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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Agromedicine and Medical Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan MNJ (Malang Neurology Journal) Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Surya Medika Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Acta Biochimica Indonesiana Oceana Biomedicina Journal SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Medica Hospitalia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis Eduvest - Journal of Universal Studies Jurnal Keperawatan Molekul: Jurnal Ilmiah Kimia Jurnal Kesehatan Indonesian Journal of Global Health Research
Zen Hafy
Universitas Sriwijaya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Correlation of the Interferon Gamma Point +874 A/T Gene Polymorphism with the Occurrence of Schizophrenia Agnes Felicia Lubis; Eddy Mart Salim; Zen Hafy
Jurnal Penelitian Pendidikan IPA Vol 9 No 11 (2023): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i11.5436

Abstract

Schizophrenia is a mental illness characterized by delusions and hallucinations. Several investigations have revealed that the immune system and genetic factors have a role in the development of schizophrenia. Interferon gamma is one of the genes thought to have a role in the development of schizophrenia, and many studies have reported the involvement of interferon-gamma (IFN-γ) in neuropsychiatry. This study aims to determine the relationship between the Interferon-γ +874 A/T Gene Polymerphism with the incidence of Schizophrenia. A case control study was conducted at the hospital. Ernaldi Bahar Palembang for 3 months (February-April). There were 100 samples that met the inclusion criteria, of which 50 patients were cases and 50 respondents were healthy controls. Analysis of data using computerized data processing applications. The sampling method in this study is the matching sampling method. The results showed that the frequency of the A allele in the case group was 50 and in the control group was 69, while the frequency of the T allele in the case group was 50 and the control group was 31. The analysis of the results showed that the frequency of the T allele was higher in the schizophrenia group than the control group with value (p = 0.006), with an OR value of 2.226. There was a significant relationship between the case group and the control group. Individuals with the T allele have a 2,226 higher risk of developing schizophrenia than individuals with the A allele
Kualitas Sperma pada Laki-Laki Defisiensi Vitamin D di Palembang Maya Eka Apriyanti; Yusuf Effendi; Zen Hafy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v8i11.13919

Abstract

Vitamin D deficiency may play some roles in male infertility. Abundant vitamin D receptors exist in male reproductive tracts, implying some significant functions of vitamin D in spermatogenesis and/or testosterone synthesis. This study aims to measure sperm parameters in males with vitamin D deficiency in Palembang, South Sumatra. This study was a conducted as observational, cross-sectional descriptive study on single mother and child hospital in Palembang. Subjects’ serum vitamin D was measured in an accredited external clinical laboratory and sperm samples were collected and examined in same laboratory according to standard protocols. Median age of subject was 30,0 (24-49) years old. Mean serum vitamin D concentration was 21.372 ± 4.202 ng/mL. Median sperm concentration was 21.75 (0.00-137.00) millions/mL. Median sperm count was 66.14 (0.00-370.80) millions. Average progressive motility was 35.64 ± 18.573%. Median normal morphology was 5.00 (0.00-7.00)%. Normal sperm parameters observed in this study implicated vitamin D plays no significant role in sperm quality.
Nephrotoxicity and Kidney Fibrosis Due to Gentamicin in Wistar Rats Lusiana, Evi; Saleh, Irsan; Sinaga, Ernawati; Hafy, Zen
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.909

Abstract

Background : Gentamicin is an aminoglycoside used as a treatment for various infections. One of the side effects reported on the use of gentamicin is nephrotoxic. However, there are still many uses of gentamicin that have not been precisely indicated. Objective : To analyze the nephrotoxic effects leading to renal fibrosis due to gentamicin induction in Wistar rats. Methods : This research is an in vivo experimental study, pre- and post-test control group design, conducted in September and October 2022 at the Animal House Laboratory of the Faculty of Medicine, Sriwijaya University, and the Palembang Health Laboratory Center. There were 4 treatment groups: Group I, placebo; Group II, gentamicin-induced (GIG I) at 80 mg/kgBW; Group III, gentamicin-induced (GIG II) at 120 mg/kgBW; and Group IV, gentamicin-induced (GIG III) at 240 mg/kgBW. Gentamicin was administered intraperitoneally for 7 days, to 8 Wistar rats per group. Blood was taken from all Wistar rats in each group on days 0, 3, 7, and 14. The results of the study were tested for normality with the Shapiro-Wilk test and homogeneity with the Levene's test. The ANOVA test and the Post-Hoc test were used to conduct the analysis. Results :  Induction of gentamicin in the GIG I and GIG II groups was significant in increasing the mean creatinine and urea levels on day 0 and day 14 of treatment (p<0.05). In the GIG III group there was a 50% mortality in experimental animals showing a Lethal dose of 50 (LD50) at that dose. Conclusion : GIG I and GIG II have significant nephrotoxic effects in increasing creatinine and urea levels which lead to renal fibrosi.
Faktor Risiko yang Mempengaruhi Peningkatan Kadar CRP dan Interleukin-6 pada Pasien dengan Operasi Katarak: Study Literature Pancarani, Muftia; Hafy, Zen; Sari, Nurmalia Purnama
Jurnal Keperawatan Vol 15 No 4 (2023): Jurnal Keperawatan: Supp Desember 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/keperawatan.v15i4.1967

Abstract

Katarak adalah modifikasi penglihatan yang disebabkan oleh lensa berkabut. Lensa adalah media bias bikonveks yang memfokuskan cahaya yang masuk ke mata untuk memungkinkannya mencapai makula.Menurut data dari (WHO), diperkirakan ada 36 juta orang buta pada tahun 2015, di antaranya 216,6 juta memiliki gangguan penglihatan yang parah. Lebih dari tiga juta orang Indonesia, atau 1,5% dari populasi. Tujuan dari penelitian ini adalah untuk mengidentifikasi variabel risiko yang berkontribusi terhadap peningkatan kadar interleukin-6 dan CRP pada individu dengan katarak.Penelitian literatur dilakukan untuk mendapatkan informasi untuk artikel ini. Pencarian terkomputerisasi dilakukan untuk menemukan berbagai artikel dari database Google Scholar, DOAJ, Science Direct, dan Garuda. Lima dari 25 publikasi yang ditinjau selama pencarian artikel, yang mencakup tahun publikasi 2014-2023, digunakan dalam penelitian ini. Setelah pencarian di 25 jurnal menghasilkan lima artikel dari publikasi yang berbeda, tinjauan literatur digunakan dalam analisis penelitian ini. Hasil pemeriksaan artikel yang diterbitkan dalam jurnal yang berbeda akan dirangkum dan disajikan dalam bentuk tabel sebagai berikutPenelitian tinjauan literatur ini adalah untuk mengidentifikasi faktor-faktor risiko yang terkait dengan peningkatan kadar CRP dan IL-6 pada katarak.Usia dan hubungan karakteristik, hubungan antara katarak dan diabetes mellitus, hubungan antara katarak dan hipertensi,hubungan antara katarak dan indeks massa tubuh (BMI), hubungan antara katarak dan rokok,interleukin-6 dan CRP dalam katarak: suatu hubungan.
The Role of Multimodalities Approach in Diagnosing Disorders of Sex Development (DSD): Brief Review Ziske Maritska; Masagus Irsan Saleh Hasani; Fachmi Idris; Zen Hafy; Didit Pramudhito; Kemas Yusuf Effendi
Sriwijaya Journal of Medicine Vol. 7 No. 3 (2024): Vol 7, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i3.238

Abstract

Disorders of Sex Development (DSD) encompass rare congenital conditions involving atypical development of chromosomes, gonads, or sex anatomy. The 2006 global consensus led to a shift in the approach to handling DSD cases, emphasizing integrated treatment involving various scientific disciplines. DSD diagnosis involves a structured and multimodality approach, including history, pedigree analysis, physical examination, imaging, hormone and chromosome analysis, and genetic testing. An in-depth anamnesis and detailed pedigree analysis help trace family history and inheritance patterns of Mendelian traits in DSD cases. Thorough physical examination, including general and specific assessments, helps screen for abnormalities in sexual development. Karyotyping, hormone level investigation, and imaging examinations are crucial for supporting the diagnosis of DSD. However, genetic or molecular examination remains the modality for definitively confirming the genetic disorder underlying DSD, subsequently leading to a better understanding and management of the condition. Considering the limited resources available in the field in efforts to establish a molecular diagnosis of DSD, it is recommended to explore the role of anamnesis, pedigree analysis, physical examination, imaging examination, hormonal laboratory examination, and chromosome analysis in efforts to approach the diagnosis of DSD.
The Effect of EGFR DNA Methylation on the Incident of Endometriosis Anisah Nida'ul Haq; Ocktariyana Ocktariyana; Zen Hafy; Irsan Saleh
Sriwijaya Journal of Medicine Vol. 7 No. 2 (2024): Vol 7, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i2.274

Abstract

Endometriosis is a gynecological condition characterized by the development of endometrial tissue outside the uterus, often leading to pain and infertility. We explore the relationship between endometriosis and the effects of DNA methylation on the Epidermal Growth Factor Receptor (EGFR) gene. DNA methylation, an epigenetic mechanism, involves adding a methyl group to cytosine bases followed by guanine in CpG islands, thereby influencing gene expression through hypermethylation or hypomethylation. In endometriosis, methylation patterns on specific genes can lead to transcriptional changes, impacting inflammatory processes and hormonal functions, such as estrogen, that support the growth of ectopic tissue. Variations in the EGFR gene's DNA methylation are linked to elevated cellular activity and expression, which aids in the pathophysiology of endometriosis. These findings highlight the potential of DNA methylation as a therapeutic target in treating endometriosis, offering hope for improved patient outcomes.
Reliability of Using the Scabies Detection Form (DESKAB) in Islamic Boarding Schools Prasasty, Gita Dwi; Anwar, Chairil; Hafy, Zen; Liberty, Iche Andriyani; Argentina, Fiva; Aryani, Inda Astri
Journal of Agromedicine and Medical Sciences Vol 10 No 3 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i3.44810

Abstract

Scabies is an infectious skin disease caused by the Sarcoptes scabiei. This mite infestations not only cause skin damage, but can develop into local, even systemic skin infections. Therefore, instruments are needed that help early detection of scabies, especially through diagnosis in communities such as Islamic boarding schools. This study aimed to analyze the reliability of the scabies detection form (DESKAB) between Madrasah Aliyah female student rater and dermatovenerologist rater. Based on the results of the examination and Cohen's kappa test, a coefficient of 0.84 was obtained, which means that the level of reliability of the DESKAB form is strong, and a p value of 0.019 means that there is agreement in the perception of the diagnosis of scabies by the two raters. The DESKAB form can be recommended as an early detection instrument for non-medical personnel before being confirmed by medical personnel Keywords: DESKAB; diagnosis; non-medic; scabies
Pengayaan pembelajaran dalam upaya peningkatan pengetahuan mengenai ambigus genitalia pada mahasiswi Sekolah Tinggi Ilmu Kesehatan Abdurrahman Palembang Maritska, Ziske; Alkaf, Syifa; Inggarsih, Rara; Hafy, Zen; Purnamasari, Septi; Nindela, Rini
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 6 No 1 (2025): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V6I1.163

Abstract

Learning Enrichment to increase knowledge about ambiguous genitalia in students at STIKES Abdurrahman Palembang. Disorders of Sex Development (DSD) is a rare disease in which atypical gonads, chromosomes, and sex anatomy are found. Although it has a significant impact on both the physical and mental health of individuals with DSD, DSD cases are often undetected and underdiagnosed. Efforts to enrich material and learning to training on DSD for prospective midwife health workers are one of the real actions that can be taken to increase knowledge and awareness of DSD which is then expected to increase early identification efforts to improve the quality of life and patient outcomes. This community service activity was carried out for one semester through a series of activities in the form of guest lectures for enrichment of learning which were carried out in stages three times online for 55 students of STIKES Abdurrahman Palembang. Measurement of the level of knowledge of STIKES Abdurrahman students was carried out twice, namely before the series of activities began (pre-test) and after the activities were completed (post-test). From the results of the pre- and post-test, an increase in knowledge was obtained, which was originally only 36.4% with a sufficient level of knowledge at the time of the pre-test, to 69.1% with a sufficient level of knowledge at the time of the post-test. It is hoped that with the enrichment of learning, prospective midwives can know and understand DSD so that in the future they can improve early screening for ambiguous genitalia cases which can lead to improving the quality of life of sufferers.
THE RELATIONSHIP OF THE CHARACTERISTICS OF ANTI-EPILEPSY DRUGS WITH THE C OGNITIVE FUNCTION OF EPILEPSY PATIENTS Handayani, Sri; Partan, Radiyati Umi; Hafy, Zen; Octaviana, Fitri; Harun, Yusril; Bahar, Erial; Lestari, Nova
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.02

Abstract

Background: One of the side effects of the use of antiepileptic drugs (AEDs) is cognitive disorder. Several studies show a relationship between the type of AEDs and cognitive disturbance in people with epilepsy. Dose-dependent side effects of AEDs have also been reported in prior research. However, there are results from different studies on different populations. Objective: This research aims to evaluate the relationship between AEDs characteristics and the cognitive function of epilepsy patients. Methods: This cross-sectional study was conducted in the Neurology Department of Dr. Mohammad Hoesin General Hospital Palembang, from 1 November 2021 to 31 March 2022. Researchers used the MoCA-Ina questionnaire to collect medical record data and conduct interviews. Results: In this research, the number of research subjects obtained was 70 people with epilepsy. Characteristics of sociodemographic sufferer Epilepsy in this study was mostly (44.3%) aged 26 – 45 years with type sex most were women (71.4%), and the majority subjects (52.9%) had level high school education. Characteristics of antiepileptic drugs consumed by people living with epilepsy: most of them, i.e., amounting to 57.1%, have consumed antiepileptic drugs for > 12 months. Most of the research subjects (64.3%) had function-impaired cognitive range MoCA-Ina scores of 8 – 30. The function most cognitively disturbed, namely in the memory domain, cancels that am, counting to 82.9%. Education level is the only variable from characteristics of sociodemographic and clinical features connected significantly to cognitive function in general (p-value 0.013). The number, duration, and type of antiepileptic drugs do not determine a significant relationship with cognitive function in general. Conclusion: There is a significant relationship between valproic acid and the number of AEDs with the naming domain, as well as between valproic acid and the duration of AEDs with the abstraction domain.
Isolation and Purification of Breast Milk Folate Binding Protein: Salting-Out and Chromatography Techniques Saleh, Mgs. M. Irsan; Subandrate, Subandrate; Gunarti, Dwirini Retno; Hermansyah, Hermansyah; Hafy, Zen; Kesuma, Yudianita; Sadikin, Mohamad
Molekul Vol 20 No 1 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.1.11303

Abstract

ABSTRACT. Folate binding protein (FBP) is a protein in breast milk that plays a role in the regulation and bioavailability of folic acid. In contrast to cow's milk FBP, information about breast milk FBP is still limited. This research aims to determine the isolation and purification methods of breast milk FBP and the molecular weight of breast milk FBP. The sample in this study was 1000 mL of breast milk. Breast milk was prepared in several stages to yield whey. Isolation and purification of FBP from whey were carried out in stages, salting-out, ion exchange chromatography, and affinity chromatography. Whey salting-out with 95% saturation of ammonium sulfate could precipitate folate-binding proteins. This precipitate showed three peaks on DEAE chromatography. Peak II DEAE 95% was thought to be a negatively charged folate-binding protein. Peak II DEAE 95% also showed the presence of two peaks on affinity chromatography. It was believed that Peak II AF 95% was a pure folate-binding protein. Peak II AF 95% showed the presence of a single band on SDS-PAGE and western blot. This indicated that the folate-binding protein was 100% pure. FBP can be isolated from breast milk by the salting-out method using 95% ammonium sulfate, DEAE chromatography, and affinity chromatography. FBP from breast milk has a molecular weight of approximately 37 kDa. The final level of FBP isolated from breast milk is approximately 0.022 mg/mL. The successful isolation of FBP from breast milk provides an opportunity to use it to understand the clinical role of FBP in increasing folic acid levels in both breast milk and infant serum, as well as to develop methods for determining folic acid levels in these fluids. Keywords: Breast milk, folate binding protein, isolation, purification, molecular weight
Co-Authors A, Rafdi A, Rafdi Abdullah Fikri Abdullah Sahab Afriyana Siregar Afriyana Siregar Agnes Felicia Lubis Agnes Felicia Lubis Agustian Dwi Putra Agustian Dwi Putra Agustina Br Haloho Amalia Amalia Anisah Nida'ul Haq Argentina, Fiva Ariesti Karmila aryani, Inda astri Aulia Annisa Rizki Bastian Bastian Bayu Winata Putera Calvin Ienawi Chairil Anwar Chairil Anwar Citra Ananta Avis Citra Dewi Defa Agripratama Ali Desi Arlindia Desi Oktariana Dian Puspitasari Didit Pramudhito Dwi Handayani Dwi Handayani Dwiana Ocviyanti Dwirini Retno Gunarti Dya Anggraeni Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim, Eddy Mart Efrieni Erial Bahar Erial Bahar Erial Bahar Erial Bahar, Erial Ernawati Sinaga Evi Lusiana Fachmi Idris Fadhyl Zuhry Lubis Fadilah, Rizka Ferry Yusrizal Ferry Yusrizal Fitri Octaviana Fitri Octaviana Franajayakk, Indra Francisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Gita Dwi Prasasty Hadi Nugraha Mustofa Haekal M Handayani, Sri Hartati Harun Hudari Harun Hudari Harun, Yusril Heni Maulani Heni Pujiastuti Henny Sulastri Hermansyah Hermansyah Iche Andriyani Liberty Iche Andriyani Liberty, Iche Andriyani Indra Franajayakk Inggarsih, Rara Irawan Mangunatmadja Irsan Saleh Irsan Saleh Jusak Nugraha Jusuf Fantoni Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kemas Ya’kub Rahadiyanto Kemas Yusuf Effendi Kms Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kodrati, Adika Krisna Murti Krisna Murti kurniati, nova Laida Neti Mulyani Legiran Legiran Legiran Legiran M, Haekal M, Haekal M. Irsan Saleh Masagus Irsan Saleh Hasani Maya Eka Apriyanti Meiliza Indriani Mgs. Irsan Saleh Mgs. Irsan Saleh Mohamad Sadikin Muhammad Irsan Saleh Nita Hertati Nora Ramkita Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Lestari Novizar S Nur Riviati Ocktariyana, Ocktariyana Owen Hu Pancarani, Muftia Phey Liana Prihantika S., Sabrina Purnamasari, Septi Puspita, Riana Sari Puspita, Riana Sari R, Sentani R, Sentani Raden Muhammad Indra Radiyati Umi Partan Radiyati Umi Partan, Radiyati Umi Rafdi A Rafika Novianti Rahadiyanto, Kemas Ya'Kub Rahmi Widiyawati Ramadhayanti, Lidya Ramzi Amin, Ramzi Rasyid, Riana Sari Puspita Ray Suga Aulia Ray Suga Aulia Sentani Riana Sari Puspita Riana Sari Puspita Rasyid Rikka Wijaya Rini Nindela Rini Nindela, Rini Rizal Sanif Rizka Fadilah Rouly Pola Pasaribu S, Novizar S, Novizar Sabri Prihantika Sabrina Prihantika Saleh, M Irsan Saleh, Mgs. M. Irsan Sari, Nurmalia Purnama selly marisdina Selvy Apriani Sentani R SEPTI WULANDARI Soilia Fertilita Sri Handayani Sri Sulpha Siregar Sri Sulpha Siregar Subandrate Sudarto Sudarto Suly Auline Rusminan Susiwati Susiwati Syifa Alkaf Tanoerahardjo, Francisca Srioetami Tungki Pratama Umar Venny Larasati Venny Larasati Veny Larasati Veny Larasati Verli Saniba Welly Salutondok Wresnindyatsih Ya’kub Rahadiyanto Yudianita Kesuma, Yudianita Yulia Iriani Yunni Diansari Yusuf Effendi Yusuf Effendi Yusuf Effendi Yusuf Effendi Zen Ahmad Zen Ahmad Zen Ahmad Ziske Maritska Zulkarnain Musa