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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Global Medical and Health Communication Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Medical Laboratory Technology Journal Indonesian Journal for Health Sciences (IJHS) SRIWIJAYA JOURNAL OF MEDICINE Jurnal Jamu Indonesia Jurnal Mandala Pharmacon Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientia Psychiatrica Indonesian Journal of Anesthesiology and Reanimation (IJAR) JK Unila (Jurnal Kedokteran Universitas Lampung) Eureka Herba Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine Journal of Community Development Indonesian Community Empowerment Journal Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Arkus Wal'afiat Hospital Journal International Journal of Islamic and Complementary Medicine Conferences of Medical Sciences Dies Natalis Sriwijaya Journal of Dentistry WAL'AFIAT HOSPITAL JOURNAL Biomedika Media Penelitian dan Pengembangan Kesehatan Indonesian Journal of Jamu Journal of Medicine and Health
Nita Parisa
Department Of Pharmacology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
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Identifikasi Polimorfisme Gen mTOR rs 2536 dan rs 2295080 serta Ekspresi ER, PR, HER-2, Ki-67 pada Penderita Kanker Payudara Anisah Nida'ul Haq; Triwani; Nita Parisa
Sriwijaya Journal of Medicine Vol. 2 No. 3 (2019): Vol 2, No 3, 2019
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v2i3.53

Abstract

Kanker payudara adalah suatu penyakit keganasan yang berasal dari transformasi neoplastik sel-sel epitelial, sebagai akibat akumulasi perubahan genetik, epigenetik dan lingkungan yang dibuktikan dengan pemeriksaan histopatologi. Kanker payudara menempati urutan pertama sebagai jenis kanker yang paling umum diderita oleh perempuan di dunia. Salah satu predisposisi genetik yang berperan pada terjadinya kanker payudara adalah polimorfisme gen mTOR yang terjadi pada 3’-UTR dan regio promoter. Polimorfisme gen mTOR akan menyebabkan aktivasi proses transkripsi gen mTOR secara terus-menerus sehingga terjadi proliferasi dan diferensiasi sel yang abnormal. Penelitian ini bertujuan untuk mengidentifikasi polimorfisme gen mTOR rs 2536 dan rs 2295080 serta ekspresi ER, PR, HER-2 dan Ki-67 pada penderita kanker payudara di Rumah Sakit Mohammad Hoesin Palembang. Penelitian ini adalah penelitian laboratorium berjenis deskriptif observasional dengan teknik PCR-RFLP menggunakan enzim EcoRI dan FokI terhadap 33 penderita kanker payudara berdasarkan metode purposive sampling. Polimorfisme gen mTOR rs 2536 paling banyak terdapat pada genotip mutan homozigot (CC) yaitu terdapat pada 27 orang (81,8%) dengan frekuensi alel C sebesar 89,4% sementara alel T hanya 10,6%. Genotip yang paling banyak ditemukan pada polimorfisme gen mTOR rs 2295080 adalah wild type(TT) yang terdapat pada 19 orang (57,6%) dengan frekuensi alel T sebesar 63,6% sementara alel G sebanyak 36,4%. Data dari bagian Patologi Anatomi menunjukkan adanya kecendrungan meningkatnya ekspresi Ki-67, ER, PR dan HER-2 pada polimorfisme gen mTOR rs 2536 dan rs 2295080. Polimorfisme gen mTOR rs 2536 (CC) pada kanker payudara lebih banyak dibanding polimorfisme gen mTOR rs 2295080 (GG).
Profil Hormon Penderita Disorder of Sex Development (DSD) di RSUP. Dr. Mohammad Hoesin Palembang Ziske Maritska; Bintang Arroyantri Prananjaya; Nita Parisa; Rovania Yantinez Quardetta
Biomedical Journal of Indonesia Vol. 5 No. 2 (2019): Vol 5, No 2, 2019
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Selain berdasarkan temuan klinis, penentuan diagnosis Disorders of sex development (DSD) juga didukung oleh ragam pemeriksaan penunjang seperti analisis kromosom, radiologi, dan pemeriksaan laboratorium yang salah satunya berupa pemeriksaan kadar hormon. Pemeriksaan kadar hormon dapat memberikan gambaran fungsi gonadal dan adrenal, yang bermanfaat baik untuk penapisan dan juga penentuan diagnosis DSD. Studi yang bertujuan untuk mengidentifikasi profil hormon pasien DSD di Indonesia masih sangat minim, dan studi ini merupakan studi pertama yang meninjau profil hormon DSD di RSUP Dr. Mohammad Hoesin Palembang. Studi ini merupakan studi deskriptif menggunakan data sekunder dari rekam medik pasien DSD yang menjalani pemeriksaan hormon selama periode 2013-2017. Dari total 173 pasien DSD yang datang berobat ke RSUP Dr. Mohammad Hoesin Palembang selama lima tahun terakhir, hanya 22 (12.72%) pasien yang menjalani pemeriksaan hormon. Ada 13 profil hormon yang diperiksa pada pasien DSD di RSUP Dr. Mohammad Hoesin Palembang dengan hormon testosteron (54.54%) sebagai hormon yang paling sering diperiksa. Pemeriksaan profil hormon sebagai salah satu alat bantu penapisan dan penegakkan diagnosa DSD belum menjadi salah satu pemeriksaan penunjang yang umum dilakukan di RSUP Dr. Mohammad Hoesin Palembang.
Efek Ekstrak Buah Ciplukan (Physallis peruvenia) Pada Kadar T4 Tikus Putih Nita Parisa
Biomedical Journal of Indonesia Vol. 5 No. 3 (2019): Vol 5, No 3, 2019
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i3.9872

Abstract

Hipertiroid adalah suatu kondisi dimana terjadi peningkatan sintesis dan sekresi hormon tiroid sehingga kadar hormon tiroid dalam darah meningkat. Pada tahun 2013 didapatkan data 0,4% penduduk Indonesia mengalami hipertiroid. Buah ciplukan (Physalis peruviana) merupakan herba Indonesia yang diduga memiliki efek terhadap hormon tiroid. Jenis penelitian adalah eksperimental in vivo dengan subyek penelitian berupa tikus putih galur Wistar berjumlah 30 ekor yang dibagi menjadi 5 kelompok yaitu kontrol negatif (Akuades), kontrol positif (PTU 100 mg/kgBB), kelompok 3, 4, dan 5 ekstrak buah Ciplukan dengan dosis 250 mg, 500 mg, dan 1000 mg per kilogram berat badan. Hasil pemeriksaan menunjukkan terjadi penurunan kadar T4 pada perlakuan dengan kontrol positif dan pemberian eksrak buah ciplukan. Terdapat perbedaan penurunan kadar T4 untuk kelompok pemberian ekstrak buah ciplukan dosis 1, 2, dan 3 (p<0,05). Dapat disimpulkan bahwa ekstrak buah Ciplukan dengan dosis 250 mg/kgBB, 500 mg/kgBB, dan 1000 mg/kgBB memiliki potensi sebagai anti hipertiroid.
Profil risiko sindrom metabolik pada komunitas Majelis Taklim Nurul Hikmah Palembang Nita Parisa; Masagus Irsan Saleh; Ziske Maritska; Bintang Arroyantri Prananjaya; Veny Larasati
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 1 No 1 (2020): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V1I1.2

Abstract

The incidence of Metabolic Syndrome is 20-25% in the world and 13.13% in Indonesia. Metabolic syndrome is not a diagnosis but a collection of various symptoms that can develop into diseases or chronic conditions such as hypertension, hypercholesterolemia and diabetes mellitus (DM), which results in cardioserebrovascular disease. Metabolic Syndrome is more common in women than men. This community service is carried out at the request of the Taklim Assembly ladies Nurul Hikmah in the neighborhood of RW.15 Unsri lecturer’s residents, Bukit Lama, Ilir Barat 1 Palembang, mostly aged over 40 years. In this activity it was found that the majority of participants' awareness of the dangers of Metabolic Syndrome was still low. This is indicated by the number of participants who had excess body weight and waist circumference (44.29%), increased blood pressure (45.71%) and increased cholesterol levels (77.14%). The participants felt very helped and hoped that these community service activities or similar could be routinely carried out in the future.
Edukasi pencegahan sindrom kelelahan (burnout) pada karyawan Pertamina MOR II Palembang veny larasati; Bintang Arroyantri P; Ziske Maritska; Nita Parisa; Diyaz Syauki Ikhsan
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 1 No 3 (2020): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V1I3.13

Abstract

Education for Preventing Burnout Syndrome to Pertamina MOR II Palembang workers. Burnout is a syndrome that occurs due to prolonged interpersonal stress due to work. Burnout can also be described as psychological fatigue caused by work. This can occur due to the high demands of the company to provide optimal work results that the employees cannot tolerate. There are three things that can trigger this syndrome, namely excessive workload, neglect of work results and feelings of underappreciation at work. Based on a survey conducted in America, the main reason of stress was due to excessive workload, 1 in 5 employees experienced burnout syndrome which is around 46%, and in Indonesia, the survey results showed that around 64% of employees experienced increased fatigue due to work, and around 20% of employees believed that psychological fatigue is the cause of the absence of employees due to illness in the company. This community service is carried out at the request of the PERTAMINA Palembang Company. Burnout syndrome is a serious problem for employees and employers. If not addressed properly, it will lead to serious psychological problems for employees such as decreased productivity, withdrawal from work, depression and even anxiety, which in turn can have a negative impact on the company. For this reason, it is necessary to have monitoring and evaluation related to the psychological condition of employees on a regular basis.
PHYSICAL COMORBIDITIES IN CHILDREN WITH AUTISM SPECTRUM DISORDERS Ziske Maritska; Rahmi Isman; Bintang Arroyantri Prananjaya; Nita Parisa
Indonesian Journal for Health Sciences Vol 6, No 2 (2022): September
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ijhs.v6i2.4615

Abstract

Autism Spectrum Disorders (ASD) is a neurodevelopmental disorder characterized by two core symptoms; impairments in social communication and restricted or repetitive behavior. ASD is a broad group of conditions where patients have a variety of abilities and needs. Their ASD related-physical and psychological comorbidities also affect their mortality risk. This study wished to investigate physical comorbidities associated with ASD in the national reference hospital in Indonesia. This is a descriptive study with a cross-sectional approach on children with ASD who visited RSUP Dr. Mohammad Hoesin, Palembang, during 2014-2018. Data were obtained from the medical records and telephone interviews with the parents. Of all the 60 participants included in the study, most are male (n=52;86,7%). The most prevalent ASD-related physical comorbidities were gastrointestinal disorders (n=27;45%), followed by nervous system disorders (n=35;58,3%), and immune system disorders (n=11;18,3%). Despite the small sample size, the prevalence of ASD-related physical comorbidities in children with ASD is profoundly high, implying the need to do early detection from both parents and health professionals to prevent morbidity and complications that may occur. Children with autism can benefit from various therapies start in early childhood and continue throughout their lives to improve their development, and quality of life.
DRUG PATTERN STUDY ON ANGIOTENSIN II RECEPTOR BLOCKER IN OUTPATIENTS AT MOHAMMAD HOESIN HOSPITAL PALEMBANG Samantha Ferlin Boentara; Nita Parisa; Theodorus Theodorus
Majalah Kedokteran Sriwijaya Vol 54, No 4 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i4.19664

Abstract

Hypertension is a global health problem due to its increasing prevalence. Hypertension is a condition where there is a persistent increase in blood pressure exceeding 140/90 mmHg. Among the many choices of antihypertensive drug classes, ARB is one of the first-line drug classes for the treatment of hypertension. Inappropriate ARB administration can reduce the effectiveness of treatment and harm the patient. This study aims to determine the pattern of ARB use in hypertensive patients. This drug pattern study has been done on October – November 2021 at the Outpatient Department of Dr. Mohammad Hoesin Central Public Hospital Palembang. The sample was using the medical record data of all hypertensive patients’ period of July – December 2020 who met the inclusion criteria, with a total of 171 data. The data was processed by using the SPSS v25 and presented in the form of a table with a descriptive explanation referring to the research variables. This study found that the prevalence of ARB use was 59.0% with the highest was in male (30.4%) and age group 41-60 years (29.2%). The most widely used ARB is candesartan (94.0%) at a dose of 16 mg (52.6%), frequency once a day (97.9%) and duration more than one month (93.7%). The drug prescribed to the patient mostly didn’t have interaction with ARB (33.0%). The prevalence of ARB administration is high in hypertensive patients (59.0%) with the most commonly used ARB is candesartan (94.0%).
Drug Pattern Study on ARB at the Outpatient Department of Mohammad Hoesin General Public Hospital Palembang Samantha Ferlin Boentara; Nita Parisa; Theodorus Parulian
Majalah Kedokteran Sriwijaya Vol 54, No 4 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i4.18899

Abstract

Backgrounds. Hypertension is a global health problem due to its increasing prevalence. Hypertension is a condition where there is a persistent increase in blood pressure exceeding 140/90 mmHg. Among the many choices of antihypertensive drug classes, ARB is one of the first-line drug classes for the treatment of hypertension. Inappropriate ARB administration can reduce the effectiveness of treatment and harm the patient. This study aims to determine the pattern of ARB use in hypertensive patients. Methods. This drug pattern study has been done on October – November 2021 at the Outpatient Department of Dr. Mohammad Hoesin Central Public Hospital Palembang. The sample was using the medical record data of all hypertensive patients period of July – December 2020 who met the inclusion criteria, with a total of 171 data. The data was processed by using the SPSS v25 and presented in the form of a table with a descriptive explanation referring to the research variables. Results. This study found that the prevalence of ARB use was 59.0% with the highest was in male (30.4%) and age group 41-60 years (29.2%). The most widely used ARB is candesartan (94.0%) at a dose of 16 mg (52.6%), frequency once a day (97.9%) and duration more than one month (93.7%). The drug prescribed to the patient mostly didn’t have interaction with ARB (33.0%). Conclusions. The prevalence of ARB administration is high in hypertensive patients (59.0%) with the most commonly used ARB is candesartan (94.0%).
GENETICS OF DEMENTIA: THE CANDIDATE GENES AND AVAILABLE GENETIC TESTINGS Ziske Maritska; Diah Andini; Febryana Ramadhani Machyar; Rachmat Taufan; Try Merdeka Puri; Tryvanie R Putra; Uswati Uswati; Bintang Arroyantri Prananjaya; Rini Nindela; Nita Parisa
Indonesian Journal for Health Sciences Vol 7, No 2 (2023): September
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ijhs.v7i2.6353

Abstract

When dementia is present, a person's memory, reasoning, behavior, and even their capacity to carry out day-to-day chores can all become distorted. This syndrome remains present and actually worsens as time passes. It's possible that synapse loss, death and dysfunction of brain cells, gliosis, and inflammation are all factors in the progression of dementia. The clinical syndrome, age, and a history of the ailment in the patient's family should dictate the choices made about counseling and testing. Dementia is known as a multifactorial condition, brought on by the combination of strong genetic factors and environmental factors. There are several candidate genes  associated with Dementia; APP, PSEN1, and PSEN2 genes, in addition to the GRN and MAPT genes. This literatura review provide insight on the genetic of Dementia, particularly in the genetic causes and testings
THE POTENTIAL OF BAY LEAVE (SYZYGIUM POLYANTHUM) AS AN ANTI-DIABETIC AGENT Wildan Dwi Putra Widodo; Nita Parisa; Nia Savitri Tamzil; Evi Lusiana; Nafrah Ardita; Amira Azra Arisa Putri; Sindy Bintang Permata; Aisyah Fristania Ditamor
International Journal of Islamic and Complementary Medicine Vol. 4 No. 2 (2023): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/IJICM.V4I2.60

Abstract

Non-communicable disease prevalence continues to increase in Indonesia. One of the top 10 causes of death is non-communicable disease, and diabetes mellitus is on the list. Genetics, advanced age, obesity, stress, hypertension, smoking, and physical inactivity are risk factors that might result in diabetes mellitus. Despite advancements in mainstream anti-diabetic treatment, traditional medical practices continue to exist in several nations. Syzygium polyanthum is the herb that diabetic patients most frequently utilize in the traditional therapy of their illness, according to research on diabetic patients at the Health Community Center in Sering, Medan, Indonesia. The research team was interested in figuring out whether bay leaves showed any potential as an anti-diabetic agent based on the previous description. In this study, secondary literature from research publications is used in a literature review with a descriptive method. Several studies have suggested that bay leaves could potentially be used for the prevention and treatment of diabetes mellitus.
Co-Authors ., Mariana Abdulwahab Hakimi Adenina, Masayu S Adnindya, Msy. Agustina Septi Hijir Aini, Nurlutfiyyah Aisyah Fristania Ditamor Alfiyah Munawwaroh Abdullah Alwi Shahab Amira Azra Arisa Putri Amirah Dhia Nabila Sinum Anisah Nida'ul Haq Aprilia Paskah Samosir Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardy Oktaviandi Arroyantri Prananjaya, Bintang Athiah, Medina Atikah M. Ihsan Ayeshah A Rosdah Az Zahra, Zaviera Azizah, Aida Nur Bagaskara, Surya Bintang Arroyantri Bintang Arroyantri P Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Carissa Delania Chris Alberto Amin Citra Yuliana Clara Alverina Dara Prameswari Debby Handayati Harahap Desi Oktariana Diah Andini Diba, Msy. Farah Diyaz Syauki Ikhsan Dwi Tantri Marylin Eka Febri Zulissetiana Ella Amalia, Ella Emelda Emelda Eskalatin, Khaira Evi Lusiana Fakhri Abdurrahman Fakhri Abdurrahman Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati, Fatmawati Febryana Ramadhani Machyar Gita Dwi Prasasty Gita Dwi Prasasty Hanifah, Masayu Haq, Anisah Nida'ul Harahap, Debby Hasbi, Alfian Hawari Martanusa Ina Rahmawati Indri Seta Septadina Inggarsih, Rara Irga, Muhammad Islami, Arya Putera Izzah, Puspita Nurul Jayawarsa, A.A. Ketut Joko Marwoto Kamaluddin, Muhammad Totong Karina Nurul Fahira Karina, Mathius Kemas Muhammad Deky Berryl Ananta Putra Larasati, Veny Leonardo Satria Lusia Hayati Lusia Hayati, Lusia M. Ivan Pratama M. Khairul Kahfi Pasaribu M. T. Kamaluddin M. T. Kamaluddin M. Totong Kamaluddin Manurung, Maya Rina Santara Maria Sidabutar, Carolina Marlyani Tamara Mayasari Mayasari Mgs Irsan Saleh Mgs Irsan Saleh Mgs. Irsan Saleh Mgs. Irsan Saleh, Mgs. Irsan Mohammad Hilal Atthariq Ramadhan MT Kamaluddin Muhammad Barkah Muhammad Fakhri Altyan Muhammad Irsan Saleh Muhammad Reagen Muhammad Totong Kamaluddin Muhammad Totong Kamaluddin Muhammad Yusuf Wijahaska Nabila, Safa Putri Nadhila Apriadhanti Nafrah Ardita Nashif, Arkan Abdullah Nia Savitri Tamzil Noviyanti Eliska, Noviyanti Nugraha, M Daffa Nurhaura, Nailah Oktariana, Desi pariyana, Pariyana Pasaribu, Rouly Pola Perawati Perawati Perryanis Perryanis Perryanis, Perryanis Prananjaya, Bintang A Prananjaya, Bintang Arroyantri Puji Rizki Suryani Purnamasari, Septi Putra, Marco Manza Putri , Marsyadilla R.A. Alda Adelia Rachmat Hidayat RACHMAT HIDAYAT Rachmat Taufan Radiyati Umi Partan Rahma Nur Islami Rahmat Hidayat Rahmat Hidayat Rahmi Isman Rasyid, Riana Sari Puspita Rini Nindela Rini Nindela Rio Dwi Arliansyah Rischka Salsabila Maulini Rohaya Rohaya Rosdah, Ayesha Augusta Rosdah, Ayeshah Rovania Yantinez Quardetta Rovania Yantinez Quardetta Rulan Adnindya Safira Azahra Saleh, M. Irsan Saleh, Masagus I Salni Salni Salni Salni Salni Samantha Ferlin Boentara Samantha Ferlin Boentara Saputra, Andre Sativandi Riza Sindy Bintang Permata Siti Rusdiana Puspa Siti Rusdiana Puspa Dewi Smaradhna, Safira Sri Nita Sri Nita Subandrate Sutandar, Vivi Sutandar, Vivi Hendra Syarinta Adenina Syifa Syifa Syifa Tahany, Hanifah Tantoro, Valyn T Theodorus Theodorus Theodorus Parulian Theodorus Parulian Theodorus Theodorus Theodorus Theodorus Theodorus Theodorus Tiara Fatrin tri wahyuni Tri Wahyuni Triwani Triwani Triwani Triwani Triwani Triwani Triwani Triwani Try Merdeka Puri Tryvanie R Putra Uswati Uswati Valentino, Albert Amadeus Venny Larasati Vincensius Hans Kristian Pratama Wicaksono, Bonanza Abi Wildan Dwi Putra Widodo Yeni Agustin Yeni Agustin Yeni Agustin Yuliana, Citra Yuliarni Yuliarni Yuliarni Yuliarni Zabila Adwie Prilishia Ziske Maritska