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Ekowati Handharyani
Departemen Klinik Reproduksi Patologi, Fakultas Kedokteran Hewan, IPB University, Kampus IPB Dramaga Bogor, 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
The effect of the extract of pasak bumi roots (Eurycoma longifoliaJack.) on liver function Panjaitan, Ruqiah Ganda Putri; Manalu, Wasmen; Handharyani, Ekowati; ., Chairul
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.396 KB) | DOI: 10.14499/indonesianjpharm0iss0pp15-20

Abstract

The  aim  of  this  research  is  to  study  the  effects  of the  methanol  extract and  its  derived  fraction  (n-hexane,  chloroform,  ethyl  acetate,  and  methanolwater)  on  liver  function  of  male  rats.  The  treatment  groups  were  administered 500  mg/kg body weight of metanol extract and its derived fractions (n-hexane, chloroform,  ethyl  acetate,  n-butanol,  methanol-water)  of  E.  longifolia for  7 consecutive  days.  Positive  control  group  received  25  mg  silymarin/kg  body weight and negative control group received 2 mL aquadest/kg body weight daily for  7  consecutive  days.  Liver  function  was  monitored  by  measuring  alanine transaminase  (ALT),  aspartate  transaminase  (AST),  total  protein,  alkaline phosphatase  (ALP),  total  bilirubin,  direct  bilirubin,  and  indirect  bilirubin consentrations  in  the  serum.  Compared  with  control,  oral  administration  of methanol  extract  and  derived  fractions  of  methanol extract  of  E.  longifolia root had  no  significant  effects  on  liver  function  (p>0.05).  Methanol-water fraction gave similar results to silymarin.Key words: Eurycoma longfolia Jack.,liver function, biochemical blood Histopathologi
Co-Authors ., Chairul A Winarto Adi Winanto Adi Winarto Afiff , Usamah Agus Buono Agus Setiyono Ahmad Biharidin Ahmad Sulaeman Akhmad Endang Zainal Hasan Aldo Yanuar Wuriyantara Armenia Eka Putriana Arni Diana Fitri Aulia Andi Mustika Aziz Kustiyo Bambang Kiranadi Bambang Sumiarto Bambang Widyo Prastowo BIBIANA W LAY Budiono, Novericko Ginger Chairul - Chairul Chairul Clara Meliyanti Kusharto Deni Noviana DEWI APRI ASTUTI Dewi Ratih Agungpriyono Dewi Ulfa Trisdiani Dhany Nugraha Ramdhany Dondin Sajuthi Dwi Santy Damayati Dwi Utari Rahmiati Eflisa Endah Putri Elly Munadziroh Eny Palupi Erni Sulistiawati Erwin Erwin Etriwati E Evy Damayanthi Fadjar Satrija Fajar Kawitan Fitri Ariyani Fitri, Arni Diana Franciscus Dhyana Giri Suyatna Geneva Ariesta Giriwono, Puspo E. Gunanti . Hadi Riyadi Handayu Untari Hapsari Mahatmi Hardi Firmansyah HERA MAHESHWARI Hernomoadi . Hernomoadi Hernomoadi Hidayah Dwiyanti Huda Shalahudin Darusman I wayan Teguh Wibawan Ikeu Ekayanti Irma Herawati Suparto K Ochiai Karsi Ambarwati Katrin Roosita KHOIRIYAH, ROMYUN ALVY Kiranadi Bambang Komariah Komariah Komariah Lili Andriani Lina Noviyanti Sutardi M.B. Malole . MARIA BINTANG Masdiana C. Padaga Masriani . Muhamad Rizal Martua Damanik Nabilah, Avida Shahnaz Nasution, Zuraidah Ni Luh Putu Ika Mayasari Nisrina Rosyida Noor Rifai Novera Nirmalasanti Nugraha, Arifin Budiman Nugroho, Setyo Widi Octarina Okti Nadia Poetri Olga Purnama Bakti Opyn Mananta Perdhana, Ika Satya Putri Puncak Anjani R. Susanti Rahayu WoroWiranti Retno Damajanti Soejoedono Retno Damayanti Soejoedono Retno Setyaningsih Retno Setyaningsih Rimbawan , Rimbawan Rimbawan Risti Rosmiati Riyadh Firdaus Ruqiah Ganda Putri Panjaitan safrina dyah hardiningtyas Sangko Sayuti Nasution SEDARNAWATI YASNI Silmi Mariya Sophia Setyawati Sri Anna Marliyati sri murtini . Sri Purwaningsih Sri Rahmatul Laila Sri Wahyuni Suhendi, Adnan Rizal Surachmi Setiyaningsih Tanjung Penataseputro Tantri, Aida Rosita Trini Suryowati Umi Cahyaningsih Wasmen Manalu Wibowo, Artdhea Regita Wisnu Jaka Dewa Wiwin Winarsih Yetty Ramli Yuli Purwandari Kristiangingrum Yuni Andriani Yusuf Ridwan Zulfa Zakiah