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All Journal Jurnal Medik Veteriner Veterinary Biomedical and Clinical Journal Ar-Rihlah: Jurnal Inovasi Pengembangan Pendidikan Islam Journal of Parasite Science Ovozoa: Journal of Animal Reproduction journal of Basic Medical Veterinary
Sunarso, Agus
Department Of Veterinary Parasitology - Faculty Of Veterinary Medicine, Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Veterinary

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Journal : journal of Basic Medical Veterinary

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Nephroprotective Activity of Ethanolic Extract of Papaya (Carica papaya) Seeds on Blood Urea Nitrogen and Creatinine Levels in Albino Rats Induced by Paracetamol Mubarok, Muhammad Syahrul; Yuliani, Gandul Atik; Sunarso, Agus; Hidayatik, Nanik; Kurnijasanti, Rochmah; Hisyam, Mirza Atikah Madarina
Journal of Basic Medical Veterinary Vol. 14 No. 2 (2025): Journal of Basic Medical Veterinary, December 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i2.78386

Abstract

Kidney damage caused by high-dose paracetamol leads to elevated Blood Urea Nitrogen (BUN) and creatinine levels as indicators of impaired renal function. This study aimed to evaluate the dose-dependent nephroprotective effects of ethanolic Carica papaya seed extract on BUN and creatinine levels in paracetamol-induced albino rats. A posttest-only control group design was applied using 25 male Wistar rats divided into five groups: negative control (1% CMC-Na), positive control (paracetamol 1000 mg/kgBW), and three treatment groups receiving Carica papaya seed extract at doses of 100, 200, and 400 mg/kgBW. The extract was administered orally for seven consecutive days before paracetamol induction on day 8 and continued until day 11. Blood samples were collected on day 11, and serum was stored at -20 °C before BUN and creatinine concentrations were analyzed spectrophotometrically. Data were statistically analyzed using one-way ANOVA followed by Duncan’s Multiple Range Test (DMRT) at a significance level of p < 0.05. The results showed a significant and dose-dependent reduction in both parameters in all treated groups compared to the positive control, with the 400 mg/kgBW dose showing the strongest effect and restoring values close to physiological levels. The nephroprotective activity was associated with the antioxidant and anti-inflammatory mechanisms of the bioactive compounds that counteract oxidative stress and preserve renal cellular integrity. In conclusion, the ethanolic extract of Carica papaya seeds demonstrates significant dose-dependent nephroprotection against paracetamol-induced kidney injury in rats.
Co-Authors Adiana Mutamsari Witaningrum Agustono, Bodhi Akbar Wijaya Putra Purnama Aksono HP., Eduardus Bimo Aldi Hamdani Andhika Yudhantama Subroto Anwar Ma'ruf Anwar Ma'ruf Arifin, Khoirul Arimbi Aryaloka, Suhita Aurandini, Nailla Ridhani Azzahra, Farah Nabila Boedi Setiawan Budi Utomo Chaerunissa, Nadya Amanda Choirul Oktavian Setiyadin Nayiron Dadik Rahardjo, Dadik Deskayanti, Asih Dyah Ajeng Suhita E Djoko Poetranto Endang Suprihati Fakhryyah Maharani Deviyanti Fania Selfiannisa Felita Widyaningsih Gandul Atik Yuliani Hani Plumeriastuti Hastutiek , Poedji Herry Agoes Hermadi Hidajati, Nove Hidayatik, Nanik Hisyam, Mirza Atikah Madarina Indah Norma Triana, Indah Norma Inggarsetya Syah Audini Ira Sari Yudaniayanti Iwan Sahrial Hamid Iwan Sahrial Hamid Iwan Sahrial Hamid Kartika Aditiya Amelia Kiki Amalia Rama Kristina, Silvia Martha Kusnoto Kusnoto Kusnoto Kusnoto Kusnoto, Kusnoto Lianny Nagoi Lucia Tri Suwanti, Lucia Tri Luluk Tri Astuti Luthfiyyah Nur Afifah Siswandi Margaretha, Josephira Intan Mega, Toafan Satrio Meles, Dewa Ketut Meyreta Doti Alcaterana Mochamad Lazuardi Mohammad Sukmanadi Mubarok, Muhammad Syahrul Mufasirin NASHIHATUS SHOLIHAH Nenny Harijani Nidom, Chairul Anwar Nining Sari Virgandina Vinola Novia Intan Kurnia Nunuk Dyah Retno Lastuti Nusdianto Triakoso octavia, Arinda Oktaviana, Vivi Permata Sari, Dian Ayu Permatasari, Dian Ayu Poedji Hastutiek Pradana, Giffari Danindra Praja, Ratih Novita Primarizky, Hardany Pudji Srianto Rahaju Ernawati Rahmi Sugihartuti Rari Noviana Rimayanti Rimayanti Rochmah Kurnijasanti ROHMAH, LAILATUL Rohmah, Miftahur Santoso, Kuncoro Puguh Saputro, Amung Logam Sardjana, I Komang Wiarsa Setiawan Koesdarto Setiawati Sigit Sherbina Bai Soeharsono Soeharsono Sri Hidanah Sri Mumpuni Sosiawati Sri Pantja Madyawati, Sri Pantja Suherni Susilowati Sulaeman, Nur Sa'adah Suprihati , Endang Suroiyah, Fifi Anik Taufik Tri Laksono Tri Suwanti, Lucia Tri Wahyu Suprayogi Trilas Sardjito Utama , Suzanita Utami, Kinanti Putri Wardhana, Dhandy Koesoemo Widodo, Oky Setyo Yeni Dhamayanti Yudhana, Aditya Yuliani, Gandul Atik