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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Global Medical and Health Communication Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Medical Laboratory Technology Journal Indonesian Journal for Health Sciences (IJHS) SRIWIJAYA JOURNAL OF MEDICINE Jurnal Jamu Indonesia Jurnal Mandala Pharmacon Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientia Psychiatrica Indonesian Journal of Anesthesiology and Reanimation (IJAR) JK Unila (Jurnal Kedokteran Universitas Lampung) Eureka Herba Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine Indonesian Community Empowerment Journal Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Arkus Wal'afiat Hospital Journal International Journal of Islamic and Complementary Medicine Conferences of Medical Sciences Dies Natalis Sriwijaya Journal of Dentistry WAL'AFIAT HOSPITAL JOURNAL Biomedika Media Penelitian dan Pengembangan Kesehatan Indonesian Journal of Jamu Journal of Medicine and Health
Nita Parisa
Department Of Pharmacology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Antibacterial Efficacy of Aloe vera Sap Against Staphylococcus aureus and Escherichia coli Safira Azahra; Nita Parisa; Fatmawati Fatmawati; Ella Amalia; Venny Larasati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 2 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i2.87

Abstract

Abstract Background Aloe vera is a plant that has been used as an alternative drug. This plant contains various compounds, like anthraquinone, saponin, flavonoid, alkaloid, and tannin that has an antibacterial effect against Staphylococcus aureus and Escherichia coli. Both of it were responsible for the infection incident. This study aims to determine the efficacy of Aloe vera sap as an antibacterial against Staphylococcus aureus and Escherichia coli. Methods An experimental study, in vitro using post-test only control group design, has been done at laboratory of Medical Faculty of Sriwijaya University, by examining the antibacterial activity of Aloe vera sap in five different concentration (5%, 10%, 20%, 40%, dan 80%) using well diffusion and solid dillusion method to determine the minimum bactericidal concentration (MBC). And then continued with the phytocemical screening to determine the compound inside the Aloe vera sap. Results Aloe vera sap were able to kill Staphylococcus aureus at 5% and Eshcerichia coli at 80%. Compatibility test showed that Aloe vera sap with concentration of 10%, 20%, 40%, and 80% are compatible with amoxicillin, therefore 80% is compatible with cefotaxime. This ability due to the compound that it contains, which is alkaloid, flavonoid, tannin, quinone, and saponin. Conclusion Aloe vera sap is effective as an antibacterial against Staphylococcus aureus and Escherichia coli. Keyword: Aloe vera sap, antibacterial, efficacy, Staphylococcus aureus, Escherichia coli.
Aphrodisiac Effects of Areca Fruit in Erectile Dysfunction Rat Model Nita Parisa; Muhammad Totong Kamaluddin; Salni Salni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 3 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i3.90

Abstract

Abstract. Erectile Dysfunction (ED) cases are quite high in both women and men and increase with age. Areca fruit, ginseng and purwoceng are plants that have been traditionally used to increase male vitality. This in vivo experimental research study with pre and post-test control group design located in the laboratory of animal house and the biomolecular laboratory Faculty of Medicine Sriwijaya University. The subjects of this study were albino rats (Rattus norvegicus), Wistar strains, divided into 6 groups are negative control, Sildenafil, Areca Fruit Extract (AFE) 50 mg/kgBW, AFE 100 mg/kgBW, Combination of Areca Fruit, Ginseng and Purwoceng (AGP) 50 mg/kgBW and AGP 100 mg/kgBW. Female rat was injected by giving 500 mg/100 g of subcutaneous progesterone and 10 μg/100 g of BB benzoate 48 hours before mating so that female mice enter the esterus phase. In this study it was found that Combination of Areca fruit, Ginseng and Purwoceng (AGP) group 50mg/kgBW significantly improved testosterone levels compared to sildenafil, while single areca fruit (AFE) dose 50mg/kgBW increased FSH and LH levels as well as sildenafil statistically. Keywords: areca fruit, erectile dysfunction, FSH, ginseng, LH, purwoceng, testosteron.
The First Look in Autism Spectrum Disorder (ASD) Geographical Distribution in National Reference Hospital, South Sumatera Region, Indonesia Ziske Maritska; Bintang Arroyantri Prananjaya; Nita Parisa
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 2 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i2.108

Abstract

Background. Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized with disorders in cognitive, behaviour, and social interaction. It is estimated to affect 1:160 children worlwide. Despite its increasing trend, the exact cause of it is yet to be known. Objective. This study wished to identify the geographical distribution of ASD cases in Dr. Mohammad Hoesin Hospital as one of the national reference hospitals in Indonesia for South Sumatera region. Methods. Medical records of the patients who are diagnosed with ASD during 2014-2018 was observed in order to identify the patients’ residential area. Results. There were 107 patients who were clinically diagnosed of having ASD during 2014-2018 in Dr Mohammad Hoesin Hospital, Palembang. Based on its residential area, ASD cases were mostly found in Palembang as the capital city of South Sumatera Province. Conclusion. ASD is found in small and big cities across the South Sumatera province, implying its common occurrence. The varied prevalence could be signifying the role of different related risk factors identified in the area.
Evaluation of Rationality in Prescribing Metformin (Biguanide Group) at Dr. Mohammad Hoesin General Hospital Palembang Nita Parisa; Dwi Tantri Marylin; Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 3 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i3.471

Abstract

Backgrounds. It is very important to evaluate and assess the rationality of the use of antidiabetic drugs, especially the biguanide (metformin) group to maintain the quality and quality of diabetes mellitus drug administration so that the target of diabetes mellitus control can be optimized. This study aims to evaluate the rationality of prescribing metformin oral antidiabetic at Dr. Mohammad Hoesin General Hospital Palembang. Methods. The research design is a descriptive study using secondary data from medical records in the medical records section of Dr. Moh Hoesin Hospital Palembang. The object of research is all medical records of patients with type 2 diabetes mellitus who used metformin at RSMH Palembang in the period July 1st, 2019-July 31st, 2020, with complete medical record data and without serious comorbidities. The rationality for using metformin that was assessed in this study was the frequency of use, drug dose, route of administration, duration of administration, and drug interactions. The frequency of drug use is assessed by how many times the drug is taken in one day. Results. The most age group of patients who received a prescription for metformin were 51-60 years old and 61-70 years old with a total of 17 patients (35.4%). The majority of patients were female as much as 60.4%. Drug interactions with metformin are still quite common, although the majority are synergistic and potentiating interactions. There are still 2 cases or 4.2 percent who experience antagonistic interactions. Conclusion. The rationality for using metformin in patients with type 2 diabetes mellitus is based on the criteria for the right dose (100%), the right frequency of drug administration (100%), the right time for giving the drug (100%), the right way of giving the drug (100%), and the right drug interaction. (95.8%).
Increasing Public Knowledge About Covid-19 Prevention through The Implementation of Health Protocol and Self Medication Nita Parisa; Evi Lusiana; Nia Savitri Tamzil
Arkus Vol. 6 No. 1 (2020): ARKUS
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/arkus.v6i1.81

Abstract

Covid-19 is a disease caused by the SARS Cov-2 virus and attacks the respiratory tract. This disease spreads very quickly through droplets. Until now, there is no definitive therapy for this disease. However, prevention that can be done to prevent this disease are implementing health protocols, social distancing, increasing endurance by consuming nutritious foods, exercising and regular rest, stress management, and self-medication.
Ruqyah Complementary Therapy in Cluster Headache Patient in Indonesia Indri Seta Septadina; Nita Parisa
Arkus Vol. 7 No. 1 (2021): ARKUS
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/arkus.v7i1.89

Abstract

This case report presents a Malay Muslim man with a severe cluster headache. The patient responded only to morphine treatment, but his condition continued to worsen. He uses the complementary therapy of ruqyah, which is based on a verse from the Qur'an, after seeking advice from a local ulama (Islamic cleric). His condition improved significantly, and he underwent preventive ruqyah therapy on television. Since switching to ruqyah, he is no longer on morphine treatment, and the level and duration of her pain is significantly reduced. Ruqyah therapy is famous for treating jinn possession but has also been found to have a therapeutic effect on organic health problems. The case illustrates that supplementing modern medicine with ruqyah can bring many benefits, especially in the Muslim community.
Indonesian Plants with Potential as Anti-diabetes Mellitus Agent Rachmat Hidayat; Lusia Hayati; Nita Parisa
Eureka Herba Indonesia Vol. 1 No. 2 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i2.7

Abstract

Diabetes Mellitus (DM) is a degenerative disease that continues to increase in number in Indonesia and is a disease that is spread throughout the world due to unbalanced nutritional conditions. Treatment of diabetes mellitus is a chronic and lifelong treatment. Treatment of diabetes mellitus, such as the use of insulin and oral antihyperglycemia drugs, is relatively expensive, is used for a long time and can cause unwanted side effects. There are many plants that have potential as antihyperglycemia drugs. One of the active compounds that act as antihyperglycemia is flavonoids.Flavonoids derived from various types of plants studied are thought to act as antihyperglycemic agents. Flavonoids are known to have the ability to scavenge free radicals or act as natural antioxidants. The antioxidant activity of flavonoids is related to phenolic –OH groups which can capture or neutralize free radicals (such as ROS or RNS). Flavonoids can play a role in pancreatic tissue damage caused by DNA alkylation due to alloxan induction as a result of improving the morphology of the rat pancreas.
Efek Sedativa dan Kebugaran Teh Celup Daun Gaharu (Aquilaria malaccensis L) Muhammad Totong Kamaluddin; Yuliarni Yuliarni; Yeni Agustin; Nita Parisa; Rahmat Hidayat; Tri Wahyuni; Citra Yuliana; Perryanis Perryanis
Jurnal Jamu Indonesia Vol. 2 No. 3 (2017): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (975.362 KB) | DOI: 10.29244/jji.v2i3.40

Abstract

Daun Gaharu (Aquilaria malaccensis) sejak lama telah digunakan masyarakat Kabupaten Bangka Tengah untuk menangkal keletihan akibat gangguan tidur ringan. Minuman yang diramu dari daun Gaharu yang diiris-iris lalu dijemur sebentar kemudian disedu air hangat kuku ternyata berkhasiat untuk menimbulkan rasa kantuk dan setelah bangun dari terlelap sejenak maka tubuh akan menjadi lebih segar. Penelitian ini ingin membuktikan manfaat tersebut di atas. Sejumlah 60 orang sukarelawan sehat terdiri dari 30 orang laki-laki dan 30 orang wanita dengan rentang umur 18 – 60 tahun berpartisipasi untuk membuktikan efek sedativa dan pengaruh kesehatan lainnya. Dengan disain pre-post test serta kerelaan sukarelawan sehat ini (dengan mengisi informed consent) sebagai responden, maka semuanya diberi minum teh celup Gaharu yang berisi 1 g simplisia kering/saset setiap hari selama 3 minggu berturut-turut. Setelah selesai satu sesi minum, semuanya diwawancarai pemeriksaan fisik, mental dengan menggunakan kuesioner model Pittsburgh Insomnia Rating Scale (PIRS) serta dikoleksi darah intravenanya. Hasil menunjukkan bahwa 32 % responden timbul rasa kantuk ringan, 10 % merasa lebih segar walaupun terasa sakit kepala ringan, serta berkurangnya rasa pegal dan nyeri sendi namun nafsu makan bertambah. Profil darah rutin tidak berubah namun kadar hormon seks seperti testosteron, progesteron, estradiol dan FSH meningkat ringan tanpa LH serta penurunan fibrinogen dan hs-CRP. Sedangkan transaminase hepar tidak berubah. Dari temuan ini disimpulkan bahwa konsumsi rutin teh gaharu memperbaiki profil tidur dan kesegaran jasmani namun tidak bersifat hepatotoksik. Perubahan kadar hormon seks, fibrinogen dan hs-CRP perlu dikaji lebih lanjut.
Efek Ekstrak Daun Salam pada Kadar Glukosa Darah Nita Parisa
Jurnal Kedokteran Universitas Lampung Vol 1, No 2 (2016): JK UNILA
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v1i2.1648

Abstract

Diabetes mellitus (DM) didefinisikan sebagai suatu penyakit metabolisme kronis yang multi etiologi ditandai dengan peningkatan kadar glukosa darah (hiperglikemia) (glukosa puasa ≥ 126 mg/dl atau glukosa sewaktu ≥ 200 mg/dl) yang disertai dengan gangguan metabolisme karbohidrat, protein dan lipid sebagai akibat insufisiensi fungsi insulin. Penelitianepidemiologi menunjukkan kecenderungan peningkatan angka insidensi dan prevalensi DM tipe 2 di berbagai penjuru dunia. Penyakit ini juga masih menjadi salah satu penyebab kematian terbesar di Indonesia, bahkan juga di dunia. Insidensi tingginya angka kematian akibat penyakit ini kebanyakan disebabkan oleh komplikasi multi organ. Selain itu, penyakit ini tidak bisa sembuh sehingga membutuhkan terapi seumur hidup. Oleh karena itu, sangat diperlukan suatu obat yang tepat sasaran, minimal efek samping dan terjangkau, salah satunya adalah dengan obat-obatan herbal. Salah satu tanaman herbal yang dianggap memiliki potensi sebagai antihiperglikemia adalah daun salam (Syzygium polyanthum). Daun salam merupakan tanaman yang umum dan mudah dijumpai di Indonesia. Tulisan ini bertujuan untuk melihat potensi efek ekstrak daun salam terhadap kadar glukosa dalam darah. Beberapa hasil penelitian yang telah dilakukan menunjukkan bahwa kandungan utama senyawa flavonoid dalam ekstrak daun salam dapat menurunkan kadar glukosa darah secara signifikan. Senyawa glikosida flavonoid yang terdapat pada daun salam berfungsi sebagai penangkap radikal hidroksil sehingga dapat mencegah aksi diabetogenik. Dengan demikian, daun salam sangat berpotensi untuk dikembangkan lebih lanjut menjadiobat herbal untuk mencegah dan mengobati kondisi hiperglikemia. [JK Unila. 2016; 1(2)]Kata kunci: flavonoid, hiperglisemia, daun salam, glukosa, obat herbal, diabetes mellitus
Antifungi Effect of Keghenyat Leaves Fraction (Acmella uliginosa) In Vitro Study Agustina Septi Hijir; Salni Salni; Joko Marwoto; Triwani Triwani; Sri Nita; Mgs Irsan Saleh; Ziske Maritska; Nita Parisa; Evi Lusiana; Nia Savitri Tamzil; Ayeshah Augusta Rosdah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 1 No. 1 (2017): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v1i1.5

Abstract

Introduction Candida is a yeast fungus classes most commonly found in the oral cavity, gastrointestinal tract, reproductive tract and skin, especially the species Candida albicans. Alternative medicines such as herbs are easily available and affordable by the community, such as keghenyat leaves (Acmella uliginosa). Aim of StudyTo determine the activity of Keghenyat leaves fraction (Acmella uliginosa) compared to Nystatin against Candida albicans in vitro. MethodsIn vitro study was held in Laboratory of Genetics and Biotechnology Department of Biology, Faculty of Science and Medical Faculty, Sriwijaya University in December 2015 and January 2016. Research stages: extraction, fractionation, sensitivity test using Nystatin and Candida albicans, fractions antifungal activity test, the determination of minimum inhibitory concentration (MIC), bioautografi test and determination of compound classes. One final stages of testing the active fraction Keghenyat leaves (Acmella uliginosa) with Nystatin. Data were analyzed using ANOVA and Post Hoc Duncan test and linear regression using SPSS 20. ResultsHexane faction of Keghenyat leaves (Acmella uliginosa) is active against the fungus Candida albicans, has a Minimum Inhibitory Concentration (MIC) of 0.625% (6250μl) against the fungus Candida albicans antifungal contain active compounds that terpenoids and flavonoids, amounting to 84.68 mg / ml equivalent to 1 mg / ml Nystatin against the fungus Candida albicans. ConclusionThere is a significance different MIC between hexane fraction of Keghenyat leaves (Acmella uliginosa) and Nystatin, Nystatin have more high activity.
Co-Authors ., Mariana Abdulwahab Hakimi Adenina, Masayu S Agustina Septi Hijir Aini, Nurlutfiyyah Aisyah Fristania Ditamor Alfiyah Munawwaroh Abdullah Alwi Shahab Amira Azra Arisa Putri Amirah Dhia Nabila Sinum Anisah Nida'ul Haq Aprilia Paskah Samosir Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardy Oktaviandi Arroyantri Prananjaya, Bintang Athiah, Medina Atikah M. Ihsan Ayeshah A Rosdah Az Zahra, Zaviera Azizah, Aida Nur Bagaskara, Surya Bintang Arroyantri Bintang Arroyantri P Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Carissa Delania Chris Alberto Amin Citra Yuliana Clara Alverina Dara Prameswari Debby Handayati Harahap Desi Oktariana Diah Andini Diba, Msy. Farah Diyaz Syauki Ikhsan Dwi Tantri Marylin Eka Febri Zulissetiana Ella Amalia, Ella Emelda Emelda Eskalatin, Khaira Evi Lusiana Fakhri Abdurrahman Fakhri Abdurrahman Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati, Fatmawati Febryana Ramadhani Machyar Gita Dwi Prasasty Gita Dwi Prasasty Haq, Anisah Nida'ul Hawari Martanusa Ina Rahmawati Indri Seta Septadina Inggarsih, Rara Irga, Muhammad Islami, Arya Putera Izzah, Puspita Nurul Jayawarsa, A.A. Ketut Joko Marwoto Kamaluddin, Muhammad Totong Karina Nurul Fahira Karina, Mathius Kemas Muhammad Deky Berryl Ananta Putra Larasati, Veny Leonardo Satria Lusia Hayati Lusia Hayati, Lusia M. Ivan Pratama M. Khairul Kahfi Pasaribu M. T. Kamaluddin M. T. Kamaluddin M. Totong Kamaluddin Manurung, Maya Rina Santara Maria Sidabutar, Carolina Marlyani Tamara Mayasari Mayasari Mgs Irsan Saleh Mgs Irsan Saleh Mgs. Irsan Saleh Mgs. Irsan Saleh, Mgs. Irsan Mohammad Hilal Atthariq Ramadhan MT Kamaluddin Muhammad Barkah Muhammad Fakhri Altyan Muhammad Irsan Saleh Muhammad Reagen Muhammad Totong Kamaluddin Muhammad Totong Kamaluddin Muhammad Yusuf Wijahaska Nabila, Safa Putri Nadhila Apriadhanti Nafrah Ardita Nashif, Arkan Abdullah Nia Savitri Tamzil Noviyanti Eliska, Noviyanti Nugraha, M Daffa Oktariana, Desi pariyana, Pariyana Pasaribu, Rouly Pola Perawati Perawati Perryanis Perryanis Perryanis, Perryanis Prananjaya, Bintang A Prananjaya, Bintang Arroyantri Puji Rizki Suryani Purnamasari, Septi Putra, Marco Manza R.A. Alda Adelia Rachmat Hidayat RACHMAT HIDAYAT Rachmat Taufan Radiyati Umi Partan Rahma Nur Islami Rahmat Hidayat Rahmat Hidayat Rahmi Isman Rasyid, Riana Sari Puspita Rini Nindela Rini Nindela Rio Dwi Arliansyah Rischka Salsabila Maulini Rohaya Rohaya Rosdah, Ayesha Augusta Rovania Yantinez Quardetta Rovania Yantinez Quardetta Rulan Adnindya Safira Azahra Saleh, M. Irsan Saleh, Masagus I Salni Salni Salni Salni Salni Samantha Ferlin Boentara Samantha Ferlin Boentara Saputra, Andre Sativandi Riza Sindy Bintang Permata Siti Rusdiana Puspa Siti Rusdiana Puspa Dewi Smaradhna, Safira Sri Nita Sri Nita Subandrate Sutandar, Vivi Hendra Syarinta Adenina Syifa Syifa Syifa Tahany, Hanifah Tantoro, Valyn T Theodorus Theodorus Theodorus Parulian Theodorus Parulian Theodorus Theodorus Theodorus Theodorus Theodorus Theodorus Tiara Fatrin Tri Wahyuni tri wahyuni Triwani Triwani Triwani Triwani Triwani Triwani Triwani Triwani Try Merdeka Puri Tryvanie R Putra Uswati Uswati Valentino, Albert Amadeus Venny Larasati Vincensius Hans Kristian Pratama Wicaksono, Bonanza Abi Wildan Dwi Putra Widodo Yeni Agustin Yeni Agustin Yeni Agustin Yuliana, Citra Yuliarni Yuliarni Yuliarni Yuliarni Zabila Adwie Prilishia Ziske Maritska