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All Journal Jurnal Kesehatan Andalas Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kesehatan Medika Saintika Jurnal Kreativitas PKM Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Kidney and Hypertension Human Care Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health Nusantara Hasana Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Multidisciplinary Science Jurnal Ilmu Kesehatan Indonesia (JIKSI) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Sciences of Pharmacy Eduvest - Journal of Universal Studies Jurnal Penyakit Dalam Indonesia Oshada Media Penelitian dan Pengembangan Kesehatan Proceeding International Health Conference
Harun Harnavi
Fakultas Kedokteran Universitas Andalas
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Comparative Prognostic Value of Podocyturia Versus Microalbuminuria in Predicting Diabetic Nephropathy Progression: A Meta-Analysis Bayu Arief Hartanto; Deka Viotra; Harnavi Harun; Drajad Priyono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1578

Abstract

Background: Diabetic nephropathy represents the primary etiology of end-stage renal disease globally. Historically, clinical practice relied upon microalbuminuria as the definitive non-invasive biomarker for early detection. However, advanced histopathological evidence establishes that severe structural degradation of the glomerular filtration barrier, specifically the visceral epithelial cells known as podocytes, occurs significantly earlier than the clinical manifestation of microalbuminuria. Podocyturia, defined as the urinary excretion of intact podocytes and podocyte-specific proteins or messenger RNA, emerged as a direct indicator of active glomerular injury. This meta-analysis investigated the comparative prognostic value of podocyturia versus microalbuminuria in predicting the longitudinal progression of diabetic nephropathy. Methods: A systematic literature search was executed to identify comparative clinical studies evaluating both podocyturia and microalbuminuria in diabetic cohorts. Seven essential manuscripts met rigorous inclusion criteria. Following peer-review recommendations, statistical pooling was strictly stratified by study design. Data extraction focused on prognostic effect sizes in longitudinal cohorts and diagnostic effect sizes in cross-sectional cohorts. Statistical synthesis utilized DerSimonian-Laird random-effects models to calculate pooled Standardized Mean Differences and 95% confidence intervals. Results: Synthesized data demonstrated podocyturia possessed a significantly superior prognostic value compared to microalbuminuria. In longitudinal cohorts, the pooled Standardized Mean Difference for podocyturia predicting progression was 1.95 (95% CI: 1.50 to 2.40, p < 0.001), whereas microalbuminuria was 0.58 (95% CI: 0.25 to 0.91, p = 0.04). Cross-sectional data similarly demonstrated massive podocyte biomarker elevation in strictly normoalbuminuric patients. Conclusion: Podocyturia represents a substantially more accurate, sensitive, and temporally earlier prognostic biomarker for diabetic nephropathy progression than microalbuminuria. Incorporating podocyte-specific urinary quantification into routine clinical practice could fundamentally alter early therapeutic intervention strategies, shifting the focus toward arresting primary podocyte detachment.
Correlation Between Oxidative Stress, SIRT1 Serum Level, and eGFR on Elderly Harnavi Harun; Evelin Veronike; Alexander Kam; Rinita Amelia
Jurnal Penelitian Pendidikan IPA Vol 9 No 8 (2023): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i8.4916

Abstract

The aging network kidney causes Oxidative Stress (OS) and damages the kidney. Studies of aging kidneys keep going growing by developing sirtuin as an antiaging. Sirtuin 1 (SIRT1) is a protein implicated in several disorders including diabetes functions as an anti-aging protein. Decreased eGFR in the elderly caused by his height prevalence factor risk disease kidney at an older age. The study aims to study the correlation between oxidative stress, SIRT1 serum levels, and eGFR in the elderly.  The method used in this research is observational with the cross-sectional method. The sample in this study was the whole elderly who met the inclusion and exclusion criteria, totaling 30 people. Exclusion criteria are patients with glomerulonephritis, nephropathy obstruction, nephropathy sour veins, and obesity. All patients complied requirements asked to fill informed consent form. The inspection was carried out by urinalysis ultrasound kidney and assessing serum MDA levels which were found to be higher in this study. This study showed SIRT1 and eGFR levels decreased in the elderly. There was a negative correlation with moderate correlation strength between serum MDA levels and serum SIRT1 levels and a strong correlation between serum MDA levels and eGFR in the elderly. There was a positive correlation with a moderate correlation between serum SIRT1 levels and eGFR in the elderly. SIRT1 is suggested to be examined in elderly patients with decreased eGFR, even without comorbidity.
Co-Authors -, Sari Setiarini Abdul Alim Rahimi Abdul Alim Rahimi Ade Asyari Ade Sukma Ade Teti Vani Afdhol Falah Afrah Diba Faisal Ajat Sudrajat Akmal M Hanif Alexander Kam Alexander Kam Alexander Kam Alvarino Alvarino Alyu, Hanifa Amelia, Rinita Anandia Putriyuni Andikha Putra Annesa Fadella Arief Rinaldy Arina Widya Murni Arnelis Arnelis Asir, Taufik Rizkian Athif Abyaz Khalil Putra ayu pathya Bayu Arief Hartanto Dasman, Hardisman Deddy Canceria Suka Rahmatsyah Deka Viotra Deka Viotra Dela Hangri Jalmas Dessy Abdullah Dewi, Amelia Fitria Dian Puspita Diana Melida Dinda Aprilia Dional Setiawan Drajad Priyono Drajad Priyono Drajad Priyono Eryati Darwin Evelin Veronike Evelin Veronike Fadrian, Fadrian Faheri, Eifel Fauzar Fauzar Fauzar Fauzar Fauzar, Fauzar Febrianti Ika Kurnia Finny Fitry Yani Genta Pradana gina ariani Hannie Qalbina Syaiful Hardisman Dasman Husna Yetti Ilmiawati Ilmiawati, Ilmiawati Indra, Syarif Indrapriyatna, Ahmad Syafruddin Ira Suryanis Irena Fathin Amelia Jalmas, Dela Hangri Jersivindo Ranazeri Jersivindo Ranazeri Kam Alexander Kam, Alexander Karmia, Rofila Dita Khairat AS Khairil Faiz Amir Kino Kino Miftah Irramah Mufidah, Athasya Aulia Murni, Arina W Nadia Purnama D Najirman, Najirman Naufal Fathi Ashari Nur Indrawaty Lipoeto Pratama, Yudha Endra Priyono, Drajad Putra, Mindy Pasuma Putri Lisna Radias Zasra Radias Zasra Rangga Lunesia Rapida Saragih RAVEINAL RAVEINAL Restu Susanti Rezki Sadeli Rini Yulia Rinita Amelia Rinita Amelia Rivai, Muhammad Iqbal Rizkianto Imannual Rose Dinda Martini Roslaini Roslaini Roza Kurniati Roza Kurniati Roza Kurniati Roza Kurniati Roza Mulyana Ruhsyahadati Ruhsyahadati Ruhsyahadati, Ruhsyahadati Rusdi, Faza Yasira Russilawati Selfi Renita Rusjdi Siana, Yusti Simajuntak, Rohayat Bilmahdi Sjaaf Fidiariani SM Rezvi Sofiani, Dinda Putri Sri Puji Rahayuningsih Suchitra, Avit Syaiful Azmi Syaiful Azmi Syaiful Azmi Syaiful Azmi Syaiful, Hannie Q Veronike, Evelin Vesri Yoga Vidiansyah, Achmad Wahyudi, Adefri Yanuar Surya Saputra Poedjijo Yerizal Karani Yudha E. Pratama Yudha Endra Pratama Yugo Berri Putra Rio Yuliarni Syafrita Yulistia Asmi Yusti Siana Zaki Mahmudi Dasril Zaki Mahmudi Dasril Zaki Mahmudi Dasril