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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Natural Science: Journal of Science and Technology e-Journal Pustaka Kesehatan Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Universa Medicina Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Nursing Care and Health Technology Journal (NCHAT) Khazanah: Jurnal Mahasiswa Malacca Pharmaceutics Indonesian Journal of Pharmacology and Therapy
Triana Hertiani
Faculty Of Pharmacy, Universitas Gadjah Mada
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Journal : INDONESIAN JOURNAL OF PHARMACY

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Protein kinase inhibitors from Indonesian Sponge Axynissa sp. Triana Hertiani; Ru Angelie Edrada-Ebel; Michael Kubbutat; rob W.M. van Soest; peter Proksch
Indonesian Journal of Pharmacy Vol 19 No 2, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.985 KB) | DOI: 10.14499/indonesianjpharm0iss0pp78-85

Abstract

A research about inhibitory activity on various cancer related protein kinases of several marine sponges collected in Indonesia was performed. This study aims were to isolate and to identify structures of biologically active sponge metabolites.A combination of a chemically-and biologically driven approach for drug discovery was employed. Sponge extracts were tested by protein kinase inhibitory assay by in vitro method in parallel to the usage of TLC, and HPLC coupled to UV spectrophotometry and mass spectrometry to isolate the chemically most interesting substances. Structure identification of active compounds was performed by using NMR spectroscopy and massspectrometry methods.This study showed that only Axynissa sp. fractions were found active in protein kinase inhibitory assay. Two bisabolene type sesquiterpenoids, (+)- curcuphenol (1) and (+)-curcudiol (2) were identified as active compounds from the sponge. Compound 1 showed SRC protein kinase inhibition with an IC50value of 7.8 μg/mL while 2 inhibited FAK with an IC50 value of 9.2 μg/mL.Key words: protein kinase inhibitor, Axynissa sp.
TOXICITY OF ETHANOLIC EXTRACT OF FRUIT, SEED AND LEAVES OF MAKUTADEWA (Phaleria macrocarpa (Scheff.) Boerl.) TO Artemia salina Leach AND THIN LAYER CHROMATOGRAM PROFILE OF ACTIVE EXTRACT Indah Purwantini; Erna Prawita Setyowati; Triana Hertiani
Indonesian Journal of Pharmacy Vol 13 No 2, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.799 KB) | DOI: 10.14499/indonesianjpharm0iss0pp101-106

Abstract

A research has been done to determine the toxicity of ethanolic extract of fruit, seed and leaves of makutadewa (Phaleria macrocarpa (Scheff) Boerl.) using Brine Shrimp Lethality Test method. Extract were made by maceration of the materials for 24 hours. The bioassay has been done using 48 hour old Artemia saline Leach. The effect of ethanolic extract was identified by determining and analysing the shrimp death percentage and LC50 of each extract using probit analysis.The result showed that these ethanolic extract were toxic to the shrimp. The ethanolic extract of seed was the most active with the LC50 of 1.60 x 102 g/ml, whereas that of the fruit has the LC50 of 30.42 g/ml. The thin layer chromatogram profile of the active extract suggested that the extract contains alkaloids.Key words : toxicity, makutadewa, brine shrimp lethality test
Effect of Indonesian medicinal plants essential oils on Streptococcus mutansbiofilm Triana Hertiani; Sylvia Utami Tanjung Pratiwi; Irami Duma Kencana Irianto; Dian Adityaningrum; Budi Pranoto
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.812 KB) | DOI: 10.14499/indonesianjpharm0iss0pp174-181

Abstract

Essential  oil’s  component  such  as  menthol  and  eucalyptol  were  already used as dental plaque inhibitors. In searching of potential dental plaque inhibitor from natural products, a study to explore the potency of essential oils extracted from  several  Indonesian  medicinal  plants  against  planktonic  growth  and  biofilm adherence  of  S.  mutans was  performed.  A  total  of  14  essential  oils  from  some selected Indonesian medicinal plants were extractedby steam-hydro distillation. Antibacterial assay was performed against S. mutansby micro dilution technique on  nutrient  broth  media.  Biofilm  formation  inhibition  assay  was  conducted  on  a flexible  U-bottom  96-wells  PVC  micro  plate  by  using BHI  enriched  with  sucrose 2%  at  36.6  °C  for  18-24  h.  After  staining  with  1%  crystal  violet,  the  optical density  was  read  at  595  nm.  A  mouthwash  commercial  product  containing essential  oil  component  was  used  as  a  positive  control.  Result  showed  that  the essential oils of  C. sintoc exhibited the highest biofilm formation inhibition (IC50 =  0.005%),  and  Z.  officinale showed  the  highest  biofilm  degradation  with  EC50 value  of  0.013%.  Both  were  active  against  bacterial planktonic  growth  but  C. sintocshowed lower MIC90 value (0.6%) in comparison to Z. officinale(0.06%). Meantime,  C.  citratus was  showed  promising  antibacterial  and  antibiofilmactivities with MIC90 value of 0.06%, MBC 0.6%, IC50 0.008% and EC50 0.026%. It is concluded that the essential oils of C. citratus, Z. officinaleand C. sintocare potential to be developed as dental plaque inhibitors.Key words: essential oils, antibacterial, biofilm, Streptococcus mutans
Phytochemical compounds and the effect of ‘bangunbangun’ leaves (Coleus amboinicus, L.) water extract on phagocytosis activity of neutrophil cell rat (Rattus norvegicus) Christin Marganingsih Santosa; Triana Hertiani
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.502 KB) | DOI: 10.14499/indonesianjpharm0iss0pp141-148

Abstract

Traditional medicine has been recognized and widely used in Indonesia for healthy care or alternative medication in certain diseases. However, without scientific evidence, traditional medicine of empirical evidence cannot be used for modern health medication. This research was designed to find out the mains compound despite of Bangun-bangun aqueous extract from Kaliurang district using phytochemistry analysis such as Thin Layer Chromatography method and determine the effect on neutrophil cell activities by observing their phagocytosis. The result showed that the main compounds of Bangun-bangun leaves from Kaliurang district are polyphenol, saponin, flavonol glycoside and essential oil. Administration of the extract with the doses of Bangun-bangun leaves treatment 19,0 g/kg bw/oral/day (group A) and 31,5 g/kg bw/oral/day (group B) increased neutrophil cell phagocytosis up to 50% and 60 %, respectively, compared to those of controls which is 10% during 30 days treatment. Neutrophil cell phagocytosis in group B and C capability increase up to 80% (p
In Vitro Antiplasmodial Activity and Cytotoxicity of Active Subfractions of Harmsiopanax aculeatus Leaves Rachel Turalely; Mahardika Agus Wijayanti; Triana Hertiani; Musthofa Mustofa
Indonesian Journal of Pharmacy Vol 31 No 1, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp51

Abstract

Harmsiopanax aculeatus leaves, a medicinal plant with locally named kapur, have been used traditionally to treat malaria in Maluku, Indonesia. However, the scientific information of this plant is still limited. In our previous study, the methanol extract of this plant leaves have been proven to possess in vitro antiplasmodial activity. This study was conducted to evaluate in vitro antiplasmodial activity and cytotoxicity of  subfractions of the plant leaves. Fractionation was performed using a column chromatography with Sephadex LH-20 as the  stationary phase and methanol as the mobile phase. The subfractions obtained were then tested for in vitro antiplasmodial activity on a chloroquine-resistant FCR3 strain of Plasmodium falciparum using a visual method. Cytotoxicity was evaluated by using MTT assay. The in vitro antiplasmodial activity and cytotoxicity were expressed as IC50, calculated using probit analysis with SPSS 16 for windows. The results showed that the four subfractions tested have a high antiplasmodial activity with IC50 values of 0.09; 0.18; 0.01; and 0.77 µg.mL-1, respectively. In addition, these subfractions had IC50 values of >400 µg.mL-1 against Vero cells indicating that they were non-toxic. In conclusion, the subfractions of H. aculeatus leaves are very active and selective against P. falciparum. Further study will be conducted to isolate the active compounds.
Chemical investigation on Pseudoceratina purpurea collected from Banyuwangi Indonesia Triana Hertiani; RuAngelie Edrada; Rob W.M. Van Soest; Werner E.G. Muller; Sudarsono .; Peter Proksch
Indonesian Journal of Pharmacy Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.691 KB) | DOI: 10.14499/indonesianjpharm0iss0pp17-26

Abstract

Chemical investigation on marine sponge Pseudoceratina purpurea collected from Banyuwangi, Indonesia has been performed. This study was aimed to isolate and to identify structures of the sponge secondary metabolites as well as to test their cytotoxicity activity on mouse lymphoma cell line L5178Y.Isolation procedure was performed by using different chromatography techniques. NMR spectroscopy and mass spectrometry methods were used to identify the compounds chemical structures. Cytotoxicity of the isolates was tested on mouse lymphoma cell line L5178Y by using the microculture tetrazolium (MTT) assay.This study yielded five known tyrosine-derived alkaloids, two of which, aplysamine-2 (1) and aeroplysinin-1 (2) showed growth inhibition of mouse lymphoma cell line L5178Y with IC50 value of 1.7 mg/mL and 0.57 mg/mL, respectively.Key words: Pseudoceratina purpurea, sponge, alkaloids.
Co-Authors ., Sudarsono ACHMAD FUDHOLI Afandi, Karima Agustina, Ikra Agustinus Yuswanto Ahmad Marzuki Ainaini, Rizkia Aini Febriana Aini Febriana  Akhmad Khumaidi Ali Djamhuri Amalia, Latifa Ardani, Marisya Atikana, Akhirta Bawon Triatmoko Bayu Irawan, Muhamad Budi Pranoto Christin Marganingsih Santosa Dellyna Feronica Manik Dewi Setyaningsih Dian Adityaningrum Dwi Salim, Rozin EDIATI SASMITO Ediati Sasmito Edrada, Ru Angelie Eka Prasasti Nur Rachmani Elza Fadia Irzani Endang Setyowati Erma Yunita Erna Prawita Setyowati Erna Prawita Setyowati Fadilah Qonitah FERRY RAHMA PUSPITA Fitri Apriliany, Fitri Fransiska Leviana Galih Pratiwi Galih Pratiwi, Galih Gemini Alam Gemini Alam Hady Anshory Hady Anshory Hady Anshory Hamzah, Hasyrul Hanif Nasiatul Baroroh Harjanti, Kestri Indah Purwantini Irami Duma Kencana Irianto Iramie Duma Kencana Irianto Irawan, Muhamad Bayu Kartika, Senda Kestri Harjanti Khafi, Muhammad Khairan Khairan Kharismatul Khasanah Lay, Caterina Siskadewi LINDA SUKMARINI LISA SOEGIANTO Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Marchaban Marchaban Marchaban Marchaban, Marchaban Maria Ulfah Maulidia, Faiqoh Nur Michael Kubbutat Mistriyani, Mistriyani Mufrod Mufrod mufrod mufrod Muller, Werner E.G. Musthofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Narastika, Longina Ni Luh Putu Vidya Paramita Novi Febrianti NURI IRIYANI Nurul Jannah Oktavia Tri Wahyuni Pamungkas, Aryaningtyas Widya peter Proksch Peter Proksch Peter Proksch, Peter Pratama, Nofran Putra Pratiwi, Agrita Eka Pratiwi, Sekar Ayu Pratiwi, Sylvia Prayoga, Muhammad Bagas Proksch, Peter Puji Astuti Puji Astuti Purnomo, Kurnia Rahayu PUSPITA LISDIYANTI Puspita, Nanda Ayu Putri Indah Sayakti Putri, Faradhyta Maharani Rachel Turalely Rachel Turalely Rachel Turalely Rachel Turalely Rahmayani, Almira Rasydi, Ahmad Retno Murwanti Rica Rica Rica Rica, Rica Rima Munawaroh Rinaldi Idroes Rizkia Ainaini rob W.M. van Soest Rob W.M. Van Soest, Rob W.M. ROCHMAT MUDJAHID Rodiata, Tsania Andaya Ronny Martien Ru Angelie Edrada-Ebel RuAngelie Edrada RuAngelie Edrada, RuAngelie Rumondang, Amanda Sanan, Antonius Oenunu Sari R Sari R, Sari Sasmito, Ediati SEPTI WULANDARI Setiawan, Vania SHANTI RATNAKOMALA Silvia Utami Tanjung Pratiwi SINTAYU PUTRI WANDAN SARI Siswadi Siswadi Siswandi Siswandi, Siswandi Sobri Iskandar Sofia Mubarika Haryana Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sudarsono . SUDIBYO MARTONO Sukarti Moeljopawiro Sumarni Sumarni Sumarni Sumarni Suryawati Suryawati SUWIJIYO PRAMONO Syamsu Nur, Syamsu Sylvia Pratiwi Sylvia Utami Tanjung Pratiwi Sylvia Utami Tunjung Pratiwi Tamhid, Hady Anshory Tantri Liris Nareswari Tho’atun Ma'rufah Titik Nuryastuti Ulfa Afrinurfadhilah Darojati Untari, Febriana Van Soest, Rob W.M. Werner E.G. Muller Wiwin Herdwiani WOUTER L.J. HINRICHS Yolanda Yolanda Yolanda Yolanda, Yolanda YOSI BAYU MURTI Yosi Bayu Murti Yuli Nurullaili Efendi Yuli Nurullaili Efendi, Yuli Nurullaili Zahra Zahra Zahra Zahra Zulbayu, L.M. Andi Zullies Ikawati