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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Industri Pertanian VALENSI JURNAL KIMIA SAINS DAN APLIKASI Jurnal Natur Indonesia JURNAL SAINS DAN TEKNOLOGI INDONESIA Microbiology Indonesia BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Penelitian Tanaman Industri Buletin Penelitian Tanaman Rempah dan Obat AGRIVITA, Journal of Agricultural Science SEMIRATA 2015 Biology, Medicine, & Natural Product Chemistry Jurnal Sumberdaya Hayati Jurnal Kimia Mulawarman Indonesia Chimica Acta Science and Technology Indonesia Al-Kimia Indonesian Journal of Chemistry Biosaintifika: Journal of Biology & Biology Education Journal of Tropical Crop Science Jurnal Penelitian Tanaman Industri (Littri) Buletin Penelitian Tanaman Rempah dan Obat Jurnal Agrotropika Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Jurna Beta Kimia Jurnal Tumbuhan Obat Indonesia Borneo Journal of Pharmacy LIMNOTEK Journal Serambi Engineering (JSE) CEFARS : JURNAL AGRIBISNIS DAN PENGEMBANGAN WILAYAH Jurnal Agribisnis dan Pengembangan Wilayah
Dyah Iswantini
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Kampus IPB Darmaga, Bogor 16680
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Veterinary

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Active Compounds of Sembung Leaves (Blumea balsamifera DC) in Silico Screening as Antihypertensives Ahmad Sjahriza; Fyrda Shellia; Dyah Iswantini
JURNAL KIMIA MULAWARMAN Vol 21 No 1 (2023)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v21i1.1263

Abstract

Hypertension is a structural or functional change in the arteries or the organs it supplies caused by increased blood pressure. Angiotensin-converting enzyme (ACE) can increase blood pressure by converting inactive angiotensin I to active (angiotensin II). Captopril is a hypertension drug that can inhibit ACE activity. Sembung leaf (Blumea balsamifera DC) is a plant that can potentially have antihypertensive activity. This study aims to identify the interaction of active compounds in sembung leaves against ACE as antihypertensive drug candidates through an in silico test based on pharmacodynamic and pharmacokinetic parameters using two docking software, Autodock Vina and PyRx. The results showed that Luteolin was the best test ligand besides having lower ΔG and Ki than control ligands and higher Kd than control ligands. Luteolin was identified to interact with Zn and hydrogen bond interactions at the active site and met the criteria in Lipinski analysis, ADME, and toxicity, so this compound is relatively safe to be used as a drug candidate for the treatment of hypertension.
Konsentrasi Optimum dan Model Isotherm Bovine Serum Albumin (BSA) dalam Matriks Silika Gel dengan Pemanfaatan Silika yang bersumber dari Pasir Alam Naat, Johnson N.; Lawa, Yosep; Neolaka, Yantus A. B.; Haki, Horiana; Lestarani, Dewi; Sugiarti, Sri; Iswantini, Dyah
Jurnal Beta Kimia Vol 1 No 2 (2021): Volume 1, Nomor 2: November 2021
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jbk.v1i2.5584

Abstract

Penelitian ini dilakukan untuk mengetahui konsentrasi optimum dan model isotherm bovine serum albumin (BSA) dalam matriks silika gel dengan pemanfaatan silika yang bersumber dari pasir alam Takari. Penelitian ini dilakukan melalui tahapan preparasi sampel, ekstraksi silika (SiO2), penentuan konsentrasi optimum, dan model isotherm BSA pada matriks silika gel yang dianalisis menggunakan spektrofotometer UV-Vis. Penentuan konsentasi optimum BSA dalam matriks silika gel dibuat dengan variasi konsentrasi 10, 20, 30, 40, dan 50 mg/L pada pH dan waktu kontak optimum. Hasil penelitian menunjukkan bahwa konsentrasi optimum adsorpsi BSA pada konsentasi 40 mg/L dengan efisiensi adsorpsi sebesar 99,06%. Adsorpsi BSA mengikuti model isotherm Langmuir tipe 2 dengan nilai R2 = 0,9492 dan kapasitas adsorpsinya sebesar 9,5057 mg/g. Proses adsorpsi BSA oleh silika dalam matriks silika gel terjadi secara kimia dan monolayer.
Phytoestrogens Therapy for Osteoporosis Treatment Using Indonesian Medicinal Plants: A Brief Review Sianipar, Rut Novalia Rahmawati; Iswantini, Dyah; Charlena, Charlena; Wahyudi, Setyanto Tri; Prasetyo, Joni
Science and Technology Indonesia Vol. 9 No. 4 (2024): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.4.949-964

Abstract

A problematic bone remodeling cycle is known to produce more osteoclasts than osteoblasts, making bones more fragile and this condition shows osteoporosis. In this context, estrogen deficiency in the human body is associated with the regulation of osteoporosis. Therefore, this study aimed to investigate the knowledge about basic concepts of bone, osteoporosis, phytoestrogens, and Indonesian medicinal plants for osteoporosis treatment. Data were obtained from literature on various databases including Science Direct, Wiley Online Library, Scopus, Pubmed, and Google Scholar. Adequate therapy is needed to increase estrogen content and an effective approach is to consume medicinal plants that contain phytoestrogens, which have identical structure and activity to human estrogen (17β-estradiol). The results showed that there were observations comprising in vitro, in vivo, and in silico studies on 18 Indonesian medicinal plants as antiosteoporosis treatments. The Leguminosae or Fabaceae family, which has a significant amount of isoflavones (the primary group of phytoestrogens) was found to dominate as an antiosteoporosis agent. Therefore, the development of phytoestrogens therapy from Indonesian medicinal plants must be implemented for the future treatment of osteoporosis.
Exploring Indonesian Sponge-Associated Marine Aspergillus hortai: Characterization of Bioactive Compounds with Potential Anti-Escherichia coli Properties Fadillah, Wendi Nurul; Sukarno, Nampiah; Iswantini, Dyah; Rahminiwati, Min; Franco, Christopher MM; Zhang, Wei; Hanif, Novriyandi; Waite, Mashuri
HAYATI Journal of Biosciences Vol. 31 No. 4 (2024): July 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.4.712-724

Abstract

Sponge-associated marine fungi are potential source for secondary metabolite compounds. The aim of this research was to investigate sponge-associated marine fungus as secondary metabolite producers against Escherichia coli. The fungus was isolated from Indonesian marine sponge Stylissa sp. and identified as Aspergillus hortai through a combination of morphological and molecular characteristics of ITS DNA and β-tubulin genes. The fungus was tested against E. coli using fungal broth and mycelial extracts. The optimized condition was achieved by fungal broth grown in corn meal broth at 6-days of shaking incubation. Fungal extract was produced using three liters of filtered fungal broth and extracted in ethyl acetate. The antibiotic activity of the extract is vulnerable to 45°C heat and basic or acidic conditions. Therefore, the extraction was done at pH 7 with evaporation at 40°C. The extract shows 7 major bands on TLC with 1 band shows activity against E. coli (Rf 0.81) on bioautogram. The band was observed as a yellow color and turned black in short-wave UV and did not show any fluorescence in long-wave UV. This research shows that sponge-associated marine fungi obtained from Indonesia has the potential as anti E. coli worth to be explored for searching new antibiotics.
The Effects of Root Endophytic and Arbuscular Mycorrhizal Fungi on Growth and Curcumin Content of Temulawak (Curcuma xanthorrhiza) : The Effects of Root Endophytic and Arbuscular Mycorrhizal Fungi on Growth and Curcumin Content of Temulawak (Curcuma xanthorrhiza) Putra, Sukma Triperdana; Iswantini, Dyah; Widyastuti, Utut; Fadillah, Wendi Nurul; Sukarno, Nampiah
Jurnal Sumberdaya Hayati Vol. 8 No. 2 (2022)
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.8.2.49-56

Abstract

Temulawak (Curcuma xanthorrhiza) is known to be used as ingredient in Jamu and traditionally utilized to cure a range of illness. The global market demand for the rhizome of the temulawak affecting the urgency of sustainable rizhome production. The aim of this research was to analyze the effects of root endophytic and arbuscular mycorrhizal fungi on growth and rhizome curcumin content of the temulawak. There were five fungal inoculation treatments on C. xanthorrhiza seedling grown in sterilized and unsterilized growth media. They were root endophytic fungi A. niger (A), Glomus sp. (G), combination of A. niger and AMF Glomus sp. applied at the same time (GA) and at different time (G-A) and control. The experiment was conducted under greenhouse condition. The plant growth parameters, fungal colonization, and rhizomes curcumin content were measured. The result showed that there was a significant interaction between fungal inoculation and control treatments. In general, fungal inoculation on both sterilized and unsterilized growth media increased the plant growth and rhizomes curcumin content. On the sterilized growth media, C. xanthorrhiza inoculated by A. niger showed the best growth parameter. On the other hand, the best growth parameter on the unsterilized media was showed by C. xanthorrhiza inoculated by mixed fungal inoculums. The highest amount of curcumin content was showed by C. xanthorrhiza inoculated by Glomus sp. as a single inoculation.
Utilization of Used Cooking Oil from Street Vendor: Recycle and Anti-Oxidant Enrichment with Moringa oleifera leaves Ismet, Rhahmasari; Sianipar, Rut Novalia Rahmawati; Adelia, Nesha; Filaila, Euis; Jovianto, Andrian; Firdaus, Ridwan; Hanifah, Hanifah; Dwiastuti, Rahma; Aninda, Yunita; Alfiona, Della; Akmalina, Rifkah; Iswantini, Dyah; prasetyo, Joni
Molekul Vol 19 No 3 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.3.11023

Abstract

Used cooking oil (UCO) is abundant in Indonesia because of lifestyle of people. Especially UCO from street vendors had very low quality based on its Free Fatty Acid (FFA) content that reached 5.074%. When UCO was deposed into drainage, it would pollute the environment. Low grade UCO from street vendors contained Unsaturated-Fatty-Acid, Saturated-Fatty-Acid, and other hydrocarbons. Recycling UCO to replace edible oil considered more desirable rather than biodiesel since higher added value. FFA was the most undesired compound affecting cooking oil quality. FFA reducing with diluted 0.1 M NaOH 10% v/v could reduce FFA from 5.07% to 0.53%. Bleaching earth (BE) content mostly Si, Nb, Al, Ca and Na was safe to treat UCO for edible cooking oil. BE played cleaning UCO but absorbed the oil 17%. ANOVA analysis for BE and Moringa oleifera leaves (MOL) treatment fits with Reduced Quadratic model. Based on the ANOVA, the model showed that the decrease of FFA was determined significantly by BE amount and temperature with P-values less than 0.05. Optimization for BE treatment was done using Response Surface Method to find out the lowest FFA. And based on the simulation, it was obtained 0.2854% while the experimental results showed 0.2908%. Furthermore, BE combined with Moringa oleifera leaves (MOL) that known anti-oxidant source was used to treat UCO. UCO originally content stronger anti-oxidant activity rather fresh palm oil with IC50 62.12 and 83.03 mg/kg, respectively. Stronger anti-oxidant in UCO allegedly derived from fried foods. Treatment 10% BE and 5% MOL considered optimal for good appearance edible oil, little yellow greenish. Moreover, GC/MS analysis showed improvement active compounds in treated UCO with 5, 7.5 and 10 g MOL in 150 ml UCO with 24.36%, 30.32% and 37.76% active compounds, respectively. Moreover, anti-oxidant measured with IC50 the treated UCO were 43.18, 42.33 and 41.78 mg/kg, respectively. Increasing the number of MOL did not significantly increase the anti-oxidant activity. Anti-oxidant detected in treated UCO identified such as ethyl acridine, indolizine derivatives, cyclotrisiloxane-hexamethyl, benzimidazoles, and Fumaric acid. Based on the results, UCO recycling is applicable for a community, save expenses and strengthen food security and food sovereign. Further thought for its implementation is to design an integrated system from collecting UCO in a reservoir tank equipped with filter, recycling process and finally product tank at mini plant scale. Keywords: Anti-oxidant enrichment, bleaching earth, edible treated UCO, Moringa oleifera leaves (MOL) , UCO recycle
Nonenzymatic Sensor Based on Glassy Carbon Electrode Modified by Platinum Nanoparticles Decorated Reduced Graphene Oxide for Glucose Detection in Human Urine Nisa, Ulfiatun; Iswantini, Dyah; Ahmad, Shahrul Nizam; Mahat, Mohd Muzamir; Putra, Budi Riza; Saskito, Dinda Iryawati Bedy; Wahyuni, Wulan Tri
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40035

Abstract

This research aims to develop a sensitive and selective nonenzymatic electrochemical sensor for glucose detection using a glassy carbon electrode modified with platinum nanoparticles (PtNPs) decorated on reduced graphene oxide (RGO). The structural properties and surface morphology of PtNPs/RGO composite were characterized using Raman spectroscopy and scanning electron microscopy (SEM). In addition, cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques were employed to investigate glucose measurements in human urine samples. The developed sensor shows an increasing anodic peak of glucose with a linear response at a concentration range from 10 to 1000 µM, with a detection limit of 5 µM. The proposed sensor also demonstrated good reproducibility, indicated by the value of relative standard deviation (%RSD) of 3.9%, and maintained its current response over seven consecutive measurements. Moreover, the proposed sensor exhibited high selectivity for glucose detection against several potential interferences, such as potassium (K+), chloride (Cl−), magnesium (Mg2+), ascorbic acid, dopamine, and urea, with recovery values of 96-102%, which are acceptable within the analytical range. Furthermore, this proposed sensor successfully detected glucose in human urine samples, and their concentrations were not significantly different when measured with a commercial glucose sensor.
Development of a Low-Cost Reflectance Visible Spectrophotometer with Chemometrics for Curcuma xanthorrhiza Roxb. Quality Control Heryanto, Rudi; Iswantini, Dyah; Rohaeti, Eti; Rafi, Mohamad; Rahma, Novia; Hafshah, Nurul; Mardiana, Eni
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40351

Abstract

A simple, portable visible reflectance spectrophotometer was developed for classifying the quality of Curcuma xanthorrhiza Roxb. The device was assembled using consumer electronic components: an LED as the light source, a DVD optical layer as the diffraction grating, and a webcam as the detector, with web-based software (Spectral Workbench) as the signal processor. The spectrophotometer's performance was evaluated using standard Sudan III samples and powdered C. xanthorrhiza samples from two quality classes (A and B). Spectral data were analysed using principal component analysis (PCA) and partial least squares (PLS) regression.  PCA successfully grouped Sudan III samples by concentration and classified C. xanthorrhiza by curcuminoid content. A PLS regression model was developed for quantifying Sudan III, yielding R² values of 0.9909 for both calibration and cross-validation, with RMSEs of 0.3821% and 0.4152%, respectively. The results closely matched those from a commercial spectrophotometer. A PLS-discriminant analysis (PLS-DA) classification model for C. xanthorrhiza was also developed, achieving sensitivity and specificity values of 1. Additionally, semi-quantitative parameters such as decision limit (26.15% B), detection capability (41.06% B), and unreliability range (26.15–41.06% B) were calculated. The classification model showed strong sensitivity, specificity, and detection capabilities within acceptable limits. These findings suggest that this low-cost reflectance spectrophotometer, combined with chemometric methods, holds promise as a practical tool for the quality control of raw herbal materials.
Potential Utilization of Palm Oil Liquid Waste as Downstream Agroindustry Products with Proximate Test and β-Carotene Concentration Karnadi; Adiarso; Dyah Iswantini; Sri Mulijani
Jurnal Serambi Engineering Vol. 10 No. 1 (2025): Januari 2025
Publisher : Faculty of Engineering, Universitas Serambi Mekkah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Since 2006, Indonesia has led global production and export of palm-based edible oils. Government policies focused on advancing agriculture and agro-industries, particularly in downstream product development, provide opportunities to increase the economic value of these products, including palm oil products. Efforts to enhance downstream products include maximizing all palm oil potentials, including its waste. Global CPO production based on 2024 data is 79.6 million tons per year, with Indonesia contributing 59%. The potential waste is also very large, including the final waste which still contains around 20-25% oil and 3-5% phytonutrients. Proximate analysis and β-carotene content studies are used to evaluate the potential of CPO liquid waste for poultry feed. Proximate analysis results show low nutrient levels, including protein (<0.04%), carbohydrates (1.37%), total carbohydrates (<0.02%), total energy (5.20%), and crude fiber (<0.02%), making it unsuitable as a poultry feed substitute. However, based on β-carotene data, the waste can be used as an additive in poultry feed if stored for less than 28 days. The β-carotene degradation process follows zero-order reaction at heating and storage conditions (under room and dark storage).
MIKROENKAPSULASI EKSTRAK FORMULA PEGAGAN-KUMIS KUCING-SAMBILOTO SEBAGAI INHIBITOR Angiotensin I Converting Enzyme SECARA In Vitro Rani, Ismarani; Pradono, Dyah Iswantini; Darusman, Latifah K
CEFARS : JURNAL AGRIBISNIS DAN PENGEMBANGAN WILAYAH Vol. 3 No. 1 (2011): CEFARS : JURNAL AGRIBISNIS DAN PENGEMBANGAN WILAYAH
Publisher : Fakultas Pertanian Universitas Islam 45 (UNISMA) Bekasi

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Abstract

Chitosan microencapsulation contained extract formula pegagan-kumis kucingsambiloto was resulted from ionic gelation process. Chitosan microencapsulation wasresulted by cleaning bath type of ultrasonication and homogenization methods. Optimum condition obtained at 2% of chitosan concentration (w/v) and 50 mL (v/v) of extract formula. The yields of chitosan microparticles was 64.24%. Characterization by SEM at 5000× magnification showed that the particle size of chitosan microparticles was not uniform. Chitosan microparticles without and contained extract formula had diameters between 0.40 μm-8.5 μm and 1 μm-6 μm, respectively. Each chitosan microparticles contained extract formula and extract formula had the ACE inhibitory activity of 78.41 %, and 75.73 %, respectively, while the captopryl as an positive control had ACE inhibitory activity of 75.24 %. Wave number peaks of chitosan spectrum was different with microparticles spectrum by using of FTIR analysis. Chitosan microparticles-sodium tripolyphosphate (STP) contained extract formula had absorbance bands of 1652.32 cm-1 (C=O) and 1565.63 cm-1 (C=C, aromatic group of benzene). New absorbance bands also appeared at wave numbers of 1153.82 cm-1 and 1154.66 cm-1 which showed absorbance band of P=O group from STP compound.
Co-Authors , Triadiati . TRIVADILA Adayani Nurjayanti Adelia, Nesha Adi Riyadhi Adiarso Afifi, Muhammad Ridho Agus Kartono Agus Sudiman Tjokrowardojo, Agus Sudiman Ahmad Sjahriza Ahmad, Shahrul Nizam Ai Susanti Akhiruddin Maddu Akmalina, Rifkah Alfiona, Della Ali Aulia Ghozali Ali Aulia Ghozali Alif, Alfiah Amalyah Febryanti Amalyah Febryanti Ana Fitriyani Anas Miftah Fauzi Anggia Murni Aninda, Yunita Anja Meryandini Bagaskoro Tuwalaid Budi Riza Putra Charlena Deden Saprudin Dewi Sondari Diah Ratnadewi Dian Siska RF Dinda Iryawati Dita Ariyanti DJUMALI MANGUNWIDJAJA Djumali Mangunwidjaja Dwiastuti, Rahma Eka Mardiah ELIZABETH MARTATILOFA Eti Rohaeti Euis Filaila Evul Winoto Evul Winoto Fadillah, Wendi Nurul Firdaus, Ridwan Fitriani Indahsari Franco, Christopher MM Fretty Yurike Fyrda Shellia Ghozali, Ali Aulia Hafshah, Nurul Haki, Horiana hanifah hanifah Harry Noviardi Hasim - Hefni Effendi Henny Purwaningsih Ida Ayu Putu Sri Widnyani Irmanida Batubara Ismet, Rhahmasari Johnson N Naat Joni Prasetyo, Joni Jovianto, Andrian Karnadi Komar Sutriah Kurniawan, Yehezkiel Steven Latifah K Darusman latifah K Darusman Latifah K. Darusman LATIFAH KOSIM DARUSMAN LATIFAH KOSIM DARUSMAN Lawa, Yosep Lenni Fitri Lenni Fitri Lestarani, Dewi M. Rafi Mahat, Mohd Muzamir Mardiana, Eni Mashuri Waite Maulidiyah Utami Muammar Yulian Nampiah Sukarno Neolaka, Yantus A B Nisa, Ulfiatun NONI NIRWANA Noor Roufiq Ahmadi Novia Rahma NOVIK NOVIK Novik Nurhidayat Novik Nurhidayat Novik Nurhidayat Novik Nurhidayat Novik Nurhidayat Novik Nurhidayat Novik Nurhidayat Novriyandi Hanif Nurdiani Nurdiani Ono Suparno Pius P. KETAREN Purbowatiningrum Ria Sarjono Purwantiningsih Sugita Putra, Sukma Triperdana Rahminiwati, Min Rani, Ismarani RESSY RIANDCI RHOITO FROISTA SILITONGA Rosihan Rosman Rosihan Rosman Rudi Heryanto Rut Novalia Rahmawati Sianipar Sagala, Zuraida Sandra Arifin Aziz Selvitia Ulandari Setyanto Tri Wahyudi Sianipar, Rut Novalia Rahmawati Sri Mulijani Subaryanti Subaryanti Subaryanti Subaryanti Subaryanti Sulitijorini, Sulitijorini SUMINAR SETIATI ACHMADI Taopik Ridwan Tatik Khusniati TRESNAWATI PURWADARIA Tuti Hayati Ramdhani Umi Cahyaningsih Upik Kesumawati Hadi UTUT WIDYASTUTI Waite, Mashuri Wasmen Manalu Wei Zhang Wendi Nurul Fadillah Wiwin Winarsih Wulan Tri Wahyuni YANTYATI WIDYASTUTI Yohana C. Sulistyaningsih Yohana Caecilia Sulistyaningsih Yulia Yellita YULIN LESTARI Zulti, Fifia