geographical sites. A total of 1107 published articles were accessed and 12 final eligible articles were reviewed. 66.67% of the included studies were conducted in Africa, 16.67% in South East Asia countries, and others were conducted in East Asia and America. These studies demonstrated that different interventions (SMS and call reminders, sticker reminders, immunization education, home-based records, and community-centered) had significant increases in immunization coverage for childhood compared to the control group with standard care or without any interventions. The present findings suggest that interventions including implementing SMS and call reminders, sticker reminders, education both from health workers and local leaders, and home-based records can potentially reduce immunization dropout. However, strategies to improve coverage for immunization uptake should also be considered preferred community-based to extend the marginal groups.
Nausea and Vomiting of Pregnancy: Multiple Contributing Factors Wahyuni, Sri; Pramono, Noor; Hadisaputro, Suharyo; Ediati, Annastasia
JURNAL INFO KESEHATAN Vol 21 No 4 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss4.1388

Abstract

Nausea and vomiting are common conditions in earlier pregnancy. Some studies have suggested that nausea and vomiting during pregnancy (NVP) is caused by multiple factors, however, few studies assessed family support and psychological factors. The present study aimed to assess the prevalence of NVP and its contributing factors. A cross-sectional study was conducted in five Primary Health Centers in Semarang during August 2023. A total of 99 eligible pregnant women were included. A logistic regression was used to determine the significant contributing factors of NVP. The prevalence of moderate to severe and mild NVP was 71.7% and 28.3% respectively. Bivariate analysis indicated that gestational age and anxiety level significantly influence NVP (p-value <0.05). Women with greater gestational age (OR= 2.462; 0.954-6.356) and mild anxiety (OR=3.337; 1.240-8.982) were more likely to experience NVP during their pregnancy. Gestational of 12 weeks and mild anxiety are strongly associated with NVP. These findings highlight the crucial of psychological factors despite other health-related conditions.
Analysis of Risk Factors for Stunting in Central Java Sumarni, Sri; Kumorowulan, Suryati; Hadisaputro, Suharyo; Nafi’ah, Eka Apriadi Farkhati
JURNAL INFO KESEHATAN Vol 23 No 1 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss1.1626

Abstract

The prevalence of stunting in Indonesia was 24.4% in 2021 in Central Java at 20.9%, which is still above the WHO target of 20%. There are many direct and indirect risk factors that cause stunting events.  The purpose of this study is to analyze the risk factors for stunting events in Central Java. This research is an observational study with a cross-sectional approach. The collected data was analyzed using the Chi-Square test to assess the relationship between the independent variable (risk factors) and the dependent variable (stunting incidence). In addition, the odds ratio calculation is used to determine the risk level of each factor in influencing the incidence of stunting. The population is all mothers who have toddlers aged 0-59 months in Central Java Province. Data were collected via Google Form for two weeks in December 2023 using the Accidental Sampling technique with a total of 2671 mothers involved in this research. The result shows that the prevalence of stunting is 24.3%. There was no relationship between maternal parity OR 0.865, working mother OR 0.878, maternal BMI OR 0.898, economic status OR 0.954, and the incidence of stunting in toddlers. There was a relationship between maternal education OR 2.120, maternal height OR 1.955, exclusive breastfeeding OR 1.616, the diet OR 3.160, gestational age OR 1.410, the birth weight OR 1.670, and the incidence of stunting in toddlers. It is concluded that several factors collaborate to the high number of stunting, which are maternal education, maternal height, exclusive breastfeeding, diet, gestational age, and birth weight. Further research needs to consider a wider sample, the number of other risk factors which are competency of health provider to diagnose stunting, family support, and extend the length of observation time.                    
Risk Factors for Dental Caries in Elementary School Children Aged 6-12 in Indonesia (Systematic Literatur Review) Rahatina, Vilianti Eka Fitri; Hadisaputro, Suharyo; Setyawan S, Henry
Jurnal Riset Kesehatan Vol 12 No 2 (2023): NOVEMBER 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v12i2.9988

Abstract

Background: The highest prevalence of dental caries was in the group of children aged 5-9 years (92.6%), and in the age group 3-4 years was 81.1%. Unhealthy teeth and mouth can affect a child's development because the condition of the milk teeth will determine the growth of the child's permanent teeth. Caries are influenced by brushing teeth, how to brush teeth, consumption of cariogenic foods, knowledge, and possibly many other factors that can affect caries. Purpose: to review the collected literature on risk factors for dental caries in children aged 6-12 years in Indonesia. Methods: This study used the literature review method which began with searching research results in 3 databases, namely PubMed, ScienceDirect, and Google Scholar with predetermined inclusion criteria. Results: The articles that have been obtained in this literature show that there are many variables in the process of dental caries in elementary school children in Indonesia. These variables are divided into several discussion groups, namely individual characteristics, parental characteristics, consumption patterns, dental and oral hygiene, socioeconomic status, and dental and oral health interventions. Conclusion: there are many variables selected to be risk factors for dental caries, but not all variables are proven to be risk factors for dental caries in elementary school children. This is because other factors make the hypothesis rejected.
Pengaruh Vitamin D terhadap Faktor Metabolik pada Perempuan dengan Sindroma Ovarium Polikisitik (SOPK): Systematic Review - Meta Analysis: Effect of Vitamin D on Metabolic Factors in Women with Polycystic Ovary Syndrome (PCOS): Systematic Review - Meta Analysis Andriana, Andriana -; Hadisaputro, Suharyo; Santjaka, Aris
Amalee: Indonesian Journal of Community Research and Engagement Vol. 3 No. 2 (2022): Amalee: Indonesian Journal of Community Research and Engagement
Publisher : LP2M INSURI Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/amalee.v3i2.2759

Abstract

Deficiency of Vitamin D is one of the causes of Polycystic Ovary Syndrome (PCOS). Vitamin D deficiency can affect metabolic factors in women with PCOS. The purpose of this study was to analyze the effect of vitamin D on the metabolic factors of women with PCOS. The method used is the Systematic Review-Meta Analysis study design. The databases used for searching articles are Sciencedirect, PubMed, and Proquest. Keywords combined with Boolean Operators Inclusion criteria: publications with RCT designs from 2015 to 2020, women aged 18 to 49 years with PCOS, type of vitamin D intervention. Outcomes measured were levels of FPG, insulin, triglycerides, total kolesterol, LDL, HDL, and HOMA-IR. The results of the research where 12 studies were analyzed because they met the eligibility criteria. Administration of vitamin D significantly affected total kolesterol (WMD, -7.94; 95% CI, -15.74 to -0.13, P = 0.05), and HDL (WMD, ̶ 3.24; 95% CI, ̶ 4.32 to ̶ 2.16, P < 0.00001). Vitamin D intervention had no significant effect on FPG, insulin, triglycerides, LDL, and HOMA-IR levels. The conclusions from this study stated that Vitamin D influenced total kolesterol and HDL levels. Defisiensi Vitamin D merupakan salah satu penyebab terjadinya Sindrom Ovarium Polikistik (SOPK). Defisiensi vitamin D dapat mempengaruhi faktor-faktor metabolik pada perempuan yang mengalami SOPK. Tujuan penelitian ini untuk menganalisis pengaruh vitamin D terhadap faktor metabolik perempuan dengan SOPK. Metode yang digunakan yaitu Desain studi Systematic Review-Meta Analysis. Database yang digunakan untuk pencarian artikel adalah Sciencedirect, PubMed, dan Proquest. Kata kunci dikombinasikan dengan Boolean Operators Kriteria inklusi: publikasi dengan desain RCT tahun 2015 sampai 2020, perempuan usia 18 sampai 49 tahun dengan SOPK, jenis intervensi vitamin D. Hasil yang diukur adalah kadar FPG, insulin, triglycerides, total kolesterol, LDL, HDL, and HOMA-IR. Hasil penelitiannya adalah 12 studi dianalisis karena memenuhi kriteria kelayakan. Pemberian vitamin D berpengaruh secara signifikan terhadap kadar total kolesterol (WMD, -7.94; 95% CI, -15.74 to -0.13, P = 0.05), dan HDL (WMD, ̶ 3.24; 95% CI, ̶ 4.32 to ̶ 2.16, P < 0.00001). Intervensi vitamin D tidak berpengaruh secara signifikan pada kadar FPG, insulin, triglycerides, LDL, dan HOMA-IR. Simpulan dari penelitian ini dinyatakan bahwa Vitamin D berpengaruh terhadap kadar total kolesterol dan HDL.
Co-Authors Abdul Ghofur Adam, Oktaviana Thresia Monika Barbara Ag Soemantri Agus Suwandono Agustinus Soemantri Amin, Dewita Rahmatul Andriana, Andriana - Ani Margawati Anies Anies Anies Annastasia Ediati Aprian, Bq. Yulia Sri Arfan, Iskandar Ari Budi Himawan Ari Suwondo Aris Santjaka Arwani Arwani Astuti, Ismi Puji Awan Hariyanto, Awan Ayu Diana Meilantika Azzahra, Ilya Nur Aulia Bagoes Widjanarko Banundari Rachmawati Bedjo Santoso Kadri Dilla, Tasya Nurlaila Diyah Fatmasari Djamaluddin Ramlan, Djamaluddin Djamil, Masrifan Djokomoeljanto Djokomoeljanto Dwi Pudjonarko Endah Aryati Eko Ningtyas Eny Retna Ambarwati Fajri, Umi Nur Fara, Yetty Dwi Farah Salsabila, Farah Ganda Gumilar, Argo Gumilar, Argo Ganda Gustiya, Sherly Dwi Hadi Hadi Hamdan, Yusuf Lensa Harfaina, Harfaina Haryana, Chyntia Haryono, Nathasia Elga Henry Setyawan Susanto Henry Setyawan Susanto Heri Nugroho Herliani, Emy Herman Kristanto Hikmah, Kholisotul Imam Djamaluddin Mashoedi Iswari Setianingsih Jaleha, Jaleha Jayawarsa, A.A. Ketut Julian Dewantiningrum K. Heri Nugroho HS, K. Heri Kamilah Budhi Rahardjani, Kamilah Budhi Khabib Mualim, Khabib Kumorwulan, Suryati Kurniawati, Erna Yovi Ladyvia, Fiyola Lestariningsih Lestariningsih Lukmono, Djoko Tri Hadi Lukmono, Djoko Trihadi Maria Mexitalia Marludia, Melani Agis Martinus, Ishak Mateus Sakundarno Adi, Mateus Sakundarno Melyana Nurul Widyawati Moedrik Tamam Muflihah Isnawati Muhammad Saleh Muliawati, Ratna Munasik Munasik Muzaroah Ermawati Ulkhasanah Nafi’ah, Eka Apriadi Farkhati Nildawati . Noor Pramono Nur Djanah, Nur Nurjanah, Fatihah Wari Nurmulia, Ayu Nurul Aeni Oktavia, Eva Zuli Oktaviarini, Eka Onny Setiani Parera, Lodri Pratiwi, Meilicha Anggraini Pratiwi, Tia Purwanti, Sumy Hastry Pusaka, Semerdanta Rahatina, Vilianti Eka Fitri Rahmah, Aulia Agyanti Rasipin Rasipin Resty Ryadinency Rini Astuti Rini, Sulistio Roesipin, Sri Wahyuningsih Rohisotul Laily Rr. Sri Endang Pujiastuti Safira, Rahma Salma, Baiq Desi Sayono Sayono Selamat Budijitno Setyawan S, Henry Shofa Chasani Siti Patimah Soejoenoes, Ariawan Soejoenoes, Ariawan Sofro, Muchlis AU Sri Rahayu Sri Sumarni Sri Wahyuni Sudiyono Suprihati - Supriyadi - Supriyana Supriyana, Supriyana Suryati Kumorowulan Sutaryo Sutaryo Thaariq, Nurul Aziza Ath Tjokorda Gde Dalem Pemayun Triana Sri Hardjanti, Triana Sri Untung Sujianto Widiastuti Samekto Widjarnarko, Bagoes Yunie Armiyati