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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Agromedicine and Medical Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan MNJ (Malang Neurology Journal) Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Surya Medika Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Acta Biochimica Indonesiana Oceana Biomedicina Journal SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Medica Hospitalia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis Eduvest - Journal of Universal Studies Jurnal Keperawatan Molekul: Jurnal Ilmiah Kimia Jurnal Kesehatan Indonesian Journal of Global Health Research
Zen Hafy
Universitas Sriwijaya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Akurasi Potong Beku, Sitologi Imprint dan Scraping Intraoperatif dalam Mendiagnosis Tumor Ovarium . Elda Rusnita, Henny Sulastri, Jusuf Fantoni, Zen Hafy
Majalah Patologi Indonesia Vol. 21 No. 3, September 2012
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

ABSTRAK Latar belakang Teknik potong beku maupun sitologi imprint dan scraping sudah digunakan sebagai konsultasi patologi intraoperatif dalam mendiagnosis tumor ovarium. Penelitian mengenai keakuratan diagnosis potong beku intraoperatif pada tumor ovarium pernah dilakukan namun terhadap sitologi imprint dan scraping belum pernah dilakukan di RSUP. Dr. Moh. Hoesin Palembang. Tujuan dari penelitian ini adalah untuk mengetahui akurasi potong beku, sitologi imprint dan scraping dalam mendiagnosis tumor ovarium dibandingkan histopatologi sebagai baku emasnya. Bahan dan cara kerja Penelitian ini merupakan uji diagnostik pada 105 sampel arsip tumor ovarium dari bulan Januari 2009 sampai Desember 2010. Hasil pemeriksaan potong beku, sitologi imprint dan scraping serta histopatologinya dibaca ulang oleh dua orang Spesialis Patologi Anatomik. Data dianalisis untuk menghitung nilai akurasi pemeriksaan potong beku serta sitologi imprint dan scraping. Hasil Didapatkan nilai akurasi potong beku sebesar 99% dan akurasi sitologi imprint dan scraping sebesar 97,14%. Kesimpulan Pemeriksaan potong beku serta sitologi imprint dan scraping merupakan pemeriksaan dengan nilai akurasi yang tinggi. Pemeriksaan sitologi imprint dan scraping dapat menjadi alternatif pemeriksaan intraoperatif untuk rumah sakit yang tidak mempunyai fasilitas potong beku. Kata kunci: Tumor ovarium, potong beku, sitologi imprint dan scraping, akurasi. ABSTRACT Background Frozen section or imprint and scrape cytology technics have been used as an intraoperative consultation measure for ovarian tumor diagnosis. Study about the accuracy of frozen section diagnosis for ovarian tumor had already been done in Dr. mohammad Hoesin General Hospital Palembang but not for imprint and scrape cytology. The aim of this study is to evaluate the accuracy of frozen section, imprint and scrape cytology in ovarian tumor diagnosis compared with histopathology as a gold standard. Methods This study was a diagnostic tes of one hundred and five samples from the archives of ovarian tumors from January 2009 to December 2010. The frozen section, imprint, scrape cytology and histopathological results were evaluated by two pathologists. The data were analized for the determination of the accuracy of frozen section and imprint and scrape cytology. Results The overall accuracy rate for frozen section, imprint and scrape cytology is 99% and 97,14% respectively. Conclusion Frozen section and imprint and scrape cytological examination revealed high accuracy, therefore imprint and scrape cytology are strongly recommended as an alternative measure for intraoperative consultation instead of frozen section mainly for hospitals that do not have facility of frozen section. Key words : Ovarian tumor, frozen section, imprint and scrape cytology, accuracy
Hubungan antara Ekspresi Ki-67 dengan Stadium Klinis dan Derajat Histopatologis Karsinoma Sel Skuamosa Serviks Nita Hertati; Heni Maulani; Zulkarnain Musa; Zen Hafy
Majalah Patologi Indonesia Vol. 23 No. 3, September 2014
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Background Cervical cancer is the third most common type and the fourth most deadly cancerian women which remains a significant health problem worldwide especially in developing coumtry. Ki-67 is a prototype protein in nuclear which influence cell proliferation rate, hence it can be used as one of parameter to evaluate progressivity of tumor cells in carcinoma cases as the cervical squamous cell carcinoma (SCC). This study aims to determine the relationship between clinical staging of cervical SCC and histopatological grading of the cervical SCC with the expression of Ki-67. Methods This was an observational study with a cross sectional design. Sixty cervical squamousa cell carcinoma archive histopathological slide samples (45 biopsy specimens and 15 radical hysterectomy tissues) were collected for this study from the Anatomical Pathology Department of RSUP dr. Mohammad Hoesin Palembang (January 2008 to July 2013). The samples were stained with Ki-67 antibody and analyzed with respect to patient’s clinical stage and histopatological grade. Results The positivity of Ki-67 expressions were more common in the age of ≤ 50 year-old group, in the non-keratinizing type, in the late clinical staging (stage IIIB) and in the moderatelly differentiated histopathological grade. High scores of the Ki-67 expressions (Ki-67>20%) was predominantly found in the late clinical stage and moderatelly differentiated histopathological grade cases. Statistically, there was a significant relationship (p=0.034) with a strong correlation (r=0.714) between the Ki-67 ecpression and the clinical stage of cervical SCC, but not histopathological grade. Conclusion The higher clinical staging of cervical SCC, the higher expression of Ki-67. Key words: cervical squamous cell carcinoma, clinical staging, histophatological grade, Ki-67.
Hubungan Ekpresi E-Cadherin dengan Invasi Limfovaskular dan Status KGB pada Karsinoma Payudara Tripel Negatif Citra Dewi; Henny Sulastri; Jusuf Fantoni; Zen Hafy
Majalah Patologi Indonesia Vol. 22 No. 1, Januari 2013
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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ABSTRAK Latar belakang Karsinoma payudara tripel negatif (KPTN) memiliki karakteristik, prognosis dan terapi yang khas dan dengan angka kematian yang tinggi. Seiring dengan berkembangnya ilmu pengetahuan biomolekuler mengenai penanda tumor, telah banyak penanda prognosis yang diteliti dan salah satunya adalah E-cadherin. Penelitian ini bertujuan untuk melihat hubungan ekspresi E-cadherin dengan invasi limfovaskular dan status kelenjar getah bening (KGB) serta ekspresi E-CD berdasarkan ukuran tumor, morfologi tumor dan derajat histologi pada KPTN. Metode Penelitian ini adalah penelitian retrospektif cross sectional. Tiga puluh sampel jaringan hasil biopsi, lumpektomi dan mastektomi diambil secara acak dari arsip di Bagian Patologi Anatomik Rumah Sakit Mohammad Hoesin (RSMH) Palembang, dilakukan pulasan dengan antibodi E-cadherin dan diteliti hubungannya dengan invasi limfovaskular serta sebaran ekspresinya berdasarkan usia, morfologi tumor dan derajat histologi. Dua puluh dua sampel jaringan hasil mastektomi diteliti untuk menilai hubungan antara ekspresi E-cadherin dengan status KGB dan sebarannya berdasarkan ukuran tumor. Hasil Sebaran ekspresi E-cadherin positif terbanyak pada KPTN dengan ukuran massa tumor >2 cm, jenis karsinoma duktal invasif, derajat histologi tinggi (43,3%). Rasio prevalens hubungan ekspresi E-cadherin dengan invasi limfovaskular dan status KGB masing-masing 1,14 (Interval Kepercayaan 0,19-0,39;p>0,01) dan 1,65 (Interval Kepercayaan-0,143-0,663; p>0,05). Kesimpulan Hasil penelitian ini menunjukkan bahwa E-cadherin belum bisa digunakan sebagai bahan pertimbangan untuk menentukan invasi limfovaskular dan status KGB pada kasus KPTN sehingga E-cadherin kurang dapat memberikan informasi mengenai prognosis penderita KPTN khususnya bagi klinisi dan penderita sendiri. Kata kunci : Karsinoma payudara tripel negatif, E-cadherin, invasi limfovaskular, status KGB. ABSTRACT Background Triple negative breast carcinoma (TNBC) has some unique characteristics, prognosis and treatment, and also a high mortality rate. Prognostic markers have been widely studied and one of them is Epithelial-Cadherin (E-cadherin). This study aims to look the relationship between E-cadherin expression with lymph vascular invasion, lymph node status, tumor size, morphology and histologic grade in TNBC. Methods This was a retrospective cross sectional study. Thirty samples of biopsy, lumpectomy and mastectomy specimens were taken randomly from the archives of the Anatomical Pathology Department of Mohammad Hoesin Hospital Palembang, stained with E-cadherin antibody, were used to investigate the relationship between the expression of E-cadherin with lymph vascular invasion, age, tumor morphology and histologic grade. Twenty-two tissue samples of mastectomy specimens were used to investigate the relationship between E-cadherin expression with lymph node status and tumor size. Results Mostly, positive expression of E-cadherin was expressed in tumor mass >2cm, in invasive ductal carcinoma type (40%) and in a high histologic grade tumor (43,3%). The prevalence ratio (PR) of E-cadherin expression of lymph vascular invasion was 1.14 (Convidence Interval 0.19-0.39; p> 0.05) and the PR of E-cadherin expression of the lymph nodes status was 1.65 (Convidence Interval -0.143-0.663; p> 0.05). Conclusion This study demonstrates that E-cadherin could’nt provide information on prognosis of TNBC as E-cadherin can’t be used as indicator for lympho-vascular invasion and lymphnode status. Key words: TNBC, E-cadherin, lymph vascular invasion, lymph node status
Ekspresi HPV16 Onkoprotein E7 pada Lesi Prakanker dan Karsinoma Sel Skuamosa Serviks Verli Saniba; Wresnindyatsih; Zulkarnain Musa; Zen Hafy
Majalah Patologi Indonesia Vol. 29 No. 2, Mei 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i2.409

Abstract

BackgroundCervical cancer is the secondmost common malignancy in women worldwide.The vast majority of cervical cancersare associatedwith high risk HPV16 infection. The persistence of HPV16 and integration of viral DNA into cell genome are necessary for thedevelopment of precancerous lesion and squamous cell carcinoma (SCC) of the cervix. The integration of viral DNA in the host cellgenome resulted in the regulation of oncoprotein E7 leading to detection of HPV16 E7 expression in precancerous lesions and SCCof the cervix.The aim of this study was to evaluate differences of HPV16 E7 expression in precancerous lesions and cervical SCC.MethodsAn observational study with cross-sectional design was performedat Department of Anatomical Pathology Faculty of MedicineUniversity of Sriwijaya/dr. Mohammad Hoesin General Hospital Palembang, from 1st July 2014 to 30st Juni 2017. The selectedsamples consisted of 25 precancerous cases lesions (13 cases of LSIL and 12 samples of HSIL) and SCC (25 cases).Immuhistochemical stained was conducted using HPV16 E7 antibody. Fisher exact’s test was used to analyze differences inexpression of HPV16 E7 among precancerous lesions and cervical SCC.ResultsThe pracancerous lesions occurred mostly between the ages of 30-40 years, while SCC were those between the ages of 51-60years. All SCC cases (100%) and 91.6% of HSIL showed weak to strong HPV16 E7 expression, and 84.6% cases of LSIL showedimmunonegative.ConclusionThe positivity of HPV16 E7 increased in HSIL and KSS lesions.
Hubungan Kepadatan Infiltrasi Sel Radang Limfosit dengan Klinikopatologik Karsinoma Kolorektal di RSUP Dr. Mohammad Hoesin Palembang Calvin Ienawi; Suly Auline Rusminan; Zen Hafy
Majalah Patologi Indonesia Vol. 29 No. 3, September 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i3.447

Abstract

BackgroundColorectal carcinoma has become one of primary problem that caused mortality and morbidity around the world. This malignancyhas contributed almost more than 9% of all cancer incidence. Lymphocyte infiltration density (TILs) is one of prognostic factors toevaluate colorectal cancer. Although some studies have found that there still have variations in sassociation lymphocyte density withclinicopathology of colorectal carcinoma which related to patient prognosis. This study was aimed to identify and analyze theassociation of lymphocyte density with clinicopathological colorectal carcinoma patients in Dr. Mohammad Hoesin General HospitalPalembang.MethodsA total of 41 HE stained slides which were diagnosed as colorectal carcinoma were observed under the light microscope.Lymphocytes were counted in five different areas that showed the highest lymphocytes density. The mean values of the lymphocytewere received from those five different areas. Determination of cutoff point was counted from the median of all mean value of thelymphocytes and being classified to become two categories, high-density lymphocytes and low-density lymphocytes.ResultsOut of 41 subjects, most patients have tumor size more than/or equal to 5 cm (63.4%), the tumors are often found in the left-sided ofcolon (39.0%), have moderate differentiated degree (65.9%), are included into T3 in tumor staging (48.8%), and no regional lymphnodes metastasis (39.0%). The most histopathological classification is adenocarcinoma (41.5%). Bivariate analysis showed thatlymphocyte density has correlation with tumor differentiation degree (p=0.021) and histopathological classification (p=0.004).ConclusionLymphocyte infiltration density has correlation with degree differentiation and histopathological classification of colorectal carcinomain Dr. Mohammad. Hoesin General Hospital-Palembang
Exploring The Potential of Gonggong Sea Snails (Laevistrombus Sp.) in Biotechnology as a Source of Natural Compounds for Wound Healing Rizka Fadilah; Zen Hafy; Veny Larasati
Eduvest - Journal of Universal Studies Vol. 5 No. 11 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i11.52441

Abstract

The gonggongsea snail(Laevistrombussp.) is a typical marine life of the Riau Islands that contains various bioactive compounds with potential as wound healing agents based on natural ingredients. This study aims to evaluate the potential of gonggong seasnailextract through a literature review of articles obtained from PubMed, ScienceDirect, Google Scholar, and Scopus. Analysis of 18 articles showed that gonggongsea snailscontain histone protein H2A, antimicrobial peptides, flavonoids, alkaloids, saponins, as well as essential amino acids such as arginine, proline, and glycine that work synergistically throughout the wound healing phase. The compound plays a role in suppressing inflammation through inhibition of the NF-κB pathway and increasing IL-10, supporting the proliferation phase by stimulating angiogenesis and collagen synthesis, and improving the remodeling phase through improved tissue quality and antioxidant activity. Histological assessment can use the SPOT score system to show relevant parameters to evaluate the effectiveness of natural ingredients in wound healing. The results of this study confirm that gonggongsea snailextract has great potential to be developed as an effective, safe, and sustainable wound therapy candidate, so experimental research is needed to validate molecular mechanisms and standardize formulations.
A Systematic Literature Review: PvK12 and PfK13 Gene Mutations as Markers of Resistance to Artemisin Susiwati Susiwati; Chairil Anwar; Zen Hafy; Iche Andriyani Liberty
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6599

Abstract

P. falciparum and P. vivax are among the most dangerous types of plasmodium , as they cause morbidity and mortality. Long-term use of Anti-Malaria Drugs (OAM) causes resistance. The purpose of this study was to determine the mutation of the pvk12 and pfk13 genes as a marker of resistance to artemisinin . This study used a systematic review method that was compiled based on the Preferred Reporting Items for Systematic Reviews and Meta Analyzes (PRISMA). The article search used five databases, namely PubMed, Google Scholar, BMC, Portal Garuda and the National Library (Perpusnas) of Indonesia. The keywords and boolean operators used in the literature search were "artemisinin", "resistance", "mutation", "gen", "plasmodium falciparum", "kelch 12", "kelch 13", "PvK12" PfK13" The inclusion criteria for this study were articles published at least in 2018 (the last 5 years). The exclusion criteria were paid articles, textbooks , articles systematic literature review , articles that use languages other than English and Indonesian. The results of a systematic review use 688 articles and finished of 10 articles showed that 8 articles found that there were no mutations in the pvk12 and pfk13 genes as markers of resistance to artemisinin and 2 articles found that there were mutations in the pvk12 and pfk13 genes as markers of resistance to artemisinin.
The Role of Toll-Like Receptor-2 in the Pathogenesis of Pulmonary Tuberculosis Sudarto Sudarto; Zen Hafy; Irsan Saleh; Iche Andriyani Liberty; Zen Ahmad; Fadhyl Zuhry Lubis; Owen Hu; Welly Salutondok
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6797

Abstract

Pulmonary tuberculosis (PTB), primarily caused by Mycobacterium tuberculosis (M.tb), remains a major global health burden. Toll-like receptor 2 (TLR-2), a critical component of the innate immune system, plays a key role in the host-pathogen interaction by recognizing specific components of the mycobacterial cell wall and initiating downstream inflammatory pathways. However, the dual role of TLR-2 in both protective immunity and immune evasion by M.tb contributes to the complexity of TB pathogenesis. This study aims to investigate the role of Toll-Like Receptor-2 (TLR-2) in the pathogenesis of pulmonary tuberculosis, including its immunological mechanisms, relationships with disease severity, and the potential of TLR-2 as a diagnostic and therapeutic target. This literature review systematically analyzed molecular mechanisms involving TLR-2 signaling in pulmonary TB using peer-reviewed primary and secondary sources from experimental and clinical studies. Emphasis was placed on signal transduction (NF-κB and MAPK), cytokine profiles, antigen presentation, and the impact of TLR-2 gene polymorphisms on TB susceptibility. Activation of TLR-2 through ligands such as lipoproteins, lipoarabinomannan (LAM), and PE/PPE proteins initiates immune responses via MyD88-dependent pathways, leading to the release of proinflammatory cytokines (TNF-α, IL-6, IL-12). TLR-2 also enhances the function of macrophages and dendritic cells, promoting Th1-mediated immunity. However, chronic or excessive stimulation of TLR-2 can suppress antigen processing, promote IL-10 expression, inhibit phagolysosome fusion, and facilitate M. tb survival within host macrophages. Polymorphisms in the TLR-2 gene (e.g., rs3804099) have been associated with increased susceptibility and variable clinical outcomes in PTB. TLR-2 plays a paradoxical role in pulmonary tuberculosis by mediating both protective immunity and facilitating immune evasion by M.tb. Understanding the balance of TLR-2 signaling and genetic variation is crucial for developing immunomodulatory therapies and personalized interventions in TB management.
Rhodomyrtus tomentosa Leaf Extract Cream Suppresses MMP-1 Expression and Epidermal Thickening in UVB-Irradiated Swiss Webster Mice Defa Agripratama Ali; Zen Hafy; Veny Larasati; Nora Ramkita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1609

Abstract

Background: Ultraviolet B (UVB) radiation induces matrix metalloproteinase-1 (MMP-1) expression and epidermal hyperplasia, contributing to photoaging. Rhodomyrtus tomentosa (karamunting) is rich in polyphenolic compounds with documented antioxidant properties, but its in vivo photoprotective effects remain unexplored. Methods: We investigated the effects of R. tomentosa leaf extract cream at varying concentrations (0%, 12.5%, 25%, 50%) on UVB-irradiated Swiss Webster mice (n=4 per group). UVB exposure was standardized at approximately 150 mJ/cm² per session over seven consecutive days. Vitamin E cream served as a positive control. Immunohistochemical staining quantified MMP-1 expression as a percentage of positive cells, while hematoxylin-eosin histology measured epidermal thickness. Results: Kruskal-Wallis testing revealed significant differences in both MMP-1 expression (H=10.43, p=0.015) and epidermal thickness (H=10.88, p=0.012). The 25% extract concentration optimally suppressed MMP-1 expression (mean 45.94% of positive cells) compared to the untreated UVB control (89.53%). A biphasic dose-response pattern emerged, with hormetic effects observed at 50% concentration (76.45%), suggesting polyphenol pro-oxidant activity at excessive concentrations. Epidermal thickness normalized with 25% treatment (71.8 μm) versus UVB control (93.4 μm). Immunohistochemical intensity decreased progressively with treatment intensification through 25%, supporting suppression of MMP-1-mediated collagen degradation. Conclusion: R. tomentosa leaf extract cream at 25% concentration effectively suppresses MMP-1 expression and normalizes UVB-induced epidermal thickening in mice. The hormetic response at higher concentrations highlights the importance of dose optimization in phytotherapeutic development. This work establishes the first in vivo evidence for karamunting leaf extract as a photoprotective agent and supports further clinical translation.
Clinical and Neurophysiological Features of Vincristine-Induced Peripheral Neuropathy in Indonesian Children with Acute Lymphoblastic Leukemia Raden Muhammad Indra; Irsan Saleh; Irawan Mangunatmadja; Yulia Iriani; Zen Hafy; Dian Puspitasari
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.584

Abstract

Vincristine-induced peripheral neuropathy (VIPN) is a common complication clinical pattern vary across populations, and data from Indonesian children remain limited. Objectives to describe the clinical and nerve conduction study (NCS) features of VIPN in children with ALL treated at a tertiary hospital in Indonesia. We conducted a cross-sectional study of children with ALL receiving chemotherapy recruited consecutively at Mohammad Hoesin Hospital, Palembang, from November 2023 to August 2025. Data were collected from detailed neurological and NCS examinations. Diagnosis of VIPN was made using NCS. Severity was graded using the Common Terminology Criteria for Adverse Events (CTCAE v5.0). Clinical features and NCS findings were evaluated. Comparisons were made between induction and maintenance phases, including the proportions of severity groups, clinical symptoms, individual nerve involvements, number of symptoms and nerves, as well as the type of lesions. A total of 118 children were enrolled; 65 (55.1%) had VIPN by NCS criteria. Neuropathy incidence was similar in induction (56.9%) and maintenance (52.8%) phases (p=0.66). Most cases were CTCAE grade 2–3. Weakness was the most frequent symptom (56.9%), while paresthesia was significantly more common in the induction phase (p=0.008). Peroneal motor nerve involvement was the most frequent NCS abnormality (91.1%), followed by median motor (50.0%) and ulnar nerves (33.7%). The induction phase was characterized by additional upper extremity nerve involvement compared to the maintenance phase, including the median (p=0.004) and ulnar (p=0.025) nerves. Sural sensory nerve abnormalities were significantly more prevalent during the maintenance phases (p=0.002). All cases demonstrated axonal, motor-predominant neuropathy, with no isolated sensory cases. VIPN is highly prevalent among Indonesian children with ALL, with motor-predominant, axonal involvement. The induction phase has more widespread nerve involvement that includes upper extremities, while the maintenance phase has more sensory sural nerve involvement, albeit more likely asymptomatic or milder. Phase-specific patterns suggest distinct pathophysiological mechanisms.
Co-Authors A, Rafdi A, Rafdi Abdullah Fikri Abdullah Sahab Afriyana Siregar Afriyana Siregar Agnes Felicia Lubis Agnes Felicia Lubis Agustian Dwi Putra Agustian Dwi Putra Agustina Br Haloho Amalia Amalia Anisah Nida'ul Haq Argentina, Fiva Ariesti Karmila aryani, Inda astri Aulia Annisa Rizki Bastian Bastian Bayu Winata Putera Calvin Ienawi Chairil Anwar Chairil Anwar Citra Ananta Avis Citra Dewi Defa Agripratama Ali Desi Arlindia Desi Oktariana Dian Puspitasari Didit Pramudhito Dwi Handayani Dwi Handayani Dwiana Ocviyanti Dwirini Retno Gunarti Dya Anggraeni Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim, Eddy Mart Efrieni Erial Bahar Erial Bahar Erial Bahar Erial Bahar, Erial Ernawati Sinaga Evi Lusiana Fachmi Idris Fadhyl Zuhry Lubis Fadilah, Rizka Ferry Yusrizal Ferry Yusrizal Fitri Octaviana Fitri Octaviana Franajayakk, Indra Francisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Gita Dwi Prasasty Hadi Nugraha Mustofa Haekal M Handayani, Sri Hartati Harun Hudari Harun Hudari Harun, Yusril Heni Maulani Heni Pujiastuti Henny Sulastri Hermansyah Hermansyah Iche Andriyani Liberty Iche Andriyani Liberty, Iche Andriyani Indra Franajayakk Inggarsih, Rara Irawan Mangunatmadja Irsan Saleh Irsan Saleh Jusak Nugraha Jusuf Fantoni Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kemas Ya’kub Rahadiyanto Kemas Yusuf Effendi Kms Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kodrati, Adika Krisna Murti Krisna Murti kurniati, nova Laida Neti Mulyani Legiran Legiran Legiran Legiran M, Haekal M, Haekal M. Irsan Saleh Masagus Irsan Saleh Hasani Maya Eka Apriyanti Meiliza Indriani Mgs. Irsan Saleh Mgs. Irsan Saleh Mohamad Sadikin Muhammad Irsan Saleh Nita Hertati Nora Ramkita Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Lestari Novizar S Nur Riviati Ocktariyana, Ocktariyana Owen Hu Pancarani, Muftia Phey Liana Prihantika S., Sabrina Purnamasari, Septi Puspita, Riana Sari Puspita, Riana Sari R, Sentani R, Sentani Raden Muhammad Indra Radiyati Umi Partan Radiyati Umi Partan, Radiyati Umi Rafdi A Rafika Novianti Rahadiyanto, Kemas Ya'Kub Rahmi Widiyawati Ramadhayanti, Lidya Ramzi Amin, Ramzi Rasyid, Riana Sari Puspita Ray Suga Aulia Ray Suga Aulia Sentani Riana Sari Puspita Riana Sari Puspita Rasyid Rikka Wijaya Rini Nindela Rini Nindela, Rini Rizal Sanif Rizka Fadilah Rouly Pola Pasaribu S, Novizar S, Novizar Sabri Prihantika Sabrina Prihantika Saleh, M Irsan Saleh, Mgs. M. Irsan Sari, Nurmalia Purnama selly marisdina Selvy Apriani Sentani R SEPTI WULANDARI Soilia Fertilita Sri Handayani Sri Sulpha Siregar Sri Sulpha Siregar Subandrate Sudarto Sudarto Suly Auline Rusminan Susiwati Susiwati Syifa Alkaf Tanoerahardjo, Francisca Srioetami Tungki Pratama Umar Venny Larasati Venny Larasati Veny Larasati Veny Larasati Verli Saniba Welly Salutondok Wresnindyatsih Ya’kub Rahadiyanto Yudianita Kesuma, Yudianita Yulia Iriani Yunni Diansari Yusuf Effendi Yusuf Effendi Yusuf Effendi Yusuf Effendi Zen Ahmad Zen Ahmad Zen Ahmad Ziske Maritska Zulkarnain Musa