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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina journal of internal medicine INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Majalah Ilmiah Fisioterapi Indonesia E-Jurnal Udayana Medica WMJ (Warmadewa Medical Journal) The Indonesian Biomedical Journal Oto Rhino Laryngologica Indonesiana ISM (Intisari Sains Medis) : Jurnal Kedokteran Bioscientia Medicina : Journal of Biomedicine and Translational Research Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) International Journal of Nasopharyngeal Carcinoma PREPOTIF : Jurnal Kesehatan Masyarakat Bioscientia Medicina : Journal of Biomedicine and Translational Research Warmadewa Minesterium Medical Journal Journal of Global Pharma Technology Eduvest - Journal of Universal Studies Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Physical Therapy Journal of Indonesia Biosaintifika: Journal of Biology & Biology Education
I Wayan Putu Sutirta Yasa
Bagian Patologi Klinik Fakultas Kedokteran Universitas Udayana
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Gambaran pemeriksaan IgM anti-Salmonella thypi 09 pada penderita demam dan gangguan pencernaan, dengan atau tanpa gangguan kesadaran di Puskesmas Denpasar Timur I IGA Ayu Ratih Pradnyadewi; Ni Nyoman Mahartini; I Wayan Putu Sutirtayasa
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.014 KB) | DOI: 10.15562/ism.v10i3.422

Abstract

Latar Belakang: Demam tifoid merupakan penyakit endemik Indonesia, yang disebabkan oleh infeksi dari bakteri Salmonella typhi. Bakteri ini dapat ditularkan melalui makanan dan juga minuman yang terkontaminasi bakteri tersebut, bisa juga akibat dari terkontaminasi dari tinja maupun urin dari orang yang telah terinfeksi bakteri tersebut. Penegakan untuk diagnosis demam tifoid saat ini dapat dilakukan secara klinis maupun dengan cara pemeriksaan laboratorium. Salah satunya ialah uji serologis yang dapat digunakan dalam demam tifoid meliputi tes Tubex.Metode: Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross-sectional. Data dalam penelitian ini berasal dari sumber data primer berupa pengambilan serum pasien di Puskesmas Denpasar Timur I sejumlah 33 sampel.Hasil: Pasien yang berobat ke Puskesmas Denpasar Timur I didapatkan kelompok yang paling banyak ialah perempuan 81,9% sedangkan laki-laki 18,1%. Sebanyak 100% datang dengan keluhan demam, sebanyak 63,7% datang dengan keluhan mual dan muntah 9,0%.Simpulan: Hasil IgM anti-Salmonella thypi 09 positif sebanyak 9,1% dan IgM anti-Salmonella thypi 09 negatif sebanyak 90,9%.Introduction: Typhoid fever is an endemic disease in Indonesia, which is caused by an infection of the bacterium Salmonella typhi. These bacteria can be transmitted through food and beverages contaminated with these bacteria, can also be caused by contamination of feces and urine from people who have been infected with these bacteria. Enforcement for the diagnosis of typhoid fever can now be done clinically or by laboratory examination. One of them is the serological test that can be used in typhoid fever including the Tubex test.Method: This research is a descriptive study with a cross-sectional approach. The data in this study came from primary data sources in the form of taking serum of patients in the East Denpasar Health Center I with 33 samples.Result: Patients who went to the East Denpasar Public Health Center I, found the most group was women 81.9% while men 18.1%. As many as 100% came with complaints of fever, 63.7% came with complaints of nausea and vomiting were 9.0%.Conclusion: The positive results of anti-Salmonella thypi 09 were 9.1% and negative IgM anti-Salmonella thypi 09 as much as 90.9%.
Pemeriksaan widal untuk mendiagnosis Salmonella typhi di Puskesmas Denpasar Timur 1 Melania Antonia Barreto Cerqueira; Ni Nyoman Mahartini; I Wayan Putu Sutirta Yasa
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.848 KB) | DOI: 10.15562/ism.v10i3.453

Abstract

Introduction: Typhoid fever is an acute systemic infectious disease caused by Salmonella typhi which is still widely found in various developing countries, especially in the tropics and subtropics. Widal test is an agglutination reaction between antigen and S. typhi O titer antibodies> 1/160 and S. typhi H titer >1/160, Aglutinin that is specific to Salmonella typhi in the serum of patients with typhoid fever.Methods: This research was descriptive observational cross sectional. The population of the study was patients from the East Denpasar Health Center 1 who presented with clinical symptoms that supported.Result: There were 10 sample (30%) aged 0-10 years, 12 sample (36%) people aged 11-20 years, 7 sample (21%) aged 21-30 years, and 4 sample (12%) people aged >30 year. Samples with clinical symptoms of fever> 37 ° C with digestive disorders (nausea, vomiting, abdominal pain) with or without impaired consciousness were 18 samples (55%). Samples with clinical symptoms of fever> 37 ° C with digestive tract disorders were 11 samples (33%). Samples with fever> 37 ° C were 4 samples (12%)Conclusion: There were 3% of positive widal test and 97% of negative widal test in the East Denpasar Health Center 1.Latar Belakang: Demam tifoid merupakan suatu penyakit infeksi akut sistemik yang disebabkan oleh Salmonella typhi yang masih dijumpai secara luas di berbagai negara berkembang terutama di daerah tropis dan subtropics. Uji Widal adalah suatu reaksi aglutinasi antara antigen dan antibody S. typhi O titer > 1/160 dan S. typhi H titer >1/160, Aglutinin yang spesifik  terhadap  Salmonella  typhi  terhadap dalam serum penderita demam  tifoid.Metode: Penelitian ini bersifat observasional cross sectional deskriptif Populasi Penelitian adalah pasien dari Puskesmas Denpasar Timur 1 datang dengan gejala klinis yang mendukung.Hasil: Rentang usia dari 33 pasien subjek penelitian, terdapat 10 sampel(30%) berusia 0 – 10 tahun, 12 sampel  (36 %) sampel berusia 11 – 20 tahun, 7 sampel (21%) berusia 21-30 tahun,  dan 4 sampel  (12 %) sampel berusia > 30 tahun. Sampel dengan gejala klinis demam > 37 °C dengan gangguan pencernaan (mual, muntah, nyeri perut) dengan atau tanpa gangguan kesadaran sebanyak 18 sampel (55%). Sampel dengan gejala klinis demam > 37°C dengan gangguan saluran pencernaan sebanyak 11 sampel (33%). Sampel dengan demam >37°C sebanyak 4 sampel (12%)Simpulan: Terdapat 3% sampel dengan widal positif dan 97% sampel dengan widal negatif di Puskesmas Denpasar Timur 1.
Prevalensi gambaran faktor risiko penyakit jantung koroner pada pasien diabetes melitus tipe-2 di RSUP Sanglah Denpasar periode 2015 Ni Putu Widya Nandasari; Desak Gde Diah Dharma Santhi; I Wayan Putu Sutirta Yasa
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.181 KB) | DOI: 10.15562/ism.v11i2.616

Abstract

Introduction: The main causes of mortality and morbidity in patients with Type-2 Diabetes Melitus (T2DM) is coronary heart disease. This study aims to describe various risk factors for coronary heart disease, modified and unmodified included among patients with T2DM in Sanglah General Hospital, within 2015.Method: The research uses descriptive cross-sectional design with total sampling technique has been used as sampling method. Data was taken from patients’s medical record within the period of January to December 2015. It was processed using SPSS 21 and presented in a frequency distribution table and crosstabulation based on risk factors. Around 48 samples which met the criteria were included in this study.Result: It was obtained that the prevalence of the unmodified risk factors of CHD in T2DM were male gender (87.5%) and aged ≥45 years old (95.8%). The modified factors are fasting blood glucose ≥126 mg/dL (83.3%), body mass index ≥25 kg/m2 (64.6%), random blood glucose ≥200 mg/dL (58.3%), HDL ≤45 mg/dL (41.7%), triglycerides ≥150 mg/dL (22.9%), blood pressure ≥140/90 mmHg (22.9%), total cholesterol ≥200 mg/dL (22.9%), and LDL ≥160 mm/dL (8.3%).Conclusion: It can be concluded that men with age ≥45 years, fasting blood glucose, body mass index, and uncontrolled random blood glucose are risk factor for CHD in T2DM in Sanglah Hospital. Therefore, monitoring of blood sugar levels and body mass index in patients with T2DM are necessary to prevent CHD. Latar Belakang: Penyebab mortalitas dan morbiditas utama pada pasien Diabetes Melitus Tipe-2 (DMT2) adalah penyakit jantung coroner (PJK). Penelitian ini bertujuan untuk mengetahui gambaran berbagai faktor risiko penyakit jantung koroner yang tidak dapat diubah dan dapat diubah pada penderita DMT2 di Rumah Sakit Umum Pusat Sanglah periode 2015. Metode: Penelitian menggunakan desain deskriptif cross-sectional, dan pengambilan sampel dilakukan dengan teknik total sampling. Data diambil berdasarkan rekam medis pasien periode Januari – Desember 2015. Kemudian data diolah menggunakan SPSS 21, dan disajikan dalam bentuk tabel distribusi frekuensi dan crosstabulation berdasarkan faktor risiko.Hasil: Didapatkan sebanyak 48 sampel penelitian yang memenuhi kriteria dan dapat digunakan dalam studi ini, diperoleh prevalensi gambaran faktor risiko PJK pada DMT2 yang tidak dapat diubah adalah jenis kelamin laki-laki (87,5%) dan usia ≥45 tahun (95,8%). Faktor yang dapat diubah seperti gula darah puasa ≥126 mg/dL (83,3%), indeks masa tubuh ≥25 kg/m2 (64,6%), gula darah sewaktu ≥200 mg/dL (58,3%), HDL ≤45 mg/dL (41,7%), trigliserida ≥150 mg/dL (22,9%), tekanan darah ≥140/90 mmHg (22,9%), kolesterol total ≥200 mg/dL (22,9%), dan LDL ≥160 mm/dL (8,3%).Conclusion: Laki-laki dengan usia ≥45 tahun, gula darah puasa, indeks masa tubuh, dan gula darah sewaktu yang tidak terkontrol merupakan faktor risiko untuk terjadinya PJK pada DMT2 di RSUP Sanglah. Sehingga diperlukan pengawasan kadar gula darah dan indeks masa tubuh pada pasien DMT2 agar tidak terjadi PJK.
Inverse Correlation between Combination of Antiretroviral Therapy with the level of Serum Interleukin-6, Ferritin, and Hepcidin in HIV Patients with Anemia Chronic Disease I Ketut Agus Somia; Ketut Tuti Parwati Merati; I Made Bakta; Ida Bagus Putra Manuaba; Wayan Putu Sutirta Yasa; I Dewa Made Sukrama; Ketut Suryana; Rudi Wisaksana
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Background: The purpose of this study was to determine whether the cARV therapy correlates with the serum level of IL-6, ferritin, and hepcidin in HIV infected patients with ACD.Methods: A cross-sectional study conducted in HIV patients with ACD, aged 15-65 years with exclusion criteria such as chronic renal disease, chronic liver disease, treated for anemia in the last 3 months, taking iron supplements in the last 3 months, history of blood transfusion in the last 1 year, suffering from acute infection, tuberculosis infection, malignancy, hepatitis C virus infection, acute hypersensitivity reaction and pregnancy. Blood specimen examined by high sensitivity human IL-6 In vitro ELISA, DRG Hepcidin- 25 ELISA, serum ferritin by agglutination method and CD4 cell count by flow cytometry. Results: A total of 86 HIV patients with ACD consist of 42 subjects with experienced cARV and 44 subjects with naive cARV. There are several differences between cARV naïve and experienced cARV including: Hb (g/dl) [ 10.8 ( 9.88 – 11.75) Vs. 11.60 (11.00 – 12.34) p: 0.058 ], serum iron (mg/dl) [ 50.00 (31 – 66.8) Vs. 71.40 (56.00 – 108.00) p: 0.121 ), serum ferritin (ug/dl) [ 630 ( 194 – 1101) Vs. 195.40 (128.25 – 589.47) p: 0.008 ], IL-6 (pg/mL) [7.20 (3.88 – 10.76) Vs. 4.03 (1.69 – 8.49) p: 0.009), serum hepcidin (ng/mL) [45.54 (16.74 – 95.31) Vs. 23.35 (6.58 – 49.99) p: 0.007] , CD4 cell count (cell/uL) [31.5 (14.25 – 90.75) Vs. 307 (168.5 – 458.75) p : < 0.001)] There is a significant inverse correlation between the cARV therapy with level of serum IL-6 ( r: - 0. 285, p: 0.008), ferritin (r: - 0.321, p: 0.007) and hepcidin (r: - 0.293, p: 0.006). While there was a significant positive correlation between the cARV therapy with CD4 cell count (r: 0.676, p: 0.001). There was no correlation between the cARV therapy with serum iron levels ( r: 0.176, p: 0.121).Conclusion: There is an inverse correlation between the cARV therapy with serum level of IL-6, ferritin, and hepcidin in HIV patients with ACD.  Keywords: cARV, ACD, IL-6, Ferritin, Hepcidin.
The Comparative Effect of Liquid and Tablet Preparation of Purple Sweet Potato (Ipomoea batatas L) Extract to Lipid Profile, MDA, and SOD Level in Male Wistar Rats After Given High-Cholesterol Diet I Wayan Putu Sutirta Yasa; I Made Jawi; Putu Astawa
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Recent developments in tablet preparation of extract have brought advantages to keep active ingredients from plants in stable forms physically and chemically. This study aims to compare the liquid and tablet preparation of purple sweet potato (Ipomoea batatas L.) extract to lipid profile, MDA, and SOD level in rats after given high-cholesterol diet. Methods: A randomized pre- and post-test control group experimental study was conducted during 4 weeks among 21 male Wistar rats. They were divided into 3 groups in this study namely: control (only high-cholesterol diet), Treatment 1 (T1) group (high-cholesterol diet and 200mg/day tablet of purple sweet potato extract), and Treatment 2 (T2) group (high-cholesterol diet and liquid form of purple sweet potato tubers extract about 2 mL/day). Lipid profile, MDA, and SOD level examination were performed twice from retro orbital sinus blood drawn and analyzed using ANOVA in SPSS version 17.Results: Mean value of lipid profile was significantly lower in T2 group (Cholesterol 84.48 ± 3.38; LDL 23.05 ± 2.32; HDL 63.39 ± 1.56; and triglycerides 96.03 ± 3.82; P < 0.05) after study period. The mean value of MDA was also significantly lower in T2 group (1.25 ± 0.09; P < 0.05) and SOD level was significantly higher in T2 group (73.72 ± 4.14; P < 0.05) in the end of study. Conclusion: Liquid preparation of purple sweet potato extract showed a better efficacy in reducing lipid profile and MDA level, as well as enhancing SOD level in rats given high-cholesterol diet.Keywords: Lipid Profile, Liquid, MDA and SOD Level, Purple Sweet Potato, Tablet.
COMPARISON THE ANTIHYPERTENSIVE AND ANTIOXIDANT POTENTIAL BETWEEN YOUNG MAHOGANY SEEDS EXTRACT WITH MATURE MAHOGANY SEEDS EXTRACT IN RATS WITH HYPERTENSION I Wayan Putu Sutirta Yasa; Putu Astawa; I Made Jawi
Journal of Global Pharma Technology Volume 09 Issue 05
Publisher : Journal of Global Pharma Technology

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Abstract

Mahogany seeds have been used in the community as an antihypertensive and antioxidant. Antihypertensive and antioxidant efficacy of mature mahogany seeds has been proven in hypertensive rats. The purpose of this study was to compare the antihypertensive and antioxidant effect of mature mahogany seeds extract with young mahogany seeds extract. This study is a laboratory experimental design with pre-test and post-test design control groups, with Wistar rats as samples. Thirty rats were divided into 5 groups, each group consist of 6 rats. The control group was given saline every day as a rat model of hypertension. 1-4 treatment groups were each given NaCl and water extract of young mahogany seeds for treatment 1, the ethanol extract of young mahogany seeds as treatment 2, water extract of mature mahogany seeds as treatment 3 and ethanol extract of mature mahogany seeds as treatments 4. Dosages of extract mahogany seeds is 100 mg / head / day for 4 weeks. Before treatment, evaluation of rat blood pressure with special sphygmomanometer was held, and examination of blood MDA as a pre-test data. Further evaluation of MDA and SOD blood pressure are at the end of the study. The data were tested by ANOVA to see the difference between the groups. The results showed a decrease in blood pressure and levels of MDA were significant in all treatments (p <0.05) compared with control as well as an increase in SOD were significantly (p <0.05). The ethanol extract of mature mahogany seeds showed the most excellent antihypertensive and antioxidant properties (p <0.05). From these results, it can be concluded that the ethanol extract of mature mahogany seeds is better than young mahogany seeds extract as an antihypertensive and antioxidant in hypertensive rats.Keywords – antioxidants, hypertensive rats, mature and young mahogany seeds
High Level of Uterine Endocervical Interleukin-8, Matrix Metalloproteinase-8, and Interleukin 1Β as a Risk Factor for Preterm Labor Suwardewa TGA; Suwiyoga K K; Mantik Astawa N; Sutirta Yasa IWP
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
Publisher : Journal of Global Pharma Technology

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The preterm birth is a birth that takes place on a gestational age between 20–36 weeks and six days. The preterm birth   is the leading cause of neonatal mortality and morbidity. Despite the current treatment procedures, the incidence of preterm birth has not changed in the last two decades. Incomplete understanding of the pathophysiological mechanisms underlying preterm labor is the major obstacle to prevent preterm birth. Recently, endocervical inflammation has been thought as a risk factor of a preterm labor. Several important substances such as endocervical IL-8, MMP-8, and IL-1β, has been considered to play a key role on preterm birth through cervical ripening. With those assumptions, the detection of a higher level of uterine endocervical IL-8, MMP-8, and IL-1β can be used to predict preterm labor. The design of this study is an observational case control study with a case group, which consisted of pregnant women with 20–36 weeks and six days of gestational age who had signs of labor, and the control group consisted of pregnant women with 20–36 weeks and six days of gestational age who had no signs of labor. The material used for this study is cervical mucous, and the enzyme-linked immunosorbent assay method was used to assess the level of IL-8, MMP-8, and IL-1β at laboratory of Veterinary Medicine of Udayana University Denpasar. In this study we used 48 samples, among which 24 were case group, and 24 as a control group. The mean age of the women, gestational age, and parity from both group are (27.04 vs 28.62 years old), (31.8 vs 29.50 weeks), and (0.96 vs 1.29) respectively, which are statistically homogenous (p > 0.05). Each level of interleukin-8, matrix metalloproteinase, and interleukin-1β suggests a risk factor of a preterm labor for: 35 times (OR = 35.00; CI 95% = 6.95–176.39; p = 0.001); 6.6 times (OR = 6.60; CI 95% = 1.25–34.95; p = 0.016), and 8.3 times (OR = 8.3; CI 95% = 2.15–32.3; p = 0.001), orderly. Among these cytokines, one that contributes most through a preterm birth is interleukin-8 (61%), followed by matrix metalloproteinase-8 (27%), and interleukin-1β (12%).Conclusion: Endocervical inflammation with high level of IL-8, MMP-8, and IL-1β is a risk factor for preterm labor. IL -8 gives the most contribution on preterm labor.Keywords: Preterm birth, Endocervical IL-8, MMP-8, and IL-1β.
Comparison of the effects of ethanol extract with aqueous extract of purple sweet potato tuber in expression of SOD-2, SOD-3, and eNOS on human vascular endothelial cells exposed by H2O2 in-Vitro I Made Jawi; I G K Arijana; I Wayan Putu Sutirta Yasa; AAN Subawa
Journal of Global Pharma Technology .
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Aqueous extract of purple sweet potato tubers have antioxidant potential in animal and human vascular endothelial, through increased expression of superoxide dismutase. This study aims to prove the comparison between ethanol extract and aqueous extract of purple sweet potato tubers increasing the expression of superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in human vascular endothelium. This study was an experimental study of the vascular endothelial cells which underwent oxidative stress in vitro, which is protected by ethanol extract or aqueous extract of purple sweet potato tuber at various concentrations. Observation of the superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in endothelial cells is done using the method immunohistochemistry with monoclonal antibodies. The results showed an increase in superoxide dismutase - 2, superoxide dismutase -3, and endothelial nitric oxide synthase was significantly (p < 0.05) in endothelium protected by ethanol extract or water extract of purple sweet potato tubers. The ethanol extract only showed its effect at concentration of 1.5625 µg/ml for superoxide dismutase -2 and superoxide dismutase -3. The effect of aqueous extract were at a concentration of 1.5625–3.125µg/ml. From these results it can be concluded that the ethanol extract or aqueous extract of purple sweet potato tubers can protect endothelial cells from oxidative stress through increased expression of superoxide dismutase -2 and superoxide dismutase -3. The ethanol extract requires much lower concentrations to show its effect compared with aqueous extracts. Keywords: Aqueous extract or ethanol  extract of purple sweet potato, Superoxide dismutase, Human umbilical vein endothelial cells.
Administration of Binahong (Anredera Cordifolia (Ten) Steenis) Leaves Extract Fixes Pancreatic β-cell Damage through Lowering Blood Glucose and Advanced Glycation End Products (AGEs) Level in Hyperglycemic Wistar Rat Sri Wahyuni; I Wayan Putu Sutirta Yasa
Journal of Global Pharma Technology .
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Background: Increasing production of free radicals is one of the factors that cause hyperglycemia. Chronic hyperglycemia can increase the production of reactive oxygen species (ROS), resulting in oxidative stress. The aim of this study is to determine the effectiveness of binahong (Anredera cordifolia (ten) steenis) leaf extract in fixing the pancreas β-cell damage rate in alloxan induced hyperglycemic Wistar rat. Methods: This study used randomized pre and post-test control group design. Fifty Wistar rats were divided into two control groups and three experimental groups administered with difference doses of binahong leaves extract; 0.5 mg/kg BW (P1), 2.0 mg/kg BW (P2), and 5.0 mg/kg BW (P3). Hyperglycemic state obtained by inducing the rats with alloxan. Results: The result showed that mean blood glucose levels were decreased in the positive control group (glibenclamide) (185.98 mg/dL) and the experimental groups; P1, P2, and P3 (181.36 mg/dL, 184.61 mg/dL, and 163.36 mg/dL, respectively). The mean differences between P1 and P2 and between P1 and P3 were statistically significant (p < 0.05). The AGEs level for the positive control group (glibenclamide) is 0.224 mol/L and for the experimental groups are 0.219 mol/L, 0.212 mol/L, and 0.188 mol/L for P1, P2, and P3, respectively. The differences were statistically significant. Conclusions: Administration of binahong leaves extract can improve the damage rate of pancreas β-cell through lowering the blood glucose and AGEs level in hyperglycemic Wistar rat and that the effect is significant at the dose of 5.00 mg/kg bw per day.Keywords: Anredera cordiofolia (ten) steenin, blood glucose and AGEs, hyperglycemia.
GAMBARAN UMUM HASIL PEMERIKSAAN DARAH LENGKAP PADA PASIEN TERINFEKSI VIRUS DENGUE PRIMER DAN SEKUNDER DI RSUP SANGLAH DENPASAR I Kadek Arya Candra; I Wayan Putu Sutirtayasa; Anak Agung Wiradewi Lestari
E-Jurnal Medika Udayana Vol 6 No 7 (2017): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Abstract

The diagnosis of primary or secondary Dengue virus infection is quite difficult because of the wide spectrum of symptoms and signs. Complete blood count testing may be the initial screening to determine diagnosis and therapy accurately. This study aimed to determine the general description of the results of a complete blood count includes the number of platelets, leukocytes, hematocrit, and hemoglobin in patients with primary and secondary Dengue virus infection. This was a descriptive cross-sectional study by taking data from medical record retrospectively with total sampling methode. Samples were patients with primary and secondary Dengue virus infection listed on Sanglah Denpasar Hospital during July 2013 - June 2014. The variables were analyzed by SPSS for Windows. The total sample were 202 peoples (46 primary-infected patients and 156 secondary-infected patients). The proportion of primary-infected patients and secondary-infected patients who has platelet count ?47.750 x 103/mL was 17.4% and 59.6%, the proportion of patients with leukocyte counts >3.965 x 103/mL was 30.4% and 55.8%, the proportion of patients with hematocrit >45.04% was 41.3% and 55.1%, and the proportion of patients with a hemoglobin level of >15.3 g/dL was 39.1% and 51.9%. It can be concluded that the majority of secondary-infected patients had lower platelet counts, but has the leukocyte count, hematocrit, and hemoglobin higher than the primary-infected patients. However, further research is needed to determine the relationship between the variables. Keywords: platelet, leukocyte, hematocrit, hemoglobin, primary and secondary Dengue virus infection.
Co-Authors Adhitya, Putu Gde Surya Agung Nova Mahendra Agung Wiwiek Indrayani Airin Que Ali Djamhuri Amaral, Meriana Barreto Anak Agung Gede Sudewa Djelantik Anak Agung Ngurah Subawa Anak Agung Wiradewi Lestari Anak Agung Wiradewi Lestari, Anak Agung Anom Suardika Astini, Dewa Ayu Agung Alit Suka Bagus Komang Satriyasa Bastianus Alfian Juatmadja Benny Supono Calvin Jonathan Cokorda Agung Wahyu Purnamasidhi Cokorda Istri Dewiyani Pemayun D.P.G. Jananuraga Maharddhika Desak Gde Diah Dharma Santhi Dewa Ayu Putu Rasmika Dewi Dewi, Ni Kadek Ari Kusuma Dharayani, Luh Anandita Dharma Santhi, Desak Gde Diah Dina Sophia Margina Divasta, I G Mahapraja Fatqur Rochman Feliciano Pinto, Feliciano Ferbian Milas Siswanto Gde Ary Putra Kamajaya Gede Agus Eka Tirta Putra Gede Agus Suwiryawan Gusti Ngurah Sutapa Hamsu Kadriyan Haneetha Yogarajah I A Putri Wirawati I Dewa Made Sukrama I Gde Raka Widiana I Gde Suranaya Pandit I Gede Juliarta I Gede Widhiantara I Gst Agung Dwi Mahasurya I Gusti Agung Dyah Ambarawati I Gusti Agung Ngurah Radhitya Wijaya Radhitya Wijaya I Gusti Kamasan Arijana I Gusti Made Aman I Kadek Arya Candra I Kadek Septiawan I Ketut Agus Somia I Ketut Suastika I Ketut Suwiyoga I Made Ady Wirawan I Made Bagus Cahya Wibawa I Made Bakta I Made Dwikayana I Made Jawi I Made Oka Adi Parwata I Made Sudarmaja I Made Tomik Nurya Wardana I NYOMAN MANTIK ASTAWA I Nyoman Wande I Nyoman Wande I W. Sudarsa I Wayan Gede Artawan Eka Putra I Wayan Rosiana I Wayan Sumardika I Wayan Wita I. B. T. Wibawa Manuaba, I. B. T. Wibawa I. B. Tjakra Wibawa Manuaba I. K. Widiana, I. K. I.A.A. Widhiartini I.B.GDE ANANTA MAHESVARA IBN Dwipayana Manuaba Ida Ayu Kemala Wasita Manuaba Ida Bagus Made Suryatika Ida Bagus Ngurah Ida Bagus Putra Manuaba Ida Bagus Verry Kusumaningrat Ida Bagus Wayan Kardika Ida Kurniawati, Ida IGA Ayu Ratih Pradnyadewi Ignatius Ferdi Yuatmadja Indah Pramita Indradewa, Rhian Indrayani, Pande Kadek Putri Rahayu Intan Astariani Kamayoga, I Dewa Gede Alit Karta Sawenda Ketut Siki Kawiyana Ketut Suega Ketut Suryana Ketut Tuti Parwati Merati Ketut Widyani Astuti Lesmana, Cokorda Agung Bagus Jaya Lesmana, I Wayan Lolik Luh Putu Sukma Diyanti Made Ayu Widyaningsih Made Dyah Khrisnadewi MADE RATNA SARASWATI . Melania Antonia Barreto Cerqueira Michael Christian Widjaja Milaviwanda, Luh Komang Ayu N. K. Niti Susila, N. K. Naw, Sin War Ni Gusti Ayu Putu Lestari Santika Dewi Ni Kadek Mulyantari Ni Kadek Nita Utami Ni Ketut Susilawati Ni Ketut Susilawati Ni Luh Candra Mas Ayuni Ni Luh Wayan Pani Ambarasari Ni Made Dharma Laksmi Ni Made Linawati Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Putu Oktaviani Rinika Pranitasari Ni Putu Widya Nandasari Ni Wayan Ari Anindita Sari Ocktaviana Saputri, Legis Pande Ayu Naya Kasih Permatananda Pande Komang Gede Bayu Wikrama Permatasari, Anak Agung Ayu Putri Poniman, S. Prabasari, Pande Visca Gayatri pradnya wibawa, komang budhi Pratiwi, Cokorda Agung Pujawan, I Made Naris Purnamawati, Susy Puspa Negara, Anak Agung Gede Angga Putu Angga Wiradana Putu Astawa Putu Budhiastra Putu Diani Wirayanti Raka-Sudewi A. A. Romdhoni, Achmad Chusnu Rudi Wisaksana S. Herawati, S. Sagung Novita Widyaningrat Saisnu Supta, I Wayan Santosa, I Gusti Ngurah Putra Eka Sianny Herawati Sri Maliawan Sri Wahyuni Susy Purnawati Swari, Kadek Gyna Yadnya Thaha .. Tirtha Yasa, I Nyoman Wawan Tjokorda Gde Agung Suwardewa Tjokorda Gede Oka Tri Pramartha, I Nyoman Valari, Putu Kavita Krisnina Wayan Suardana Widiyanti, I Gusti Ayu Wijaya Kusuma Yayang Christian Yenny Kandarini