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All Journal Pharmasipha Jurnal Delima Harapan Jurnal Farmasi Indonesia Jurnal Analis Farmasi Jurnal Kefarmasian AKFARINDO Jurnal Riset Kefarmasian Indonesia PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN Jurnal Peduli Masyarakat Indonesian Journal of Global Health research Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Medfarm: Jurnal Farmasi dan Kesehatan JOURNAL SCIENTIFIC OF MANDALIKA (JSM) Jurnal Kesehatan Tambusai Jurnal Ilmiah Wahana Pendidikan Jurnal Buana Farma JAF (Jurnal Analis Farmasi) Proceedings of the International Conference on Nursing and Health Sciences JIFI (Jurnal Ilmiah Farmasi Imelda) Sehat Rakyat: Jurnal Kesehatan Masyarakat JURNAL JAMU KUSUMA Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Jurnal Ilmiah Kesehatan Jurnal Medika Nusantara Parapemikir Jurnal Ilmiah Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Sains dan Kesehatan Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Science and Community Pharmacy Journal Green Health: Journal of Health Sciences, Nursing and Nutrition Jurnal Pengabdian Ilmu Kesehatan MURAKES
Listyani, Tiara Ajeng
Universitas Duta Bangsa Surakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Antibacterial Activity Test Of Ethanol Extract And N-Hexane Fraction, Ethyl Acetate, Moringa Leaf Water (Moringa Oleifera L) Against Streptococcus Mutans ATCC 25175 Bacteria Wahdah Sri Rahayu; Tatiana Siska Wardani; Tiara Ajeng Listyani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.662

Abstract

Dental caries remains a major oral health problem globally and in Indonesia, triggered by Streptococcus mutans biofilm. Chemical agents such as chlorhexidine have side effects, encouraging the use of natural alternatives from Moringa oleifera L. leaves. This study aims to evaluate the antibacterial activity of ethanol extracts and n-hexane, ethyl acetate, and water fractions against Streptococcus mutans ATCC 25175, identify the most active fraction, and determine the MIC and MBC. This quantitative study used diffusion and dilution methods. Bacteria: Streptococcus mutans ATCC 25175; samples: ethanol extract of Moringa oleifera L. leaves and n-Hexane, ethyl acetate, and water fractions. Data analysis used SPSS 25 One-Way ANOVA, Tukey (p<0.05). Results showed that the ethyl acetate fraction was the most active with 12.36 mm inhibition at 45%; MIC and MBC were 30% ANOVA significant (p=0.000). The ethyl acetate fraction has strong caries prevention potential, supporting herbal development.
In-Silico Study Of The Potential Of Neem Leaf Active Compounds (Azadirachta Indica) As A-Amylase Enzyme Inhibitors Through Molecular Docking And ADMET Analysis Mutiara Marzalina Wardhani; Tiara Ajeng Listyani; Tatiana Siska Wardani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.687

Abstract

Indonesia has reached 20.4 million adults with the fifth highest number of diabetes in the world and is estimated to be 28.6 million by 2050. The use of acarbose has side effects such as digestive problems to potential for the liver and kidneys, so these problems can be overcome with herbal plant treatment, one of which is the active compound of neem leaves (Azadirachta indica). This study aims to analyze the interaction of 20 neem leaf compounds with α-amylase enzymes through the molecular docking approach, ADMET prediction, and modification of potential new compounds as antidiabetic candidates. This research was conducted in silico using PyRx-AutoDock Vina for docking, VegaZZ, PyMOL, and Discovery Studio for optimization and visualization, SwissADME for ADME prediction, and Toxtree for toxicity test. The docking method validation is expressed in RMSD values of <2 Å. The docking results showed that Kaempferol had a ΔGBinding of -7.9 kcal/mol, an RMSD value of 1.229 Å and had a similarity of amino acid residues to the native ligands ASP:197. Kaempferol has a good ADME profile, High (III) category toxicity and is mutagenic and carcinogen. The design of the new compound of Kaempferol i.e. 2-(4-hydroxycyclohexyl)-1-methoxybutane-1,4-diol has amino acid residue similarity to the native ligands ASP A:197, ΔGBinding -5.6, RMSD value 1,704 Å and has good ADME, Low (I) category toxicity. The active compound of neem leaves has the potential to be an inhibitor of the enzyme α-Amylase.
Pemanfaatan Kombucha Bunga Telang (Clitoria ternatea L.) sebagai Antidiabetes Pada Tikus Putih Anita Dwi Septiarini; Bagas Ardiyantoro; Tiara Ajeng Listyani
MUARA KESEHATAN : Jurnal Ilmiah Ilmu Kesehatan Vol. 2 No. 1 (2026): MUARA KESEHATAN : Jurnal Ilmiah Ilmu Kesehatan & Medis
Publisher : CV. Muara Edukasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64365/murakes.v2i1.168

Abstract

Diabetes Melitus merupakan penyakit yang ditandai dengan peningkatan kadar glukosa darah. Terapi pengobatan diabetes melitus dengan obat sintesis dapat menimbulkan efek samping yang tidak diinginkan, sehingga masyarakat mulai menggunakan obat bahan alam sebagai terapi pengobatan. Kombucha merupakan minuman hasil fermentasi yang menggunakan simbiosis antara bakteri dan yeast yang dikenal dengan SCOBY. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antidiabetes kombucha bunga telang (Clitoria ternatea L.) pada tikus putih yang diinduksi streptozotocin. Pengujian aktivitas antidiabetes dilakukan dengan 25 ekor tikus dibagi menjadi 5 kelompok yaitu CMC Na 0.5% (kontrol negatif), gloibenklamid 5 mg (kontrol positif), kombucha bunga telang dosis 5 mL/kg BB; 10 mL/ kg BB; dan 15 mL/kg BB. Dari hasil penelitian dapat disimpulkan bahwa Kombucha bunga telang (Clitoria ternatea L.) mempunyai aktivitas antidiabetes dengan dosis efektif terhadap penurunan kadar gula darah adalah 5 ml/kg BB.
ANALISIS DOCKING MOLEKULER BESERTA PREDIKSI ADME SENYAWA DERIVAT FLAVONOID SEBAGAI INHIBITOR ENZIM 15-LIPOXYGENASE-2 Tiara Ajeng Listyani; Diza Aulia Ramadhani; Danang Raharjo
Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Vol 15 No 2 (2024)
Publisher : UNIVERSITAS BHAMADA SLAWI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36308/jik.v15i2.626

Abstract

Derivat flavonoid merupakan metabolit sekunder dari polifenol dan banyak ditemukan pada tumbuhan serta makanan dengan berbagai aktivitas biologi seperti antivirus dan antiinflamasi. Analisis docking molekuler senyawa derivat flavonoid terhadap enzim 15-lipoxygenase-2 bertujuan untuk menyelidiki potensi senyawa derivat flavonoid sebagai penghambat enzim 15-lipoxygenase-2 menggunakan program AutoDock Vina berdasarkan energi bebas pengikatan (ΔG), nilai RMSD, interaksi residu asam amino, serta prediksi ADME yang memenuhi kriteria dari Aturan Lipinski. Hasil docking dari tujuh senyawa derivat flavonoid ditemukan lima senyawa yang berpotensi sebagai penghambat 15-lipoxygenase-2 berdasarkan energi bebas pengikatan (ΔG), nilai RMSD, dan asam amino yang berkontribusi terhadap interaksi dengan ikatan hidrogen asam amino Leu, Ile, Phe, Asn dimana interaksi tersebut mirip dengan interaksi senyawa XRP yang merupakan ligan asli protein target yaitu epicatechin, epicatechin 3 gallat, luteolin, luteolin 7 glukosidase, dan quercetin. Prediksi nilai ADME pada penelitian ini menggunakan program SwissADME di mana tujuh senyawa derivat flavonoid memiliki berat molekul, nilai donor maupun akseptor ikatan hidrogen, dan nilai log P yang memenuhi kriteria dari Aturan Lipinski.
Molecular Docking Study of Active Compounds of Ketapang Leaves (Terminalia Catappa L.) Against Inhibitors Maltase Glucoamylase And Modification of New Compounds Tiara Ajeng Listyani; Nissa Syahraningtyas Putri; Bagas Ardiyantoro
Green Health International Journal of Health Sciences Nursing and Nutrition Vol. 3 No. 3 (2026): July: Green Health: Journal of Health Sciences, Nursing and Nutrition
Publisher : International Forum of Researchers and Lecturers

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70062/greenhealth.v3i3.317

Abstract

The prevalence of diabetes mellitus is projected to reach 853 million by 2050. Postprandial hyperglycemia induced by the maltase glucoamylase enzyme can exacerbate the condition of diabetic patients. Although acarbose is widely used, it causes gastrointestinal side effects; thus, natural alternatives like ketapang leaves (Terminalia catappa L.) serve as a potential source of antidiabetic active compounds. This study aimed to evaluate the binding affinity, root mean square deviation (RMSD) values, and amino acid interactions of 70 active compounds from ketapang leaves against the maltase-glucoamylase enzyme using a molecular docking approach, alongside designing a novel potential compound modification as an antidiabetic drug candidate. In silico docking simulations were performed using PyRx-AutoDock Vina, structural optimization via VegaZZ, method validation using PyMOL, visualization through Discovery Studio Visualizer, and 2D/3D structural preparation using ChemDraw. The docking results of the 70 test compounds revealed that 41 compounds exhibited ΔGBinding values ranging from -6.3 to -8.5 kcal/mol, 66 compounds showed RMSD values ≤ 2Å, and 5 compounds shared similar amino acid residue interactions with the positive control, acarbose. Structural modification of gallic acid 3-O-(6-galloylglucoside) yielded a novel compound, 4-hydroxy-3-(2-hydroxyethoxy)-5-methoxybenzoic acid, which demonstrated a ΔGBinding value of -5.5 kcal/mol, an RMSD of 1.673 Å, and a matching amino acid residue interaction with the positive control at ASP A:649. In conclusion, active compounds from ketapang leaves and the newly modified compound show promising potential as maltase-glucoamylase enzyme inhibitors via molecular docking.
Transfer Ilmu Pengetahuan dan Teknologi Produksi Kombucha Bunga Kupu-kupu Antidiabetes bagi Karang Taruna Katajanom di Kelurahan Jayengan Surakarta Tiara Ajeng Listyani; Puguh Ika Listyorini; Anna Fitriawati
Jurnal Pengabdian Ilmu Kesehatan Vol. 6 No. 2 (2026): Juli: Jurnal Pengabdian Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jpikes.v6i2.7832

Abstract

Type-2 Diabetes Mellitus (T2DM) remains the second highest non communicable disease burden in Surakarta City after hypertension, with regional facilities like Puskesmas Jayengan recording substantial patient visits. Principal risk factors include high sugar and calorie-dense diets, insufficient physical activity, advancing age, and hereditary predisposition. In response, a community service team, chaired by Tiara Ajeng Listyani with members Puguh Ika Listyorini and Anna Fitriawati, implemented an empowerment program for the Katajanom Jayengan Youth Organization (Karang Taruna), supported by the Directorate of Research and Community Service, the Directorate General of Research and Development, the Ministry of Higher Education, Science, and Technology, and Universitas Duta Bangsa Surakarta for the 2026 period. The program transferred knowledge and technology for producing butterfly pea flower (Clitoria ternatea) kombucha as a functional nutraceutical beverage with natural antidiabetic properties. Methods included healthy lifestyle education, self administered blood glucose screening training, SCOBY based fermentation technology transfer, mentorship in production standardization and halal certification, and pre-test/post-test evaluations with daily blood glucose monitoring of partners. Results showed successful development of a nutraceutical product prototype, achieving an initial production target of at least 50 liters of consumption-grade output, along with improved community health evidenced by a 15–20% reduction in blood glucose levels during routine monitoring. The program has broader implications for establishing a self-sustaining, community based production unit supporting community health independence, while opening pathways toward a youth driven creative economy grounded in locally sourced functional food products.
Uji Stabilitas dan Penetapan Kadar Antosianin Sediaan Eyeshadow Cream Ekstrak Etanol Kembang Sepatu (Hibiscus rosa sinensis L.) dengan Metode Spektrofotometer UV-Vis Ferlinda Ayu Astuti; Tiara Ajeng Listyani; Rahmat Hidayat
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 5 (2026): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i5.2451

Abstract

The use of synthetic colorats in cosmetics, particularly eyeshadow, may pose risks of irritation and allergic reactions when used excessively. Therefore, safer alternatives are needed, including natural colorants such as anthocyanins from hibiscus flowers (Hibiscus rosa sinensis L.), which provide natural color and antioxidant activity. This study aimed to formulate hibiscus flower extract as a natural colorant in an eyeshadow cream preparation, determine ist anthocyanin content, and evaluate the physical quality and stability of the preparation at various extract concentrations. The study employed a laboratory experimental method involving the preparation of crude drugs, extraction using 70% ethanol by maceration, standardization of the crude drug and extract, phytochemical screening, formulation of eyeshadow cream with F0 (0%), F1 (10%), F2 (15%), and F3 (20%) extract concentrations, physical quality and stability testing, and determination of anthocyanin content using UV-Vis spectrophotometry. The result showed an extract yield of 30% and a moisture content of 1,24%. The extract met the requirements for ethanol and heavy metal-free testing and contained alkaloids, flavonoids, saponin, triterpenoid, tannins, and anthocyanins. All formulations met the physical quality and stability requirements. Anthocyanin contents were 16,53, 17,19, 23,21, and 25,88 mg/L for F0,F1,F2, and F3, respectively. Increasing the extract concentration resulted in a more intense eyeshadow cream color. These findings indicate that hibiscus flower extract has potential as a natural colorant in eyeshadow cream preparations.
Co-Authors Achsantya, Raden Roro Karyna Cindy Addawiyyah, Muniroh Agung Eru Wibowo Aini, Riszki Nur Aisyah Rabitha Alisi Akhmad, Khabib Alia Anita Dwi Septiarini Anna Fitriawati Aprilia Rika Alvita Apriliawan, Hidayah Aqila Widya Sari Ariyanti Ariyanti Artini, Kusumaningtyas Siwi Azizah, Dinar Bagas Ardiyantoro Bagas Ardiyantoro Danang Raharjo Deniessa, Ardelea Desy Ayu Irma Permatasari Diza Aulia Ramadhani Dwi Bagus Pambudi Effendi Nursalim Ekarani, Meisyah Litang Endang Suciati Erick Ferdian Fadila, Vera Nurhidayatul Fazlin Fauzi Ferlinda Ayu Astuti Galuh Puspitasari Guterres, Agostinha Hafalika, Aviv Ifalahma, Darah Ika Dwi Ningrum Kharisma, Putri Nur Khilda Hilyatul 'Ulya Krisnantari, Ni Luh Novelia Kusumaningtyas Siwi Artini Kusumaningtyas Siwi Artini Kusumasedya, Willyana Pratiwi Lende, Yulianus Erman Luthfiyanti, Niken Masruroh, Sururul Kamalin Muniroh Addawiyyah Mutiara Marzalina Wardhani Nabillah Sirli Okta Maharani Niken Luthfiyanti ningsih, endang wahyu Nissa Syahraningtyas Putri Nugraha, Novanda Satria Nur Azmi, Tasya Nabila Oktaviana, Aptika Pang Jyh Chyang Pratama, Kharisma Jayak Puguh Ika Listyorini Puspitasari, Rara Ayu Rafidah Hanifah Rahardian Ariana Putri Rahmasari, Ikrima Rahmat Hidayat Rahmat Hidayat Ratna Safitri Rezky Ardika Pamungkas Rina Herowati Rohmana, Vivin Marwiyati Sari, Cantyka Eka Viemala Sejati, Siti Laila Utari Septian Maulid Wicahyo Septiarini, Anita Dwi Silvia Devi Silvia Mawardani Siregar, sherina Sarifitri Suwardi, Nisa Aura Rizky Tanoyo, William Tatiana Siska Wardani Tatiana, Siska Wardani Ucik Susilowati Urip, Sri Khanti Veranita, Weri Wahdah Sri Rahayu Wahyu Budi Utomo Wardani, Tatiana Siska Wargani, Rizki Nugraha Yosua Christabel Natanael Yuliana, Ana Yuliana, Silvia Zanjabila, Chanida Zavitra, Mei Nanda