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All Journal Farmaka Tadbir: Jurnal Manajemen Pendidikan Islam Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Pendas : Jurnah Ilmiah Pendidikan Dasar SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Kreativitas PKM JURNAL MITRA KENCANA KEPERAWATAN DAN KEBIDANAN JURNAL FARMASI GALENIKA Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Riset Kefarmasian Indonesia Science Midwifery Jurnal Health Sains Jurnal Insan Farmasi Indonesia Reputasi: Jurnal Rekayasa Perangkat Lunak JURNAL PENDIDIKAN INDONESIA: Teori, Penelitian, dan Inovasi Bayani Sciences of Pharmacy Jurnal Farmasi Indonesia Sinergi International Journal of Management and Business Civilization Research: Journal of Islamic Studies Cendikia Pendidikan Zona Education Indonesia Advances in Applied Accounting Research Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Proceeding Of International Conference On Education, Society And Humanity Jurnal Farmasi Galenika International Journal of Health, Medicine, and Sports Research Psychologie, Orientation et Conseil
Yani Mulyani
School of Pharmacy, Institute of Technology Bandung. Jl. Ganesa No. 10 Bandung
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Antidiabetic and Antidyslipidemic Activity of Ethyl Acetate Fraction of Binahong Leaves in Streptozotocin (STZ)-induced Diabetic Rats Mulyani, Yani; Hasimun, Patonah; Apriliyanti, Nida Putri
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.100960

Abstract

Diabetes mellitus (DM) is a disease characterized by hyperglycemia and impaired glucose, protein, and fat metabolism due to insulin deficiency or resistance. In type 2 DM, insulin resistance potentially causes dyslipidemia through increased lipolysis and glucose production in the liver as well as reduced glucose absorption into cells. According to previous reports, the prevalence of dyslipidemia is relatively high, ranging from 72-85%. One of the plants that has the potential for antidiabetic and antidyslipidemic is binahong (Anredera cordifolia (Ten.) Steenis). Therefore, this research aims to determine the antidiabetic and antidyslipidemic activity as well as the effective dose of ethyl acetate fraction from ethanol extract of binahong leaves to reduce blood sugar levels, total cholesterol, triglycerides, LDL, IAP, increase HDL levels, and improve the histological profile of the pancreas and aorta. The experiment was conducted curatively using 30 rats divided into 5 treatment groups, namely normal (Na-CMC 0.5%), diabetic group (Streptozotocin 35 mg/kgBW), positive control (Simvastatin 10 mg/kgBW), and the test group given ethyl acetate fraction of ethanol extract at dose 1 (100 mg/kgBW) and 2 (150 mg/kgBW). All groups except normal received streptozotocin induction for 3 days until a diabetic rat model was formed, then the test drug treatment was given for 28 days. Blood sugar levels were measured on days 0, 3, 14, and 28 using a glucometer, and lipid profile levels were measured on days 0 and 28 enzymatically using a microlab 300. The results showed that the ethyl acetate fraction of binahong leaves ethanol extract at a dose of 100 mg/kgBW demonstrated antidiabetic and antidyslipidemic effects. It reduced blood glucose and lipid levels by 36–62% compared to the diabetic group and showed similar results to the positive control. This dose also improved the histological structure of the pancreas and aorta.
Co-Authors Adang Hambali, Adang Agus Sulaeman Aligita, Widhya Amini, Nadia Ushfuri Ani Anggriani, Ani Apriliyanti, Nida Putri Assalam, Sunan Hanif Ihsan Bachrudin, Panji Badrudin Bagus Suryadi, Bambang Baihaqi, Mohammad Aqil Bambang Kelana Simpony Choirunnisa, Zulfy Davronov, Istamkhuja Olimovich dirgahayu, inggrid Elin Yulinah Embas Saraswati, Dewa Ayu Eti Rahmawati Fahmi, Dede Ropi Fajeri, Nur Iman Garnadi Jafar, Garnadi Hadiantini, Dian Hasan Basri Hasimun, Patonah Hidayat, Abdilah Alam Hernan I Gusti Agung Ayu Hari Triandini I Ketut Adnyana Ihsan Assalam, Sunan Hanif Ika Kurnia Sukmawati Ilham Suparman, Muhamad Iskandar Jioe, Yulius Isvahanie, Salsha Rifa Jajang Jafar Sodik Jajang Japar Sodik Jamaludin . Khotimah, Nur Intan Husnul Kurnia Sukmawati, Ika Kurniasih, Imas Marita Kaniawati Maulana, Rizka Husnu Melysa, Melysa Mohamad Erihadiana, Mohamad Muhtadin Mukhlishah Muslikhin Muyassar M, Raihan Mu’atawakil, Raihan Muyassar Nopriyanti, Selly Nugraha, Budy Nugraha, Eka Rahmat Nurswardiana, Hanna Pasha, ED. Yunisa Mega Patonah, Patonah Pratiwi, Lili Dinda Prawestyi, Poety Putriyanti, Al-fira Rahayu, Sri Mulyati Rofi Fahmi, Dede Ruswandi, Uus Saifurrohman, Arip Salam, Mochamad Fadlani Sam'un, Sam'un Sapitri, Wina Sari, Mela Mustika Sholiehah, Nurul Siti Balqis, Salwa Siti Saidah Solihah Sari Rahayu Solihah, Nurlaella Sriwantika, Ika Sumarna, Rendi Supala Sutrisno, Entris Tambunan, Irisanna Utami, Pujani Vitniawati, Vina