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Journal : Berkala Kedokteran

Anti Inflammatory Effect Of Toman Fish (Channa micropeltes) Extract In Wound Healing Process Maharani Laillyza Apriasari; Dewi Puspitasari; Amy Nindia Carabelly
Berkala Kedokteran Vol 14, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.431 KB) | DOI: 10.20527/jbk.v14i2.5335

Abstract

 Abstract: One phase of wound healing is the inflammatory phase. Haruan fish extract has shown to accelerate the healing process up because it has anti-inflammatory effects. Toman fish originates from the same genus as the Haruan fish, but its anti-inflammatory effect remains unknown. It was done to analyzed anti-inflammatory effects of Toman fish extract. This study was true experimental design with posttest-only control design. Twenty-seven male mice of Balb-C strain were divided into 3 groups. Incision wound of 1 cm was made along the back of the mice. Nine mice in each group were sacrificed on 3rd days, then histopathology examination was conducted with Haematoxylin eosin. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract, and also compared to the negative control group in PMN cell examination. There were significant differences between treatment group given Toman fish extract and positive control group given Haruan fish extract compared to negative controls on the number of macrophage cells. Toman fish extract could lower the number of PMN cells and was able to increase the number of macrophages on the 3rd days. Toman fish has anti-inflammatory effects on the wound healing process. Keywords: Anti-inflammatory effects, haruan fish extract, macrophages, PMN cells, toman fish extract
Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model Amy Nindia Carabelly; Beta Widya Oktiani; Nurashfia Nurashfia; Maharani Laillyza Apriasari; Dewi Puspitasari
Berkala Kedokteran Vol 19, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i1.15703

Abstract

Abstract: Patients with diabetes mellitus (DM) may experience vascular impairment, wounds that emerged from dental practice require special attention in people who suffer from DM. Toman fish has the potential as an alternative medicine to accelerate the healing process in normal and diabetic wound. Erythrocyte and hemoglobin are two components of blood profile which can be used as the parameter to identify the effect of material toxicity. This study aims to test the acute toxicity of Toman fish extract at 16 mL/Kg BW dosage on the number of erythrocyte and the level of hemoglobin in normal and diabetic Wistar rat model after 14 days treatment. This is a true experimental study with post-test only and control group design. Samples were comprised of 21 male Wistar rats allocated to three different groups; normal rats given Toman fish extract (A), diabetic rats given Toman fish extract (B), and diabetic rats given BR2 feed only (C). The results showed that in group A, the number of erythrocytes was 8.67x106/mm3 and the level of hemoglobin was 17.30 g/dL. In group B, the number of erythrocytes was 7.39x106/mm3 and the level of hemoglobin was 16.32 g/dL. In group C, the erythrocyte number was 4.88x106/ mm3 and the hemoglobin level was 11.54 g/dL. It can be concluded that Toman fish extract at the dosage of 16 mL/Kg BW after 14 days administration is not toxic which was indicated by erythrocyte number and hemoglobin level in the blood of normal and diabetic Wistar rats models.
Co-Authors Abdul Aziz Abdulloh, Isa Yuanata Agnes Widiyaningrum Agung Satria Wardhana Agung Satria Wardhana Akhmad Afroni Amina Khairima Amy Nindia Carabelly Andi Lukman Andi Sukainah Andi Yasir Amsal Andita Nataria Fitri Ganda Andreas Winardhi Andrew Tedjohartoko Anto Sukamto Arya Mahendra Sakti Aspriyanto, Didit Astuti Noviyani Aulia Rahma Annisa Beta Widya Oktiani Debby Saputera, Debby Debby Saputra Devi Puspita Handayani Devi Rosalinda Dewi Izzatus Tsamroh Dewi Nurdiana Dewi Rahayu Diana Wibowo Dwi Ariani Elda Rosemarwa Ellyza Herda Eriwati, Yosi Kusuma Erni Marlina Fajar Ramadhan Saputra Fitri Kabeakan Fitri Syahrina Gita Puspa Ningrum Grina Adila Milawati Hamdani, Riky Hartini Ramli Hasvina Sofrullah Hatta, Isnur Hendry H Husna Maulida I Wayan Arya Khrisnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Ilma Wulansari Imelia Ayu Soraya Inayah, Faidhul Indrayani Indri Indah Tari Intan Hanni Alfiany Irsyadi Yani Ismail Thamrin Jailudin Muhammad Akbar Karina Nandini Putri Khristianto Kurnia Fatwati Lahming Lahming Lahming Lu'luuzzahro, Alfina Maharani Laillyza Apriasari Mala Nurilmala Maman Diki Wahyudi Maria Tanumihardja, Maria Marsya Nur Shaqinah Mira Hadistiana Misbakhudin Muhammad Hasanu Reksi Muhammad Ilman Nur Sasongko Muhammad Nabiel Taqiyuddin Ham Muhammad Rizki Ridho Muhammad Shulthoni Muhammad Wiharto Mukhlis, Andi Muhammad Akram Nadya Fatimah Alzahrah Najwa Anandita Fatimah Nalim Nani Kurnia Naqiyya Najla Ibrahim Niketa Khairina Noor Malihah Noor Rizki Aulia Nor Diane Razibi Norma Nofiyanto Norman Nofianto Nur Rahma Nur Rahmah Nurah Tajjalia Nurashfia Nurashfia Nurmila Pindobilowo Pramudia Aqsa Azizi Priyawan Rachmadi Putra, Agus Dwi Rahmad Arifin Ramli, Hartini Ramos Somya Renie Kumala Dewi Reski Praja Putra Riezki Amalia Rahmah Riskiana Ristiana, Evi Rizky Noor Anisyah Rosdiana Ngintung Rully Angraeni Safitri Safitri Yosita Ratri Sarifah, Norlaila Sherli Diana Siti Zubaidah Subariyanto Suci Fikriyati Sukma Ayu Wardani Titin Martini Utami, Juliyatin Putri Wildan Mufti Wirdana Wulandari Wulandari Yazirin, Cepi Yulia Resti Yusrinie Wasiaturrahmah Zulkarnain Zulkarnain