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All Journal International Journal of Evaluation and Research in Education (IJERE) Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Pendidikan Sains Biogenesis: Jurnal Ilmiah Biologi Biotropika Proceeding International Conference on Global Resource Conservation Jurnal Pendidikan Biologi Indonesia Biology, Medicine, & Natural Product Chemistry Mutiara Medika: Jurnal Kedokteran dan Kesehatan Bioeksperimen: Jurnal Penelitian Biologi Journal of Tropical Biodiversity and Biotechnology Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Jurnal Pendidikan Biologi Sekolah Dasar: Kajian Teori dan Praktik Pendidikan BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Penelitian Pendidikan IPA (JPPIPA) BIOEDUKASI Biosfer: Jurnal Pendidikan Biologi Saintifik : Jurnal Matematika, Sains, dan Pembelajarannya Jurnal Jamu Indonesia Bio-Inoved : Jurnal Biologi-Inovasi Pendidikan JPPIPA (Jurnal Penelitian Pendidikan IPA) JPP (Jurnal Pendidikan dan Pembelajaran) Proceeding Biology Education Conference Prosiding Seminar Nasional Biologi, Teknologi dan Kependidikan (Biotik) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal PRIMED:Primary Education Journal atau Jurnal Ke-SD An Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Jurnal Kedokteran Hewan Jurnal Ilmu Hayat Indonesian Journal of Jamu
Betty Lukiati
Universitas Negeri Malang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Potential of Single Garlic to Prevent Pro Inflammatory Macrophage and Inflammation in HFD Mice Putri Diyah Anggraini; Miftahul Mufinadiroh; Hendra Susanto; Betty Lukiati; Sri Rahayu Lestari
Journal of Tropical Life Science Vol. 12 No. 1 (2022)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.12.01.10

Abstract

A high-fat-enriched diet causes an increase in the level of oxidized LDL (Ox-LDL) in the blood. The presence of Ox-LDL will activate macrophages to secrete pro-inflammatory cytokines and lead to severe inflammation. Single bulb garlic has a potential anti-inflammatory effect due to of high-fat diet. This research aimed to investigate the effect of single bulb garlic extract (SBGE) on the pro-inflammatory cytokines TNF-α (CD11b+TNF-α+) and IL-1b (CD11b+IL-1b+) in the spleen, spleen weight, and TNF-α secretion in HFD mice. Twenty-four mice were divided into six groups: normal (healthy mice); HFD (HFD mice without any treatment); HFD + Simvastatin (HFD mice receiving simvastatin); HFD + SBGE 100; HFD + SBGE 200; and HFD + SBGE 400 (HFD mice receiving 100, 200, and 400 mg/kg BW of SBGE for 4 weeks). Blood serum was collected at the end of treatment, and macrophage was isolated from the spleen. The relative number of CD11b+TNF-α+ and CD11b+IL-1b+ were examined using flow cytometry. SBGE treatment significantly (p<0.05) reduced the spleen weight and the relative number of CD11b+TNF-α+ and CD11b+IL-1b+ in the spleen of HFD mice. SBGE treatment also prevents the elevation of TNF- α levels in the blood serum. The optimal dose of SBGE to diminish the relative number of CD11b+TNF-α+, CD11b+IL-1b+ in the spleen, and TNF-α in the serum was 100 mg/kg BW.
Co-Authors Abda Abda Abdul Fattah Noor Abdul Gofur Abdul Gofur AD. Corebima Agus Muji Santoso Alif Rofiqotun Nurul Alimah Alvina Putri Purnama Sari Alvina Putri Purnama Sari Anindya Nirmala Permata Anindya Nirmala Permata Arwinda Probowati Atik Kurniawati Balqis balqis Bayu Guruh Binangkit Dian Eka A. F. Ningrum Dianing Eka Pupitasari Dina Aribah Dina Maulina DYAH ASTRIANI Eko Sri Sulasmi Endang Suarsini Fatchur Rohman Fathul Zannah Fitriani, Rita Frida Kunti Setiowati Hadi Suwono Hanzen, W.F Edi Hendra Susanto Hera Adiwijaya Herawati Susilo Ibrohim Ida Rahmawati Ihya Fakhrurizal Amin Jeni Jeni Jeni Jirana, Jirana Khaq, Rizki Amalia Nurul Kurniawan Setia Putra Liah Badriah M. Amien Rais M. Saiful Fahmi M. Saiful Fahmi, M. Saiful Fahmi Mariana Ade Cahaya Miftahul Mufinadiroh Mimien Henie Irawati Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohammad Amin Mohammad Amin Mohammad Amin Mohammad Amin Muhamad Khoirul Anwar, Muhamad Khoirul Muhammad Khalil Muhammad Saefi Muhammad Shobirin Mumun Nurmilawati Murni Sapta Sari Muslihasari, Adzimatnur Nanda Earlia Nazilatul Khoiroh Nelda Anasthasia Serena Ningrum, Dian Eka A. F. Novia Sigma Amalina Nugrahaningsih N, Nugrahaningsih Nugrahaningsih Nugrahaningsih Nur Fitriana Nur Fitriana Nursyahbani Saraha Poppy Rahmatika Primandiri Puspitasari, Dianing Eka Putri Diyah Anggraini Putri Purnama Sari, Alvina Putri Purnama Sari, Alvina Risanti Dhaniaputri Serena, Nelda Anasthasia Siti Aisyah Firdani Siti Imroatul Maslikah Siti Nur Arifah Sitoresmi Parabaningtyas Sitoresmi Prabaningtyas Sitorus, Mido Ester Solly Aryza Sri Rahayu Lestari Sulistiono Sulistyo Dwi Kartining Putro Sulistyo Dwi Kartining Putro, Sulistyo Dwi Kartining Susriyati Mahanal Sutiman Bambang Sumitro Tahir, Jirana Triastono Imam Prasetyo Umi Hasanah, Umi Umie Lestari Utami Sri Hastuti W. F. Edi Hanzen W.F Edi Hanzen Widodo Widodo Yayoi Kodama Yessi Hermawati Zauhara Faiqohtun Wuriana