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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences BIOTROPIA - The Southeast Asian Journal of Tropical Biology The Journal of Experimental Life Sciences (JELS) Journal of Indonesian Tourism and Development Studies Biotropika Jurnal Pembangunan dan Alam Lestari AGRIVITA, Journal of Agricultural Science Journal of Tropical Biodiversity and Biotechnology TREUBIA JSMARTech : Journal of Smart Bioprospecting and Technology Proceeding Biology Education Conference RISTEC : Research in Information Systems and Technology Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Nia Kurniawan
Brawijaya University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary

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Computational Design of a Truncated Javan Spitting Cobra (Naja sputatrix) Venom Cardiotoxin Analogue as a Promising Insulinotropic Agent Dinana, Ichda Arini; Widodo, Widodo; Kurniawan, Nia
Biotropika: Journal of Tropical Biology Vol. 11 No. 3 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.03.03

Abstract

Treatment options for diabetes may vary widely, however, around 50% of all diabetic patients do not reach the minimum glycemic target. Therefore, drugs that are able to lower glucose levels through unconventional targets are still needed for the treatment of type 2 diabetes. This study aimed to investigate the activity of cardiotoxins from Naja sputatrix towards Kv channels as potential targets for glucose level reduction. Molecular docking analysis was conducted using the ClusPro web server, and the resulting protein-ligand interactions were visualized using BioVia Discovery Studio and LigPlus v.4.5.3. The stability of the docking structures was further examined through molecular dynamics simulations. The CTX-1, CTX-3, CTX-4, CTX-5, and CTX-KJC3 sequences from N. sputatrix were aligned and modeled, focusing on the 62-81 amino acid residues. The CTX-3, CTX-4, and CTX-5 models demonstrated interactions with the binding site of the KcsA receptor. Additionally, substituting the Val73 residue in the CTX62-81 fragment with Lys73 resulted in reduced binding energy and mitigated the cytotoxic effects of CTX while maintaining its insulinotropic activity.
FURTHER STUDY ON TWO SPECIES OF LOACH FISHES (Cypriniformes: Nemacheilidae: Nemacheilus) BASED ON MORPHOLOGY AND MOLECULAR DATA Rahayu, Dwi Anggorowati; Kuntjoro, Sunu; Budijastuti, Widowati; Winarsih, Winarsih; Ambarwati, Reni; Nugroho, Endik Deni; Basith, Abdul; Kurniawan, Nia; Haryono, Haryono
BIOTROPIA Vol. 30 No. 3 (2023): BIOTROPIA Vol. 30 No. 3 December 2023
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2023.30.2.1942

Abstract

The identities of two local loaches, Nemacheilus chrysolaimos (Valenciennes, 1846) and N. fasciatus (Valenciennes, 1846) from six rivers, were obtained through a comprehensive examination of their morphology and molecular characteristics in Biltar Regency, East Java, Indonesia. Therefore, this study identified Nemacheilus spp. from Blitar based on morphology and partial sequence of COI. The meristic data obtained for N. chrysolaimos included DII. 7–8 (dorsal fin), AI. 3–5 (anal fin), PI. 9 (pectoral fin), VI. 6–7 (ventral fin), and C. 17 (caudal fin). On the other hand, N. fasciatus exhibited the following meristic data, namely D II 7–8 (dorsal fin), AI. 6 (anal fin), PI. 9–10 (pectoral fin), VI. 6–7 (ventral fin), and C. 17 (caudal fin). A significant difference was observed in the morphometric characteristics of N. fasciatus across various sampling sites, as determined by the Kruskal-Wallis Test. Furthermore, the nucleotide base composition sequences of Nemacheilus spp. consisted of Thiamine (T), Cytosine (C), Adenine (A), and Guanine (G) with a mean of 29.565%, 32.023%, 23.88%, and 16.244%. Maximum Likelihood (ML) and Minimum Evolution (ME) phylogenetic analysis was also conducted using the Kimura 2 Parameter model to establish two major clades on Nemacheilus spp. and one out-group significantly different from the Nemacheilus spp. The results showed that these major clades exhibited a close relationship at 100% bootstrap support and were grouped under the genus Nemacheilus. The study on Nemacheilus spp. from the Blitar locality differentiated COI sequences between N. fasciatus and N. chrysolaimos. Additionally, N. chrysolaimos, as inferred from reference sequences, was identified as the ancestral species to N. chrysolaimos MZB 26540 and MZB 26539. ABGD analyses, employing a prior maximal distance of 0.025, also indicated the separation of these species into distinct partitions. The integration of morphology and genetic data for Nemacheilus spp. should provide valuable insights for future genetic population studies and conservation initiatives.
The Potential of Butterflies in Tourism Diversification Product: Case Study at Coban Rais Waterfall, Batu, East Java Kurnianto, Agung Sih; Wafa, Imti Yazil; Alifianto, Faldy; Kurniawan, Nia
Journal of Indonesian Tourism and Development Studies Vol. 4 No. 3 (2016)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitode.2016.004.03.04

Abstract

The diversity of Butterfly in Coban Rais is one of the potential resources for tourism product diversification and development. The aims of this paper are to determine the magnitude of the butterfly potential as a form of tourism products diversification and development in a sustainable tourism industry. There are 107 species of butterfly that come from six families was found in Coban Rais waterfall. Some species have a very large population in a specified activity, such as mud-puddling and mating. Udara akasa has the highest potential to make colony and Cyrestis lutea is a species that have the potential as a major attraction in the mud-puddling activity. Sector 3, the location of riparian with sand and gravel, is the site of the largest butterfly visits. The dry season is the highlight of a butterfly visit in Coban Rais. Development of human resources is important for the tourism products diversification in Coban Rais, i.e. the butterflies observer and visitors services. We recommend establishing a breeding center for butterfly population recovery and educational goals for visitors.Keywords: butterflies, Coban Rais, product diversification.
Understanding Bird Preference on Agroforestry System: Is There a Potential Case for Birdwatching Development? Kurnianto, Agung Sih; Batoro, Jati; Kurniawan, Nia
Journal of Indonesian Tourism and Development Studies Vol. 5 No. 2 (2017)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitode.2017.005.02.03

Abstract

The main objective of this study is to understand the bird preference on the different types of agroforestry management and the implication on the development of birdwatching as a potential ecotourism. The study was conducted at the agroforestry area of Gubugklakah Village, Malang Regency, East Java Province, Indonesia, from May to November 2016. Five observation sites were chosen: 1) agroforestry developed by ethno-conserving system; 2) agroforestry close to the national park; 3) agroforestry; 4) conventional agriculture area; and 5) houses area. Point Count was applied in this study by determining 5 sampling sites that separated 100-150 m. Survey was conducted once a week and observed every 15 minutes from 6.00 to 9.00 am. The species of bird that observed and heard were noted, identified and result of the field identification was stored in field book. The result shows that the highest Importance Value Index (IVI) was presented by Cave swiftlet and some species that specialized in farmland. Agroforestry area was showing more potential as the birdwatching spot compared to conventional agriculture area and houses area. In addition, agroforestry area showing a high Value of Interest (VOI) that represented a nativity on the birds settler and made it to be the suitable area for birdwatching activities.Keywords: agroforestry, birdwatching, management, preference.
Exploration of Herpetofauna Habitat as Tourism Attraction: Ecology, Preferences, and Potentials Kurniawan, Nia; Ananda, Alif Aulia; Kamila, Fatiha; Ardiantoro, Ari; Bagaskara, Satria Wira; Kurnianto, Agung Sih
Journal of Indonesian Tourism and Development Studies Vol. 6 No. 1 (2018)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitode.2018.006.01.01

Abstract

Herpetofauna (Class: Reptilia, Amphibia) has potential value as tourist attraction and its sustainability could be preserved by ecotourism program. We propose a new fauna-based tourism attraction by conducting herpetofauna survey in a few locations inside Sukamade, Meru Betiri National Park (MBNP), and using their habitat as spots for ecotourism potential sites. Visual Encounter Survey method was conducted in 6 locations (200 m transect pathway). We found 166 individuals, belonging to 32 species in 15 families. Leptobrachium hasselti has the biggest Important Value Index (16.55%), making this species potentially become one of the potential herpetofauna as a tourist attraction. Chelonia mydas, an endangered species, is one of the interesting species to be observed in Sukamade.This species is full migrant and does long migration in its feeding ground in Borneo, Australia, and Pacific, then back to Sukamade to lay eggs. Sumbersari and Glintungan forest became a habitat for amphibians that need clean water, such as L. Hasselti and Leptophryne borbonica, and potentially become the location of herpetofauna observation. Occidozyga lima, Fejervarya limnocharis, and Limnonectes microdiscus were found in four survey sites (Sumber Langsep, Glintungan, Estuary, and Jungle Track). Keywords: Herpetofauna, Sukamade, Tourism  
Community Structure of Coral Reef at Pasir Putih Beach In Situbondo East Java, Indonesia Khusnah, Asmaul; Retnaningdyah, Catur; Kurniawan, Nia
Journal of Indonesian Tourism and Development Studies Vol. 7 No. 1 (2019)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitode.2019.07.01.05

Abstract

Pasir putih beach of Situbondo has coral reefs as the potential of underwater beauty. The purpose of this study is to evaluate the structure of coral reef community in Pasir putih beach. This study was taken place at four sites namely; Batu lawang, Teluk pelita, Karang mayit, and Karang pon-pon. Method used was Ex Post Facto using belt transect sampling technique with size 1x1m and length 30m and 11 times repetition. The observed physic-chemistry parameters are temperature, salinity, conductivity, pH, turbidity, DO, nitrate, and orthophosphate. The results showed that the four sites almost have the same conditions. Batu Lawang location is dominated by Porites mayeri (Poritidae) which is vulnerable to severe conditions. The second location (Teluk pelita) has a high index value of diversity. The third location (Karang Mayit) is dominated by Poritidae family. The fourth location (Karang Pon-pon) is dominated by the Acroporidae family which is a clear water indicator and has a fast growth rate. However, in the fourth location, the sedimentation is quite high compared to other sites. The value of abiotic factor in the Pasir putih beaches of Situbondo has a relatively normal value, the pH of value from 7.55 to 7.56, temperature 29.99°C to 30.4°C, salinity 32.33 to 32.66 ‰, conductivity 37.8 to 40.2 µS.cm-1, DO 7.73 to 10 ppm, turbidity 0.57-1.56 NTU, nitrate from 0.32-0.1 mg.L-1 and orthophosphate 0.02 to 0.54 mg.L-1, the water in Pasir Putih Situbondo was still suitable for support the growth of coral reefs. Keywords: Coral Reefs, Community Structures, Pasir putih Beach.
Evaluation of Water Quality Based on Macrozoobenthos as a Bioindicator in the Four Springs of Wana Wiyata Widya Karya Tourism Area, Cowek Village, Purwodadi District, Pasuruan Regency Darojat, Mas Khoirud; Kurniawan, Nia; Retnaningdyah, Catur
Journal of Indonesian Tourism and Development Studies Vol. 8 No. 1 (2020)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitode.2020.008.01.01

Abstract

The purpose of this study was to determine water quality based on the physicochemical of water and biotic indices from macrozoobenthos in four springs in the Wana Wiyata Widya Karya tourism area, Cowek Village, Pasuruan. Identification and calculation of macrozoobenthos were used to determine the macrozoobenthos community structure and some biotic indices (ASPT, FBI, EPT indices, and water quality index) as bioindicators of water quality. Water quality grouping based on physicochemical of water and biotic indices was analyzed using Cluster Analysis, and Biplot. The results showed that several physical-chemical parameters of water observed had values exceeding water quality standards for drinking water raw materials (BOD, DO, temperature and pH), based on Government Regulations No. 82 of 2001. Based on the NSF-Water Quality Index, water quality in four springs in the Wana Wiyata Widya Karya tourism area is in good category (72.77-88.37), which indicates that the waters are not contaminated with organic matter. Water quality based on the macrozoobenthos diversity index value indicates the category of moderate to mild contamination (H value 1.40-1.97). The Bray-Curtis similarity index resulted in a high level of similarity between of Alang-Alang and Sumber Bendo in 86.49%. Keywords: biotic index, macrozoobenthos, springs, Wana Wiyata Widya Karya, water quality
Phylogenetic Patterns of Genus Megophrys (Anura: Megophryidae) from Java and Sumatra Kurniawan, Nia; Affandi, Aminuddin; Wardani, Erintha Eka; Chomsy, Indah Nur; Firdaus, Anggun Sausan; Kurnianto, Agung Sih
The Journal of Experimental Life Science Vol. 7 No. 2 (2017)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1128.003 KB) | DOI: 10.21776/ub.jels.2017.007.02.03

Abstract

The emergence of Java and Sumatra islands at the end of Miocene, has impact to the diversity of fauna that living in the islands. Amphibia, as one of a genetic information series, can be used as a good phylogenetic comparison. Genus Megophrys (Anura: Megophryidae), is a member of amphibians that live isolated at an altitude of 1000 ASL (Above Sea Level) or more. The purpose of this research is to analyze the phylogenetic patterns of genus Megophrys in Java and Sumatra based on the analysis of 16s rRNA gene. We also analyzed the zoogeography to understand the history of relationship and the establishment of these islands. We took samples on 12 localities: 10 areas of Sumatra and 2 areas of Java. We used Qiamp Blood and Tissue Kit to extract the DNA from tissues. Qualitative analysis of DNA was done by running electrophoresis on 1% agarose gel. Qualitative analysis of DNA was done by running electrophoresis on 1% agarose gel. Results show that Clade A has 2 subclasses: I and II. Subclade I consists of Sumatran specimens, whereas subclade II consists of Javanese specimens. Subclaude I and II have paraphyletic connections. Clade B classified as politomy clade consists of Megophrys sp. from West Pasaman, Megophrys sp. from West Sumatra and Megophrys sp. from Pasawaran, Lampung. The result shows that Megophrys sp. of subclade I (clade A) and clade B, belongs to the same group, both of them were originated from Sumatra. Megophrys sp. subclade I (clade A) originated from Tanggamus (Lampung) and West Lampung (Lampung) separated with 2 species of Megophrys sp. of clade B originated from Pasawaran (Lampung).Keywords: 16s rRNA, Java, Megohprys, Sumatra, zoogeography
Phylogenetics and Biogeography of Cobra (Squamata: Naja) in Java, Sumatra, and Other Asian Region Kurniawan, Nia; Putri, Mulyadiane M.; Kadafi, Ahmad M.; Chrestella, Dea J.; Fauzi, Muhammad A.; Kurnianto, Agung S.
The Journal of Experimental Life Science Vol. 7 No. 2 (2017)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1441.886 KB) | DOI: 10.21776/ub.jels.2017.007.02.06

Abstract

The separation of Sumatra and Java occurred at the end of the Miocene (10 mya) to the end of Pliocene (1.8 mya). The existence of ecological variations and geographic barriers inhibits gene flow through the isolation of adaptation, geography, reproduction, inbreeding, and leading to population segregation. Cobra (genus Naja) distribution became greatly influenced by the geologic condition and sea level. This study was conducted by phylogenetic analysis towards the 16S rRNA gene. Survey was done with Visual Encounter Survey (VES) method on 6 localities. There were 3 locations in Sumatra Island and the others in Java Island. Sample from other Asian region was obtained from Genbank, which are 11 individuals from China, Thailand, and Nepal. DNA extraction was done according to the QIAmp® DNA Mini Kit standard protocol. The forward and reverse 16S sequences are combined with the SequencherTM version 4.1.4 program, then in BLAST (Blast Local Alignment Search Tool) at www.ncbi.nlm.nih.gov.  Phylogenetic analyzes of clade A (MP = 60, ML = 54, BI = 88) indicate the presence of division into two monophyletic subclade (AI and AII). Subclade AI consists of groups of Cobra  from Sunda (Thailand, Sumatra and Java). Subclade AII is a group of species N. kaouthia originating from Chumpon Province, Southern Thailand with (MP = 96, ML = 95, BI = 100). Clade B is divided into two subclasses (BI and BII). The result is supported by bootstrap value MP = 93, ML = 99, BI = 100. N. atra of Fujian Province is a sister lineage of the same species from Jiangxi Province (MP = 86, ML = 86, BI = 100).Keywords: Asian, 16s rRNA, Java, Cobra, Sumatra.
Microsatellite Marker for Cross-Species Amplification: Study Case for Indonesian Sundaland Python (Serpentes: Pythonidae) Maulidi, Andri; Fatchiyah, Fatchiyah; Hamidy, Amir; Kurniawan, Nia
The Journal of Experimental Life Science Vol. 8 No. 1 (2018)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1180.778 KB) | DOI: 10.21776/ub.jels.2018.008.01.10

Abstract

The python of Indonesian Sundaland has been traded for its distinct skin colour and patterns. The need for rapid method in cross-species amplification for Indonesian Sundaland python is useful to contribute in management of sustainability harvesting system. In this research, we screened 10 microsatellite primers which are previously used for Australian, New Guinean, Chinese and Burmese pythons and 7 potentially amplifiable primers for African and Asian reptiles. Python breitensteini showed a greater number of alleles (2-8 alleles) than Python bivittatus (1-3 alleles) and Python brongersmai (1-2 alleles). The observed and expected heterozygosity for all species were ranged from 0 to 1.00 and 0 to 0.79, respectively. According to the high cross-species amplification rates, 15 out of 17 primers were useful in assessing the genetic diversity and conservation genetic of Indonesian Sundaland python. Among the 15 primers, MS3 generated the highest number of allele for P. breitensteini (8 alleles), P. bivittatus (3 alleles), and P. brongersmai (2 alleles). We proposed MS3 locus as a suitable marker for Indonesian Sundaland python.Keywords: microsatellite, Python, Sundaland.
Co-Authors Abdul Basith Abdullah Abdullah Achmad Dadang Burhanuddin Agung Pramana W.M Agung Pramana W.M Agung Pramana Warih Marhendra, Agung Pramana Warih Agung S. Kurnianto Agung Sih Kurnianto Agung Sih Kurnianto Agung Sih Kurnianto Agus Nurrofik Agus Suryanto Aguung Sih Kurnianto Ahmad Muammar Kadafi Alvionita, Cicin Vinolia Amin Setyo Leksono Aminuddin Affandi AMIR HAMIDY Ananda, Alif Aulia Andri Maulidi Andri Maulidi Andyni, Regina Shania Anggun Sausan Firdaus Aninnas, Afina Ardiansyah, Franky Ardiantoro, Ari Ardyah Ramadhina Irsanti Putri Arief Sugiharto Arifianto, Adityas Asmaul Khusnah Asmaul Khusnah Assiddiqy, Miftah Farid Azrianingzih, Rodiyati Azrianingzih, Rodliyati Badiul Ulum Badiul Ulum Bagaskara, Satria Wira Bagus Priambodo Bagyo Yanuwiadi Bayu Hendra Prakosa Catur Retnaningdyah Chomsy, Indah Nur Chrestella, Dea J. Darojat, Annisa Zakiyah Darojat, Mas Khoirud Dinana, Ichda Arini Djong Hon Tjong Dwi Anggorowati Rahayu Eldi Mulyana, Eldi Endik Deni Nugroho Estri Laras Arumingtyas Fahmi, Muhamad Faldy Alifianto Faldy Alifianto fatchiyah . Fauzi, Muhammad A. Fauzi, Muhammad Alif Firdaus, Anggun Sausan Firmansyah, Richo Fitra Arya Dwi Nugraha Fitra Arya Dwi Nugraha Franky Ardiansyah Gigih Setia Wibawa Haryanti Haryanti Haryono Haryono Herlin Aprilia Kartini Herlin Aprilia Kartini Hermanto, Feri Eko Imti Yazil Wafa Jati Batoro Kadafi, Ahmad M. Kamila, Fatiha Karina hanum wardany Karina hanum wardany Karuniawan Puji Wicaksono Kholilah, Tsaniyah Nur Kurnianingsih, Nia Kurnianto, Aguung Sih Lekatompessy, Vanela Chatrin Lingga Nugraha Liu, Fu-Guo Robert Luchman Hakim Lutfita Fitriana Lutviyana Rahman Lutviyana Rahman Maharani, Tri Mahmudul Hasan, Mahmudul Maisuroh, Dalilatul Masayuki Sumida, Masayuki Mufti, Elsa Muhammad Fathoni, Muhammad Mumpuni Mumpuni Narwasthu, Sekararum Nashi Widodo Nasirudin, Mohamad Nobukazu Nakagoshi Nopharipaldi Rohman, Slamet Nugraha, Yopi Nugroho, Agung Nurrofik, Agus Prabasari, Kartika Pramudya, Muhammad Alif Imam Putri Ramadhani, Putri Putri, Mulyadiane M. Putri, Nenis Try Melani Putri, Siti Aqila Kharisma Qothrun Izza Qothrun Izza Ramadani, Shima Reni Ambarwati Rijalullah, Muhammad Asyraf Rikardo, Novy Kurnia Riyanto, Awal Robiatul Adawiyah Rodiyati Azrianingsih Rosyada, Nabila Nur Rosyadah, Nuraini Rudi Candra Aditama Rudi Candra Aditama Septiadi, Luhur Shahroni, Abdul Mutholib Smith, Eric Nelson SRI RAHAYU Sugiharto, Arief Suharjono, Suharjono Sunu Kuntjoro Suparno, Kelik Supriyatna, Asep Takeshi Igawa, Takeshi Tesri Maideliza Tetep Tri Maharani Triani Widyanti, Triani Vendy Adrinanda Vendy Adrinanda Wafa, Imti Yazil Wardani, Erintha Eka Wibi Riawan Widodo Widodo WIDOWATI BUDIJASTUTI Widyananda, Muhammad Hermawan Winarsih Winarsih Zain, Dhiyaa Syahlaa Bianca Febrinnisa