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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina journal of internal medicine INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Majalah Ilmiah Fisioterapi Indonesia E-Jurnal Udayana Medica WMJ (Warmadewa Medical Journal) The Indonesian Biomedical Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Bioscientia Medicina : Journal of Biomedicine and Translational Research Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) International Journal of Nasopharyngeal Carcinoma PREPOTIF : Jurnal Kesehatan Masyarakat Bioscientia Medicina : Journal of Biomedicine and Translational Research Warmadewa Minesterium Medical Journal Journal of Global Pharma Technology Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Physical Therapy Journal of Indonesia Biosaintifika: Journal of Biology & Biology Education
I Wayan Putu Sutirta Yasa
Bagian Patologi Klinik Fakultas Kedokteran Universitas Udayana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Exploring Meditation Influence on Stem Cell: A Review of Current Evidence Santosa, I Gusti Ngurah Putra Eka; Jawi, I Made; Bakta, I Made; Yasa, I Wayan Putu Sutirta; Wirawan, I Made Ady; Lesmana, Cokorda Agung Bagus Jaya; Kandarini, Yenny; Purnamawati, Susy
Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Vol. 7 (2025): PROSIDING SINTESA
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/snts.v7i.3716

Abstract

Endogenous stem cells play a critical role in maintaining tissue homeostasis, repair, and regeneration. The interconnectedness of mind and body has long been recognized as influencing physical health, with practices such as yoga and meditation demonstrating positive effects on overall well-being. This review aims to synthesize current evidence on the effects of meditation on stem cell function, focusing on both indirect (telomere-related) and direct pathways. Meditation appears to influence stem cell function through various mechanisms. Indirectly, meditation may impact stem cells by modulating telomere length and activity. This modulation is likely mediated through stress reduction, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, melatonin elevation, immune system modulation, and reduction of oxidative stress. Directly, meditation may influence stem cell trafficking and differentiation. While studies suggest potential benefits of meditation on stem cell function, further research is needed to fully elucidate the underlying mechanisms. Emerging evidence suggests that meditation may positively influence stem cell function through both indirect and direct pathways. Future research should focus on clarifying the precise mechanisms, investigating the role of meditation parameters, and conducting clinical trials to assess the therapeutic potential of meditation in promoting stem cell-mediated tissue regeneration and repair. A multidisciplinary approach involving researchers from various fields is crucial for comprehensively understanding the complex interplay between meditation, stem cells, and overall health.
FAKTOR – FAKTOR YANG MEMPENGARUHI FUNGSI LUTUT DAN KESIAPAN KEMBALI BEROLAHRAGA PASCA ACLR PADA KOMUNITAS ACL INDONESIA Dewi, Ni Kadek Ari Kusuma; Adhitya, Putu Gde Surya; Pramita, Indah; Yasa, I Wayan Putu Sutirta; Kurniawati, Ida
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.43792

Abstract

Rekonstruksi ACL merupakan operasi cangkok jaringan ACL yang digunakan untuk mengembalikan stabilitas dan fungsi pada sendi lutut sehingga memungkinkan pasien untuk kembali ke tingkat aktivitas pra-cedera ACL. Tindakan anterior cruciate ligament reconstruction (ACLR) di Indonesia meningkat sebanyak 42% pada tahun 2019 dibandingkan dengan tahun 2018 dengan total 2.236 tindakan ACLR di tahun 2019 serta diperkirakan meningkat seiring dengan semakin tingginya partisipasi individu remaja serta dewasa muda di bidang olahraga. Tujuan dilakukannya penelitian ini adalah mengetahui faktor-faktor yang mempengaruhi fungsi lutut dan kesiapan kembali berolahraga pasca ACLR. Desain penelitian ini menggunakan desain penelitian studi observasional analitik dengan pendekatan cross-sectional dengan total sampel yang terlibat pada penelitian ini berjumlah 62 orang yang telah tergabung dalam Komunitas ACL Indonesia dengan teknik pengambilan sampel menggunakan purposive sampling. Hasil : Uji deskriptif pada penelitian ini dilakukan untuk menggambarkan distribusi karakteristik variabel seperti usia, jenis kelamin, body mass index (BMI), pendidikan, tipe graft, waktu operasi, jenis rehabilitasi setelah operasi, fungsi lutut menggunakan Lysholm Knee Scale, serta kesiapan kembali berolahraga menggunakan ACL-RSI. Simpulan : Secara statistik BMI dan waktu operasi dapat mempengaruhi fungsi lutut serta usia dan tingkat pendidikan mempengaruhi kesiapan kembali berolahraga pasca ACLR.
From Tradition to Translation: A Systematic Review on the Pharmacological Actions of Eugenol Extracted from Ocimum Plants in Oxidative Stress, Inflammation, and Diabetes Mellitus Permatananda, Pande Ayu Naya Kasih; I Wayan Putu Sutirta Yasa; I Wayan Sumardika; Made Ratna Saraswati; I Gde Suranaya Pandit
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1302

Abstract

Background: Ocimum species, commonly known as basil, have a rich history in traditional medicine for various ailments. Eugenol, a primary bioactive compound found in several Ocimum species, has garnered significant scientific attention for its potential therapeutic properties. This systematic review aimed to comprehensively evaluate the pharmacological actions of eugenol extracted from Ocimum plants in the context of oxidative stress, inflammation, and diabetes mellitus. Methods: A systematic literature search was conducted across major scientific databases for studies published between 2013 and 2024 that investigated the effects of eugenol derived from Ocimum plants on oxidative stress, inflammation, and diabetes mellitus. The search strategy included keywords such as "eugenol," "Ocimum," "antioxidant," "anti-inflammatory," and "antidiabetic." Inclusion criteria for studies involving in vitro, in vivo, and clinical studies that specifically examined the pharmacological actions of eugenol extracted from Ocimum species in the aforementioned conditions. Data on study design, intervention, outcomes, and key findings were extracted and synthesized narratively. Results: The review identified ten key studies that met the inclusion criteria. These studies collectively suggested that eugenol extracted from Ocimum plants exhibited significant antioxidant activity by scavenging free radicals and enhancing endogenous antioxidant enzymes. Furthermore, eugenol demonstrated anti-inflammatory effects by modulating pro-inflammatory cytokines and inhibiting key inflammatory pathways such as NF-κB and COX. In the context of diabetes mellitus, studies indicated that eugenol could improve glucose metabolism by enhancing insulin sensitivity, protecting pancreatic beta cells, and inhibiting carbohydrate metabolizing enzymes. Conclusion: This systematic review provided a comprehensive overview of the pharmacological actions of eugenol extracted from Ocimum plants in mitigating oxidative stress, inflammation, and diabetes mellitus. The findings from the included studies supported the traditional uses of Ocimum species and highlighted the therapeutic potential of eugenol as a natural agent in managing these conditions. Further well-designed clinical trials are warranted to validate these preclinical findings and translate them into clinical applications.
Expression of CD8+ and Foxp3+ T Lymphocyte as Predictor for Response to Neoadjuvant Chemotherapy in Stage III Breast Cancer Yasa, I Nyoman Wawan Tirtha; Sudarsa, I Wayan; Niryana, I Wayan; Sriwidyani, Ni Putu; Jawi, I Made; Yasa, I Wayan Putu Sutirta; Manuaba, Ida Bagus Tjakra Wibawa; Suryawisesa, Ida Bagus Made
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3680

Abstract

BACKGROUND: Neoadjuvant chemotherapy (NAC) in breast cancer is usually utilized to eradicate micro-metastasis, induce apoptosis in tumor cells, and reduce the primary tumor size, enabling surgical intervention. Recent studies have shown that tumor-infiltrating lymphocytes (TILs), especially cytotoxic CD8+ T cells and immunosuppressive Foxp3+ regulatory T cells, influence tumor response to treatment. However, their role as predictive markers for NAC response remains unclear. Therefore, this study was performed to investigate whether high expression of CD8+ and low expression of Foxp3+ T lymphocytes are associated with better response to NAC in stage III breast cancer patients.METHODS: Total of 60 biopsy samples from stage III breast cancer patients were included, comprising 30 subjects in the response group (+) and 30 subjects in the non-response group (−). The expression levels of CD8+ and Foxp3+ T lymphocytes in tumor tissue were assessed semi-quantitatively by immunohistochemistry (IHC), using a scoring system based on the proportion and intensity of positively stained cells (Black’s grading criteria).RESULTS: Stage III breast cancer with high expression of CD8+ T lymphocytes was significantly associated with a better response to NAC (p=0.004; OR=6.882). Meanwhile, low expression of Foxp3+ T lymphocytes was not significantly associated with chemotherapy response (p=0.067; OR=3.250). A higher tumor grade was also associated with an improved response to treatment. The probability of achieving a positive response to NAC in subjects presenting with high CD8+ expression, low Foxp3+ expression, and high tumor grade was estimated at 96.98%.CONCLUSION: The combination of high expression of CD8+ T lymphocyte, low expression of Foxp3+ T lymphocyte and high tumor grade might be useful to predict good response to NAC in stage III breast cancer.KEYWORDS: CD8+ T lymphocyte, Foxp3+ T lymphocyte, neoadjuvant chemotherapy, breast cancer
From Tradition to Translation: A Systematic Review on the Pharmacological Actions of Eugenol Extracted from Ocimum Plants in Oxidative Stress, Inflammation, and Diabetes Mellitus Permatananda, Pande Ayu Naya Kasih; I Wayan Putu Sutirta Yasa; I Wayan Sumardika; Made Ratna Saraswati; I Gde Suranaya Pandit
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1302

Abstract

Background: Ocimum species, commonly known as basil, have a rich history in traditional medicine for various ailments. Eugenol, a primary bioactive compound found in several Ocimum species, has garnered significant scientific attention for its potential therapeutic properties. This systematic review aimed to comprehensively evaluate the pharmacological actions of eugenol extracted from Ocimum plants in the context of oxidative stress, inflammation, and diabetes mellitus. Methods: A systematic literature search was conducted across major scientific databases for studies published between 2013 and 2024 that investigated the effects of eugenol derived from Ocimum plants on oxidative stress, inflammation, and diabetes mellitus. The search strategy included keywords such as "eugenol," "Ocimum," "antioxidant," "anti-inflammatory," and "antidiabetic." Inclusion criteria for studies involving in vitro, in vivo, and clinical studies that specifically examined the pharmacological actions of eugenol extracted from Ocimum species in the aforementioned conditions. Data on study design, intervention, outcomes, and key findings were extracted and synthesized narratively. Results: The review identified ten key studies that met the inclusion criteria. These studies collectively suggested that eugenol extracted from Ocimum plants exhibited significant antioxidant activity by scavenging free radicals and enhancing endogenous antioxidant enzymes. Furthermore, eugenol demonstrated anti-inflammatory effects by modulating pro-inflammatory cytokines and inhibiting key inflammatory pathways such as NF-κB and COX. In the context of diabetes mellitus, studies indicated that eugenol could improve glucose metabolism by enhancing insulin sensitivity, protecting pancreatic beta cells, and inhibiting carbohydrate metabolizing enzymes. Conclusion: This systematic review provided a comprehensive overview of the pharmacological actions of eugenol extracted from Ocimum plants in mitigating oxidative stress, inflammation, and diabetes mellitus. The findings from the included studies supported the traditional uses of Ocimum species and highlighted the therapeutic potential of eugenol as a natural agent in managing these conditions. Further well-designed clinical trials are warranted to validate these preclinical findings and translate them into clinical applications.
Light physical activity and vitamin D improve sperm quality of male Rattus norvegicus exposed to cigarette smoke Amaral, Meriana Barreto; Satriyasa, Bagus Komang; Yasa, I Wayan Putu Sutirta; Sudarmaja, I Made; Jawi, I Made; Manuaba, Ida Bagus Putra; Linawati, Ni Made; Widiyanti, I Gusti Ayu
Physical Therapy Journal of Indonesia Vol. 6 No. 1 (2025): January-June 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i1.261

Abstract

Background: Male infertility is a significant global health issue, with rising prevalence linked to environmental factors such as secondhand smoke, which impairs sperm quality. This study aimed to examine how light physical activity and vitamin D supplementation improved sperm quality in rats exposed to cigarette smoke. Methods: This study used a randomized experimental design with 38 rats, divided into two groups. The control group was exposed to cigarette smoke and received vitamin D at 18 IU/kg body weight (BW) daily. The treatment group was exposed to cigarette smoke, received the same vitamin D dose, and underwent light physical activity. The 35-day research period involved the analysis of evaluated parameters. Differences between these parameters were assessed using an independent t-test, with statistical significance set at a P-value < 0.05. Results: Compared to the control group (p-values< 0.001), the treatment group, receiving light physical activity and vitamin D supplementation, exhibited significantly lower malondialdehyde (MDA) levels (0.96 ± 0.14 nmol/mL), higher vitamin D receptor expression (2.44 ± 0.58 cells/HPF), and increased testosterone levels (4.33 ± 0.76 ng/dL). Sperm quality was also significantly improved in the treatment group, showing higher sperm count (2.24 ± 0.81 × 10⁶/mL), motility (4.20 ± 0.23%), viability (3.07 ± 0.39%), and normal morphology (5.34 ± 0.17%) (p-values< 0.001). Conclusion: Light physical activity and vitamin D supplementation improved sperm quality in cigarette smoke-exposed male rats, correlating with reduced MDA and elevated vitamin D receptor expression and testosterone. Further clinical trials are warranted to explore human applications.
The Role of Antioxidant Therapy in the Management of Type 2 Diabetes Mellitus: A Literature Review Astini, Dewa Ayu Agung Alit Suka; Yasa, I Wayan Putu Sutirta; Jawi, I Made; Wande, I Nyoman
Review of Primary Care Practice and Education Vol 8, No 1 (2025): January
Publisher : Faculty of Medicine, Public Health, and Nursing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/rpcpe.104276

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disease and has become a global problem due to the rapid increase in the number of cases. This disease is characterized by chronic hyperglycemia caused by insulin resistance and pancreatic beta cell dysfunction. The occurrence of oxidative stress is known to play a central role in the development of T2DM complications, through increased reactive oxygen species (ROS) that worsen insulin resistance, worsen beta cell function, and trigger complications such as cardiovascular complications, nephropathy, and neuropathy. Objectives: This literature review aims to evaluate the scientific evidence supporting the use of antioxidant therapy as an additional approach in the management of T2DM, focusing on the effectiveness and mechanism of action of antioxidant compounds on glycemic parameters, oxidative stress, and diabetes complications. Methods: A literature search was conducted through databases on ScienceDirect, PubMed, and Google Scholar, with the keywords "antioxidant therapy", "type 2 diabetes mellitus", "oxidative stress", and "diabetes management". The selected articles included in vitro, in vivo studies, and clinical trials published in the period 2013-2023. Literature review focused on the biochemical mechanisms of antioxidant compounds and clinical outcomes related to glycemic parameters and diabetes complications. The literature extraction process was carried out from January to March 2024. Results: Supplementation of vitamin D, vitamin E, vitamin C, polyphenols, saponins, and flavonoids has been proven to reduce blood glucose levels and increase insulin sensitivity in type 2 diabetes mellitus. The mechanism involves increasing antioxidant activity, regulating glucose homeostasis, as well as modulating signaling pathways such as AMPK, PPAR, and GLUT4. Conclusions: This bioactive compound has potential as an adjunct therapy in the management of type 2 diabetes mellitus by targeting oxidative stress and insulin resistance. Further research is needed to determine optimal dosage and long-term effectiveness.
Co-Authors Adhitya, Putu Gde Surya Agung Nova Mahendra Agung Wiwiek Indrayani Airin Que Ali Djamhuri Amaral, Meriana Barreto Anak Agung Gede Sudewa Djelantik Anak Agung Ngurah Subawa Anak Agung Wiradewi Lestari Anak Agung Wiradewi Lestari, Anak Agung Anom Suardika Astini, Dewa Ayu Agung Alit Suka Bagus Komang Satriyasa Bastianus Alfian Juatmadja Benny Supono Calvin Jonathan Cokorda Agung Wahyu Purnamasidhi Cokorda Istri Dewiyani Pemayun D.P.G. Jananuraga Maharddhika Desak Gde Diah Dharma Santhi Dewa Ayu Putu Rasmika Dewi Dewi, Ni Kadek Ari Kusuma Dharayani, Luh Anandita Dharma Santhi, Desak Gde Diah Dina Sophia Margina Divasta, I G Mahapraja Fatqur Rochman Feliciano Pinto, Feliciano Ferbian Milas Siswanto Gde Ary Putra Kamajaya Gede Agus Eka Tirta Putra Gede Agus Suwiryawan Gusti Ngurah Sutapa Hamsu Kadriyan Haneetha Yogarajah I A Putri Wirawati I Dewa Made Sukrama I Gde Raka Widiana I Gde Suranaya Pandit I Gede Juliarta I Gede Widhiantara I Gst Agung Dwi Mahasurya I Gusti Agung Dyah Ambarawati I Gusti Agung Ngurah Radhitya Wijaya Radhitya Wijaya I Gusti Kamasan Arijana I Gusti Made Aman I Kadek Arya Candra I Kadek Septiawan I Ketut Agus Somia I Ketut Suastika I Ketut Suwiyoga I Made Ady Wirawan I Made Bagus Cahya Wibawa I Made Bakta I Made Dwikayana I Made Jawi I Made Oka Adi Parwata I Made Sudarmaja I Made Tomik Nurya Wardana I NYOMAN MANTIK ASTAWA I Nyoman Wande I Nyoman Wande I W. Sudarsa I Wayan Gede Artawan Eka Putra I Wayan Niryana I Wayan Rosiana I Wayan Sumardika I Wayan Wita I. B. T. Wibawa Manuaba, I. B. T. Wibawa I. B. Tjakra Wibawa Manuaba I. K. Widiana, I. K. I.A.A. Widhiartini I.B.GDE ANANTA MAHESVARA IBN Dwipayana Manuaba Ida Ayu Kemala Wasita Manuaba Ida Bagus Made Suryatika Ida Bagus Ngurah Ida Bagus Putra Manuaba Ida Bagus Verry Kusumaningrat Ida Bagus Wayan Kardika Ida Kurniawati, Ida IGA Ayu Ratih Pradnyadewi Ignatius Ferdi Yuatmadja Indah Pramita Indradewa, Rhian Indrayani, Pande Kadek Putri Rahayu Intan Astariani Kamayoga, I Dewa Gede Alit Karta Sawenda Ketut Siki Kawiyana Ketut Suega Ketut Suryana Ketut Tuti Parwati Merati Ketut Widyani Astuti Lesmana, Cokorda Agung Bagus Jaya Luh Putu Sukma Diyanti Made Ayu Widyaningsih Made Dyah Khrisnadewi MADE RATNA SARASWATI . Manuaba, Ida Bagus Tjakra Wibawa Melania Antonia Barreto Cerqueira Michael Christian Widjaja Milaviwanda, Luh Komang Ayu N. K. Niti Susila, N. K. Naw, Sin War Ni Gusti Ayu Putu Lestari Santika Dewi Ni Kadek Mulyantari Ni Kadek Nita Utami Ni Ketut Susilawati Ni Ketut Susilawati Ni Luh Candra Mas Ayuni Ni Luh Wayan Pani Ambarasari Ni Made Dharma Laksmi Ni Made Linawati Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Putu Sriwidyani Ni Putu Widya Nandasari Ni Wayan Ari Anindita Sari Ocktaviana Saputri, Legis Pande Ayu Naya Kasih Permatananda Pande Komang Gede Bayu Wikrama Permatasari, Anak Agung Ayu Putri Poniman, S. Prabasari, Pande Visca Gayatri pradnya wibawa, komang budhi Pratiwi, Cokorda Agung Pujawan, I Made Naris Purnamawati, Susy Puspa Negara, Anak Agung Gede Angga Putu Angga Wiradana Putu Astawa Putu Budhiastra Putu Diani Wirayanti Raka-Sudewi A. A. Romdhoni, Achmad Chusnu Rudi Wisaksana S. Herawati, S. Sagung Novita Widyaningrat Santosa, I Gusti Ngurah Putra Eka Sianny Herawati Sri Maliawan Sri Wahyuni Suryawisesa, Ida Bagus Made Swari, Kadek Gyna Yadnya Thaha .. Tirtha Yasa, I Nyoman Wawan Tjokorda Gde Agung Suwardewa Tjokorda Gede Oka Tri Pramartha, I Nyoman Valari, Putu Kavita Krisnina Wayan Suardana Widiyanti, I Gusti Ayu Wijaya Kusuma Yasa, I Nyoman Wawan Tirtha Yayang Christian Yenny Kandarini