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All Journal Jurnal Gizi dan Pangan Jurnal Kesehatan Andalas Paediatrica Indonesiana Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Penyakit Dalam Indonesia Jurnal Sains, Teknologi dan Kesehatan
Efrida Efrida
Bagian Patologi Klinik Dan Kedokteran Laboratorium, Fakultas Kedokteran, Universitas Andalas, Padang
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Journal : Paediatrica Indonesiana

 1 
Procalcitonin for detecting community-acquired bacterial pneumonia Devi Gusmaiyanto; Finny Fitry Yani; Efrida Efrida; Rizanda Machmud
Paediatrica Indonesiana Vol 55 No 2 (2015): March 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.416 KB) | DOI: 10.14238/pi55.2.2015.65-69

Abstract

Background Pneumonia is a major cause of morbidity andmortality in children under five years of age. Pneumonia can be ofbacterial or viral origin. It is difficult to distinguish between thesetwo agents based on clinical manifestations, as well as radiologicaland laboratory examinations. Furthermore, bacterial cultures taketime to incubate and positive results may only be found in 10-30%of bacterial pneumonia cases. Procalcitonin has been used as amarker to distinguish etiologies, as bacterial infections tend toincrease serum procalcitonin levels.Objective To determine the sensitivity, specificity, positivepredictive value and negative predictive value of procalcitoninin community-acquired bacterial pneumonia.Method This cross-sectional study was conducted in thePediatric Health Department of Dr. M. Djamil Hospital, Padang.Subjects were selected by consecutive sampling. Procalcitoninmeasurements and PCR screening were performed on bloodspecimens from 32 pneumonia patients and compared.Results Of the 32 subjects, most were boys (56.25%), under 5years of age (99%), and had poor nutritional status (68.75%).Using a cut-off point of 0.25 ng/mL, procalcitonin level hada sensitivity of 92%, specificity 50%, positive predictive value 88%, and negative predictive value 60% for diagnosing bacterial pneumonia. Using a cut-off point of 0.5 ng/mL, procalcitonin level had a specificity of 46%, specificity 83%, positive predictive value 91%, and negative predictive value 25%.Conclusion A cut-off point of 0.25 ng/mL of procalcitonin level may be more useful to screen for bacterial pneumonia than a cutoff point of 0.5 ng / mL. However, if the 0.25 ng/mL cut-off point is used, careful monitoring will be required for negative results, as up to 40% may actually have bacterial pneumonia. [PaediatrIndones. 2015;55:65-9.].
Co-Authors A.A. Ketut Agung Cahyawan W Ade Asyari Afriwardi Afriwardi Aghnia Jolanda Putri Akmal M. Hanif Al Hafiz Almurdi Almurdi Alya Binti Azmi Amirah Zatil Izzah Andani E Putra Andani Eka Putra Angela Lovena Anggun Hatika Riska Arnelis Arnelis Asman Manaf Asterina Asterina Bakma, Isphandra Besri, Hanifa Zahra Bestari Jaka Budiman Desmawati Desmawati Desywar Desywar Desywar Desywar Desywar Desywar Desywar, Desywar Devi Gusmaiyanto Dia Rofinda, Zelly Dia Dian Eka Putri Dian Eka Putri, Dian Eka Dian Pertiwi Dian Pertiwi Dona Mirsa Putri Donaliazarti Donaliazarti Dwi Amelisa Edwina Dwi Yulia Dwitya Elvira, Dwitya Effy Huriyati Efiariza, Nurul Navela Ega Purnamasari Eka Musmita Sabebegen Eka Nofita Elisda Yusra Ellyza Nasrul Ellyza Nasrul Elmatris Sy Elvinawaty Elvinawaty Endang Primawaty Harahap Endrinaldi Eryati Darwin Eti Yerizel Ety Yerizel Eugeny Alia Fachzi Fitri Fadil Oenzil Fathiyyatul Khaira, Fathiyyatul Febria Prima Utari Finny Fitry Yani Fiona Septi Mulya Fitria, Syarifah Tridani Fitrina, Dewi Wahyu Hanifah Maani Hanny Hafiar Harahap, Endang Primawaty Hasmiwati Hendra Permana Herman, Deddy Husni Husni Husnil Kadri Ida Parwati Ike Sri Redjeki Ilhamifithri Ilhamifithri Ilmiawati, Ilmiawati Ima Septia Indah Fitriani Isphandra Bakma Jacky Munilson Jamsari Jamsari Kartika Aulia Sari Lestari, Rahmi Lillah Lillah Malinda Meinapuri Masrul Basyar Masrul Syafri Mefri Yanni Mega Redha Putri Mira Purwinanty Mohamad Reza Mulya, Fiona Septi Nanda Oktavia Narlis Narlis Netti Suharti Nirza Warto Novialdi . Nur Afrainin Syah Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nuzulia Irawati Oktavia, Nanda Prihandani, Tuty Prima O Damhuri Puja, Annisa Fitria Putri Yuriandini Yulsam Rahmadina, Rahmadina Rahmatini . Ramadhani, Jihan Regina Ivanovna Rendi Dwi Prasetyo Reni Lenggogeni Rikarni Rikarni Rike Puspasari Rismawati Yaswir Rizanda Machmud Rizqy Auliya Lubis Rossy Rosalinda Roza Kurniati Rudy Afriant Russilawati, Russilawati Sabebegen, Eka Musmita Saptino Miro Sari, Kartika Aulia Selfi Renita Rusjdi Siti Nurhajjah Sofitri Sofitri Suchi Ilmi Herman Sukri Rahman Syarifah Tridani Fitria Trisuliandre, Muhammad Rizki Tuty Prihandani Ulya Uti Fasrini Vanny Syafitri Vika Rahma Velina Yan Edward Yulia, Dwi Yulistini, Yulistini Yusrawati Yusrawati Yusri Dianne Jurnalis Yustini Alioes Zahira, Aisyah Dhia Zelly Dia Rofinda Zhuhra, Rahma Tsania