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All Journal Jurnal Kesehatan Andalas Majalah Obat Tradisional Media Ilmu Kesehatan Majalah Kedokteran Andalas Jurnal Sehat Mandiri Bioscientia Medicina : Journal of Biomedicine and Translational Research Andalas obstetrics and gynecology journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) SENTRI: Jurnal Riset Ilmiah Innovative: Journal Of Social Science Research Jurnal Riset Ilmiah Jurnal Kedokteran Meditek Jurnal Akademika Baiturrahim Jambi
Zelly Dia Rofinda
Unknown Affiliation
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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The Role of Transforming Growth Factor Beta (TGF-β) in Pelvic Organ Prolapse : A Systematic Review Yulia Margaretta Sari; Bobby Indra Utama; Zelly Dia Rofinda; Elliyanti, Aisyah
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.58-69.2026

Abstract

Introduction: Pelvic organ prolapse (POP) is a gynaecological disorder with a rising prevalence, significantly affecting quality of life. While the pathogenesis of POP is multifactorial, alterations in the extracellular matrix (ECM) have been implicated, particularly the role of transforming growth factor-beta (TGF-β) in ECM remodelling. However, the precise relationship between TGF-β and POP remains unclear. Methods: A systematic review was conducted following PRISMA guidelines. Relevant studies were identified from PubMed, Scopus, Web of Science, and the Cochrane Library. Inclusion criteria focused on studies investigating TGF-β expression in women with POP. Data extraction included study design, patient demographics, TGF-β detection methods, and key findings. Results: Analysis of nine studies revealed mixed findings. Four studies reported a significant reduction in TGF-β1 expression in POP patients, suggesting impaired ECM regulation via the TGF-β1/Smad3 pathway. Three studies found no significant differences in TGF-β levels between POP and control groups, while one study linked increased TGF-β1 levels to severe prolapse, possibly as a compensatory response. Variations in methodology, sample size, and patient characteristics contributed to inconsistencies across studies. Conclusion: Current evidence suggests that TGF-β1 plays a role in POP pathogenesis, with lower levels potentially weakening ECM integrity and higher levels in advanced cases reflecting a failed reparative response. Further research is needed to explore TGF-β interactions with other biomarkers and assess its potential as a therapeutic target.
GAMBARAN KADAR TIROGLOBULIN PADA PASIEN KARSINOMA TIROID BERDIFERENSIASI POST TOTAL TIROIDEKTOMIDI RSUP DR. M. DJAMIL PADANG Furqan, Muhammad; Kurniawati, Yulia; Rofinda, Zelly Dia
SINERGI : Jurnal Riset Ilmiah Vol. 3 No. 4 (2026): SINERGI : Jurnal Riset Ilmiah, April 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v3i4.2488

Abstract

Thyroid carcinoma is the most common malignancy found in the endocrine glands and accounts for 1% of all malignancies. The average incidence of thyroid carcinoma cases according to the National Cancer Institute (NCI) from 2012-2017 was 14.3 per 100,000 total population per year, with an average mortality rate of 0.5 per 100,000 population per year. In Indonesia in 2000, thyroid carcinoma ranked ninth out of the ten most common carcinomas (4.3%) and covered 90% of all endocrine carcinomas. Based on medical record data at Dr. M. Djamil Padang General Hospital, the incidence of thyroid carcinoma in 2015 was 373 people and increased in 2016 to 850 people. Based on the problems described above, and there has not been much research on Thyroglobulin levels as a prognostic factor for recurrence of thyroid carcinoma in Indonesia, especially Padang. Encourage the author to conduct research on differentiated thyroglobulin levels after total thyroidectomy at Dr. M. Djamil Padang General Hospital.
Effect of Kawa Gambir (Uncaria gambir Roxb.) Leaves on Serum LDL in Diabetic Model Rats Siregar, Muhammad Abi Ghoffari; Rita, Rauza Sukma; Reza, Mohamad; Ali, Hirowati; Rofinda, Zelly Dia; Welan, Rahmani
Jurnal Kedokteran Meditek Vol 32 No 2 (2026): MARET
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i2.4012

Abstract

Background: Kawa gambir leaves, dried in a furnace and brewed as tea, are rich in flavonoids, phenolics, steroids, and tannins and have antioxidant, antihyperglycemic, and antidyslipidemic properties. In diabetes, elevated low-density lipoprotein (LDL) is a dyslipidemic abnormality that increases atherogenic risk. However, the effect of Kawa gambir on LDL in diabetic conditions remains unclear. Objective: To evaluate the effect of Kawa gambir leaf administration on LDL in alloxan-induced diabetic rats. Methods: This experimental study used a post-test-only control group design in 36 Wistar rats randomized into six groups: K−, K+, MET, P1, P2, and P3. Diabetes was induced with alloxan in K+, MET, and P1–P3. MET received metformin, whereas P1, P2, and P3 received Kawa gambir infusions at 1, 2, and 4 g/100 mL once daily for 4 weeks. Serum LDL was estimated using the Friedewald formula. Data were analyzed by one-way ANOVA followed by Least Significant Difference post hoc testing. Results: Mean±SD LDL levels (mg/dL) were 37.16±3.03, 59.90±8.91, 41.30±6.74, 40.60±5.75, 38.95±10.15, and 40.33±7.01 in K−, K+, MET, P1, P2, and P3, respectively. Group differences were significant (p=0.001). The largest numerical reduction versus K+ was found in P2, with a difference of 20.95 mg/dL (95% CI 8.64–33.26). Conclusion: Kawa gambir infusion significantly reduced LDL compared with the untreated diabetic control. Although the 2 g/100 mL group showed the lowest LDL numerically, no significant differences were observed among active treatment groups. These findings support Kawa gambir as an antidyslipidemic agent in diabetic dyslipidemia.
Co-Authors Adrial Adrial, Adrial Afdal Afdal, Afdal Afriwardi Afriwardi Aisah Aisah Aisyah Elliyanti Alfitri, Maura Salsabila Alinia, Hessa Sena Almurdi Almurdi Alvarino Alvarino Ami Tri Nursasmi Amirah Zatil Izzah Aprilia, Dinda Arina Widya Murni Ashal, Taufik Aswiyanti Asri Atmi, Serly Rahma Azahra, Azizah Firda Azura, Rahla Beni Indra, Beni Bobby Indra Utama Desiekawati Desmawati Desmawati Dessy Arisanti Deswita Sari Desywar Dian Pertiwi Dian Pertiwi Dwi Yulia Dwitya Elvira, Dwitya Efrida Efrida Elfira Yusri Elizabeth Bahar Elmatris Sy Endrinaldi Eti Yerizel Etriyel Myh Eva Decroli Evynatra, Evynatra Fadhillah, Ilham Arief Fadila, Zurayya Fathiyyatul Khaira, Fathiyyatul Fereshti Lailani Finny Fitry Yani Gestina Aliska Hasmiwati Herinda, Dwi Putri Hessa Sena Alinia Hirowati Ali, Hirowati Husni Husni Husni Ihsan, Indra Julizar Nazar Khaulah Karimah Kurniawan Lili Novri Yanti Mahata, Liganda Endo Masnadi, Nice Rachmawati Masrul Mohamad Reza Muhammad Abi Ghoffari Siregar Muhammad Furqan, Muhammad Mulya, Fiona Septi Nur Indrawaty Lipoeto Nurhajjah, Sitti Purwati, Desta Rahmatini . Rahmi Dina Indra Rahmi, Yannisa Mutiara Rauza Sukma Rita Reza, Mohamad Rikarni Rikarni Rikarni Rismawati Yaswir Rosfita Rasyid Rudy Afriant Santril, Nitri Ramadhani Sari, Deswita Selfi Renita Rusjdi Suchitra, Avit Syofiati Ulya Uti Fasrini Wahyuni, Febby Genta Yashinta Octavian Gita Setyanda Yoshie Anto Chicamy Yufani, Hevrina Yulia Kurniawati Yulia Margaretta Sari Yulia, Dwi Yulistini, Yulistini Yusri, Elfira Zahira, Aisyah Dhia zahra salsabila Zulmitra, Elsa