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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN BALI MEDICAL JOURNAL (BMJ) Medicina Jurnal Studi Jender SRIKANDI Buletin Udayana Mengabdi INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Jurnal Farmasi Klinik Indonesia E-Journal Obstetric & Gynecology Udayana Indonesian Journal of Cancer Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Patologi Indonesia Neurologico Spinale Medico Chirurgico JURNAL USM LAW REVIEW Babali Nursing Research Indonesian Journal of Perinatology Indonesian Journal of Cancer Public Health and Preventive Medicine Archive INCOME: Indonesian Journal of Community Service and Engagement Journal of Global Pharma Technology Cermin Dunia Kedokteran

I Ketut Suwiyoga

Departemen Obstetri Dan Ginekologi, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Bali, Indonesia

Author-ID : 397979

Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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HER2/Neu Expression was Different between Benign, Borderline and Malignant Epithelial Ovarian Tumors Hadisubroto, Yona S.; Suwiyoga, Ketut
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the difference of HER2/neu expression in benign, borderline and malignant epithelial ovarian tumor. Method: An analytic cross-sectional study was performed on 49 samples of epithelial ovarian cases which were divided into three groups: twelve cases of benign epithelial ovarian tumor, 9 cases of borderline epithelial ovarian tumor and 28 cases of malignant epithelial ovarian tumor. Paraffin embedded tissue samples was cut, stained with HER2/neu imunohistochemistry and examined in Pathology Laboratory at Sanglah Hospital. The other data was collected from medical record samples. The data was analysed using One Way Anova test and Chi-square test with level of confidence α = 0.05. Result: There were 13 cases (46.43%) of the HER2/neu over expression in malignant epithelial ovarian tumors, 2 cases (22.22%) of the HER2/neu over expression in borderline epithelial ovarian tumors and 1 case (9.09%) of the HER2/neu over expression in benign epithelial ovarian tumors. With p = 0.048 (p < 0.05), there are differentiation of HER2/neu expression in benign, borderline and malignant epithelial ovarian tumors. Conclusion: In this study HER2/neu expression was different between benign, borderline and malignant epithelial ovarian tumors. Keywords: benign epithelial ovarian tumor, borderline epithelial ovarian tumor, HER2/neu, malignant epithelial ovarian tumor, ovarian cancer.

Evaluation of the Accuracy of Human Kallikrein6, Cancer Antigen125, and Human Epididymis 4 in Predicting Ovarian Cancer Wenas, Yongki; Suwiyoga, Ketut; Sanjaya, I Nyoman H
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 2, April 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To evaluate the accuracy of hK6, HE4, and CA125 in predicting the malignancy of ovarian mass. Methods: The design of this study was cross-sectional. This study was conducted in the Obstetrics and Gynecology Clinic, Sanglah Hospital, Denpasar, between the period of September 2014 and August 2016. Samples were all patients with ovarian tumors who underwent surgery at Sanglah Hospital, Denpasar. Data analysis was performed using McNemar and chi square test in SPSS for windows version 17.0. Results: 22 samples were obtained. P > 0.05 value of age and parity variables indicated no differences between the two groups. There is no accuracy differences (sensitivity, specificity, positive predictive value, negative predictive value) of hK6 compared to histopathology examination in diagnosing ovarian cancer (p = 1). There is no accuracy differences (sensitivity, specificity, positive predictive value, negative predictive value) of HE4 compared to histopathology examination in diagnosing ovarian cancer (p = 1). There is no accuracy difference (sensitivity, specificity, positive predictive value, negative predictive value) of CA125 compared to histopathology examination in diagnosing ovarian cancer (p = 0.687). Conclusion: There was no accuracy differences (sensitivity, specificity, positive predictive value, negative predictive value) found between hK6, CA125, HE4 compared to histopathology examination in predicting ovarian cancer. [Indones J Obstet Gynecol 2017; 5-2: 110-113] Keywords: cancer antigen 125, human epididymis-4, human kallikrein 6, ovarian cancer

Elevated Serum Ferritin and Interleukin-6 Level as the Risk Factor in Preterm Labor Kawilarang, Stella; Suwiyoga, I Ketut; Suwardewa, Tjokorda GA
Indonesian Journal of Obstetrics and Gynecology Volume 7 No. 2 April 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

  Objective : To investigate the association ofserum ferritin and Interleukin-6 (IL-6) elevation as the risk factors for preterm labor. Method : This study was a case-control study conducted at the Obstetrics and Gynecology Outpatient and Emergency Department at Sanglah General Hospital Denpasar, Bali in November 2014 until June 2015. The sample selection was done by consecutive sampling with total sample as many as 20 case samples (women with preterm labor) and 20 control samples (women with normal preterm pregnancy). Results : Based on the analysis, there was no significant difference of patient demografic such as age, gestational age, and parity among the two groups. Chi-square analysis showed that the increased serum ferritin level had 5 fold increased risk of developing preterm labor (OR = 4.89, 95% CI = 1.20-19.94; p = 0.022), and increased serum IL-6 level had 9 fold increased risk of developing preterm labor (OR = 9.33, 95% CI = 2.18-39.96; p = 0.001) compared to normal preterm pregnancy. Conclusion : It can be concluded that level of IL-6 and serum ferritin was the risk factor for preterm labor. Keywords: Interleukin-6, preterm labor, serum ferritin   Abstrak Tujuan :Untuk membuktikan hubungan kadar ferritin dan Interleukin-6 (IL-6) serum yang tinggi sebagai faktor risiko terjadinya persalinan preterm. Metode :Penelitian ini bersifat observasional dengan studi case-control yang dilakukan di Poliklinik dan IRD Kebidanan dan Penyakit Kandungan RSUP Sanglah Denpasar, yang dilakukan mulai bulan November 2014 hingga Juni 2015. Pemilihan sampel dilakukan dengan cara berurutan dengan sampel penelitian sebanyak 20 sampel kasus (ibu dengan persalinan preterm) dan 20 sampel kontrol (ibu hamil preterm normal). Hasil :Tidak didapatkan perbedaan bermakna dari demografik pasien yaitu usia, umur kehamilan, dan paritas pada kedua kelompok. Analisa chi-square menunjukkan peningkatan kadar ferritin serum memiliki peningkatan risiko 5 kali terjadinya persalinan preterm (OR = 4,90, IK 95% = 1,20-19,94; p = 0,022), dan peningkatan kadar IL-6 serum memiliki peningkatan risiko 9 kali terjadinya persalinan preterm (OR = 9,33, IK 95% = 2,18-39,96; p = 0,001) dibandingkan dengan kelompok ibu hamil preterm normal. Kesimpulan : Kadar feritin dan IL-6 serum adalah faktor risiko terjadinya persalinan preterm. Kata kunci: Interleukin-6, persalinan preterm, ferritin serum

DIFFERENCES OF TUMOR MASSES AND HEMOGLOBIN LEVELS IN CERVICAL CANCER SQUAMOUS CELL TYPE PATIENTS TREATED WITH COMBINATION OF PACLITAXEL AND CARBOPLATIN CHEMOTHERAPY Noviyani, R.; Suwiyoga, K.; Lesmana, I.; Niruri, R.; Tunas, K.; Budiana, and I N. K.
BALI MEDICAL JOURNAL Vol 3 No 1 (2014)
Publisher : BALI MEDICAL JOURNAL

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Background: Paclitaxel and carboplatin are standard operating procedure for chemotherapy treatment of cervical cancer squamous cell carcinoma at Sanglah General Hospital, Bali-Indonesia. Chemotherapy improves outcome of cancer treatment. However, chemotherapy brings also a variety of adverse effects and complications. This study aims to evaluate the therapeutic and adverse effects of chemotherapy in patients with squamous cell cervical cancer. Methods: This is a case study of six patients with cervical cancer underwent chemotherapy paclitaxel and carboplatin 3-series at Sanglah General Hospital, Bali-Indonesia during January to November 2013. The therapeutic effect of chemotherapy was assessed from cervical cancer tumor mass measured before and after chemotherapy 3-series. The adverse effect of chemotherapy was determined from hemoglobin levels measured before and after chemotherapy. Data were analyzed using a paired t-test with a level of confidence of 95% using the SPSS to find out the differences. Results: In this study we found that there is a difference between tumor mass pre and post 3 series chemotherapy within p < 0.05. In term of toxic effect, we also obtained that there were difference of hemoglobin between pre and post of treatment within p < 0.05. Conclusion: Paclitaxel carboplatin as a chemotherapy drug in patients with cervical cancer is highly recomended when seen from the effects of reduced tumor size, and has a low side effect of anemia (anemia grade 1).

ALAT KONTRASEPSI DALAM RAHIM TIPE CU T 380 A SEBAGAI FAKTOR RISIKO TERJADINYA ANEMIA DEFISIENSI BESI DAN LESI SERVIKS Yudasmara, I Putu Kusuma; Suwiyoga, Ketut; Mayura, I Gusti Putu Mayun
Medicina Vol 46 No 2 (2015): Mei 2015
Publisher : Medicina

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Desain penelitian adalah case-control analitik untuk mengetahui risiko terjadi anemia defisiensi besidan lesi serviks pada akseptor AKDR tipe Cu T 380 A pada pemakaian minimal 1 tahun. Penelitiandimulai pada tanggal 1 Juli2011 sampai 15 Juli 2014 di RSUP Sanglah. Sampel penelitian adalahwanita usia reproduktif yang datang ke RSUP Sanglah Denpasar,memenuhi kriteria inklusi daneksklusi, diambil secara consecutive sampling. Pada sampel dilakukan pengambilan sampel darahuntuk diperiksa kadar profil besi dengan teknik ELISA di laboratorium RSUP Sanglah. Uji analisiskomparatif dengan Chi-square. Hasil penelitian menunjukkan pemakaian AKDR tipe Cu T 380 Amerupakan faktor risiko terjadinya anemia sebesar 4 kali (RO = 4,80; IK 95% = 1,04 sampai 22,10; P=0,036) dibandingkan tidak memakai AKDR tipe Cu T 380 A, dan pemakaian AKDR tipe Cu T 380 Amerupakan faktor risiko terjadinya lesi serviks sebesar 7 kali (RO = 7,65; IK 95% = 1,37 sampai 42,71;P =0,012) dibandingkan tidak memakai AKDR tipe Cu T 380 A. Simpulan dari penelitian adalahterdapat peningkatan risiko terjadi anemia defisiensi besi dan lesi serviks pada akseptor AKDRtipeCu T 380 A minimal 1 tahun. [MEDICINA 2015;46:82-5].Case-control analytic study at the Obstetrics and Gynaecology Department of Sanglah Hospital wasconducted on Jully 1. 2011 until Jully 15. 2014. Samples were obtained from women who werereproductive age and attended Obstetrics Gynecology Outpatient clinic of Sanglah Hospital, Denpasar.Samples were selected based on the consecutive sampling of the accessible population after fulfilledthe inclusion and exclusion criteria. Peripheral blood sampling of haemoglobin and profile iron levelconducted by ELISA technique at Prodia laboratory and done gynecology examination at ObstetricsGynecology Outpatient clinic of Sanglah Hospital to obtained cervical lession. Data was statisticallyanalyzed comparative test with the Chi-Square. The result of this study were the risk of iron deficiencyanemia in IUD Cu T 380 A acceptor group was four times greater than the non-acceptor group[OR =4.80; 95% CI = 1.04 to 22.10; P =0.036], while the risk of cervical lession in IUD Cu T 380 A group wasseven times greater than non-acceptor group [OR = 7.65; 95% CI = 1.37 to 42.71; P =0.012].We wereconclude that risk of iron deficiency anemia was four times greater and cervical lesions was seven timesgreater after IUD type Cu T 380 A application. [MEDICINA 2015;46:82-5].

HUBUNGAN ANTARA DIAMETER FOLIKEL DENGAN MATURITAS INTI OOSIT PADA SIKLUS ANTAGONIS FERTILISASI IN VITRO Anggli, Fido; Suwiyoga, Ketut; Wardhiana, IPG
Medicina Vol 46 No 1 (2015): Januari 2015
Publisher : Medicina

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Salah satu tahap dalam fertilisasi in vitro (FIV) adalah seleksi inti oosit matur yang akan digunakandalam fertilisasi. Inti oosit yang matur tersebut ditandai dengan adanya polar body di dalamnya.Cara yang sederhana dan praktis dalam menentukan maturitas inti oosit adalah pengukuran diameterfolikel. Terdapat perbedaan pendapat mengenai diameter folikel yang berhubungan terhadap maturitasinti oosit.Penelitian ini bertujuan untuk mengetahuihubungan antara diameterfolikeldenganmaturitasintioositpada program FIV.Rancangan penelitian ini observasional analitik(cross-sectional) yang dilaksanakan di Klinik Bayi Tabung Graha Tunjung, RSUP Sanglah, Denpasar.Sampel penelitian adalah folikel-folikel yang mengandung inti oosit (61 folikel), dilakukan dengancara consecutive sampling mulai 1 September 2011-31 Agustus 2012. Data dianalisismemakai ujiFisher Exact. Sebanyak 61 sampel diukur diameternya dengan menggunakan transvaginalsonography.Didapatkansebanyak 33folikeldengan diameter > 18 mm denganperincian 32mengandungoositmatur (96,97%) dan1 mengandungoositimatur (3,03%), sedangkandari 28folikeldengan diameter < 18 mm, didapatkansebanyak 21 folikelyang mengandungoositmatur (75%)dan 7 folikel yang mengandung oositi matur (30%). Hasil penelitian menunjukkan bahwa terdapathubungan antara diameter folikeldengan maturitas inti oosit pada siklus antagonis FIV secarabermakna (x2=4,63; P=0,019). Disimpulkan bahwa terdapat hubungan antara diameter folikel denganmaturitas inti oosit pada siklus antagonis FIV. [MEDICINA 2015;46:12-15].One of the stages in in vitro fertilization (IVF) is the selection of mature oocyte nucleus. This matureoocyte nucleus is characterized by the presence of polar body inside. Simple and practical way todetermine the maturity of the oocytenucleus is the measurement of follicle?s diameter. There aredifferences of opinion on the follicle?s diameter associated with the maturity of the oocyte nucleus. Thisstudy is purposed to know the relationship between follicle?s diameter with oocyte nucleus maturity inantagonist cycle IVF. This study?s design is observational analytic study (cross-sectional). This studywas done at Graha Tunjung IVF Clinic, Sanglah Hospital. Sample from this study were follicles thathave oocyte nucleus (61 follicles). Samples were collected with consecutive sampling from September1st 2011?August 31st 2012. Datas were analyzed with Fisher Exact test. As many as 61 samplesmeasure follicle?s diameter was count by transvaginal sonography.We analyzed 34 follicles withdiameter > 18 mm which is consist of 32 mature oocytes (96.97%) and 1 immature oocyte (3.03%), thenfrom 28 follicles with diameter < 18 mm, we found 21 follicles withmature oocyte (75%) and 7 follicleswith immature oocyte (30%).This study?s design shows relationship between follicle?s diameter andoocyte nucleus maturation in antagonist cycle IVF significantly (x2=4.63; P=0.019). It is concluded thatthere is a relationship between follicle?s diameter with oocyte nucleus maturity in antagonist cycleIVF. [MEDICINA 2015;46:12-15].

TIDAK TERDAPAT PERBEDAAN YANG BERMAKNA ANTARA NILAI ABSOLUT CLUSTER DIFFERENTIATION4 DAN PERSENTASE CLUSTER DIFFERENTIATION4 IBU HAMIL 162 TERINFEKSI HUMAN IMMUNODEFICIENCY VIRUS PADA TRIMESTER II DAN III Pangkahila, Evert Solomon; Suwiyoga, Ketut; Mahayasa, Putu Doster
Medicina Vol 46 No 3 (2015): September 2015
Publisher : Medicina

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Nilai absolut cluster differentiation 4 (CD4) diduga dipengaruhi oleh tingkat hemodilusi yang berbeda pada tiap trimester, sedangkan nilai persentase CD4 diduga tidak dipengaruhi oleh tingkat hemodilusi. Oleh karena itu penelitian mengenai perbandingan antara nilai aboslut CD4 dan persentase CD4 pada trimester yang berbeda pada kehamilan dengan HIV penting untuk dilakukan untuk melihat variasi nilai hitung CD4 (absolut dan persentase).Untuk membuktikan pengaruh kehamilan terhadap variasi nilai hitungabsolut CD4 dan persentase CD4 pada kehamilan dengan HIVtrimester II dan III,penelitian observasional dengan menggunakan rancangan studi kohort dilakukan untuk melihat bagaimana variasi nilai absolut CD4 dibandingkan persentase CD4 pada wanita hamil dengan HIV trimester II dan III. Penelitian dilaksanakan selama dua tahun dimulai dari Oktober 2011 sampai Oktober 2013. Dua puluh sampel penelitian dianalisis secara statistik. Hasil uji t menunjukkan nilai P>0.05 pada nilai absolut CD4 maupun persentase CD4. Hasil penelitian menunjukkan bahwa nilai absolut CD4 dan persentase CD4 tidak mengalami fluktuasi yang bermakna selama trimester II dan III pada kehamilan dengan HIV. Nilai absolut CD4 merupakan metode yang dapat dipercaya dalam menilai status imun ibu hamil dengan HIV, tanpa perlu melakukan pemeriksaan persentase CD4. Nilai persentase CD4 dapat dipertimbangkan dalam menilai status imun ibu hamil dengan HIV apabila terdapat faktor lain selain kehamilan yang dapat memengaruhi nilai absolut CD4. [MEDICINA 2015;46:162-5].Absolute cluster differentiation 4 (CD4) count is suspected to be influenced by the degree of hemodilution which is different in each trimester of pregnancy, while percentage of CD4 is thought not to be under significant influence of hemodilution. Thus, a study about the comparison between absolut CD4 and percentage of CD4 at different trimester (2nd and 3rd trimester) of pregnancy with HIV infection, are important to evaluate the variation of CD4 (absolute and percentage). To prove the influence of pregnancy to the variation of absolute CD4 count and percentage of CD4 in pregnancy with HIV infection at 2 nd and 3 trimester, an observational study using cohort design was conducted to evaluate the variation of absolute CD4 and percentage of CD4 in pregnant woman with HIV infection at 2 nd and 3 rd rd trimester. This study was held from October 2011 until October 2013.Twenty sample were statistically analyzed. T-paired test showed that the P value >0.05 in both CD4 count. It means that there was no significant difference in mean of CD4, either absolute or percentage in 2 trimester. The result showed that the absolute and percentage of CD4 did not fluctuate significantly during the 2 nd and 3 trimester of pregnancy. Absolute CD4 count is a valid method to asses the immune status of pregnant woman with HIV, and its not necesarry to count the percentage of CD4. Percentage of CD4 probably should be considered if there are any other factors beside the pregnancy itself that can interfere with the absolute CD4 count. [MEDICINA 2015;46:162-5].

JUMLAH CD4+ ABSOLUT IBU HAMIL YANG TERINFEKSI HUMAN IMMUNODEFICIENCY VIRUS PADA TRIMESTER III LEBIH RENDAH DIBANDINGKAN SAAT PASCA-PERSALINAN Widianti, Lidia; Suwiyoga, Ketut; Adnyana, Ida Bagus Putra
Medicina Vol 46 No 3 (2015): September 2015
Publisher : Medicina

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Human immunodeficiency virus (HIV) merupakan penyakit infeksi yang hingga saat ini masihmemiliki insidens yang cukup tinggi dikalangan wanita hamil. Wanita hamil yang terinfeksi HIVakan lebih rentan mengalami kematian langsung maupun kematian obstetric seperti perdarahan postpartum,sepsis puerpuralisdan komplikasi dari sectiocaesaria.Kematian yang disebabkan oleh karenaAIDSbisa terjadi secara langsung saat kehamilan maupun sebagai penyebab tidak langsung akibatdariinfeksi opportunistik. Penelitian ini bertujuan untuk membuktikan bahwa jumlah clusterofdiffrentiation+ (CD4+) absolut ibu hamil yang terinfeksi HIV saat trimester III lebih rendah dari padasaatpasca-persalinan. Metode penelitian ini adalah studi longitudinaldi Poliklinik PMTCT KebidanandanKandungan Rumah Sakit Umum Pusat (RSUP) Sanglah, Denpasar yang dilakukan mulai bulanAgustus2011 hingga Desember 2013 dengan sampel penelitian sebanyak 20 pasien. Sampel adalahibuhamil terinfeksi HIV saat trimester III. Kemudian dilakukan perhitungan kadar CD4+ absolut,dandilakukan pengukuran CD4+ absolut kembali saat 7 hari pasca-persalinan. Analisis data dilakukandenganuji t-paireddenganbantuan SPSSfor windows 17.0 versiondengan batas kemaknaan (P)<0,05.Ujit-pairedsaattrimester III mendapatkan rerata jumlah CD4+ absolut sebesar 357,90 (SB 238,81)dandibandingkan dengan saat 7 hari pasca-persalinan dengan rerata jumlah CD4+ absolut sebesar421,50(SB 213,57) [beda rerata -63,60 (IK 95% -122,8 sampai -4,4), P= 0,037]. Disimpulkan bahwajumlahCD4+ absolut pada wanita hamil terinfeksi HIV saat hamil trimester III lebih rendahdibandingkansaat pasca-persalinan. [MEDICINA2015;46:166-9].Human immunodeficiency virus (HIV) is an infectious disease that still have high incidence amongpregnancy women. Pregnancy women with HIV infection are more vulnerable to direct mortality eitherobstetric mortality such as haemoragic post-parturition, septic puerpuralis and caesarean sectioncomplication. Mortality due to AIDS could become direct cause due to obstetric complication or indirectcause due to opportunistic infection. The aim of this study was to prove that CD4+ absolute level inpregnancy infected by HIV in third trimester is lower than on post-parturition. The study method waslongitudinal study that conducted in PMTCT Clinic Obstetrics and Gynecology, Sanglah Hospital,Denpasar, which was taken from August 2011 to December 2013 with a sample of 20 patients. Sampleswere pregnant women infected with HIV during the third trimester. Then calculate the absolute levelsof CD4 + and the measurements of CD4 + absolute were repeated at 7 days post-parturition. Dataanalysis was wearing paired t-test using SPSS for windows version 17.0 with significance value (P)<0.05.Analysis result showed that mean CD4+ absolute levels that were obtained on third trimester was357.90 (SD 238.81) and compared with the 7 days after delivery was 421.50 (SD 213.57) with meandifferences -63.60 (95% CI -122.8 to -4.4), P= 0.037. It was concluded that CD4+ absolute levels inpregnant women with HIV during the third trimester of pregnancy is lower than on post-parturition.[MEDICINA 2015;46:166-9].

KARAKTERISTIK UMUR, PENDIDIKAN, DAN PEKERJAAN ISTRI SERTA STATUS SUAMI SEBAGAI FAKTOR RISIKO TERJADINYA INFEKSI HUMAN IMMUNODEFICIENCY VIRUS PADA IBU HAMIL Saspriyana, Kade Yudi; Suwiyoga, Ketut; Darmayasa, I Made
Medicina Vol 46 No 1 (2015): Januari 2015
Publisher : Medicina

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Prevalensi HIV di Bali adalah nomor dua setelah Papua dan cenderung meningkat mengikuti deretukur yang sebagian besar ditemukan pada usia muda reproduktif. Penularan utama adalah melaluihubungan seksual,yang selanjutnya diketahui bahwa peran umur, pendidikan, dan pekerjaan ibudiduga sangat besar. Penelitian ini bertujuan untuk mengetahui apakah umur, pendidikan, danpekerjaan pada ibu hamil serta status HIV suami sebagai faktor risiko ibu hamil terinfeksi HIV.Metode yang digunakan adalah berupa kasus kontrol tidak berpasangan di Bagian Obstetri danGinekologi RSUP Sanglah Denpasar selama dua bulan, yakni bulan Oktober-Nopember 2011. Sampeladalah ibu hamil terinfeksi HIV sebagai kelompok kasus dan tanpa infeksi HIV sebagai kelompokkontrol. Diagnosis HIV ditegakkan dengan rapid test serum, yaitu dinyatakan positif kalau reaktifdan negatif kalau non reaktif. Analisis data memakai uji Chi Square untuk mengetahui rasio odds.Lima puluh orang sampel dibagi atas 25 kelompok kasus dan 25 kelompok kontrol. Diperoleh bahwarisiko terinfeksi HIV wanita hamil pada umur tua vs muda, pendidikan tinggi vs rendah, dan pekerjaanberisiko vs tidak berisiko adalah tidak tidak bermakna pada kedua kelompok. Rasio odds masing-masing adalah 0,35 (IK 95% = 0,08 sampai 1,55; P = 0,157), 0,85 (IK 95% = 0,28 sampai 2,59; P =0,777), dan 2,09(IK 95% = 0,18 sampai 24,62;P= 1,00).Rasio odds status HIV suami adalah 12,67 (IK95% = 3,31 sampai 48,50; P = 0,001).Dapat disimpulkan bahwa suami terinfeksi HIV meningkatkanrisiko HIV pada ibu hamil 12 kali lebih besar dibanding dengan suami tidak terinfeksi HIV. Faktorumur, pendidikan, dan pekerjaan ibu bukan merupakan faktor risiko terjadinya infeksi HIV pada ibuhamil. [MEDICINA 2015;46:3-8].The prevalence of HIV in Bali is number two after Papua and likely to rise following a geometricprogression that is mostly found at the young age of reproductive. The main transmission throughsexual intercourse, the role of age, education, and the work of the mother allegedly is huge.This studyaims to know the relationships between age, education and occupation on the pregnant women and theHIV status of the husband against the risk of being infected with HIV.Study design was a not pairedcase control study at the Obstetrics and Gynecology Department Sanglah Hospital Denpasar was fortwo months, the month of October-November 2011. The sample were pregnant women who are willingto participate in this study, which are distinguished as groups of HIV-infected cases and without HIVinfection as a control group. Diagnosis of HIV rapid test with serum enforced, that is positive if reactiveand the stated negative if a non reactive. Data analysis using the Chi Square test to know the oddsratio.A number of 50 samples was divided into 25 groups of case and control group 25. Obtained thatthe risk of HIV-infected pregnant women in the age old vs. young, low vs. higher education, and occupationsat risk vs. not at risk is not meaningless in the two groups. Each odds ratio is 0.35 (95% CI = 0.08 to1.55; P = 0.157), 0.85 (95% CI = 0.28 to 2.59;P = 0.777), and 2.09(95% CI = 0.18 to 24.62;P= 1.00).Meanwhile, the odds ratio of the husband HIV status was 12.67 (95% CI = 3.31 to 48.50;P = 0.001).Final conclusions are husbands infected with HIV increases the risk of HIV in pregnant women 12times greater than the husband was not infected with HIV. Age, education, and the occupation ofmothers is not a

KADAR SERUM 8-HIDROKSI-2’-DEOKSIGUANOSIN LEBIH TINGGI PADA ABORTUS INKOMPLIT DIBANDINGKAN DENGAN KEHAMILAN NORMAL TRIMESTER I Suciani, Ni Made; Surya, I Gede Putu; Suwiyoga, Ketut
Medicina Vol 46 No 2 (2015): Mei 2015
Publisher : Medicina

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Abortus merupakan salah satu penyumbang kematian ibu akibat perdarahan yang ditimbulkan sertakomplikasi lain yang bisa muncul adalah infeksi, infertilitas dan abortus berulang. Penanganan abortussebagian besar terhadap komplikasi yang ditimbulkan bukan terhadap penyebabnya. Di Indonesiasampai saat ini belum pernah ditemukan penelitian tentang 8-hidroksi-2’-deoksiguanosin (8-OHdG).Tingginya kadar 8-OHdG berhubungan dengan tingginya agresi radikal hidroksil dan atau rendahnyakecukupan antioksidan yang bisa menyebabkan kerusakan DNA atau kelainan kromosom. Kelainankromosom merupakan salah satu penyebab terbesar abortus pada trimester I. Tujuan penelitian iniadalah untuk membuktikan bahwa kadar serum 8-OHdG pada abortus inkomplit lebih tinggidibandingkan dengan kehamilan normal trimester I. Desain pada penelitian ini adalah studi crosssectionalanalytic yang melibatkan 68 orang wanita yang dikelompokkan menjadi 34 orang denganabortus inkomplit dan 34 orang wanita hamil normal umur kehamilan < 14 minggu yang memenuhikriteria inklusi dan eksklusi yang datang ke Rumah Sakit Umum Sanglah Denpasar. Dilakukanpemeriksaan kadar 8-OHdG serum pada kedua kelompok dengan metode ELISA. Berdasarkan uji tindependentdidapatkan perbedaan yang signifikan (P=0,001) antara kadar 8-OHdG serum antarakelompok abortus inkomplit (5,00 ng/ml) dengan kelompok hamil normal (3,03 ng/ml). Beda reratakedua kelompok adalah 1,97 (IK95% 1,38 sampai 2,56). Dalam hal umur ibu, umur kehamilan danparitas tidak terdapat perbedaan yang signifikan antara kedua kelompok. Berdasarkan kurva ROCdiperoleh nilai cut of point 3,73 ng/ml. Dengan uji Chi-Square rasio prevalensi adalah 8,66 (RP=8,66IK95%=2,93 sampai 25,62 P=0,001). Kadar serum 8-OHdG secara bermakna lebih tinggi pada kelompokabortus inkomplit dibandingkan dengan kelompok hamil normal. Pada kadar 8-OHdG yang tinggikejadian abortus inkomplit adalah 8,7 kali lebih banyak dibandingkan hamil normal. [MEDICINA2015;46:99-103].Miscarriage or abortion is one contributor to maternal mortality due to bleeding caused as well asother complications can arise are infection, infertility and recurrent miscarriage. Handling most of thecomplications is not against the cause. In Indonesia until now has not been found research on eighthydroxy-2’-deoxyguanosine (8-OHdG). High level of this compounds is associated with high aggressionof hydroxyl radicals or low of antioxidant adequacy can cause DNA damage or chromosomalabnormalities. Chromosomal abnormalities arte the biggest cause of abortion in the first trimester.The purpose of this research was to prove that 8-OHdG serum level in incompete abortion was higherthan first trimester normal pregnancy. The design of this research was cross-sectional analytic studyinvolving 68 women, grouped into 34 women with Incomplete Abortion and 34 women with normalpregnancy less or equal than 14 weeks which meet the criteria of inclusion and exclusion that came tothe Sanglah Hospital Denpasar. Blood serum examination was conducted to know the 8-OHdG levelson both groups by the method of ELISA. Based on t-independent test, there were significant differences(P=0.001) between 8-OHdG serum level in incomplete abortion (5.00 ng/ml) and normal pregnancy(3.03 ng/mL) with mean difference was 1.97 (CI95% 1.38 to 2.56). In terms of mother’s age, pregnancy’sage and the parity, there were no significant differences between groups. Based on ROC curve, cut ofpoint of 8-OHdG serum level was 3.73 ng/ml. From Chi-Square test, prevalence ratio was 8.66 (RP=8.66CI95%=2.93 to 25.62 P=0.001). The serum level of 8-OHdG was significantly higher in incompleteabortion group compared to normal pregnancy. In the 8-OHdG serum levels were high, the incidence ofincomplete abortion was 8.7 times larger compared to normal pregnancy. [MEDICINA 2015;46:99-103].

Co-Authors Anak A. A. W. P. Dewi Anak Agung Gede Duwira Hadi Santosa Anak Agung Ngurah Jaya Kusuma Analysa, Analysa and I G. Alit-Artha Anom Suardika Anwar, Meirisa Afifah Nurmalia Arthawan Arthawan Aryana, Made Bagus Dwi Astawa, I Made Mulya Budiana, Nyoman Budiman, Ardelia Clara Candijaya, Gita Sirini Christyani, Fenyta Danny Aguswahyudi Darmayasa, Putu Bagus Desak Putu Oki Lestari Deviyanti, Gery Puspa Dewi, Anak A. A. W. P. E. Joewarini Evert Solomon Pangkahila Feliciano Pinto, Feliciano Ferry Santoso Fido Anggli, Fido Fransiskus C Raharja Gde Ari Putra, Orion Reffa Gede Fajar Manuaba, Ida Bagus Hadisubroto, Yona S. Hanny Aditanzil Hanny Aditanzil Harrista, Daniel Victor Heni Sunyoto I Dewa Made Sukrama I Gde Adnyana Sudibya I Gde Raka Widiana I Gde Sastra Winata I Gede Adnyana Sudibya, I Gede Adnyana I Gede M Putra I Gede Mahendra Adiguna Dira I Gede Mega Putra I Gede Putu Surya I Gusti Ayu Putri Kartika, I Gusti Ayu I Gusti Ayu Sri Mahendra Dewi I Gusti Putu Mayun Mayura I Ketut Labir I Ketut Labir I Ketut Surya Negara I Ketut Tunas I Made Darmayasa I Nyoman Gede Budiana I Nyoman H Sanjaya I NYOMAN MANTIK ASTAWA I Putu Kusuma Yudasmara, I Putu Kusuma I Wayan Artana Putra I Wayan Megadhana I Wayan Putu Sutirta Yasa I Wayan Suranadi I. F. W. Putra I. Lesmana I.W. Weta Ida Bagus Gde Fajar Manuaba Ida Bagus Putra Adnyana Ika Widi Astuti, Ika Widi Ines Kurniaty Hartono Intan Puspa Intizam, Marwa Humaira IPG Wardhiana IPG Wardhiana, IPG Janet Sumampouw Jessica Nathalia JOHANA SENSY LENI MANNA K Tangking Widarsa KADE YUDI SASPRIYANA Kadek Fajar Marta Kerans, Fransiscus Anthony Ketut S. Negara Kirana, Ni Wayan Prabasiwi Kusuma, I Komang Wira Ananta L.S. Ani Leonardo ., Leonardo Leony Lim Lidia Widianti, Lidia Luh Putu Iin Indrayani Maker Luh Seri Ani Made Bagus Dwi Aryana Mahendrata, Prayascita MANNA, JOHANA SENSY LENI Mantik AN Manuaba, Ida Bagus Gede Fajar Marta, Kadek Fajar Moestikaningsih . Mona Mariana Mona Mariana Muhammad Freddy Candra Sitepu Muliawan, Erlin Purnama N.W.A. Utami Nathalia, Jessica Negara, Ketut S. Ngurah Harry Wijaya Surya, I Gede Ni Ketut Karneli Ni Ketut Karneli Ni Ketut Supasti Dharmawan Ni Made Suciani Nyoman Bayu Mahendra Pramana, Bagus Andika Pratama, I Gede Bayu Adi Puspa, Intan Putra, I Gede M Putra, Ida Bagus Agung Widnyana Putri, Desak Agung Istri Padma Putu Adi Sujana Putra Putu Ayu Indrayathi Putu Doster Mahayasa R. Niruri Raharja, Fransiskus C Rasmaya Niruri Rasmaya Niruri Rasmaya Niruri Rastiti, Ni Putu Riasa, I Nyoman Putu Rini Noviyani Riza Firman Satria Sanjaya, I Nyoman H Santoso, Ferry Sari, Jayanti Purnama Satriawan, Nyoman Gede Dikawijaya Setiawan, William Alexander Stella Kawilarang Stella Kawilarang, Stella Sugianto Sugianto Sumampouw, Janet Tjokorda Gde Agung Suwardewa Wenas, Yongki Widia, Made Yudha Ganesa Wikantyas William Alexander Setiawan Wiraputri, Anak Agung Ratih Kusumadewi Yona S. Hadisubroto Yongki Wenas Yosevangelika Hutabarat

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