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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Jurnal Kedokteran Brawijaya Jurnal Ilmiah Kursor Indonesian Journal of Urology Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi Medical Laboratory Technology Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Majalah Patologi Indonesia Prosiding Seminar Nasional Multidisiplin Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Indonesia Journal of Physical Medicine and Rehabilitation Indonesia Journal Physical Medicine and Rehabilitation Cermin Dunia Kedokteran Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Pengabdian Masyarakat Bangsa Enrichment: Journal of Multidisciplinary Research and Development Jurnal Widya Medika
Willy Sandhika
Departemen/ SMF Patologi Anatomi , Fakultas Kedokteran Universitas Airlangga/ RSU Dr. Soetomo, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Pemeriksaan Imunofluoresen Direk pada Henoch Schonlein Purpura Willy Sandhika; Marina Rimadhani; Sunarso Suyoso
JURNAL WIDYA MEDIKA Vol. 3 No. 1 (2015)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v3i1.765

Abstract

Henoch-Schönlein purpura (HSP) is an acute immunoglobulin A (IgA)–mediated vasculitis involving the small vessels. This disease cause systemic involvement of many organ especially the skin, the gastrointestinal (GI) tract and the kidneys. The etiology of HSP is not clear. Precipitating factors include drugs, chemicals, viruses and bacteria. Pathogenesis of HSP involve Ig A–mediated immune complex that are circulated in blood vessel and deposited in many organs. The presence of IgA-mediated immune complex deposits will activate the complement system, causing inflammation in the form of vasculitis that damage the small blood vessels in many organs. Hsp is a self-limiting disease that require supportive therapy. The problem that arises is how to distinguish HSP with other vasculitis diseases. A skin biopsy in patients with hsp will reveal leukocytoclastic vasculitis in small vessel. That kind of vasculitis are also found in urticarial vasculitis, hypersensitivity vasculitis and vasculitis due to cryoglobulinemia. Direct Immunofluorescence test from skin biopsy tissue will help to make the diagnosis of HSP. The presence of IgA deposits in small blood vessels wall can distinguish HSP from other vasculitis.
Intravascular Lymphoma, Jenis Limfoma Yang Jarang Dijumpai Dengan Prognosis Buruk Willy Sandhika; Aries Sasongko; Irene Lingkan Parengkuan
JURNAL WIDYA MEDIKA Vol. 5 No. 2 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v5i2.2205

Abstract

Intravascular lymphoma is a rare type of lymphoma with some fundamental differences compared to other types of non–Hodgkin lymphoma in general. Its clinical manifestations vary greatly and depend on the affected organs. There is no pathognomonic signs of intravascular lymphoma, either in clinical, laboratory or radiological findings. This case is challenging to detect and often misdiagnosed because it does not show symptoms that are commonly found in other types of lymphoma, such as mass or nodules formation. The treatment is relatively similar to other lymphoma in general, but the prognosis is worse because it was mostly diagnosed in the advanced stage. These specific conditions become the main reason to separate this case as a special entity of lymphoma.
ANALYSIS FACTORS OF BREAST LESION CASE IN RSUD DR. SOETOMO SURABAYA Wilda Fitria Rachmadina; Willy Sandhika; Widati Fatmaningrum
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.3615

Abstract

Introduction: Data from Indonesian Health Ministry stated that there was an increase in the prevalence of breast tumors in 2015 – 2017 by 1.8 per 100 to 21.3 per 100,000 women aged 30-50 years. The most common types of benign breast lesions found in women worldwide are fibrocystic changes of breast and fibroadenoma. Aim: This research aims to analyze the factors of age, age at menarche, parity, use of hormonal drugs, and family history with the incidence of benign breast lesions in RSUD Dr. Soetomo Surabaya. Methods: This research method is observational analytic with a case-control approach, consisting of a case group and a control group of 41 respondents in each group. The statistical test of the study used the Chi-Square Test, Independent t-test, Mann Whitney, and Odds Ratio (OR). Results: The results of statistical tests obtained age factor p(sig)=0.002, hormonal use p(sig) 0.000, family history p(sig) 0.016, age at menarche p(sig) 0,282, and parity p(sig) 0.568. Conclusion: Conclusion there is a relationship between age, use of hormonal drugs, and family history and there is no relationship between age at menarche and parity with the incidence of benign breast lesions in RSUD Dr. Soetomo Surabaya. Family history has an Odds Ratio (OR) of 4.796. Keywords: Breast Lesions, Reproductive Health
IL-10 Expression and Pulmonary Fibrosis in COVID-19 and Non-COVID-19: A Cross-sectional Study yasmin, dzakiyah; Anang Marhana, Isnin; Sandhika, Willy
Enrichment: Journal of Multidisciplinary Research and Development Vol. 2 No. 11 (2025): Enrichment: Journal of Multidisciplinary Research and Development
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/enrichment.v2i11.289

Abstract

Indonesia was declared the country with the highest number of COVID-19 cases in ASEAN, and East Java was the province with the highest confirmed case fatality rate (7.3%) in 2021. In the case of COVID-19, there was a drastic elevation of the anti-inflammatory cytokine IL-10. This study aimed to ensure the role of IL-10 against pulmonary fibrosis in COVID-19 and non-COVID-19 patients. This study is a cross-sectional (non-experimental) study. The study sample consisted of 40 lung tissue samples from COVID-19 and non-COVID-19 patients at Dr. Soetomo General Academic Hospital, Surabaya. The IL-10 antibody reagent (GTX632359, GeneTex) was used to assess IL-10 expression, and hematoxylin and eosin (H&E) were used to determine the degree of pulmonary fibrosis. For Spearman's correlation, the data were analyzed using Statistical Package for the Social Sciences (SPSS). The mean percentage of IL-10 expression in COVID-19 patients (40.07%) was higher than in non-COVID-19 patients (26.60%). However, the mean for the degree of pulmonary fibrosis score in non-COVID-19 patients (4.43) was higher than in COVID-19 patients (3.67). Furthermore, a negative correlation (p=0.000; r=-0.281) was found between the percentage of IL-10 expression and the degree of pulmonary fibrosis. The percentage of IL-10 expression in macrophage cells had a significant negative correlation with the degree of pulmonary fibrosis score.
Program Pengabdian Masyarakat: Edukasi dan Deteksi Dini Kanker Serviks melalui Pemeriksaan Pap Smear di Kecamatan Bangkalan Sari, Aditya Sita; Kurniasari, Nila; Rahaju, Anny Setijo; Rahniayu, Alphania; Mastutik, Gondo; Fauziah, Dyah; Kusumastuti, Etty Hary; Sandhika, Willy; Wiratama, Priangga Adi; Ariani, Grace; Ridholia, Ridholia; Heriyawati, Heriyawati; Sudiana, I Ketut; Ilmiah, Khafidhotul; Qonitatillah, Ana
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 3 (2025): Mei
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i3.2310

Abstract

Kegiatan pengabdia masyarakat ini bertujuan untuk meningkatkan pemahaman tenaga kesehatan dan masyarakat mengenai deteksi dini serta pencegahan kanker serviks. Pelatihan tenaga kesehatan dilakukan agar mereka dapat melakukan prosedur Pap smear dengan benar dan sesuai standar, sementara penyuluhan masyarakat bertujuan untuk meningkatkan kesadaran akan pentingnya deteksi dini dan pencegahan kanker serviks. Studi ini menggunakan metode deskriptif observasional dengan pendekatan cross-sectional, mencakup dua kegiatan utama: pelatihan tenaga medis secara daring dan penyuluhan masyarakat secara langsung. Pelatihan Pap smear diikuti oleh 51 peserta yang terdiri dari perawat, bidan, dan dokter. Evaluasi sebelum dan sesudah pelatihan menunjukkan peningkatan pemahaman yang signifikan, di mana peserta dengan skor 80-100 meningkat dari 58,82% menjadi 82,35%. Penyuluhan kanker serviks diikuti oleh 74 peserta. Sebelum penyuluhan, hanya 12,16% peserta yang memperoleh nilai 80-100, namun setelahnya meningkat menjadi 100%. Sebanyak 62,2% peserta telah menikah, 8,1% memiliki riwayat hubungan seksual sebelum usia 17 tahun, dan 9,5% memiliki lebih dari satu pasangan. Selain itu, 98,6% belum pernah menerima vaksin HPV, dan 78,4% jarang melakukan Pap smear, menunjukkan rendahnya kesadaran pencegahan kanker serviks. Setelah penyuluhan, 60 peserta menjalani skrining kanker serviks. Mayoritas (41,7%) berusia 31-40 tahun. Hasil skrining dengan sistem Bethesda menunjukkan 100% NILM. Berdasarkan klasifikasi Papanicolaou, 88,1% termasuk kelas II (96,2% inflamasi, 1,9% bacterial vaginosis, 1,9% atrofi), dan 11,1% kelas I. Program ini terbukti efektif dalam meningkatkan pemahaman tenaga kesehatan dan masyarakat, serta keterampilan tenaga kesehatan dalam prosedur Pap smear, yang berkontribusi pada peningkatan kualitas layanan deteksi dini kanker serviks di RSIA Hikmah Sawi Bangkalan.
Co-Authors A.A. Ketut Agung Cahyawan W Afif Nurul Hidayati, Afif Nurul Agung Dwi Wahyu Widodo Agustin Nurliani Aisha Grayli Cahyani Alief Yudo Astuti Alphania Rahniayu Anny Setijo Rahaju, Anny Setijo Ariani, Grace Aries Sasongko Astindari Astindari Astindari Astindari, Astindari Ayu Tyasmara Bagus Haryo Kusumaputra, Bagus Haryo Baiq Ratna Kumaladewi Bernadetta Jonan Betty Agustina Tambunan Brama Rachmantyo Budiono Budipramana, Vicky Sumarki Cita Rosita Sigit Prakoeswa Densy Violina Harnanti Dian Eskaningrum Djoni Susanto Dwi Murtiastutik DYAH FAUZIAH, DYAH Endi Prilansa Mahadi Erlina Erlina Faizah, Zakiyatul Fanny Gunawan Fertilita, Soilia Firda Azizah Gatut Hardianto, Gatut Gilda Hartecia Gondo Mastutik Grace Ariani Hartanto, Felix Hartecia, Gilda Heny Arwati Heriyawati, Heriyawati Heryawati Heryawati I Wayan Yudiana Ibrahim, Azarya Ida Septika Wulansari Ilmiah, Khafidhotul Imam Susilo INDROPO AGUSNI Irene Lingkan Parengkuan Irmadita Citrashanty, Irmadita Isnin Anang Marhana Iswinarno Doso Saputro iwan Syarif Jimmy Hadi Widjaja Jonan, Bernadetta Junita Jeanne Paliman Kartika Arum Wardani Kholida Nur Aini Kiki Apnita Sari Kintan Putri KUSUMASTUTI, ETTY HARY LaleMaulin Prihatina Linda Astari, Linda M. Yulianto Listiawan Mappamasing, Hasnikmah Marina Rimadhani Marina Rimadhani Martha Kurnia Kusumawardani Maylita Sari Maylita Sari, Maylita Meita Ardini Pratamasari, Meita Ardini Muhammad Miftahussurur Nanda Amalia Ramadhanti Navisa, Claudia Clary Nidya Ulfana Tsania Nila Kurniasari Novia Indriyani Adisty Nurina Hasanatuludhhiyah Nurul Wiqoyah, Nurul Poernomo, Adinda Sandya PUNGKY MULAWARDHANA, PUNGKY Purwati Purwati Purwati Puteri, Agnes Ilene Suprapto Qonitatillah, Ana R. Heru Prasetyo R.A. Astrid Putri Wandhita Rahel Yuana Sadikim Ratna Darjanti Haryadi Regina Martina Cilik Ridholia, Ridholia Rizaldi, Fikri Rulisiana Widodo Rusdamayanti Rusdamayanti Rwahita Satyawati Dharmanta Ryski Meilia Novarina Ryski Meilia Novarina, Ryski Meilia S.Pd. M Kes I Ketut Sudiana . Sabilal Alif Sari, Aditya Sita Sari, Festi Artika savitri, Lisa Sawitri Sawitri Sawitri Sawitri Sawitri Soilia Fertilita Sunarso Suyoso Sunaryo Hardjowijoto Suprabawati, Desak Gede Agung Tessy Badriyah, Tessy Theresia Fifi Judikristiani Tri Hartini Yuliawati Trisniartami Setyaningrum Tyasmara, Ayu Umi Choviva, Farida Ummi Maimunah Vinna Chrisdianti Widati Fatmaningrum Wilda Fitria Rachmadina Windya Tri Hapsari Winona May Hendrata Wiratama, Priangga Adi yasmin, dzakiyah Yusfita Evi Rosdiana