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Circular Economy Development Policy in Magetan Regency: Case Study of the Leather Industry and its Impact on Improving the Community's Economy: Kebijakan Pengembangan Ekonomi Sirkuler di Kabupaten Magetan: Studi Kasus Industri Kulit dan Dampaknya terhadap Peningkatan Ekonomi Masyarakat Sukarsono, Faza Muhammad; Gamaputra, Gading; Winata, Muhammad Danu; Kurniawan, Badrudin; Noviyanti; Lestari, Yuni; Wibisono, Haryo Kunto
JKMP (Jurnal Kebijakan dan Manajemen Publik) Vol 13 No 1 (2025): April
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/jkmp.v13i1.1818

Abstract

This study aims to analyze the circular economy development policy in Magetan Regency, focusing on the leather industry and its impact on improving the community's economy, especially on Jalan Sawo, Selosari Village. The method used is a qualitative approach, which includes in-depth interviews with industry players, direct observation at the location, and analysis of documents related to the policy. The results of the study indicate that the implementation of the circular economy policy not only increases community income through the creation of new jobs but also contributes to waste reduction and increased environmental awareness among the community. In addition, this study identifies challenges faced in implementing the policy, such as lack of training and technical support. Recommendations are provided to improve the effectiveness of this policy, including the need for collaboration between the government, private sector, and the community in creating a sustainable circular economy ecosystem. This research is expected to contribute to the development of better policies in the future.
FUNCTIONAL ROLE OF VIMENTIN'S CYSTEINE IN XIST-MEDIATED EMT INHIBITION IN BREAST CANCER Jayanti; Melisa; Arnando; Mur'ah; Noviyanti
Journal of Stem Cell Research and Tissue Engineering Vol. 9 No. 1 (2025): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v9i1.73554

Abstract

Breast cancer is the most commonly diagnosed malignancy among women worldwide and a leading cause of cancer-related mortality, primarily due to its high metastatic potential. One mechanism underlying metastasis is the epithelial-to-mesenchymal transition (EMT), which enhances cancer cell mobility, invasiveness, and resistance to treatment. Vimentin, a type III intermediate filament protein, is a hallmark of EMT and plays a structural and regulatory role in cytoskeletal organization and cellular stress responses. Recent studies have highlighted the importance of a single cysteine residue at position 328 (C328) in vimentin, which functions as a redox-sensitive site influencing filament dynamics. However, the role of C328 in cancer progression remained largely unexplored. This literature review investigates the effect of a single amino acid substitution—C328 to serine (C328S)—on breast cancer cell behavior, focusing on findings published between 2020 and 2025, sourced from PubMed and Google Scholar. Evidence from MCF-7 breast cancer cell models reveals that expression of C328S-VIM induces morphological changes, cytoskeletal disorganization, and increased proliferation, migration, and invasion. Notably, C328S-VIM upregulates the long non-coding RNA XIST, which promotes EMT, estrogen independence, and stem-like properties. These findings indicate that the native C328 residue serves a tumor-suppressive function, partly through modulation of XIST activity. Overall, this review presents a novel insight into how a single amino acid mutation in vimentin can reprogram breast cancer cells toward a more aggressive and stem-like phenotype. The study highlights C328 as a potential therapeutic target and broadens our understanding of the molecular mechanisms driving breast cancer progression.
Improving the Education Development Contribution Payment Model at SMK Istiqomah Maruyung Using the C4.5 Algorithm Noviyanti; Purnamasari, Ade Irma; Bahtiar, Agus; Tohidi, Edi
Journal of Artificial Intelligence and Engineering Applications (JAIEA) Vol. 4 No. 3 (2025): June 2025
Publisher : Yayasan Kita Menulis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59934/jaiea.v4i3.729

Abstract

  Payment of tuition fees is one of the important aspects of school financial management. At SMK Istiqomah Maruyung, the management of SPP payments is still done manually, which causes student non-compliance in paying on time. The purpose of the research is to improve the SPP payment model by using the C4.5 algorithm to classify the level of student compliance and identify the main factors that influence late payments. The method used is the Knowledge Discovery in Databases (KDD) approach which includes the stages of data selection, preprocessing, transformation, data mining, and result evaluation. The research data was taken from 206 students in the 2023/2024 academic year with attributes such as parental income, number of siblings, scholarship status, and academic grade point average. The C4.5 algorithm was applied to build a decision tree model, with evaluation using five-fold cross validation. The result of this study is that the C4.5 algorithm is able to classify student compliance levels with an average accuracy of 93.55%. The main factors that influence late payment are academic grade point average, class, and parental income. Although the model is very good at predicting compliant students (precision 95%, recall 98%), it shows weakness in predicting lateness (precision 67%, recall 40%). It is concluded that the C4.5 algorithm can improve the efficiency of managing tuition payments and provide data-driven insights for policy making. With further implementation, this algorithm is expected to be adopted by other educational institutions to address similar challenges in financial management.
Penerapan Akupresure untuk Mengurangi Nyeri Haid pada Remaja Putri Eva Tresanita Damanik; Yekti Murbarani; Florida; Noviyanti; Syalmah; Melgita Sari Nurjayanti Saputri; Ari Widyaningsih
Prosiding Seminar Nasional dan CFP Kebidanan Universitas Ngudi Waluyo Vol. 4 No. 1 (2025): Prosiding Seminar Nasional dan Call for Paper Kebidanan Universitas Ngudi Waluy
Publisher : Universitas Ngudi Waluyo

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Abstract

Dysmenorrhea is pain that occurs during menstruation and can be very disruptive to daily activities. Menstrual pain is a common complaint experienced by many women and is a symptom, Adolescence is a problem of transition from puberty to adulthood or the process of growing towards mental, emotional, social and physical maturity. During adolescence, physical changes occur accompanied by changes in the reproductive organs. Dysmenorrhea in some adolescents is a torture in itself that must be experienced every month. In general, the treatment of dysmenorrhea pain is divided into two categories, namely pharmacological and non-pharmacological. One of the midwifery care that can be given to reduce menstrual pain or dysmenorrhea is acupressure. Acupressure is a massage or pressure on the meridian points of the body. The problem of menstrual pain or dysmenorrhea still occurs in many adolescent girls at the Tanjung Palas but there is no treatment to overcome it. In fact, menstrual pain or dysmenorrhea can affect the daily activities of adolescent girls including difficulty concentrating, emotional conflict, tension, anxiety, and disrupting the learning process, feeling uncomfortable, decreased activity in the learning process. Based on the problems that arise, community service activities are needed to overcome this. The activity began with an opening and pre-test, secondly the delivery of material about Acupressure to reduce menstrual pain in adolescent girls as well as the practice of doing acupressure to reduce menstrual pain, thirdly the closing and post-test which was attended by 16 adolescent girls. From these activities, it was found that there was an increase in the knowledge of adolescent girls about acupressure to reduce menstrual pain in adolescent girls.   Abstrak Dismenore adalah rasa nyeri yang terjadi saat menstruasi dan bisa sangat mengganggu aktivitas sehari-hari. Nyeri haid ini merupakan keluhan umum yang dialami oleh banyak perempuan dan merupakan gejala, Masa remaja merupakan masalah peralihan dari pubertas ke dewasa atau proses tumbuh kearah kematangan mental, emosional,sosial dan fisik. Pada masa remaja terjadi perubahan fisik yang disertai dengan perubahan organ reproduksi. Dismenore pada sebagian kaum remaja merupakan siksaan tersendiri yang harus dialami setiap bulannya. Secara umum penanganan nyeri dismenore terbagi dalam dua kategori yaitu farmakologis dan non farmakologis. Salah satu asuhan kebidanan yang dapat diberikan untuk mengurangi nyeri haid atau dismenore adalah akupresure. Akupresure adalah pemijatan atau penekanan pada titik-titik meridian tubuh. Permasalahan nyeri haid atau dismenore ini masih banyak terjadi pada remaja putri di Tanjung Palas namun belum ada penanganan untuk mengatasinya. Padahal, nyeri haid atau dismenore dapat mempengaruhi aktivitas sehari-hari remaja putri diantaranya sulit berkonsentrasi, konflik emosional, ketegangan, kecemasan, dan mengganggu proses belajar, merasa kurang nyaman, penurunan keaktifan dalam proses pembelajaran. Berdasarkan masalah yang muncul, maka diperlukanlah kegiatan pengabdian masyarakat untuk mengatasi hal tersebut. Kegiatan diawali dengan pembukaaan dan pree test , kedua penyampaian materi tentang Akupresure untuk mengurangi nyeri haid pada remaja putri sekaligus praktik melakukan akupresure untuk mengurangi nyeri haid, ketiga penutup dan post tes yang di hadiri oleh 16 remaja putri. Dari kegiatan tersebut didapatkan ada peningkatan pengetahuan remaja putri tentang akupresure untuk mengurangi nyeri haid pada remaja putri.
PENERAPAN SISTEM INFORMASI MANAJEMEN DALAM MANAJEMEN BERBASIS SEKOLAH (STUDI KASUS PADA SISTEM INFORMASI AKADEMIK STIT AL-IHSAN BALEENDAH) Noviyanti; Amalia, Rosemila; Mustika, Sri; Salinan; Warta, Waska
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 03 (2025): Volume 10 No. 03 September 2025
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i03.30414

Abstract

The rapid development of information and communication technology has significantly impacted the education sector, particularly in improving the effectiveness, efficiency, and accountability of school management. This study aims to analyze the implementation of a Management Information System (MIS) to support School-Based Management (SBM) at STIT Al-Ihsan Baleendah. Using a descriptive qualitative case study approach, the research explores planning, organizing, implementation, and evaluation of MIS in the institution. Data were collected through interviews, observations, and document analysis, then analyzed interactively. The findings show that MIS has accelerated academic administrative services, improved data accuracy, and facilitated data-driven decision-making. However, challenges remain, including limited infrastructure, insufficient digital literacy among staff, and lack of formal documentation. Regular evaluation and continuous improvement efforts are crucial for sustainable system performance. This study contributes to both theory and practice by providing insights into the integration of MIS and SBM in Islamic higher education contexts. Keywords: Management Information System, School-Based Management, Higher Education, Academic Administration, Digital Literacy;
Antioxidant Activity Test Of Red Spinach Leaf (Amaranthus Tricolor L.) Extract And Fraction With Methode (2,2-Diphenyl-1 Picrylhydrazyl) Noviyanti; Asterina, Yolanda; Khairunnisa, Anita
SPECTA Journal of Technology Vol. 9 No. 2 (2025): Specta Journal of Technology
Publisher : LPPM ITK

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35718/specta.v9i2.8481340

Abstract

Abstract Red spinach (Amaranthus tricolor L.) is a leafy vegetable known for its high antioxidant potential due to its bioactive compounds. This study aimed to evaluate the antioxidant activity of extracts and fractions of red spinach leaves using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Extraction was conducted through cold maceration with ethanol 96%, followed by fractionation using solvents of varying polarity: n-hexane, ethyl acetate, and water. Phytochemical screening revealed the presence of alkaloids, flavonoids, quinones, saponins, steroids, and tannins, which contribute to the plant's antioxidant properties. The antioxidant activity of the ethanol extract and fractions was assessed based on their IC50 values. The ethanol extract demonstrated moderate antioxidant activity with an IC50 of 122.09 µg/mL, while the n-hexane and water fractions showed similar moderate activity with IC50 values of 117.33 µg/mL and 124.36 µg/mL, respectively. The ethyl acetate fraction exhibited strong antioxidant activity with an IC50 value of 64.77 µg/mL, attributed to the presence of semi-polar compounds such as flavonols. The results confirmed the significant free radical scavenging potential of red spinach, particularly in its ethyl acetate fraction. This study highlights the potential of red spinach leaves as a natural source of antioxidants with applications in the pharmaceutical, health, and food industries. Keywords: Red spinach, Amaranthus tricolor L., DPPH, antioxidant activity, IC50.
IDEALITAS DAN REALITAS KEMAMPUAN GURU MI/SD DALAM MENGIMPLEMENTASIKAN PEMBELAJARAN TEMATIK Nurkhairina; Hidayatullah, Agus; Rosyidah, Neneng Aida; Noviyanti
Ta'dibiya Vol 3 No 1 (2023): Ta'dibiya: Jurnal Agama dan Pendidikan Islam
Publisher : Staisman Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61624/japi.v3i1.23

Abstract

Learning in the 2013 curriculum uses integrated thematic learning. This causes teachers to master and carry out thematic learning well. However, there are many problems that occur, then what is the ideal of the teacher in carrying out thematic learning. This research intends to know and explain in detail about the ideals and reality of MI/SD teachers' abilities in implementing thematic learning. The results of this study are; Ideally the teacher in this thematic learning is to provide meaningful teaching and experiences to students. Not only that, a teacher in addition to being a professional educator, is also an educator, teacher, mentor, director, assessor, and evaluator of students, especially in early childhood education and basic education. There are two factors that impact on the obstacles for teachers to implement, namely: internal factors and external factors. Teachers are still lacking in comprehensive education and training; teachers also still find it difficult to integrate tactics in the learning theme.
IDEALITAS DAN REALITAS KEMAMPUAN GURU MI/SD DALAM MENGIMPLEMENTASIKAN PEMBELAJARAN TEMATIK Nurkhairina; Hidayatullah, Agus; Rosyidah, Neneng Aida; Noviyanti
Ta'dibiya Vol 3 No 1 (2023): Ta'dibiya: Jurnal Agama dan Pendidikan Islam
Publisher : Staisman Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61624/japi.v3i1.23

Abstract

Learning in the 2013 curriculum uses integrated thematic learning. This causes teachers to master and carry out thematic learning well. However, there are many problems that occur, then what is the ideal of the teacher in carrying out thematic learning. This research intends to know and explain in detail about the ideals and reality of MI/SD teachers' abilities in implementing thematic learning. The results of this study are; Ideally the teacher in this thematic learning is to provide meaningful teaching and experiences to students. Not only that, a teacher in addition to being a professional educator, is also an educator, teacher, mentor, director, assessor, and evaluator of students, especially in early childhood education and basic education. There are two factors that impact on the obstacles for teachers to implement, namely: internal factors and external factors. Teachers are still lacking in comprehensive education and training; teachers also still find it difficult to integrate tactics in the learning theme.
Analisis Indeks Kepuasaan Masyarakat Pada Layanan Kepengurusan Surat Keterangan Tanda Lapor Kehilangan (SKTLK) di Polsek Jambangan Kusuma Dewi, Novian; Noviyanti
Jurnal Inovasi Administrasi Negara Terapan (Inovant) Vol. 1 No. 1 (2023): Kebijakan dan Tatakelola Lembaga Publik untuk Tujuan Pembangunan Berkelanjutan
Publisher : Universitas Negeri Surabaya

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Abstract

The problems that exist in the service of managing the Certificate of Loss Report (SKTLK), Polsek Jambangan has not implemented the IKM, lack of human resources which results in less than optimal service, lack of publication related to information about the service of managing the Certificate of Loss Report (SKTLK) and lack of infrastructure. Therefore, the purpose of this study is to describe and analyze the results of the Community Satisfaction Index (SMI) on the service of managing the Certificate of Loss Report (SKTLK) at the Jambangan Police. This research uses a quantitative approach with a survey method. In this study to measure public satisfaction with the services provided by Jambangan Police is to use the Community Satisfaction Index in accordance with the Regulation of the Minister of Administrative Reform of Bureaucratic Reform (Permenpan RB) Number 14 of 2017 concerning Guidelines for Preparing Community Satisfaction Surveys for Public Service Delivery Units. The sampling technique used Accidental Sampling with a population of 250 people and a sample size of 71 people using data collection techniques in the form of questionnaires. The results showed that the Community Satisfaction Index at Jambangan Police fell into the "GOOD" category with an interval value of 81.57. Suggestions given to Jambangan Police in improving elements that have not fully run smoothly.
Analisis Indeks Kepuasan Masyarakat Pada Layanan Sirkulasi Perpustakaan di Kementerian Desa, Pembangunan Daerah Tertinggal dan Transmigrasi Matulessy, Stella Maria; Noviyanti
Jurnal Inovasi Administrasi Negara Terapan (Inovant) Vol. 1 No. 1 (2023): Kebijakan dan Tatakelola Lembaga Publik untuk Tujuan Pembangunan Berkelanjutan
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Library circulation services are essential to carry out a satisfaction survey to determine the level of satisfaction from the community's point of view to improve and develop services in the future. The problems found in the library circulation service of the Ministry of Villages, Development of Disadvantaged Regions, and Transmigration (Kemendesa PDTT) are that they have not implemented the Community Satisfaction Index (IKM), the system has not been computerized, the lack of utilization of complaints, suggestions, and input. Therefore, the purpose of this study is to describe and analyze the results of the Community Satisfaction Index on library circulation services at Kemendesa PDTT. The type of research used is quantitative with a descriptive method using Community Satisfaction Index measurements by the Regulation of the Minister of Administrative Reform and Bureaucratic Reform Number 14 of 2017 concernin guidelines for Compiling Public Satisfaction Surveys in Public Service Delivery Units. Sampling technique using Accidental Sampling with a total sample of 73 respondent. Data collection techniques include questionnaires, interviews, observation, and documentation. Data analysis techniques use tabulation, data verification, IKM analysis, and conclusion. The results showed that the Community Satisfaction Index in the Kemendesa PDTT library was included in the "GOOD" category with a value of 81.82. The element that has the highest score is cost/tariff which is worth 100.00 and the element that has the lowest score is complaint, suggestion, and input which is worth 77.05.
Co-Authors Agus Prasetyawan Agus Sutarjo Ainy, Afra Nur Amalia , Rosemila Amalia, Rosemila AMBAR WIDYA LESTARI Andriani Angga Domeos Manggara Antonio Constantino Soares Ari Widyaningsih Arianti, Gisela Arnando Asma, Nurul ASNI Asterina, Yolanda Aulia Rosida, Nabila Azizah, Maulia Salsanabila Azwar, Yessi Badrudin Kurniawan Basuki Batubara, Hamidah Sari Bella, Ivvon Septina Berliani, Dedek Bunga Tiara Carolin DIAN ARLUPI UTAMI Dirgayusa Febrianaga, Pipit Eliyah Emy Susanti EVA AULIA MUKTI Eva Tresanita Damanik Faisal R Dongoran, Faisal R Fernando, Ronal Fitrianingrum, Aditya Pratiwi Florida Gading Gamaputra Handayani, Sri Hidayatullah, Agus Hikmah, S.E., M.Si. Hutasoit, Eva Santi Ice Irawati Imanudin Siregar Indera Hayati, Aulia Dian Isnaini Fitri Effendi Jayanti Juliani, Wahyuni Karimah, Arzetya Fitri Al Keristanti, Ruri Khairunnisa, Anita Khummad Robby, Tasbikhy Kusuma Dewi, Novian Leni Utami Lina Haryani Lukmawati, Luthfi Rizky Mar'atus Sholikhah Matulessy, Stella Maria Mauizatul Hasanah Maulida Mega Dewi Lestari Melgita Sari Nurjayanti Saputri Melisa Misriningsih, Dwi Cahyani Muhammad Zaini Mur'ah Murni Murniati Nanik Cahyati Natasha, Ayu Naufal Hanif Ramadhan Norwanda Nur Rachma, Dita Laela Nurkhairina Nurlina Nurmayana Oskar Pardosi, Renhad Andreas Permana, Handy Januar Pinata, Putri Prasetyo Isbandono Punarbawa, Gede Purnamasari, Ade Irma Putri Fatahillah, Ratu Egalitarian Ranti Widayanti Ratna Sari, Monika Retno Widuri, Aliffionia Sindy Hendrati Rice Haryati Rinanti, Maghalita Rinanti Rita Dewi Triastianti Rizka Hadya Robby Cokro Buwono Rosyidah, Neneng Aida Salinan Sarasati, Inda Siti Maesaroh Sophia Sri Mustika Sujarwo Putri, Tarisa Sukarsono, Faza Muhammad Suwiase, Putu Syalmah Tahlia Wahyuning Tias Takharus Awal, Annisa Zahra Tanosida K Tohidi, Edi Triatmi Sri Widyaningsih Wahyuni, Rika Sri Warsiyah Warta, Waska Wati, Norlidia WENI ROSDIANA Wibisono, Haryo Kunto Widyaningtyas, Dwi Wilujeng, Vianti Winata, Muhammad Danu Yekti Murbarani Yeni Rosyeni Yulistia Yuni Lestari Yuni Lestari Yusuf, Salsabila Zalikha Zulfahmi