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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Agromedicine and Medical Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan MNJ (Malang Neurology Journal) Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Surya Medika Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Acta Biochimica Indonesiana Oceana Biomedicina Journal SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis Eduvest - Journal of Universal Studies Jurnal Keperawatan Molekul: Jurnal Ilmiah Kimia Jurnal Kesehatan
Zen Hafy
Universitas Sriwijaya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Procalcitonin Levels in Pulmonary Tuberculosis and Bacterial Pneumonia: A Cross-Sectional Study at a Tertiary Hospital in Indonesia Abdullah Fikri; Hadi Nugraha Mustofa; Zen Ahmad; Zen Hafy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1245

Abstract

Background: Pulmonary tuberculosis (TB) and bacterial pneumonia are respiratory infections with high morbidity and mortality rates. Despite having similar clinical symptoms and radiological findings, these conditions require different treatment approaches. Procalcitonin is a potential biomarker to differentiate these conditions, as its levels tend to increase in bacterial infections but not in TB. This study aims to compare procalcitonin levels in patients with pulmonary TB and bacterial pneumonia. Methods: This research employed an observational analytic design with a cross-sectional approach conducted at Dr. Mohammad Hoesin General Hospital (RSMH), Palembang. The study subjects were patients with pulmonary TB and bacterial pneumonia who met the inclusion and exclusion criteria. Procalcitonin levels were measured using ELISA methods. Data were analyzed to determine differences in procalcitonin levels between the two groups. Results: The study found that procalcitonin levels in bacterial pneumonia patients were significantly higher than those in pulmonary TB patients (p<0.05). These findings indicate that procalcitonin levels can serve as a diagnostic parameter to distinguish between the two conditions. Conclusion: Procalcitonin levels can be a useful biomarker for differentiating pulmonary TB from bacterial pneumonia. This biomarker is expected to assist clinicians in making more accurate diagnoses and expediting clinical decision-making.
Exploring The Potential of Gonggong Sea Snails (Laevistrombus Sp.) in Biotechnology as a Source of Natural Compounds for Wound Healing Fadilah, Rizka; Hafy, Zen; Larasati, Veny
Eduvest - Journal of Universal Studies Vol. 5 No. 11 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i11.52441

Abstract

The gonggongsea snail(Laevistrombussp.) is a typical marine life of the Riau Islands that contains various bioactive compounds with potential as wound healing agents based on natural ingredients. This study aims to evaluate the potential of gonggong seasnailextract through a literature review of articles obtained from PubMed, ScienceDirect, Google Scholar, and Scopus. Analysis of 18 articles showed that gonggongsea snailscontain histone protein H2A, antimicrobial peptides, flavonoids, alkaloids, saponins, as well as essential amino acids such as arginine, proline, and glycine that work synergistically throughout the wound healing phase. The compound plays a role in suppressing inflammation through inhibition of the NF-κB pathway and increasing IL-10, supporting the proliferation phase by stimulating angiogenesis and collagen synthesis, and improving the remodeling phase through improved tissue quality and antioxidant activity. Histological assessment can use the SPOT score system to show relevant parameters to evaluate the effectiveness of natural ingredients in wound healing. The results of this study confirm that gonggongsea snailextract has great potential to be developed as an effective, safe, and sustainable wound therapy candidate, so experimental research is needed to validate molecular mechanisms and standardize formulations.
Peran Polimorfisme Promotor Gen Interleukin-10 pada Penyakit Kusta: Tinjauan Sistematik Desi Oktariana; Irsan Saleh; Zen Hafy; Iche Andriyani Liberty
Majalah Kedokteran Indonesia Vol 73 No 1 (2023): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.73.1-2023-816

Abstract

Introduction: Leprosy remains a significant problem in Indonesia as the number of cases has not been eliminated until now. One of the cytokines that plays a role in the disease is interleukin-10 (IL-10), which has a dominant anti-inflammatory effect and influences the immunopathogenesis of leprosy. Genetic factors, including the IL-10 gene promoter polymorphism, affect the amount of IL-10 produced, thereby increasing the risk of leprosy. Therefore, the objective of this study is to gather information on the role of IL-10 gene promoter polymorphism in the development of leprosy.Method: A systematic review method was used to identify, evaluate, and extensively discuss published works through national and international journals such as Google Scholar, Science Direct, Elsevier, EBSCO, Medline, PubMed, Proquest, and Wiley. The study was conducted by searching relevant keywords related to the research topic in these databases. Subsequently, article selection was performed based on predetermined inclusion and exclusion criteria. The selected articles were then evaluated for quality to ensure accuracy and reliability of the presented information. Finally, the results of this systematic review were used to obtain accurate and up-todate information regarding the role of IL-10 gene promoter polymorphism in leprosy.Results: This systematic review analyzed a total of 14 articles and revealed that results varied among study populations. However, there is consistent evidence to suggest that the IL-10 gene promoter polymorphism is associated with leprosy, which was found in the majority of the study populations.Conclusion: IL-10 gene promoter polymorphism tends to be associated with leprosy.
Improvement IL -10 and Reactive Oxygen Species (ROS) in HIV patients : Narrative Review Franajayakk, Indra; Legiran; Salim, Eddy Mart; Hafy, Zen
Jurnal Kesehatan - STIKes Prima Nusantara Vol 16 No 1 (2025): Jurnal Kesehatan Volume 16 Nomor 1 Tahun 2025
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v16i1.1234

Abstract

Background: Infection Human Immunodeficiency Virus (HIV) is still become problem scary health​ for world community . This virus infection causes a bunch symptom disease characterized by with weakening system immunity body . A collection of symptoms This known with designation Acquired Immune Deficiency Syndrome (AIDS). Consequence the decline system immunity , HIV sufferers will prone to For caught various disease infections that can have fatal consequences. Objective: For know How improvement IL-10 and Reactive Oxygen Species (ROS) levels in HIV patients . Research methods: This use Narrative Review design . Articles searched from Google Scholar, PubMed, Science Direct, and EMBASE/ Elviser with use relevant keywords , then chosen based on criteria that have been set , and objectives study . Results: Increased levels of IL-10 and Reactive Oxygen Species (ROS) in patients results in a decrease in the immune system, this is characterized by increased virus replication, deactivation macrophages and depletion of the number of lymphocytes, so that the progression of the infection towards AIDS can occur. Conclusion: HIV infection causes the occurrence dysfunction mitochondria and enhancement production Reactive Oxygen Species (ROS) in cells CD4 + T lymphocytes. Various viral proteins, such as the envelope proteins Gp120, Tat, Nef and Vpr , are able to increase ROS production through various different pathways. The increase in ROS that occurs can increase mRNA expression through activation Nuclear Factor Kappa B ( NFκB ), increased IL-10 mRNA expression ultimately will increase IL-10 levels
Rhodomyrtus tomentosa Leaf Extract Cream Suppresses MMP-1 Expression and Epidermal Thickening in UVB-Irradiated Swiss Webster Mice Defa Agripratama Ali; Zen Hafy; Veny Larasati; Nora Ramkita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1609

Abstract

Background: Ultraviolet B (UVB) radiation induces matrix metalloproteinase-1 (MMP-1) expression and epidermal hyperplasia, contributing to photoaging. Rhodomyrtus tomentosa (karamunting) is rich in polyphenolic compounds with documented antioxidant properties, but its in vivo photoprotective effects remain unexplored. Methods: We investigated the effects of R. tomentosa leaf extract cream at varying concentrations (0%, 12.5%, 25%, 50%) on UVB-irradiated Swiss Webster mice (n=4 per group). UVB exposure was standardized at approximately 150 mJ/cm² per session over seven consecutive days. Vitamin E cream served as a positive control. Immunohistochemical staining quantified MMP-1 expression as a percentage of positive cells, while hematoxylin-eosin histology measured epidermal thickness. Results: Kruskal-Wallis testing revealed significant differences in both MMP-1 expression (H=10.43, p=0.015) and epidermal thickness (H=10.88, p=0.012). The 25% extract concentration optimally suppressed MMP-1 expression (mean 45.94% of positive cells) compared to the untreated UVB control (89.53%). A biphasic dose-response pattern emerged, with hormetic effects observed at 50% concentration (76.45%), suggesting polyphenol pro-oxidant activity at excessive concentrations. Epidermal thickness normalized with 25% treatment (71.8 μm) versus UVB control (93.4 μm). Immunohistochemical intensity decreased progressively with treatment intensification through 25%, supporting suppression of MMP-1-mediated collagen degradation. Conclusion: R. tomentosa leaf extract cream at 25% concentration effectively suppresses MMP-1 expression and normalizes UVB-induced epidermal thickening in mice. The hormetic response at higher concentrations highlights the importance of dose optimization in phytotherapeutic development. This work establishes the first in vivo evidence for karamunting leaf extract as a photoprotective agent and supports further clinical translation.
Rhodomyrtus tomentosa Leaf Extract Cream Suppresses MMP-1 Expression and Epidermal Thickening in UVB-Irradiated Swiss Webster Mice Defa Agripratama Ali; Zen Hafy; Veny Larasati; Nora Ramkita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1609

Abstract

Background: Ultraviolet B (UVB) radiation induces matrix metalloproteinase-1 (MMP-1) expression and epidermal hyperplasia, contributing to photoaging. Rhodomyrtus tomentosa (karamunting) is rich in polyphenolic compounds with documented antioxidant properties, but its in vivo photoprotective effects remain unexplored. Methods: We investigated the effects of R. tomentosa leaf extract cream at varying concentrations (0%, 12.5%, 25%, 50%) on UVB-irradiated Swiss Webster mice (n=4 per group). UVB exposure was standardized at approximately 150 mJ/cm² per session over seven consecutive days. Vitamin E cream served as a positive control. Immunohistochemical staining quantified MMP-1 expression as a percentage of positive cells, while hematoxylin-eosin histology measured epidermal thickness. Results: Kruskal-Wallis testing revealed significant differences in both MMP-1 expression (H=10.43, p=0.015) and epidermal thickness (H=10.88, p=0.012). The 25% extract concentration optimally suppressed MMP-1 expression (mean 45.94% of positive cells) compared to the untreated UVB control (89.53%). A biphasic dose-response pattern emerged, with hormetic effects observed at 50% concentration (76.45%), suggesting polyphenol pro-oxidant activity at excessive concentrations. Epidermal thickness normalized with 25% treatment (71.8 μm) versus UVB control (93.4 μm). Immunohistochemical intensity decreased progressively with treatment intensification through 25%, supporting suppression of MMP-1-mediated collagen degradation. Conclusion: R. tomentosa leaf extract cream at 25% concentration effectively suppresses MMP-1 expression and normalizes UVB-induced epidermal thickening in mice. The hormetic response at higher concentrations highlights the importance of dose optimization in phytotherapeutic development. This work establishes the first in vivo evidence for karamunting leaf extract as a photoprotective agent and supports further clinical translation.
PERAN IMUNOMODULATOR VITAMIN D TERHADAP INTERLEUKIN 6 PADA PENDERITA DIABETES MELITUS TIPE 2 Wulandari, Septi; Hafy, Zen; Liana, Phey
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.11119

Abstract

Diabetes Melitus Tipe 2 (DMT2) adalah penyakit metabolik kompleks dengan peradangan kronis sebagai salah satu mekanisme penting dari patogenesisnya. Interleukin-6 (IL-6) memiliki peran signifikan dalam memperburuk resistensi insulin dan meningkatkan risiko komplikasi vaskular pada penderita DMT2. Vitamin D diketahui tidak hanya berfungsi dalam metabolisme tulang tetapi juga bertindak sebagai imunomodulator yang mampu memodulasi respons inflamasi. Tinjauan literatur ini bertujuan untuk menganalisis peran vitamin D dalam mengatur tingkat IL-6 pada pasien DMT2 berdasarkan studi yang dipublikasikan sebelumnya. Literature review ini bertujuan untuk menjelaskan pengaruh vitamin D dalam menurunkan sitokin proinflamasi IL-6 pada pasien diabetes mellitus tipe 2. Metode yang digunakan dalam artikel ini adalah penelusuran artikel melalui database Pubmed, Springer Link dan Google Scholar. Tahun penerbitan sumber pustaka adalah dari tahun 2011 hingga 2025 dengan 27 sumber pustaka. Hasil: Beberapa literatur menunjukkan bahwa kadar vitamin D serum yang cukup atau pemberian suplemen vitamin D memiliki kemampuan untuk mengurangi IL-6 dan berkontribusi terhadap perbaikan kontrol glikemik Hasil yang diperoleh antar studi belum sepenuhnya konsisten karena adanya perbedaan metodologi, dosis suplementasi, durasi intervensi, serta karakteristik subjek penelitian. Beberapa literatur menunjukkan bahwa kadar vitamin D serum yang cukup atau pemberian suplemen vitamin D memiliki kemampuan untuk mengurangi IL-6 dan berkontribusi terhadap perbaikan kontrol glikemik
Co-Authors A, Rafdi A, Rafdi Abdullah Fikri Abdullah Sahab Afriyana Siregar Afriyana Siregar Agnes Felicia Lubis Agnes Felicia Lubis Agustian Dwi Putra Agustian Dwi Putra Agustina Br Haloho Ahmad, Zen Amalia Amalia Anisah Nida'ul Haq Argentina, Fiva aryani, Inda astri Aulia Annisa Rizki Bastian Bastian Bayu Winata Putera Calvin Ienawi Chairil Anwar Citra Ananta Avis Citra Dewi Defa Agripratama Ali Desi Arlindia Desi Oktariana Didit Pramudhito Dwi Handayani Dwi Handayani Dwiana Ocviyanti Dwirini Retno Gunarti Dya Anggraeni Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim, Eddy Mart Efrieni Erial Bahar Erial Bahar Erial Bahar Erial Bahar, Erial Ernawati Sinaga Evi Lusiana Fachmi Idris Fadilah, Rizka Ferry Yusrizal Ferry Yusrizal Fitri Octaviana Fitri Octaviana Franajayakk, Indra Francisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Gita Dwi Prasasty Hadi Nugraha Mustofa Haekal M Handayani, Sri Hartati Harun Hudari Harun Hudari Harun, Yusril Heni Maulani Heni Pujiastuti Henny Sulastri Hermansyah Hermansyah Hu, Owen Iche Andriyani Liberty Iche Andriyani Liberty, Iche Andriyani Indra Franajayakk Inggarsih, Rara Irsan Saleh Irsan Saleh Jusak Nugraha Jusuf Fantoni Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kemas Ya’kub Rahadiyanto Kemas Yusuf Effendi Kms Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kodrati, Adika Krisna Murti Krisna Murti kurniati, nova Laida Neti Mulyani Legiran Legiran Legiran Legiran Lubis, Fadhyl Zuhry M, Haekal M, Haekal M. Irsan Saleh Masagus Irsan Saleh Hasani Maya Eka Apriyanti Meiliza Indriani Mgs. Irsan Saleh Mgs. Irsan Saleh Mohamad Sadikin Muhammad Irsan Saleh Nita Hertati Nora Ramkita Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Lestari Novizar S Ocktariyana, Ocktariyana Pancarani, Muftia Phey Liana Prihantika S., Sabrina Purnamasari, Septi Puspita, Riana Sari Puspita, Riana Sari R, Sentani R, Sentani Radiyati Umi Partan Radiyati Umi Partan, Radiyati Umi Rafdi A Rafika Novianti Rahadiyanto, Kemas Ya'Kub Rahmi Widiyawati Ramadhayanti, Lidya Ramzi Amin, Ramzi Rasyid, Riana Sari Puspita Ray Suga Aulia Ray Suga Aulia Sentani Riana Sari Puspita Riana Sari Puspita Rasyid Rikka Wijaya Rini Nindela Rini Nindela, Rini Rizal Sanif S, Novizar S, Novizar Sabri Prihantika Sabrina Prihantika Saleh, M Irsan Saleh, Mgs. M. Irsan Salutondok, Welly Sari, Nurmalia Purnama selly marisdina Selvy Apriani Sentani R SEPTI WULANDARI Soilia Fertilita Sri Handayani Sri Sulpha Siregar Sri Sulpha Siregar Subandrate Sudarto Sudarto Suly Auline Rusminan Susiwati, Susiwati Syifa Alkaf Tanoerahardjo, Francisca Srioetami Tungki Pratama Umar Venny Larasati Venny Larasati Veny Larasati Verli Saniba Wresnindyatsih Ya’kub Rahadiyanto Yudianita Kesuma, Yudianita Yunni Diansari Yusuf Effendi Yusuf Effendi Yusuf Effendi Yusuf Effendi Zen Ahmad Ziske Maritska Zulkarnain Musa