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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina journal of internal medicine INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Majalah Ilmiah Fisioterapi Indonesia E-Jurnal Udayana Medica WMJ (Warmadewa Medical Journal) The Indonesian Biomedical Journal Oto Rhino Laryngologica Indonesiana ISM (Intisari Sains Medis) : Jurnal Kedokteran Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) International Journal of Nasopharyngeal Carcinoma PREPOTIF : Jurnal Kesehatan Masyarakat Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Global Pharma Technology Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA)
I Wayan Putu Sutirta Yasa
Bagian Patologi Klinik Fakultas Kedokteran Universitas Udayana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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The Role of Antioxidant Therapy in the Management of Type 2 Diabetes Mellitus: A Literature Review Astini, Dewa Ayu Agung Alit Suka; Yasa, I Wayan Putu Sutirta; Jawi, I Made; Wande, I Nyoman
Review of Primary Care Practice and Education Vol 8, No 1 (2025): January
Publisher : Faculty of Medicine, Public Health, and Nursing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/rpcpe.104276

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disease and has become a global problem due to the rapid increase in the number of cases. This disease is characterized by chronic hyperglycemia caused by insulin resistance and pancreatic beta cell dysfunction. The occurrence of oxidative stress is known to play a central role in the development of T2DM complications, through increased reactive oxygen species (ROS) that worsen insulin resistance, worsen beta cell function, and trigger complications such as cardiovascular complications, nephropathy, and neuropathy. Objectives: This literature review aims to evaluate the scientific evidence supporting the use of antioxidant therapy as an additional approach in the management of T2DM, focusing on the effectiveness and mechanism of action of antioxidant compounds on glycemic parameters, oxidative stress, and diabetes complications. Methods: A literature search was conducted through databases on ScienceDirect, PubMed, and Google Scholar, with the keywords "antioxidant therapy", "type 2 diabetes mellitus", "oxidative stress", and "diabetes management". The selected articles included in vitro, in vivo studies, and clinical trials published in the period 2013-2023. Literature review focused on the biochemical mechanisms of antioxidant compounds and clinical outcomes related to glycemic parameters and diabetes complications. The literature extraction process was carried out from January to March 2024. Results: Supplementation of vitamin D, vitamin E, vitamin C, polyphenols, saponins, and flavonoids has been proven to reduce blood glucose levels and increase insulin sensitivity in type 2 diabetes mellitus. The mechanism involves increasing antioxidant activity, regulating glucose homeostasis, as well as modulating signaling pathways such as AMPK, PPAR, and GLUT4. Conclusions: This bioactive compound has potential as an adjunct therapy in the management of type 2 diabetes mellitus by targeting oxidative stress and insulin resistance. Further research is needed to determine optimal dosage and long-term effectiveness.
Bioautography of dewandaru leaf ethanol extract thin-layer chromatography against Pseudomonas aeruginosa Lesmana, I Wayan Lolik; Yasa, I Wayan Putu Sutirta; Pranitasari, Ni Putu Oktaviani Rinika
Oto Rhino Laryngologica Indonesiana Vol. 55 No. 2 (2025): VOLUME 55, NO. 2 JULY - DECEMBER 2025
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v55i2.733

Abstract

Background: Ear infections are a significant health concern due to their impact on hearing function. One ear infection that frequently occurs is Chronic Suppurative Otitis Media (CSOM), which is commonly caused by Pseudomonas aeruginosa. The development of therapies using natural ingredients appears to be a promising option for treating various infectious diseases. The potential of the Dewandaru leaves (Eugenia uniflora L.) has long been recognized, and several studies have demonstrated its antibacterial properties. Dewandaru leaves extract contains several active compounds with antibacterial activity, as evidenced by various in vitro studies. Purpose: To test the antibacterial activity of flavonoids, saponins, tannins, and terpenoids from Dewandaru leaves extract against American Type Culture Collection (ATCC) strain of Pseudomonas aeruginosa, ATCC 9027, as the most common cause of CSOM. Method: Antibacterial activity was assessed using the Thin-Layer Chromatography–Bioautography (TLC–bioautography) contact method using a clear area on the TLC plate. Result: Dewandaru leaf extract showed antibacterial activity against Pseudomonas aeruginosa with a significant zone of inhibition. The phytochemical substances in the extract that exhibit antibacterial activity were flavonoids. Conclusion: Dewandaru leaves had the potential to be a natural antibacterial agent against Pseudomonas aeruginosa.
Ekstrak Air Biji Pepaya (Carica Papaya) dapat Menurunkan Kadar Kolesterol Total dan Kadar Serumglutamat Piruvat Transaminase (Sgpt) pada Tikus Putih Jantan Galur Wistar yang Hiperkolesterolemia Legis Ocktaviana Saputri; Bagus Komang Satriyasa; Wayan Putu Sutirta Yasa
WMJ (Warmadewa Medical Journal) Vol 2 No 1 (2017): Mei 2017
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.2.1.73.1-10

Abstract

Hiperkolesterolemia merupakan kelainan metabolisme lemak yang dianggap sebagai faktor yang berkontribusi dalam peningkatan risiko PJK. Biji pepaya diduga memiliki aktivitas hipolipidemik karena mengandung senyawa fitokimia yang berpengaruh pada metabolisme lemak. Penelitian ini menggunakan model eksperimental randomized pretest-posttestcontrol-group design terhadap 30 ekor tikus yang hiperkolesterolemia setelah diinduksi pakan tinggi kolesterol selama 48 hari. Tikus tersebut dibagi ke dalam 3 kelompok yaitu kelompok kontrol negatif (P0), kontrol positif (P1), dan kelompok perlakuan (P2).Aktivitas antihiperkolesterolemik dinilai melalui pengukuran kadar kolesterol total dan SGPT pretest dan posttest. Berdasarkan hasil penelitian, ekstrak air biji pepaya dosis 300 mg/kg/hari mampu menurunkan kadar kolesterol total sebesar 13,39% dan kadar SGPT sebesar 31,4% (p<0,05). Uji One Way Anova menunjukkan bahwa kadar kolesterol total dan SGPT posttest antar kelompok berbeda bermakna (p<0,05). Uji LSD menunjukkan bahwa pemberian ekstrak air biji pepaya dapat secara signifikan menurunkan kadar kolesterol total pada tikus yang hiperkolesterolemia jika dibandingkan dengan kelompok placebo. Kadar tersebut tidak berbeda signifikan dengan kelompok yang diberi simvastatin (beda rerata 0,6 mg/dL; p>0,05). Penurunan kadar SGPT diketahui berbeda bermakna jika dibandingkan kelompok placebo. Hasil tersebut dapat membuktikan bahwa pemberian ekstrak air biji pepaya dapat menurunkan kadar kolesterol total dan SGPT pada tikus putih jantan galur wistar yang hiperkolesterolemia.Kata Kunci: hipekolesterolemia, ekstrak biji papaya, kolesterol total, SGPT. [Aqueous Extract of Papaya (Carica Papaya) Seeds Decreased Total Cholesterol and Alanine Aminotransferase (Alt) Levels in Hypercholesterolemic Male Wistar Rats]Hypercolesterolemic is fat metabolism disorder which contributes to increase the risk of CHD. Papaya seeds issuspected having anti-hipercholesterolemic activity, because contains several phytochemical compounds. This study uses a model of experimental randomized pretest-posttestcontrol-group design in 30 rats that had induced hypercholesterolemia with high cholesterol diet for 48 days. Rats were divided into 3 groups: negative control (P0), positive control (P1), and the treatment group (P2). Antihypercholesterolemic activities were assessed through total cholesterol and ALT pretest and posttest levels. Results of this study has shown that aqueous extract of papaya seeds dose 300 mg/kg/day can reduce total cholesterol by 13.39% and ALT by 31.4% (p<0.05). One Way ANOVA test showed that the levels of total cholesterol and SGPT posttest are significantly different between groups (p<0.05). Further test with LSD showed that the aqueous extract of papaya seeds can significantly reduce total cholesterol when compared to P0. These results do not differ significantly from group that given simvastatin (mean difference 0.6 mg/dL; p>0.05). Decreased levels of ALT are also known significantly different when compared to P0.These result proved that aqueous extract of Carica papaya seeds can decreased total cholesterol and ALT levels in hypercholesterolemic male wistar rats.Keywords: hypercholesterolemic, papaya seeds extract, total cholesterol, ALT
Exploring Meditation Influence on Stem Cell: A Review of Current Evidence Santosa, I Gusti Ngurah Putra Eka; Jawi, I Made; Bakta, I Made; Yasa, I Wayan Putu Sutirta; Wirawan, I Made Ady; Lesmana, Cokorda Agung Bagus Jaya; Kandarini, Yenny; Purnamawati, Susy
Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Vol. 7 (2024): PROSIDING SINTESA
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/snts.v7i.3716

Abstract

Endogenous stem cells play a critical role in maintaining tissue homeostasis, repair, and regeneration. The interconnectedness of mind and body has long been recognized as influencing physical health, with practices such as yoga and meditation demonstrating positive effects on overall well-being. This review aims to synthesize current evidence on the effects of meditation on stem cell function, focusing on both indirect (telomere-related) and direct pathways. Meditation appears to influence stem cell function through various mechanisms. Indirectly, meditation may impact stem cells by modulating telomere length and activity. This modulation is likely mediated through stress reduction, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, melatonin elevation, immune system modulation, and reduction of oxidative stress. Directly, meditation may influence stem cell trafficking and differentiation. While studies suggest potential benefits of meditation on stem cell function, further research is needed to fully elucidate the underlying mechanisms. Emerging evidence suggests that meditation may positively influence stem cell function through both indirect and direct pathways. Future research should focus on clarifying the precise mechanisms, investigating the role of meditation parameters, and conducting clinical trials to assess the therapeutic potential of meditation in promoting stem cell-mediated tissue regeneration and repair. A multidisciplinary approach involving researchers from various fields is crucial for comprehensively understanding the complex interplay between meditation, stem cells, and overall health.
Co-Authors Achmad Chusnu Romdhoni Adhitya, Putu Gde Surya Agung Nova Mahendra Agung Wiwiek Indrayani Airin Que Ali Djamhuri Anak Agung Gede Sudewa Djelantik Anak Agung Ngurah Subawa Anak Agung Wiradewi Lestari Anak Agung Wiradewi Lestari, Anak Agung Anom Suardika Astini, Dewa Ayu Agung Alit Suka Bagus Komang Satriyasa Bastianus Alfian Juatmadja Benny Supono Calvin Jonathan Cokorda Agung Wahyu Purnamasidhi Cokorda Istri Dewiyani Pemayun D.P.G. Jananuraga Maharddhika Desak Gde Diah Dharma Santhi Dewa Ayu Putu Rasmika Dewi Dewi, Ni Kadek Ari Kusuma Dharayani, Luh Anandita Dharma Santhi, Desak Gde Diah Dina Sophia Margina Divasta, I G Mahapraja Fatqur Rochman Feliciano Pinto, Feliciano Ferbian Milas Siswanto Gde Ary Putra Kamajaya Gede Agus Eka Tirta Putra Gede Agus Suwiryawan Gusti Ngurah Sutapa Hamsu Kadriyan Haneetha Yogarajah I A Putri Wirawati I Dewa Made Sukrama I Gde Raka Widiana I Gde Suranaya Pandit I Gede Juliarta I Gede Widhiantara I Gst Agung Dwi Mahasurya I Gusti Agung Dyah Ambarawati I Gusti Agung Ngurah Radhitya Wijaya Radhitya Wijaya I Gusti Kamasan Arijana I Gusti Made Aman I Kadek Arya Candra I Kadek Septiawan I Ketut Agus Somia I Ketut Suastika I Ketut Suwiyoga I Made Ady Wirawan I Made Bagus Cahya Wibawa I Made Bakta I Made Dwikayana I Made Jawi I Made Oka Adi Parwata I Made Tomik Nurya Wardana I NYOMAN MANTIK ASTAWA I Nyoman Wande I Nyoman Wande I W. Sudarsa I Wayan Gede Artawan Eka Putra I Wayan Rosiana I Wayan Sumardika I Wayan Wita I. B. T. Wibawa Manuaba, I. B. T. Wibawa I. B. Tjakra Wibawa Manuaba I. K. Widiana, I. K. I.A.A. Widhiartini I.B.GDE ANANTA MAHESVARA IBN Dwipayana Manuaba Ida Ayu Kemala Wasita Manuaba Ida Bagus Made Suryatika Ida Bagus Ngurah Ida Bagus Putra Manuaba Ida Bagus Verry Kusumaningrat Ida Bagus Wayan Kardika Ida Kurniawati, Ida IGA Ayu Ratih Pradnyadewi Ignatius Ferdi Yuatmadja Indah Pramita Indradewa, Rhian Indrayani, Pande Kadek Putri Rahayu Intan Astariani Kamayoga, I Dewa Gede Alit Karta Sawenda Ketut Siki Kawiyana Ketut Suega Ketut Suryana Ketut Tuti Parwati Merati Ketut Widyani Astuti Lesmana, Cokorda Agung Bagus Jaya Lesmana, I Wayan Lolik Luh Putu Sukma Diyanti Made Ayu Widyaningsih Made Dyah Khrisnadewi MADE RATNA SARASWATI . Melania Antonia Barreto Cerqueira Michael Christian Widjaja Milaviwanda, Luh Komang Ayu N. K. Niti Susila, N. K. Ni Gusti Ayu Putu Lestari Santika Dewi Ni Kadek Mulyantari Ni Kadek Nita Utami Ni Ketut Susilawati Ni Ketut Susilawati Ni Luh Candra Mas Ayuni Ni Luh Wayan Pani Ambarasari Ni Made Dharma Laksmi Ni Made Linawati Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Putu Oktaviani Rinika Pranitasari Ni Putu Widya Nandasari Ni Wayan Ari Anindita Sari Ocktaviana Saputri, Legis Pande Ayu Naya Kasih Permatananda Pande Komang Gede Bayu Wikrama Permatasari, Anak Agung Ayu Putri Poniman, S. Prabasari, Pande Visca Gayatri pradnya wibawa, komang budhi Pratiwi, Cokorda Agung Pujawan, I Made Naris Purnamawati, Susy Puspa Negara, Anak Agung Gede Angga Putu Astawa Putu Budhiastra Putu Diani Wirayanti Raka-Sudewi A. A. Rudi Wisaksana S. Herawati, S. Sagung Novita Widyaningrat Santosa, I Gusti Ngurah Putra Eka Sianny Herawati Sri Maliawan Sri Wahyuni Swari, Kadek Gyna Yadnya Thaha .. Tirtha Yasa, I Nyoman Wawan Tjokorda Gde Agung Suwardewa Tjokorda Gede Oka Tri Pramartha, I Nyoman Valari, Putu Kavita Krisnina Wayan Suardana Wijaya Kusuma Yayang Christian Yenny Kandarini