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All Journal Jurnal Kesehatan Andalas Majalah Obat Tradisional Media Ilmu Kesehatan Majalah Kedokteran Andalas Jurnal Sehat Mandiri Bioscientia Medicina : Journal of Biomedicine and Translational Research Andalas obstetrics and gynecology journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) SENTRI: Jurnal Riset Ilmiah Innovative: Journal Of Social Science Research Jurnal Riset Ilmiah Jurnal Akademika Baiturrahim Jambi
Zelly Dia Rofinda
Unknown Affiliation
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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The Role of Transforming Growth Factor Beta (TGF-β) in Pelvic Organ Prolapse : A Systematic Review Yulia Margaretta Sari; Bobby Indra Utama; Zelly Dia Rofinda; Elliyanti, Aisyah
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.58-69.2026

Abstract

Introduction: Pelvic organ prolapse (POP) is a gynaecological disorder with a rising prevalence, significantly affecting quality of life. While the pathogenesis of POP is multifactorial, alterations in the extracellular matrix (ECM) have been implicated, particularly the role of transforming growth factor-beta (TGF-β) in ECM remodelling. However, the precise relationship between TGF-β and POP remains unclear. Methods: A systematic review was conducted following PRISMA guidelines. Relevant studies were identified from PubMed, Scopus, Web of Science, and the Cochrane Library. Inclusion criteria focused on studies investigating TGF-β expression in women with POP. Data extraction included study design, patient demographics, TGF-β detection methods, and key findings. Results: Analysis of nine studies revealed mixed findings. Four studies reported a significant reduction in TGF-β1 expression in POP patients, suggesting impaired ECM regulation via the TGF-β1/Smad3 pathway. Three studies found no significant differences in TGF-β levels between POP and control groups, while one study linked increased TGF-β1 levels to severe prolapse, possibly as a compensatory response. Variations in methodology, sample size, and patient characteristics contributed to inconsistencies across studies. Conclusion: Current evidence suggests that TGF-β1 plays a role in POP pathogenesis, with lower levels potentially weakening ECM integrity and higher levels in advanced cases reflecting a failed reparative response. Further research is needed to explore TGF-β interactions with other biomarkers and assess its potential as a therapeutic target.
Co-Authors Adrial Adrial, Adrial Afdal Afdal, Afdal Afriwardi Afriwardi Aisah Aisah Aisyah Elliyanti Alfitri, Maura Salsabila Alinia, Hessa Sena Almurdi Almurdi Alvarino Alvarino Ami Tri Nursasmi Amirah Zatil Izzah Aprilia, Dinda Arina Widya Murni Ashal, Taufik Aswiyanti Asri Atmi, Serly Rahma Azahra, Azizah Firda Azura, Rahla Beni Indra, Beni Bobby Indra Utama Desiekawati Desmawati Desmawati Dessy Arisanti Deswita Sari Desywar Dian Pertiwi Dian Pertiwi Dwi Yulia Dwitya Elvira, Dwitya Efrida Efrida Elfira Yusri Elizabeth Bahar Elmatris Sy Endrinaldi Eti Yerizel Etriyel Myh Eva Decroli Evynatra, Evynatra Fadhillah, Ilham Arief Fadila, Zurayya Fathiyyatul Khaira, Fathiyyatul Fereshti Lailani Finny Fitry Yani Gestina Aliska Hasmiwati Herinda, Dwi Putri Hessa Sena Alinia Hirowati Ali, Hirowati Husni Husni Husni Ihsan, Indra Julizar Nazar Khaulah Karimah Kurniawan Lili Novri Yanti Mahata, Liganda Endo Masnadi, Nice Rachmawati Masrul Mohamad Reza Mulya, Fiona Septi Nur Indrawaty Lipoeto Nurhajjah, Sitti Prima Astuti Handayani Purwati, Desta Rahmatini . Rahmi Dina Indra Rahmi, Yannisa Mutiara Rauza Sukma Rita Reza, Mohamad Rikarni Rikarni Rikarni Rismawati Yaswir Rosfita Rasyid Rudy Afriant Santril, Nitri Ramadhani Sari, Deswita Selfi Renita Rusjdi Suchitra, Avit Syofiati Ulya Uti Fasrini Wahyuni, Febby Genta Yashinta Octavian Gita Setyanda Yoshie Anto Chicamy Yufani, Hevrina Yulia Margaretta Sari Yulia, Dwi Yulistini, Yulistini Yusri, Elfira Zahira, Aisyah Dhia zahra salsabila Zulmitra, Elsa