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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) JMM (Jurnal Masyarakat Mandiri) Pharmasipha Jambura Journal of Health Sciences and Research Jambura Journal of Chemistry Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Indonesian Journal of Pharmaceutical Education Indonesian Community Journal Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products
Mahdalena Sy Pakaya
UNIVERSITAS NEGERI GORONTALO
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Formulasi Sampo Kombinasi Ekstrak Seledri (Apium graveolens) dan Ekstrak Kayu Manis (Cinnamomum burmanii) Serta Uji Aktivitasnya pada Jamur AM. Andy Suryadi; Muhammad Taupik; Mahdalena SY. Pakaya; Endah Nurrohwinta Djuwarno; Juliyanty Akuba
Jambura Journal of Chemistry Vol 3, No 2 (2021): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v3i2.11199

Abstract

Rambut merupakan salah satu bagian vital pada tubuh yang berasal dari ektoderm di kulit dan juga sebagai pelengkap pelindung pada tubuh (aksesoris). Masalah pada rambut dan kulit kepala yang sering terjadi adalah ketombe. Gejala umum yang sering terjadi yaitu mulai timbulnya sisik-sisik putih pada kulit kepala, gatal, dan juga bisa juga disertai dengan kerontokan rambut. Hal ini disebabkan karena adanya beberapa mikroorganisme yang terdapat pada ketombe seperti Malassezia furfur dan Candida albicans. Tanaman yang kaya senyawa flavonoid diketahui memiliki aktivitas sebagai anti bakteri dan anti jamur. Penggunaan formulasi herbal dapat dijadikan sebagai alternatif yang baik untuk terapi dalam mengatasi mikroorganisme yang terdapat pada ketombe. Di Indonesia, seledri dan kayu manis secara tradisional dapat digunakan untuk mengatasi pertumbuhan jamur. Pada penelitian ini memformulasikan sampo kombinasi antara ekstrak seledri dan ekstrak kayu manis sebagai anti jamur dalam bentuk sedian gel. Hasil evaluasi fisik menunjukkan formula gel memiliki stabilitas yang baik. Aktivitas anti jamur dari kombinasi ekstrak seledri dan ektrak kayu manis mempunyai daya hambat paling besar dengan pengulangan berturut-turut pada jamur Mallasezia furfur (35mm; 34mm; 35mm) dan pada jamur Candida albicanus (30mm; 31mm; 30mm) dengan konsentrasi (20%; 20%).
Analisis Kadar Senyawa Rhodamin B Pada Sediaan Lipstik Menggunakan Metode Spektrofotometri UV-Vis Faramita Hiola; Mahdalena Sy Pakaya; Juliyanty Akuba
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.13598

Abstract

Rhodamine B is a syntheticdye use in paper, textile, and ink dyes. This compound can irritate the respiratory tract and cause cancer with liver damage. The present study aimed to find out the levels of rhodamine B contained in lipstick. It relied on qualitative and quantitative testing. The qualitative testing applied the thin-layer chromatography method with ethyl acetat eluent: n-buthanol : ammonia with the best ratio of 20:55:25. Meanwhile quantitative testing used the UV-Vis Specrophotometry method. It was shown from the quantitative test using thin-layer chromatography that three samples of lipstick contained rhodamine B. Further, the quantitative test with the UV-Vis spectrophotometry indicated that the levels of rhodamine B were measured at 6.62 µg/mL with 0.662%
Tingkat Pengetahuan Pasien Penderita Tuberculosis Dalam Program Pengobatan Tuberculosis di Puskesmas Madania Madania; Mahdalena Sy Pakaya; Teti Sutriati Tuloli; Widysusanti Abdulkadir
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14220

Abstract

Tuberculosis is an infectious disease caused by bacteria known as mycobacterium tuberculosis. In Indonesia, tuberculosis is the third common public health problem the prevalence of the disease in this country is among the highest in the world after China and India. Sufficient knowledge of diseases and medicines correlates with the result of therapy in general. Knowledge about drugs is important for patients since it helps them to consume drugs properly (which result in maximum therapy) and to avoid complications. The purpose of this descriptive study is to determine the level of knowledge of patients suffering from tuberculosis in the tuberculosis treatment program at Bulango Utara Puskesmas (Community Health Center) by a questionnaire. It applied a cross-sectional approach with primary data obtained from the result of a sample questionnaire totaling 24 patients taken by saturated sampling. The result of this present study reveal that the level knowledge of patients with tuberculosis in the area is still relatively low at 75%, while only 25% is classified as moderate.
Pemanfaatan Limbah Kulit Buah Matoa (Pometia Pinnata) Sebagai Obat Kumur Herbal Solusi Pencegah Karies Gigi Mahdalena Sy. Pakaya; Nazwah Buana Putri Kalangi; Santi Santi; Nurdiandra Jahja; I Made Hariadi Wijaya; Fajar Dwi Agung
Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Vol 10, No 3 (2021): Jurnal Sibermas (Sinergi Bersama Masyarakat)
Publisher : Univeristas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/sibermas.v10i3.11673

Abstract

Dental health problems are a common problem for the entire world population, including Indonesia. The incidence of dental caries worldwide has a fairly high number, namely 80-90% in children under 18 years. One of the main factors causing dental caries is the presence of caries-causing bacteria, namely Streptococcus mutans which is a normal flora of the oral cavity. The type of business that will be made is the production and marketing business of mouthwash with the composition of extracts from the waste of the matoa fruit peel as a solution in overcoming dental caries. Based on research by Kai (2021), where the results of the potency test of matoa fruit peel extract against Streptococcus mutans bacteria showed concentrations of 25%, 50%, and 75% with the resulting inhibition zones of 11.75 mm, 15.82 mm and 18.75. This mouthwash formulation consists of Matoa Fruit Peel Extract, Sorbitol, Glycerin, Sodium Benzoate, Aquadest, and Pipermint. This product has promising business prospects because there are no similar products on the market, the basic ingredients are easy to get and in terms of financial analysis and business feasibility, an overview of the planned business can get promising profits
Efektivitas Penurunan Kadar Glukosa Darah Daun Lamtoro (Leucaena leucocephala L.) Pada Mencit Jantan (Mus muscullus L.) Juliyanty Akuba; Endah Nurrohwinta Djuwarno; Faramita Hiola; Mahdalena Sy. Pakaya
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14913

Abstract

Diabetes mellitus (DM) is defined as a disease or metabolic disorder characterized by high blood glucose levels. The management of diabetes mellitus therapy in the community is diverse, ranging from synthetic drugs to herbal medicines. Many people assume that herbal medicines are relatively cheaper and safer compared to synthetic drugs. One of the plants commonly used as herbal medicine is Lamtoro. This research aimed to determine the effectiveness of Lamtoro leaves (LeucaenaleucocephalaL) on decreasing blood glucose levels on lab mice (Mus musculus L). This study used 27 male house mice divided into nine groups; each group consisted of three male house mice, i.e., glucose control (group I), negative control Na-CMC 1% w/v (group II), Positive control of chlamyd Gliben 1.56% w/v (group III), administered N-Hexan extract of Lamtoro leave 1% w/v (group IV), the extract of N-Heksan Lamtoro leaf 2.5% w/v (group V),  the extract of N-Heksan Lamtoro leaf 5% w/v (group VI), ethanol extract of Lamtoro leaf 1% w/v (group VII), ethanol extract of Lamtoro leaf 2.5% b/v (group VIII), and ethanol extract of Lamtoro leaves 5% w/v (group IX). The results were analyzed using the One Way ANOVA test. It showed that N-Hexane and Ethanol extract of Lamtoro leaves with a concentration of 1% w/v, 2.5% w/v and 5% w/v was able to reduce the blood glucose levels. The extract which had the best activity in reducing blood glucose levels was found in ethanol extract 96% at a concentration of 5% w/v with a decrease in the percentage by 59%. This was because the 96% ethanol extract contained a number of secondary metabolite compounds, i.e., flavonoids, alkaloids and tannins as blood glucose levels reducer
Isolasi dan Karakterisasi Bakteri Endofit dari Akar Pare (Momordica charantia L.) Mahdalena Sy. Pakaya; Julianty Akuba; Dizky Ramadani Putri Papeo; Andi Makkulawu; Ade Ari Puspitadewi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.15536

Abstract

Endophytic bacteria are microbes that grow on plant tissue and can form a colony on plant tissue without producing a negative effect on the host. The endophytic bacteria have the potential to have the same activity and produce secondary metabolite as their host. The root of bitter melon (momordica charantia L.) has been known to have antibacterial activity, thus enabling the presence of endophytic bacteria, which also have antibacterial potential.This present research aims to isolate and characterize endophytic bacteria found in bitter melon (Momordica charantia L. The method used in the isolation stage is direct lanting so that the endophytic bacteria are obtained from plant tissue; macroscopic and microscopic characterization stage; inhibition test stage; inhibition test stage using disc method (Kirby-Bauer). In accordance with the results of macroscopic and microscopic characterization, the two bacteria indicate different characteristics.
Formulasi Dan Evaluasi Fisik Sediaan Mouthwash Ekstrak Etanol Kulit Buah Matoa (Pometia Pinnata) Nur Ain Thomas; Mahdalena Sy. Pakaya; Ariani H. Hutuba; Yayah Rachmatiyah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15538

Abstract

Matoa peels contained phenolic, saponin, tannin, flavonoid and terpenoid which functions as anti-bacterias to Streptococcus mutans that can cause dental caries and active ingridients for mouthwash preparations. Mouthwash is a solution to be used as a cleansing agent that can improve mouth hygiene, esthetics and breath freshness. This study aimed to identify the etanol extract of Matoa peels to be formulated mouthwash preprations and its physical evalutions. This study employed methods that includes peels extraction, extract phytochemical screening, mouthwash preparation productions and mouthwash preparations evluations consisting of organoleptic, pH and viscosity test. The testing was conducted in day 0, 7, 14, 21 and 28. The findings revealed formula 2 as the best formula with 10% of glycerin concentration.
Isolasi dan Karakterisasi Jamur Endofit Lamun (Thalassia hemprichii) Dari Kawasan Teluk Tomini Mahdalena Sy. Pakaya; Wiwit Zuriati Uno; Dizky Ramadani Putri Papeo; Dewi Rahmawaty Moo
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15852

Abstract

Endophytic fungi live in their host tissues. Endophytic fungi can produce compounds similar to their hosts as well. In this case, the use of endophytic fungi can reduce the exploitation of seagrass (Thalassia hemprichii) populations in Tomini Bay. This study aims to isolate and determine the characteristics of the endophytic fungus of seagrass (Thalassia hemprichii) from the Tomini Bay area. The test method used is the isolation and characterization macroscopically and microscopically. The results of the isolation obtained two isolates of endophytic fungi coded J1 and J2 with different characteristics. The isolate code J1 had microscopic characteristics of a yeast-like shape, while the isolate code J2 had the characteristic of non-septate hyphae.
Isolasi dan Uji Aktivitas Antiinflamasi Ekstrak Daun Andong (Cordyline fructicosa (L) A.Chev) Endah Nurrohwinta Djuwarno; Hamsidar Hasan; Mahdalena Sy. Pakaya; Faramita Hiola; Dewa Ayu Puspita
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15740

Abstract

Andong (Cordyline fructicosa (L) A. Chev) is used as traditional medicine, the use of this traditional medicine is related to the content of secondary metabolites contained in the andong plant. Empirically people use this plant as an antioxidant, the compound that acts as an antoixidant is related to antiinflamasi. The purpose of this study was to isolate secondary metabolites from the extracts of N-Hexane, Ethyl Acetate, and Methanol from Andong (Cordyline fructicosa (L) A. Chev) leaves and to determine the anti-inflamatory effect of the isolated secondary metabolites of Andong (Cordyline fructicosa (L) A. Chev) leaves through in vitro with red blood cell stabilization method. Several methods are used in the isolation of these compounds, namely extraction, identification of compound, fractionation of KCV and KKG, KLT,KLTP, and characterizationof compounds using UV-VIS spectrophotometry and FTIR. The results of UV-VIS characterization show a maximum wavelength of 434 nm, and the results of  FTIR characterization indicate the presence of a functional groups namely O-H (Hidroxyl) at a wave number of 3448,72 cm-1, C-H (Aliphatic) at a wave number of 2954,95 cm-1, 2920,23 cm-1, and 2852,72 cm-1, aliphatic compounds are supported by the presence of CH2 and CH3 at wave number of 1463,97 cm-1 and 1379,10 cm-1, C=O (conjugated carbonyl) at wave number of 1721,79 cm-1, C=C at wave number of 1633,71 cm-1, C-O at wave number of 1294,24 cm-1. So it is very likely that the compounds in Andong leaves isolate are flavonoid compounds. Furthermore, the activity of results of the isolation is tested where the isolate whit a concentration of 100 ppm signifies the highest anti-inflamatory activity, with the ability to stabilize red blood cell membranes of 80,142 %.
Standarisasi Mutu Tanaman Herbal Aur-Aur (Commelina longifolia L.) dan Tanaman Bungango (Flueggea virosa Royle) Andi Makkulawu; A. Mu’thi Andy Suryadi; Muhammad Taupik; Mahdalena Sy. Pakaya; Ariani. H Hutuba
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16044

Abstract

In the developing materials for traditional medicines, it is necessary to standardize the quality of plant materials. Tuhus, quality, stability, and safety. This study aims to determine several standardization parameters and determine the flavonoid content of the 70% ethanol fraction of aur-aur leaves (Commelina longifolia L.) and bungango leaves (Flueggea virosa Royle) to ensure that the fractions have quality and measurable parameter values. The fraction was standardized with two parameters, thus specific and non-specific, and flavonoid content test using UV-Vis spectrophotometry method. The results of phytochemical screening, the fraction containing flavonoid compounds is 70% ethanol fraction. Standardization of specific parameters showed the organoleptic results of both aur-aur (Commelina longifolia L.) and bungango (Flueggea virosa Royle) leaf fractions in the form of a semi-solid viscous fraction, black in color, and characteristic odor. The content of water soluble extract and ethanol soluble extract of aur-aur (Commelina longifolia L.) leaf fraction were 22.84%, ethanol soluble extract 25.03%, while the fraction of Bungango (Flueggea virosa Royle) leaf was 30.70%. and 27.31%. Standardization of non-specific parameters showed the results of water content 21.40%, total ash content 8.92%, acid insoluble ash content 0.043%, drying shrinkage 10.48%. The results of non-specific standardization of bungango leaves (Flueggea virosa Royle) showed a moisture content of 14.45%, a total ash content of 9.62%, an acid insoluble ash content of 1.31%, a drying shrinkage of 10.64%. The results for the analysis of the flavonoid content of the 70% ethanol fraction of aur-aur leaves and bungango leaves were carried out at a wavelength of 438.36 nm. The total flavonoid content was calculated by the standard linear equation of quercetin, namely y= 0.0648x + (-0.0232) with a correlation coefficient (r2) = 0.9948 with the total flavonoid content of aur-aur leaf and bungango leaf each of 3.57. % and 9.578%.
Co-Authors A. Mu’thi Andy Suryadi Abas, Siti Nur Rahmatiya Abdullah, Rahayu Anatasya Putri Ade Ari Puspitadewi Akuba, Juliyanti Ali, Muthiah Rahmah Aliya Ibrahim Ibrahim alkatiri, ahmad alkatiri AM Andy Suryadi AM. Andy Suryadi Andi Makkulawu Ariani H. Hutuba Arista Idris, Pinkan Arona Salama Dewa Ayu Puspita Dewi Rahmawaty Moo Dizky Ramadani Papeo djuarno, endah nurrohwinta Djuwarno, Endah Nurrowinta Dr. Apt. Hamsidar Hasan S.Si.,M.Si dwi pratiwi, susi Endah Nurrohwinta Djuwarno Fajar Dwi Agung Faradila Ratu Cindana Fatimah Azzahra Fika Nuzul Ramadhani Grasela Mbae Hamsidar Hasan Hamsidar Hasan Hamsidar Hasan Handriansyah pakaya Hartati Hartati Hendrawan Dwikarunia Datukramat Hiola, Faramita Hunawa, Rachmawaty Dirham I Made Hariadi Wijaya Ibrahim, Annisa Humairah Jihan Astuti Kai Julianty Akuba Khofifa Nurul Magfira Maspeke La Ode Aman Latif, Multiani S. Liberto, Frith F. Lisa Efriani Puluhulawa Madania Madania, Madania Madania, Madania Magfirah Nur Cahyani Makkulawu, Andi Manno, Mohamad Reski Moh. Adam Mustapa Mohamad Adam Mustapa Mohamad Aprianto Paneo Mohamad Reski Manno Muhammad Taupik Muhammad Taupik Multiani S. Latif Mustapa, Moh. Adam Muthiah Rahmah Ali Nazwah Buana Putri Kalangi Niluh Sri Purnama Nur Ain Thomas Nur Rasdianah Nurdiandra Jahja Pakaya, Meri Isriani Papeo, Dizky Ramadani Putri Papeo, Pirdawati priliya wati d.as'ali Puluhulawa, Lisa Efriani Rahmawati Hunawa Rahmulia Thamrin Ramly Abudi Robert Tungadi Santi Santi Selvi Marcellia Suryadi,, A. Mu'thi Andy Teti Sutriyati Tuloli Teti Sutriyati Tuloli Tolulu, Sri Noviani umar, linsih Wicita, Prisca S. Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widysusanti Abdulkadir Wiwit Zuriati Uno Yayah Rachmatiyah Yunus, Fitriah Ayu Magfirah