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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Agromedicine and Medical Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan MNJ (Malang Neurology Journal) Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Jurnal Kesehatan Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Surya Medika Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Acta Biochimica Indonesiana Oceana Biomedicina Journal SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis Jurnal Keperawatan Molekul: Jurnal Ilmiah Kimia
Zen Hafy
Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Hubungan Polimorfisme Gen Klotho C1818t dengan Kejadian Preeklamsia Efrieni; Legiran; Mgs. Irsan Saleh; Kms. Yusuf Effendi; Ferry Yusrizal; Rizal Sanif; Zen Hafy
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 8 No. 3 (2021): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v8i3.184

Abstract

Angka kematian ibu akibat preeklamsia baik di dunia maupun di Indonesia masih tinggi. Preeklamsia merupakan penyakit multifaktorial yang memiliki berbagai faktor risiko, diantaranya usia ibu, jumlah anak (paritas) dan riwayat preeklamsia pada kehamilan sebelumnya. Polimorfisme Gen Klotho C1818T dapat menyebabkan terjadi kelainan vaskularisasi plasenta yang akan mengakibatkan disfungsi endotel sehingga terjadi preeklamsia. Tujuan dari penelitian ini adalah untuk mengetahui hubungan polimorfisme gen Klotho C1818T dengan kejadian preeklamsia. Penelitian ini merupakan penelitian analitik dengan desain kasus kontrol, yaitu dengan cara membandingkan antara kelompok kasus yaitu ibu hamil dengan preeklamsia sebanyak 55 subjek dan kelompok kontrol yaitu ibu hamil normal sebanyak 55 subjek. Total sampel pada penelitian ini sebanyak 110 subjek. Hasil analisis statistik dengan menggunakan uji Chi-Square didapatkan hasil pada variabel usia nilai p value 0,022 ; OR = 2,667 ; CI 95% = 1,136-6,258, variabel paritas dengan nilai p value 0,179 ; OR = 0,596 ; CI 95% = 0,279-1,272, variabel riwayat preeklamsia dengan nilai p value 0,000 ; OR = 10,494 ; CI 95% = 4,345-25,345. Pada genotipe CT dan TT terhadap kejadian preeklamsia didapatkan nilai p value 0,003 ; OR = 4,310 ; CI 95% = 1,564-11,878. Pada Alel T didapat nilai p value 0,000 ; OR = 3,973 ; CI 95% = 1,934-8,160. Kesimpulan dari penelitian ini yaitu ada hubungan yang bermakna antara polimorfisme gen Klotho C1818T dengan kejadian preeklamsia.
The Expression of NFATc1 is more Predominant in Triple Negative Breast Carcinoma Patients Riana Sari Puspita Rasyid; Krisna Murti; Zen Hafy
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 9 No. 1 (2022): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v9i1.193

Abstract

Karsinoma payudara adalah keganasan paling umum pada wanita di negara maju dan berkembang. Karsinoma payudara invasif diklasifikasikan menjadi 4 subtipe yaitu luminal A dan B, human epidermal growth factor receptor 2 (HER2) dan triple negative yang memiliki prognosis terburuk. Nuclear factor of activated T cell (NFATc) 1 merupakan faktor transkripsi penting dalam proses transformasi dan perkembangan keganasan. Oleh karena itu, ekspresi NFATc1 dapat menentukan prognosis karsinoma payudara. Penelitian ini bertujuan untuk mengetahui peran NFATc1 pada progresivitas karsinoma payudara. Bahan dan metode, 52 blok parafin dipilih dan disiapkan untuk menilai ekspresi NFATc1 dengan imunohistokimia. Data ini diambil dari rekam medis: yaitu klasifikasi molekuler, usia pasien, ukuran tumor, invasi limfovaskular dan grade tumor. Ekspresi NFATc1 positif diamati pada 4 sampel yaitu pada inti luminal A (1 dari 12; 8,8%), luminal B (1 dari 15; 6,7%), dan triple negative (2 dari 12; 16,7%), tetapi tidak ada ekspresi NFATc1 yang terdeteksi dalam sampel HER2. Secara klinis, pasien ini lebih banyak pada usia dekade kelima (38,5%), dengan ukuran tumor lebih besar (≥2 cm; 90%), invasi limfovaskular positif (80,8%), dan derajat tinggi (3; 59,6%). Ekspresi NFATc1 lebih dominan pada karsinoma payudara triple negative.
Demographic, Clinical, and Tumor Profile Of Meningioma In Mohammad Hoesin Hospital Palembang, Indonesia Dya Anggraeni; Yunni Diansari; Zen Hafy
Biomedical Journal of Indonesia Vol. 8 No. 1 (2022): Vol 8, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i1.122

Abstract

Introduction. Meningioma was the most frequently reported primary intracranial tumor. There had been a few reports about meningioma profile in Indonesia. The objective of this study is to identify the profile of meningioma based on demographic, clinical, and tumor characteristics. Methods. This is a cross-sectional study using secondary data from medical records. There were 67 meningioma patients based on histopathological examination at Mohammad Hoesin Hospital  from January to December 2018. Various data were recorded, including demografic profile,  history of hormonal contraceptive use, neurologic symptoms, and tumor characteristic. Results. During 2018, the incidence of meningioma was 68,3% of all primary CNS tumors. Meningioma was mostly found in the age group 35-44 years (44.8%). Most of the patients was female (92.5%) and 29 patients (46.8%) had a history of hormonal contraceptive use. Headache showed the highest rate of clinical manifestation in meningioma patient (34.3%). Based on the location, convexity meningioma was the most frequently found (65.7%). Of the 67 meningioma patients, only 26 datas were obtained regarding a history of radiation exposure and all without a history of radiation. There was only one patient (1.5%) with a family history of malignancy (breast tumor). Based on histopathological examination, 60 patients (89.6%) reported as WHO grade I, mostly the meningothelial subtype (40%). The outcome was generally good in most patients (88.1%). Conclusion. In our institution, meningioma is the most commonly found primary brain tumor. Headache was the most common clinical manifestation and these tumors were mostly located in convexity of the brain, with the majority being WHO grade I and meningothelial subtype.
Correlation of the Interferon Gamma Point +874 A/T Gene Polymorphism with the Occurrence of Schizophrenia Agnes Felicia Lubis; Eddy Mart Salim; Zen Hafy
Jurnal Penelitian Pendidikan IPA Vol 9 No 11 (2023): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i11.5436

Abstract

Schizophrenia is a mental illness characterized by delusions and hallucinations. Several investigations have revealed that the immune system and genetic factors have a role in the development of schizophrenia. Interferon gamma is one of the genes thought to have a role in the development of schizophrenia, and many studies have reported the involvement of interferon-gamma (IFN-γ) in neuropsychiatry. This study aims to determine the relationship between the Interferon-γ +874 A/T Gene Polymerphism with the incidence of Schizophrenia. A case control study was conducted at the hospital. Ernaldi Bahar Palembang for 3 months (February-April). There were 100 samples that met the inclusion criteria, of which 50 patients were cases and 50 respondents were healthy controls. Analysis of data using computerized data processing applications. The sampling method in this study is the matching sampling method. The results showed that the frequency of the A allele in the case group was 50 and in the control group was 69, while the frequency of the T allele in the case group was 50 and the control group was 31. The analysis of the results showed that the frequency of the T allele was higher in the schizophrenia group than the control group with value (p = 0.006), with an OR value of 2.226. There was a significant relationship between the case group and the control group. Individuals with the T allele have a 2,226 higher risk of developing schizophrenia than individuals with the A allele
The Relationship Between Quantitative C-Reactive Protein (CRP) and the Number of Leukocytes and Blood Edition Rate (ESR) in Optic Neuritis Patients Lidya Ramadhayanti; Zen Hafy; Nurmalia Purnama Sari
Indonesian Journal of Global Health Research Vol 6 No 3 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i3.3164

Abstract

Optic neuritis (ON) is a demyelinating inflammatory process that causes sudden visual impairment that can occur in one or both eyes simultaneously or successively. Optic neuritis (ON) can be caused by demyelinating diseases of the central nervous system, immune system diseases, infectious diseases, and can also be caused by inflammatory responses and vaccinations. This study aimed to determine the relationship between quantitative c-reactive protein (CRP) and leukocyte count and blood edition rate (ESR) in patients with optic neuritis. The most common pathophysiology of optic neuritis is inflammatory optic neuropathy associated with multiple sclerosis. In optic neuritis, demyelination occurs due to inflammation of the optic nerve with a lesion pathology similar to plaque in the central nervous system of someone with multiple sclerosis. There will be perivascular swelling, edema of the myelinated nerve sheath, and myelin damage. Inflammation of the retinal vascular endothelium may precede demyelination. Myelin damage is more severe than the damage found in axons. This research was conducted to determine the correlation between quantitative CRP levels and leukocyte counts and erythrocyte sedimentation rate levels in optical neuritis patients. The type of research used is quantitative research with an analytical observational research design, namely a cross-sectional approach. CRP and ESR are two commonly performed laboratory tests that may help physicians in accurately diagnosing and following many complex disease conditions. The relationship between CRP levels and leukocyte counts is to evaluate the effectiveness of treatment response.
Kualitas Sperma pada Laki-Laki Defisiensi Vitamin D di Palembang Maya Eka Apriyanti; Yusuf Effendi; Zen Hafy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v8i11.13919

Abstract

Vitamin D deficiency may play some roles in male infertility. Abundant vitamin D receptors exist in male reproductive tracts, implying some significant functions of vitamin D in spermatogenesis and/or testosterone synthesis. This study aims to measure sperm parameters in males with vitamin D deficiency in Palembang, South Sumatra. This study was a conducted as observational, cross-sectional descriptive study on single mother and child hospital in Palembang. Subjects’ serum vitamin D was measured in an accredited external clinical laboratory and sperm samples were collected and examined in same laboratory according to standard protocols. Median age of subject was 30,0 (24-49) years old. Mean serum vitamin D concentration was 21.372 ± 4.202 ng/mL. Median sperm concentration was 21.75 (0.00-137.00) millions/mL. Median sperm count was 66.14 (0.00-370.80) millions. Average progressive motility was 35.64 ± 18.573%. Median normal morphology was 5.00 (0.00-7.00)%. Normal sperm parameters observed in this study implicated vitamin D plays no significant role in sperm quality.
Nephrotoxicity and Kidney Fibrosis Due to Gentamicin in Wistar Rats Lusiana, Evi; Saleh, Irsan; Sinaga, Ernawati; Hafy, Zen
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.909

Abstract

Background : Gentamicin is an aminoglycoside used as a treatment for various infections. One of the side effects reported on the use of gentamicin is nephrotoxic. However, there are still many uses of gentamicin that have not been precisely indicated. Objective : To analyze the nephrotoxic effects leading to renal fibrosis due to gentamicin induction in Wistar rats. Methods : This research is an in vivo experimental study, pre- and post-test control group design, conducted in September and October 2022 at the Animal House Laboratory of the Faculty of Medicine, Sriwijaya University, and the Palembang Health Laboratory Center. There were 4 treatment groups: Group I, placebo; Group II, gentamicin-induced (GIG I) at 80 mg/kgBW; Group III, gentamicin-induced (GIG II) at 120 mg/kgBW; and Group IV, gentamicin-induced (GIG III) at 240 mg/kgBW. Gentamicin was administered intraperitoneally for 7 days, to 8 Wistar rats per group. Blood was taken from all Wistar rats in each group on days 0, 3, 7, and 14. The results of the study were tested for normality with the Shapiro-Wilk test and homogeneity with the Levene's test. The ANOVA test and the Post-Hoc test were used to conduct the analysis. Results :  Induction of gentamicin in the GIG I and GIG II groups was significant in increasing the mean creatinine and urea levels on day 0 and day 14 of treatment (p<0.05). In the GIG III group there was a 50% mortality in experimental animals showing a Lethal dose of 50 (LD50) at that dose. Conclusion : GIG I and GIG II have significant nephrotoxic effects in increasing creatinine and urea levels which lead to renal fibrosi.
Faktor Risiko yang Mempengaruhi Peningkatan Kadar CRP dan Interleukin-6 pada Pasien dengan Operasi Katarak: Study Literature Pancarani, Muftia; Hafy, Zen; Sari, Nurmalia Purnama
Jurnal Keperawatan Vol 15 No 4 (2023): Jurnal Keperawatan: Supp Desember 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/keperawatan.v15i4.1967

Abstract

Katarak adalah modifikasi penglihatan yang disebabkan oleh lensa berkabut. Lensa adalah media bias bikonveks yang memfokuskan cahaya yang masuk ke mata untuk memungkinkannya mencapai makula.Menurut data dari (WHO), diperkirakan ada 36 juta orang buta pada tahun 2015, di antaranya 216,6 juta memiliki gangguan penglihatan yang parah. Lebih dari tiga juta orang Indonesia, atau 1,5% dari populasi. Tujuan dari penelitian ini adalah untuk mengidentifikasi variabel risiko yang berkontribusi terhadap peningkatan kadar interleukin-6 dan CRP pada individu dengan katarak.Penelitian literatur dilakukan untuk mendapatkan informasi untuk artikel ini. Pencarian terkomputerisasi dilakukan untuk menemukan berbagai artikel dari database Google Scholar, DOAJ, Science Direct, dan Garuda. Lima dari 25 publikasi yang ditinjau selama pencarian artikel, yang mencakup tahun publikasi 2014-2023, digunakan dalam penelitian ini. Setelah pencarian di 25 jurnal menghasilkan lima artikel dari publikasi yang berbeda, tinjauan literatur digunakan dalam analisis penelitian ini. Hasil pemeriksaan artikel yang diterbitkan dalam jurnal yang berbeda akan dirangkum dan disajikan dalam bentuk tabel sebagai berikutPenelitian tinjauan literatur ini adalah untuk mengidentifikasi faktor-faktor risiko yang terkait dengan peningkatan kadar CRP dan IL-6 pada katarak.Usia dan hubungan karakteristik, hubungan antara katarak dan diabetes mellitus, hubungan antara katarak dan hipertensi,hubungan antara katarak dan indeks massa tubuh (BMI), hubungan antara katarak dan rokok,interleukin-6 dan CRP dalam katarak: suatu hubungan.
The Role of Multimodalities Approach in Diagnosing Disorders of Sex Development (DSD): Brief Review Ziske Maritska; Masagus Irsan Saleh Hasani; Fachmi Idris; Zen Hafy; Didit Pramudhito; Kemas Yusuf Effendi
Sriwijaya Journal of Medicine Vol. 7 No. 3 (2024): Vol 7, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i3.238

Abstract

Disorders of Sex Development (DSD) encompass rare congenital conditions involving atypical development of chromosomes, gonads, or sex anatomy. The 2006 global consensus led to a shift in the approach to handling DSD cases, emphasizing integrated treatment involving various scientific disciplines. DSD diagnosis involves a structured and multimodality approach, including history, pedigree analysis, physical examination, imaging, hormone and chromosome analysis, and genetic testing. An in-depth anamnesis and detailed pedigree analysis help trace family history and inheritance patterns of Mendelian traits in DSD cases. Thorough physical examination, including general and specific assessments, helps screen for abnormalities in sexual development. Karyotyping, hormone level investigation, and imaging examinations are crucial for supporting the diagnosis of DSD. However, genetic or molecular examination remains the modality for definitively confirming the genetic disorder underlying DSD, subsequently leading to a better understanding and management of the condition. Considering the limited resources available in the field in efforts to establish a molecular diagnosis of DSD, it is recommended to explore the role of anamnesis, pedigree analysis, physical examination, imaging examination, hormonal laboratory examination, and chromosome analysis in efforts to approach the diagnosis of DSD.
The Effect of EGFR DNA Methylation on the Incident of Endometriosis Anisah Nida'ul Haq; Ocktariyana Ocktariyana; Zen Hafy; Irsan Saleh
Sriwijaya Journal of Medicine Vol. 7 No. 2 (2024): Vol 7, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i2.274

Abstract

Endometriosis is a gynecological condition characterized by the development of endometrial tissue outside the uterus, often leading to pain and infertility. We explore the relationship between endometriosis and the effects of DNA methylation on the Epidermal Growth Factor Receptor (EGFR) gene. DNA methylation, an epigenetic mechanism, involves adding a methyl group to cytosine bases followed by guanine in CpG islands, thereby influencing gene expression through hypermethylation or hypomethylation. In endometriosis, methylation patterns on specific genes can lead to transcriptional changes, impacting inflammatory processes and hormonal functions, such as estrogen, that support the growth of ectopic tissue. Variations in the EGFR gene's DNA methylation are linked to elevated cellular activity and expression, which aids in the pathophysiology of endometriosis. These findings highlight the potential of DNA methylation as a therapeutic target in treating endometriosis, offering hope for improved patient outcomes.
Co-Authors A, Rafdi A, Rafdi Abdullah Fikri Abdullah Sahab Afriyana Siregar Afriyana Siregar Agnes Felicia Lubis Agnes Felicia Lubis Agustian Dwi Putra Agustian Dwi Putra Agustina Br Haloho Ahmad, Zen Amalia Amalia Anisah Nida'ul Haq Argentina, Fiva aryani, Inda astri Aulia Annisa Rizki Bastian Bastian Bayu Winata Putera Calvin Ienawi Chairil Anwar Citra Dewi Desi Arlindia Didit Pramudhito Dwi Handayani Dwi Handayani Dwiana Ocviyanti Dwirini Retno Gunarti Dya Anggraeni Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim, Eddy Mart Efrieni Erial Bahar Erial Bahar Erial Bahar Erial Bahar, Erial Ernawati Sinaga Fachmi Idris Ferry Yusrizal Ferry Yusrizal Fitri Octaviana Francisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Gita Dwi Prasasty Hadi Nugraha Mustofa Haekal M Handayani, Sri Hartati Harun Hudari Harun Hudari Harun, Yusril Heni Maulani Heni Pujiastuti Henny Sulastri Hermansyah Hermansyah Hu, Owen Iche Andriyani Liberty, Iche Andriyani Indra Franajayakk Inggarsih, Rara Irsan Saleh Jayawarsa, A.A. Ketut Jusak Nugraha Jusak Nugraha Jusak Nugraha Jusak Nugraha Jusuf Fantoni Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kemas Ya’kub Rahadiyanto Kemas Yusuf Effendi Kms Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kodrati, Adika Krisna Murti Krisna Murti kurniati, nova Laida Neti Mulyani Larasati, Veny Legiran Legiran Legiran Legiran Lidya Ramadhayanti Lubis, Fadhyl Zuhry M, Haekal M, Haekal M. Irsan Saleh Masagus Irsan Saleh Hasani Maya Eka Apriyanti Meiliza Indriani Mgs. Irsan Saleh Mgs. Irsan Saleh Mohamad Sadikin Muhammad Irsan Saleh Nita Hertati Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Lestari Novizar S Nurmalia Purnama Sari Ocktariyana, Ocktariyana Oktariana, Desi Pancarani, Muftia Phey Liana Prihantika S., Sabrina Purnamasari, Septi Puspita, Riana Sari Puspita, Riana Sari R, Sentani R, Sentani Radiyati Umi Partan Radiyati Umi Partan, Radiyati Umi Rafdi A Rafika Novianti Rahadiyanto, Kemas Ya'Kub Rahmi Widiyawati Ramzi Amin, Ramzi Rasyid, Riana Sari Puspita Ray Suga Aulia Ray Suga Aulia Sentani Riana Sari Puspita Riana Sari Puspita Rasyid Rikka Wijaya Rini Nindela, Rini Rizal Sanif S, Novizar S, Novizar Sabri Prihantika Sabrina Prihantika Saleh, M Irsan Saleh, Mgs. M. Irsan Salutondok, Welly Sari, Nurmalia Purnama Selvy Apriani Sentani R SEPTI WULANDARI Soilia Fertilita Sri Sulpha Siregar Sri Sulpha Siregar Subandrate Sudarto Sudarto Suly Auline Rusminan Susiwati, Susiwati Syifa Alkaf Tanoerahardjo, Francisca Srioetami Tungki Pratama Umar Venny Larasati Venny Larasati Verli Saniba Wresnindyatsih Ya’kub Rahadiyanto Yudianita Kesuma, Yudianita Yunni Diansari Yusuf Effendi Yusuf Effendi Yusuf Effendi Yusuf Effendi Zen Ahmad Ziske Maritska Zulkarnain Musa