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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Farmasi Indonesia Jurnal Riset Kesehatan Poltekkes Depkes Bandung Abdimasku : Jurnal Pengabdian Masyarakat Bioscientist : Jurnal Ilmiah Biologi JAGO TOLIS : Jurnal Agrokompleks Tolis Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal Agroteknologi Jurnal Pengabdian dan Pengembangan Masyarakat Indonesia PCJN Pharmaceutical and Clinical Journal of Nusantara Jurnal Relawan dan Pengabdian Masyarakat REDI Jurnal Pengabdian Masyarakat Ilmu Kesehatan Jurnal Paradigma Pengabdian Pharmacia Ar-Rasyid: Jurnal Publikasi Penelitian Ilmiah Jurnal Kesehatan Tujuh Belas (Jurkes TB)
Rifkarosita Putri Ginaris
Stikes Tujuh Belas
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DAYA HAMBAT ENZIM TIROSINASE DARI FORMULASI SEDIAAN HAND SANITZER GEL SEBAGAI ANTIAGING BERBAHAN AKTIF TANAMAN KOMODITAS HORTIKULTURA BERUPA KOMBINASI EKSTRAK BUAH NAGA MERAH DAN BUAH LEMON Tri Yudianto; Arti Wahyu Utami; Rifkarosita Putri Ginaris; Nai’matul Retno Faizah; Octaviana Dyah Oentari; Alfina Nurrahman; Fitria Eka Resti Wijayanti; Sukardi Sugeng Rahmad; Reni Purbanova
Jurnal Kesehatan Tujuh Belas (Jurkes TB) Vol. 4 No. 1 (2022): November 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Tujuh Belas, Karanganyar, JAwa, Indonesia

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Abstract

One of the long-term losses in homeostatic balance for any organism is a sign of aging skin. The state of hyperpigmentation caused by the activity of the tyrosinase enzyme is an indicator of aging. The solution that can be recommended to prevent premature signs of aging is by caring for the skin using the most affordable pharmaceutical preparation, namely Hand Sanitizer Gel. Hand Sanitizer Gel which has anti-aging properties can be produced from bioactive compounds from horticultural commodity plants because it has been proven and is quite popular. Apart from being able to be used as an active ingredient in functional food, it can also be used as a pharmaceutical, namely the preparation of active cosmetic ingredients. This is due to the content of vitamins, antioxidants, essential oils, proteins, even phenolic compounds and other environmentally friendly active ingredients found in horticultural commodity plants, especially the fruit group used in this research. Red dragon fruit has been proven to contain organic compounds such as gallic acid, elagic acid and ferulic acid which can inhibit the melanogenesis process both in vitro and in vivo from the results of previous findings. Lemons contain saponins, flavonoids, alkaloids and tannins so they can be designed to inhibit the tyrosinase enzyme. This research aims to determine the inhibitory power of the tyrosinase enzyme from extracts of horticultural commodity plants, both red dragon fruit and lemon peels in the form of hand sanitizer gel formulations and preparations. The results of this research have proven that based on the IC50 value, horticultural commodity plant extracts from lemon peel have better inhibitory power for the tyrosinase enzyme compared to red dragon fruit, namely 3,509 µg/mL. The conclusion in this research is that horticultural commodity plants in the form of lemon peel extract are more recommended as an active substance in inhibiting the tyrosinase enzyme when compared with red dragon fruit extract based on the IC50 value even though the hand sanitizer gel dosage form has the potential to inhibit the tyrosinase enzyme.
Formula Gel Ekstrak Daun Andong Merah (Cordyline Fruticose L.) Dengan Kombinasi Gelling Agent Karbopol 940 Dan HPMC Sebagai Antioksidan Irfan Bagus Setyawan; Alfina Nurrahman; Rifkarosita Putri Ginaris
Jurnal Kesehatan Tujuh Belas (Jurkes TB) Vol. 5 No. 1 (2024): November 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Tujuh Belas, Karanganyar, JAwa, Indonesia

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Abstract

Radikal bebas adalah atom atau molekul dengan elektron tidak berpasangan, dan yang paling reaktif adalah radikal hidroksil (OH). Tanaman Andong Merah (Cordyline fruticosa L.) dikenal memiliki efek antioksidan, berkat kandungan saponin, tanin, flavonoid, polifenol, steroida, polisakarida, kalsium oksalat, dan zat besi. Flavonoid, salah satu senyawa dalam tanaman ini, efektif sebagai penangkap radikal bebas. Penelitian ini menilai efek kombinasi karbopol 940 dan HPMC sebagai agen pengental dalam gel ekstrak etanol daun andong merah terhadap sifat fisiknya. Metode penelitian yang digunakan yaitu maserasi menggunakan etanol 70%. Hasil pengamatan menunjukkan bahwa gel stabil baik secara organoleptis maupun homogen sebelum dan setelah penyimpanan. Viskositas gel mengalami perubahan selama penyimpanan. Formula I dengan kombinasi karbopol 940 dan HPMC pada konsentrasi 1,50% dan 3,50% menunjukkan pH yang stabil dalam rentang fisiologis kulit (4,5-6,5). Daya sebar gel, baik pada Formula I, II, III, dan IV, juga stabil dengan diameter 3-5 cm. Kesimpulan analisis spektrofotometri UVVis FI menunjukkan absorbansi yang sesuai dengan hukum Lambert-Beer, dengan grafik linear dan nilai R² mendekati 1, menandakan hasil yang akurat.
Isolation and Characterization of Endophytic Bacteria from Curcuma Aeruginosa Roxb As Antibacterial Candidates Againts Pneumonia Utami, Arti Wahyu; Rezaldi, Firman; Ginaris, Rifkarosita Putri; Nabilla, Jihan; Bramantyo; Setiawati, Puput; Fatikha, Zulfania Shandra; Pujiastuti, Nanik; Wahyuni, Dwi
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 4 (2025): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i4.18148

Abstract

This study aimed to isolate and characterize endophytic bacteria from black turmeric rhizomes (Curcuma aeruginosa Roxb) and test their potential as antibacterial agents against Streptococcus pneumoniae. This experimental research began with the isolation of endophytic bacteria from surface-sterilized black turmeric rhizomes. The obtained pure isolates were characterized macroscopically (colony shape, margin, elevation, pigment) and microscopically (cell shape, Gram staining). The growth curve of potential isolates was determined, and antibacterial activity was tested using the disc diffusion method against S. pneumoniae, with ciprofloxacin as a positive control. Six endophytic bacterial isolates (PS1, PS2, PS3, PS4, PS5, PS6) were successfully isolated, showing variations in colony morphology, and all were classified as Gram-negative bacilli. All isolates exhibited strong antibacterial activity against Streptococus pneumoniae, with inhibition zone diameters ranging from 15.3 mm to 20.6 mm. Black turmeric rhizomes (Curcuma aeruginosa Roxb) harbor diverse endophytic bacteria with significant potential as antibacterial agents against the pneumonia pathogen, Streptococcus pneumoniae.
Penyuluhan Inovasi Kosmetik dalam Sediaan Lulur Herbal pada Siswa SMA Muhammadiyah 1 Karanganyar Ginaris, Rifkarosita Putri; Sadida, El Santi; Istikhomah, Rekha Aulia; Pratiwi, Reza Safinda; Putri, Desvita Maharani; Rezaldi, Firman
Jurnal Pengabdian Masyarakat Ilmu Kesehatan Vol 7, No 1 (2026): Januari
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jpmik.v7i1.6816

Abstract

Kulit merupakan organ terluar tubuh yang berperan penting dalam menjaga kesehatan dan penampilan. Paparan sinar matahari, polusi, dan debu, dapat menurunkan kualitas kulit, sehingga diperlukan perawatan preventif yang aman, terutama pada remaja. Salah satu upaya perawatan adalah penggunaan lulur berbahan alami. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan siswa SMA Muhammadiyah 1 Karanganyar, mengenai perawatan kulit yang sehat dan aman, melalui edukasi inovasi lulur herbal berbahan kopi (Coffea arabica L.) dan temu giring (Curcuma heyneana). Biji kopi diketahui mengandung senyawa antioksidan yang bermanfaat bagi kesehatan kulit dan Temu Giring mengandung banyak bioaktivitas seperti antioksidan, antikanker dan antiinflamasi. Kebaruan dari kegiatan pengabdian kepada masyarakat ini terletak pada pemanfaatan inovasi lulur herbal berbahan kopi dan temu giring sebagai media edukasi kesehatan kulit bagi remaja SMA melalui pendekatan edukatif dan aplikatif. Metode yang digunakan adalah edukasi melalui penyuluhan interaktif, praktik pembuatan lulur, serta evaluasi menggunakan pre-test dan post-test berbentuk kuesioner. Media yang digunakan meliputi, presentasi PowerPoint, dan leaflet. Sampel pengabdian diambil secara sampling terhadap 40 siswa berasal dari siswa kelas X. Hasil kegiatan ini menunjukkan adanya peningkatan pengetahuan peserta, ditandai dengan kenaikan nilai post-test sebesar 94% dibandingkan nilai pre-test. Tingkat partisipasi peserta tergolong baik, dengan 60% aktif dalam diskusi dan 40% aktif mengajukan, serta menjawab pertanyaan. Kegiatan ini efektif dalam meningkatkan pengetahuan dan partisipasi siswa SMA terkait perawatan kulit alami dan aman.
Optimalisasi nutrisi generasi emas: edukasi gizi dan pemanfaatan kacang gude untuk pencegahan stunting di Panti Asuhan Yatim Putri IPHI Karanganyar Rifkarosita Putri Ginaris; Jihan Nabilla; Dea Nurfadhillah; Na’imatul Retno Fauzah; Sinta Wisma Sari; Fitria Eka Resti W.; Andri Tri Cahyono; Puput Setiawati; Nova Seftiyanti
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 4 (2025): Juli
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i4.31897

Abstract

Abstrak Stunting merupakan permasalahan kesehatan yang masih menjadi fokus nasional dalam upaya meningkatkan kualitas sumber daya manusia Indonesia. Berdasarkan data Dinas Kesehatan Karanganyar, angka stunting di wilayah ini masih tinggi, terutama di kalangan remaja, salah satunya kelompok yang rentan terhadap anemia remaja ini adalah remaja putri di Panti Asuhan Yatim IPHI, Karanganyar. Mitra sasaran adalah Panti Asuhan Yatim Putri IPHI Karanganyar dengan jumlah peserta sebanyak 10 remaja putri berusia 12-18 tahun. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan gizi berbasis kacang gude sebagai upaya pencegahan stunting dalam olahan pangan seperti cookies. Metode pelaksanaan meliputi sosialisasi dan edukasi gizi, demonstrasi pembuatan produk olahan kacang gude (cookies), serta pendampingan kewirausahaan dan evaluasi pengetahuan melalui pre-test dan post-test. Hasil yang diperoleh menunjukkan bahwa peserta mengalami peningkatan nilai rata-rata dari 78,00 (pre-test) menjadi 84,00 (post-test). Sebanyak 60% peserta menunjukkan peningkatan skor, dengan nilai maksimum mencapai 100. Hasil uji pairet t-test menunjukkan perbedaan signifikan (p=0,031). Peserta mampu menjelaskan proses pembuatan produk cookies kacang gude dan memahami konsep gizi seimbang. Kata kunci: edukasi gizi; panti asuhan; pemanfaatan kacang gude; remaja putri; stunting. AbstractStunting remains a major public health issue and a national priority in efforts to improve the quality of Indonesia’s human resources. According to data from the Karanganyar Health Office, the prevalence of stunting in this region remains high, especially among adolescents. One vulnerable group is adolescent girls living at the IPHI Orphanage in Karanganyar. The target partner in this program was the IPHI girls Orphanage, involving 10 adolescent girls aged 12-18 years. This program aimed to increase nutritional knowledge based on the use of pigeon pea (Cajanus cajan) as a stunting prevention effort through food products such as cookies. The methods included nutrition education and awareness, demonstration of pigeon pea-based cookie production, entrepreneurship mentoring, and knowledge evaluation through pre-test and post-test. The results showed an increase in average scores from 70.00 (pre-test) to 84.00 (post-test). A total of 60% of participants showed improvement, with a maximum score of 100. The paired t-test analysis indicated a significant difference (p=0,031). Participants were able to explain the process of pigeon pea cookie production and demonstrated an understanding of the balanced nutrition concept. Keywords: nutrition education; orphanage; utilization of pigeon pea; adolescent girls; stunting
Potential of Hanjeli (Coix lacryma-jobi) as an antifungal Microsporum Gypseum Causes Skin Infections: Extract, Boiled Water, Kombucha, and Bath Soap Tri Saptari Haryani; Mutiara Siti Nurfajriah; Cecep Sudrajat; Firman Rezaldi; Tri Yudianto; Rifkarosita Putri Ginaris; Sukardi Sugeng Rahmad
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.11744

Abstract

Job's tears (Coix lacryma-Jobi L.) are known to contain chemical compounds of the alkaloid, flavonoid and tannin groups that have the potential as antifungals. Microsporum gypseum is one of the dermatophyte fungi that causes dermatitis, a disease that infects skin of both animals and humans. The study aims to test the activity and determine optimal concentration of Job's tears seed extract, Job's tears seed boiled water, Job's tears leaf kombucha, and Job's tears seed extract bath soap formulation as antifungals against Microsporum gypseum which causes skin disease infections. The research method used agar diffusion with the well technique (Agar Well Diffusion), the research parameters included phytochemical tests of the extract, measuring diameter inhibition area. The results phytochemical test obtained alkaloid compounds, and results of activity test of the Job's tears seed extract formulation, Job's tears seed boiled water, Job's tears leaf kombucha, and Job's tears seed extract bath soap obtained optimal diameter of the inhibition area overall at an extract concentration of 40%. Conclusion,  activity of ethanol extract of hanjeli seeds, boiled water of hanjeli seeds, hanjeli leaf kombucha, and hanjeli seed extract bath soap at a concentration of 40% have antifungal activity against Microsporum gypseum which causes skin diseases.
Suppression of Staphylococcus epidermidis Skin Wound Infection by Citrus aurantifolia Lime Peel Ethanolic Extract: A Concentration-Response Analysis Putri, Amalia Eka; Santoso, Arif; Ginaris, Rifkarosita Putri
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 2 No. 01 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v2i03.56

Abstract

Staphylococcus epidermidis is a coagulase-negative Staphylococcus (CoNS) that causes a spectrum of superficial skin infections including wound infections, folliculitis, and burn-associated skin sepsis, particularly through its capacity to form highly resistant biofilms. The emergence of methicillin-resistant S. epidermidis (MRSE) with polysaccharide intercellular adhesin (PIA)-mediated biofilm has severely limited available therapeutic options. This study assessed the concentration-dependent bacteriostatic activity and minimum inhibitory concentration (MIC) of Citrus aurantifolia lime peel ethanolic extract against S. epidermidis ATCC 12228 using the Kirby-Bauer disc diffusion method on Muller Hinton Agar (MHA). Extract from lime peels sourced in Tulungagung, East Java was prepared by ethanol maceration. Fourteen concentrations (0.5–150 mg/mL) were tested in triplicate. The MIC was 1 mg/mL (inhibition zone 6.73 ± 0.06 mm). Inhibition zones increased progressively from 6.73 mm (MIC, 1 mg/mL) to 11.60 ± 0.35 mm (150 mg/mL), with the very strong threshold (>10 mm) first crossed at 70 mg/mL. Concentration-response linearity was confirmed (R² > 0.97). The positive control (tetracycline 30 µg) produced 28.17 ± 0.59 mm. These findings establish a pharmacological basis for incorporating lime peel extract into wound care and topical antiseptic formulations targeting S. epidermidis.
Minimum Inhibitory Concentration of Ethanol Extract of Vernonia amygdalina Delile. against Escherichia coli, Salmonella typhi, Staphylococcus aureus, and Bacillus cereus by Disc Diffusion Putri, Amalia Eka; Ginaris, Rifkarosita Putri; Indrayati, Lyna Lestari
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 4 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i03.146

Abstract

Diarrhea remains a major global health challenge caused by pathogenic bacteria including Escherichia coli, Salmonella typhi, Staphylococcus aureus, and Bacillus cereus. African leaf (Vernonia amygdalina Delile.) contains bioactive compounds such as flavonoids, saponins, tannins, and alkaloids with recognized antibacterial properties. This study determined the Minimum Inhibitory Concentration (MIC) of ethanol extract of V. amygdalina prepared by Ultrasonic-Assisted Extraction (UAE) at three extraction times (5, 15, and 30 minutes) against four diarrhea-causing bacteria using the disc diffusion method. Extraction yields were 8.8%, 10.45%, and 11.9% for UAE at 5, 15, and 30 minutes, respectively. Antibacterial testing at concentrations ranging from 300 to 1.56 mg/mL demonstrated predominantly moderate inhibition zones (5–10 mm), with some concentrations reaching the strong category (10–20 mm). The MIC for B. cereus and S. aureus was 1.56 mg/mL across all extraction times. For S. typhi, the MIC was 1.56 mg/mL (5 and 30 min UAE) and 12.5 mg/mL (15 min UAE). For E. coli, the MIC was 6.25 mg/mL (5 min UAE) and 1.56 mg/mL (15 and 30 min UAE). One-way ANOVA confirmed statistically significant differences among concentrations (p < 0.05). The 30-minute UAE produced the highest yield and generally superior antibacterial activity, supporting its selection as the optimal extraction condition. These findings highlight the potential of V. amygdalina ethanol extract as a natural antibacterial agent for diarrheal disease management.
Formulasi Nanoenkapsulasi Ekstrak Kacang Gude (Cajanus cajan L. (Huth.)) sebagai Antidiabetes Ginaris, Rifkarosita Putri; Aryadi, Anggi; Afifa, Nadya; Wardani, Arief Kusuma; Indrayati, Lyna L.; Santoso, Blegoh Iwan
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.126

Abstract

Pigeon pea (Cajanus cajan L. (Huth.)) contains flavonoids that exhibit potential antidiabetic activity through the inhibition of the α-glucosidase enzyme. The main limitation in the application of flavonoid compounds is their low solubility and stability. Nanoencapsulation using chitosan–TPP via a simple ionic gelation method can enhance the stability and bioactivity of active compounds. This study aimed to develop a nanoencapsulation formulation of pigeon pea extract and to evaluate its physical characteristics, stability, and α-glucosidase inhibitory activity. The research was conducted using variations in nanoencapsulation extract concentrations: F1 (0.2%), F2 (0.4%), and F3 (1%). Physical characterization included particle size, polydispersity index (PDI), and zeta potential, along with a freeze–thaw stability test for five cycles. Antidiabetic activity was assessed by measuring α-glucosidase inhibition and determining the IC₅₀ value. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test (p < 0.05). The results showed that particle size decreased from 290.40 nm (F1) to 198.30 nm (F3), with polydispersity index values below 0.3 for F2 and F3. The zeta potential ranged from −28.10 to −36.10 mV. F3 demonstrated the highest stability and the strongest antidiabetic activity with an IC₅₀ value of 68 ppm (p < 0.05). In conclusion, the nanoencapsulation formulation of pigeon pea extract produced small-sized, stable particles with effective α-glucosidase inhibitory activity. The optimal formulation was F3, which shows potential for further development as a natural-based antidiabetic nanoencapsulation system.
Co-Authors Afifa, Nadya Alfina Nurrahman Alfina Nurrahman Alfina Nurrahman Amalia Eka Putri Andri Tri Cahyono Andri Tri Cahyono Arif Santoso Arti Wahyu Utami Arti Wahyu Utami Arti Wahyu Utami Arti Wahyu Utami Aryadi, Anggi Bramantyo Cahyono, Andri Tri Cecep Sudrajat Dea Nurfadhillah Dea Nurfadhillah Desi Trisnawati Detria Wulandari Dwi Wahyuni Dyah Rohma Wati Edi Pramono Eman eman Erni Suminar Esa Aji Pratama Faizah, Nai’matul Retno Faizah, Na’imatul Retno Fatchani, Sathi Fatikha, Zulfania Shandra Fauzah, Na’imatul Retno Firman Rezaldi Fitria Eka Resti W. Fitria Eka Resti Wijayanti Fitria Eka Resti Wijayanti Gumilar, Roni Hariningsih, Yetti Heny Sasmita Indrayati, Lyna L. Ira Maya Irfan Bagus Setyawan Istikhomah, Rekha Aulia Iyan Sopyan Jihan Nabilla Jihan Nabilla Kurniawan, Maskun Kustyarini, Farida Lyna Lestari Indrayati M. Fariz Fadillah Misbakhul Munir Mu'jijah, Mu'jijah Muhammad Faizal Fathurrohim Mutiara Siti Nurfajriah Nabilla, Jihan Nai’matul Retno Faizah Na’imatul Retno Faizah Na’imatul Retno Fauzah Nova Seftiyanti Novi Ayuwardani Nurahman, Alfina Nurrahman, Alfina Octaviana Dyah Oentari Oentari, Octavina Dyah Pamungkas, Barolym Tri Pamungkas, Pratiwi May Pratiwi, Reza Safinda Pujiastuti, Nanik Puput Setiawati Purbanova, Reni Putri, Amalia Eka Putri, Desvita Maharani R, Herowati Rahmad, Sukardi Sugeng Ratna Fitry Yenny Rekha Aulia Istikhomah Rekha Aulia Istikhomah Reni Purbanova Reni Purbanova Resti Wijayanti, Fitria Eka Rohmatulloh, Rizal Sadida, El Santi Saifullah, Ipul Santoso, Blegoh Iwan Sari, Sinta Wisma Sasmita, Heny Setiawati, Puput Setyawan, Irfan Bagus Sinta Wisma Sari Sinta Wisma Sari Sitanggang, Andrianus Bilhot Sugiono Sugiono Sukardi Sugeng Rahmad Sukardi Sugeng Rahmad Sukardi Sugeng Rahmad TN Saifullah Sulaiman Tri Saptari Haryani Tri Yudianto Tri Yudianto Trisnawati, Desi Ucu Wandi Somantri Ucu Wandi Somantri Usman Setiawan Vevi Maritha W, Fitria Eka Resti Wardani, Arief Kusuma Widyaningsih, Ragil Wijayanti Wijayanti Wijayanti, Fitria Eka Resti Yanti, Jamilah Hamidi Yenny, Ratna Fitry Yudianto, Tri Yuliana Kolo Zulananta, Shohihunnatiq