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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN BALI MEDICAL JOURNAL (BMJ) Medicina Jurnal Studi Jender SRIKANDI Buletin Udayana Mengabdi INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Jurnal Farmasi Klinik Indonesia E-Journal Obstetric & Gynecology Udayana Indonesian Journal of Cancer Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Patologi Indonesia Neurologico Spinale Medico Chirurgico JURNAL USM LAW REVIEW Babali Nursing Research Indonesian Journal of Perinatology Indonesian Journal of Cancer Public Health and Preventive Medicine Archive INCOME: Indonesian Journal of Community Service and Engagement Journal of Global Pharma Technology Cermin Dunia Kedokteran

I Ketut Suwiyoga

Departemen Obstetri Dan Ginekologi, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Bali, Indonesia

Author-ID : 397979

Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Kadar heat shock protein 70 cairan amnion yang tinggi sebagai faktor risiko terjadinya ketuban pecah dini pada kehamilan aterm Ines Kurniaty Hartono; Ketut Suwiyoga; I Ketut Surya Negara; I Gede Mega Putra; Made Bagus Dwi Aryana; I Gde Sastra Winata; I Wayan Megadhana
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Background: Premature rupture of membranes (PROM) is a condition that complicates labor with an unclear pathogenesis. HSP70 is thought to be involved in this pathogenesis process and the presence of HSP in the extracellular compartment reflects tissue damage and induces an immunologic response. Therefore, this study aimed to study the relationship between HSP70 levels in amniotic fluid and the incidence of PROM.Methods: This study used a case-control design in the ER delivery room and the laboratory of Sanglah Hospital, Denpasar. Samples were taken from mothers who gave full term delivery in the emergency room at Sanglah Hospital Denpasar with mothers who gave birth at term with KPD as cases and mothers who gave full term delivery without KPD as controls. Data was taken from medical records and measured levels of HSP70 at the Sanglah Hospital Denpasar Laboratory. Data analysis was performed using the Mann-Whitney test and ROC test.Results: A total of 28 cases and 28 controls were recruited. There were no significant differences in baseline characteristics between cases and controls. The MannWhitney test found significant differences in the mean levels of HSP70, 11.58 (±8.16) ng/mL in controls and 17.15 (±6.51) ng/mL in cases, respectively. ROC analysis found an AUC of 0.737 with an optimal cutoff value of 12.5 ng/mL. An amniotic fluid HSP70 level of more than 12.5 ng/mL was associated with PROM with an OR of 17.33 (95% CI 3.43 - 87.70).Conclusion: High amniotic fluid HSP 70 level is a risk factor for PROM in term pregnancy. Latar belakang: Ketuban pecah dini (KPD) merupakan suatu kondisi yang mempersulit persalinan dengan patogenesis yang belum jelas. HSP70 dianggap terlibat dalam proses patogenesis ini dan keberadaan HSP di kompartemen ekstraseluler mencerminkan kerusakan jaringan dan menginduksi respon imunologi. Oleh karena itu, penelitian ini bertujuan untuk mempelajari hubungan kadar HSP70 dalam cairan ketuban dengan kejadian KPD.Metode: Penelitian ini menggunakan desain kasus kontrol di ruang bersalin IGD dan Laboratorium RSUP Sanglah Denpasar. Sampel diambil dari ibu yang bersalin cukup bulan di ruang bersalin IGD RSUP Sanglah Denpasar dengan ibu yang melahirkan cukup bulan dengan KPD sebagai kasus dan ibu yang bersalin cukup bulan tanpa KPD sebagai kontrol. Data diambil dari rekam medis dan dilakukan pengukuran kadar HSP70 di Laboratorium RSUP Sanglah Denpasar. Analisis data dilakukan dengan menggunakan uji Mann-Whitney dan uji ROC.Hasil: Sebanyak 28 kasus dan 28 kontrol direkrut. Tidak ada perbedaan yang signifikan dalam karakteristik dasar antara kasus dan kontrol. Uji MannWhitney menemukan perbedaan yang signifikan dalam tingkat rata-rata HSP70, masing-masing 11,58 (± 8,16) ng/mL pada kontrol dan 17,15 (± 6,51) ng/mL dalam kasus. Analisis ROC menemukan AUC 0,737 dengan nilai cutoff optimal 12,5 ng/mL. Tingkat HSP70 cairan ketuban lebih dari 12,5 ng/mL dikaitkan dengan PROM dengan OR 17,33 (95% CI 3,43 - 87,70).Simpulan: kadar HSP 70 cairan amnion yang tinggi merupakan faktor risiko terjadinya KPD pada kehamilan aterm.

Skor assessment of different neoplasias in the adnexa (ADNEX) untuk memprediksi keganasan ovarium di RSUP Sanglah Denpasar I Nyoman Gede Budiana; Ketut Suwiyoga; Tjokorda Gde Agung Suwardewa; Anom Suardika; Made Bagus Dwi Aryana; Heni Sunyoto
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i1.1328

Introduction: Ovarian cancer is cancer of the female reproductive organs with the highest mortality and is in the third position of female cancer after mammary and cervical cancer. The mortality rate and survival rate of ovarian cancer is mainly determined by the stage at which ovarian cancer is diagnosed. Until now there is no method for early detection of ovarian cancer with good sensitivity and specificity. Assessment of different neoplasias in the adnexa (ADNEX) is a model proposed by international ovarian tumor analysis (IOTA) to help distinguish benign or malignant adnexa tumors.Methods: This study is a observational clinical test to find out the accuracy of ADNEX model to predict ovarian malignancy conducted at the Obstetric and Gynecology Outpatient Ward in Sanglah hospital, Denpasar from November 2019 to April 2020. Consecutive sampling was done and 88 sample was recruited with a diagnosis of ovarian tumors. Then the research sample was sent to the Pathology Anatomy laboratory of Sanglah Hospital for histopathological examination. This result would then be compared to the prediction results of the ADNEX model.Results: 35 samples of benign ovarian tumors and 53 samples of ovarian cancer were found with the ADNEX method. There were 46 samples with malignant tumor both by the ADNEX model and histopathology results, 7 samples of malignant tumor at histopathology result but benign by the ADNEX model, 6 samples of benign tumor according to histopathology but malignant using the ADNEX model, and 29 samples of benign tumor according to histopathology and the ADNEX model. Using cut off of 49,6%, the study reported a sensitivity level of 86.8%, specificity 82.6%, positive predictive value 88.5%, negative predictive value 80.6%, and 85.2% accuracy.Conclusion: The ADNEX model has a high level of specificity, sensitivity and diagnostic accuracy in diagnosing ovarian cancer and can be used in combination with other clinical markers for early detection of malignancy in ovarian tumors. Pendahuluan: Kanker ovarium merupakan salah satu jenis kanker organ reproduksi wanita dengan mortalitas tertinggi dan berada pada posisi ke-tiga kanker perempuan setelah kanker mammae dan serviks. Angka mortalitas dan survival rate kanker ovarium sangat ditentukan oleh stadium saat kanker ovarium terdiagnosis. Hingga saat ini belum tersedia metode pemeriksaan untuk deteksi dini kanker ovarium dengan sensitivitas dan spesifisitas yang memadai. Assessment of different neoplasias in the adnexa (ADNEX) adalah model yang diajukan oleh International Ovarian Tumor Analysis (IOTA) untuk membantu membedakan tumor adnexa sebagai tumor jinak atau ganas. Metode: Penelitian ini merupakan penelitian observasional uji klinik untuk mengetahui akurasi model ADNEX untuk memprediksi keganasan ovarium yang dilakukan di Poliklinik Kebidanan dan Penyakit Kandungan RSUP Sanglah, Denpasar pada bulan November 2019 hingga April 2020. Sampling dilakukan secara consecutive dan didapatkan 88 orang dengan diagnosis tumor ovarium. Sampel penelitian dikirimkan ke laboratorium Patologi Anatomi RSUP Sanglah dan dilakukan pemeriksaan histopatologi untuk kemudian dibandingkan dengan hasil prediksi dari model ADNEX.Hasil: Dalam penelitian ini didapatkan 35 sampel dengan tumor jinak ovarium dan 53 sampel dengan kanker ovarium dengan menggunakan metode ADNEX. Terdapat 46 sampel dengan hasil pemeriksaan model ADNEX ganas dan hasil pemeriksaan histopatologi ganas, 7 sampel histologi ganas namun model ADNEX jinak, 6 sampel histopatologi jinak namun model ADNEX ganas, dan 29 sampel histopatologi jinak dan model ADNEX jinak. Hasil penelitian memperlihatkan tingkat sensitifitas 86,8%, spesifisitas 82,6%, nilai prediksi positif 88,5%, nilai prediksi negatif 80,6%, dan akurasi 85,2%.Simpulan: Model ADNEX memiliki tingkat spesifisitas, sensitivitas dan akurasi diagnostik yang tinggi dalam mendiagnosis kanker ovarium dan dapat digunakan bersama dengan penanda klinis lain untuk deteksi dini keganasan pada tumor ovarium.

Akurasi kadar serum Secretory Leukocyte Protease Inhibitor (SLPI) dalam menunjang diagnosis kanker ovarium: suatu uji diagnostik Putu Adi Sujana Putra; Ketut Suwiyoga; I Nyoman Gede Budiana; I Wayan Megadhana; I Nyoman Bayu Mahendra; I Made Darmayasa
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Ovarian cancer is one of the most common malignant tumors found in reproductive organs in vitro. Secretory Leukocyte Protease Inhibitor (SLPI) protein is essential for the growth of ovarian cancer cells, a protein that maintains the survival of ovarian cancer cells, inhibits antiproliferative effects, and reverses the proapoptotic effect of elastase. This study aims to evaluate the role of SLPI in diagnosing ovarium cancer. Methods: The research was conducted at the Obstetrics and Gynecology Polyclinic, Sanglah Hospital, Denpasar and the Prodia Laboratory. Sampling of this study has been carried out by previous researchers in research on the accuracy of serum levels of insulin-like growth factor binding protein 2 in diagnosing ovarian cancer. The research sample (intended sample) was women aged 18 years and over with ovarian tumors who came to the Obstetrics and Gynecology Polyclinic, Sanglah Hospital, Denpasar. Data were analyzed using SPSS versi 22 for Windows. Results: The proportion of epithelial types was significantly higher in the ovarian cancer group. In ovarian cancer samples, the most samples were obtained at FIGO III Stage. Median CA125 levels, RMI scores, and SLPI levels were significantly higher in the group with ovarian cancer. The cut off value of serum SLPI used in this study was 54,000 pg/ml which was obtained from preliminary analysis on 26 training samples. Sensitivity: 78.3; specificity:66.7%; Positive predictive value: 78.3%; Negative predictive value: 66.7% Accuracy: 73.6%. Conclusion: In a diagnostic test study to assess the accuracy of SLPI serum in supporting the diagnosis of ovarian cancer, it was found that SLPI serum had good sensitivity, specificity, PPV, NPV, and accuracy values. Latar Belakang: Kanker ovarium merupakan salah satu tumor ganas yang paling sering ditemukan pada organ reproduksi secara in vitro. Protein Secretory Leukocyte Protease Inhibitor (SLPI) sangat esensial untuk pertumbuhan sel kanker ovarium, protein yang menjaga kelangsungan hidup sel kanker ovarium, inhibisi efek antiproliferatif, dan membalikkan efek proapoptosis dari elastase. Penelitian ini bertujuan untuk mengevaluasi peran SLPI dalam mendiagnosis kanker ovarium. Metode: Penelitian dilakukan di Poliklinik Kebidanan dan Penyakit Kandungan RSUP Sanglah Denpasar dan Laboratorium Prodia. Pengambilan sampel penelitian ini sudah dilakukan oleh peneliti sebelumnya pada penelitian tentang akurasi kadar serum insulin-like growth factor binding protein 2 dalam mendiagnosis kanker ovarium. Sampel penelitian (intended sample) adalah wanita berusia 18 tahun ke atas dengan tumor ovarium yang datang ke Poliklinik Kebidanan dan Penyakit Kandungan RSUP Sanglah Denpasar. Hasil: Proporsi tipe epitelial secara signifikan lebih banyak pada kelompok kanker ovarium. Pada sampel kanker ovarium, didapatkan sampel paling banyak pada Stadium FIGO III. Median kadar CA125, skor RMI, dan kadar SLPI secara signifikan lebih tinggi pada kelompok dengan kanker ovarium. Nilai cut off serum SLPI yang digunakan pada penelitian ini adalah 54.000 pg/ml yang didapatkan dari analisa pendahuluan pada 26 training sample Sensitivitas:78,3; spesifisitas:66,7%; Nilai prediksi positif: 78,3%; Nilai prediksi negatif: 66,7% Akurasi: 73,6%. Kesimpulan: Pada penelitian uji diagnostik untuk menilai akurasi serum SLPI dalam menunjang diagnosis kanker ovarium didapatkan bahwa serum SLPI memiliki nilai sensitivitas, spesifisitas, PPV, NPV, dan akurasi yang baik.

Anemia among pregnant women first and second trimester increases risk for low birth weight babies in Wangaya Hospital, Denpasar I Ketut Labir; I Ketut Tangking Widarsa; Ketut Suwiyoga
Public Health and Preventive Medicine Archive Vol. 1 No. 1 (2013)
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53638/phpma.2013.v1.i1.p05

Low birth weight is one of the major contributors to infant mortality rate (IMR). One of the dominant risk factors for the low birth weight is anemia. This study aimed to investigate the effect of anemia in pregnant women at first and second trimester to the incidence of low birth weight at Wangaya Hospital Denpasar. This study is a retrospective cohort design. The total samples were 150 respondents; 50 pregnant women with anemia in the first trimester, 50 pregnant women with anemia in the second trimester and 50 pregnant women without anemia. Samples were taken from medical records at Wangaya Hospital Denpasar using simple random sampling method. Data were collected by documentation study and data analysis was done using logistic regression. The results showed that pregnant women with anemia in the first trimester were having a risk of 10 times to give low birth weight compared to pregnant women who are not anemia [RR=10.29; 95%CI: 2.21-47.90], whereas pregnant women with anemia in the second trimester were at risk 16 times greater of having a low birth weight baby compared to pregnant women who are not anemia [RR=16; 95%CI: 3.49-73.41]. There was no difference in the incidence of low birth weight among anemia first and second trimester [p=0.297]. We can conluded that anemia among pregnant women in the first and second trimester increased the risk of low birth weight. The results of this study can be used by policy makers to planning prevention strategies to reduce the incidence of low birth weight babies including intensify the antenatal care program for pregnant women.

Parental willingness to pay the cervical cancer vaccination cost of senior high school aged students in Badung District Ni Ketut Karneli; Ketut Suwiyoga; I Gede Adnyana Sudibya
Public Health and Preventive Medicine Archive Vol. 1 No. 1 (2013)
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53638/phpma.2013.v1.i1.p11

The incidence of cervical cancer is high in Bali (0.8%), and more than 70% of cases are detected at an advanced stage (above 2B), making it difficult to treat. Prevention efforts are still very low; the Badung District only financed 1567 vaccinations from 8784 senior high school students, accounting for around 17.8%. Vaccination requires substantial funds, and its sustainability required community participation. This cross-sectional study aims to determine the relationship between the variables of perceived susceptibility, perceived severity, perceived benefits, perceived barriers, education and employment with the willingness of the parents to cover the costs of vaccination. A study was conducted using 196 samples from 595 populations selected by systematic random sampling, consisting of mothers of grade one high school students at SMU Petang, SMU 2 Mengwi, and SMU 1 North Kuta. The data was obtained through self-administered questionnaires. Perceived benefits and severity were measured by assessing the answers to open questions and pre-coded. Chi square and logistic regression tests were applied when analyzing the data. The results of the analysis show that willingness of parents to cover the cost is still low (43%) with 70% of respondents willing to pay less than Rp. 237,500 for three doses. Bivariate analysis found that: perceived susceptibility [RP=1,31; 95%CI: 1,04-1,67], perceived severity [RP=1,57; 95%CI: 1,20-2,05], perceived benefits [RP=1,84; 95%CI: 1,39-2,45], education [RP=1,64; 95%CI: 1,05-2,57], perceived barriers [RP=0,89; 95%CI: 0,70-1,15] and occupation [RP=1,18; 95%CI: 0,87-1,60]. From the results it can be concluded that the perceived susceptibility, perceived severity, perceived benefits and education are related to the willingness of the parents to cover vaccine costs, however, perceived barriers and occupation were not shown to be associated. The related dominant factor is perceived benefits. It is suggested that health promotion should emphasise on the benefits of the vaccination and cervical cancer malignancy rates in order to increase people's willingness to cover cervical cancer vaccination costs.

High Expression F2-Isoprostan (F2-IsoP), High Sterol Regulatory Element Binding Protein-2 (SREBP-2) and Low 2-Methoxyestradiol (2-ME) On Placenta Tissue as a Risk Factor of Pre-Eclampsia Jaya Kusuma AAN; Suwiyoga K; Mantik AN; Sukrama DM
Journal of Global Pharma Technology Volume 09 Issue 09
Publisher : Journal of Global Pharma Technology

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To date, pre-eclampsia (PE) still a problem of Maternal Fetal Medicine related to high incidence, maternal and neonatal morbidity and mortality. Pre-eclampsia is caused by pregnancy; however, the mechanism has not been established so it is still a disease of theories. This relates to differences in treatment, resulting in different ways of prevention and output of PE itself. Recently, the role of F2-IsoP ,SREBP-2 and 2-ME was suspected to be very important in the mechanism of the PE. Meanwhile, the placenta acts as a source regulatory protein production, so that the material of this study was taken from placental tissue. The study objective was to prove the high F2I-soP, high SREBP-2 and low 2-ME expression in the placenta as risk factors for PE Case control study has been conducted in the department of obstetrics and gynecology Sanglah Hospital with 62 samples in 2015. The case group consisted of 31 mothers with PE and control groups consisted of 31 non-PE mother. The study material is a placental tissue. F2-IsoP and SREBP-2 expression study was performed using immunohistochemistry and 2-ME with ELISA techniques in Pathobiology Laboratory Faculty of Veterinary Medicine Udayana University. Data were analyzed with chi square test and discriminant using SPSS. The statistical test results are presented in tabular form and narrative. In this study, it was found that high expression of F2-IsoP increased the risk of PE 4 times higher (OR = 4.44; 95% CI = 1.53 to 12.94; p = 0.005) ; high expression of SREBP-2 increased the risk of PE 8 times higher (OR = 8.19, CI95% = 2,311 to 29.073; p = 0.001) and low expression of 2-ME increased the risk of PE 5 times higher (OR = 5.23; CI95% = 1.75 to 15.55; p = 0.002). On the discriminant test, we obtained contributing risk factor for the occurrence of PE were SREBP-2, F2Isop and 2-ME (p = 0.002) respectively. Conclusion, high F2-IsoP expression, high SREBP-2 expression and low 2-ME expression in placenta were risk factors for PE. The most dominant risk factor of PE mechanism was SREBP-2.Keywords: Pre-eclampsia, F2-Isoprostane, Sterol Regulatory Element Binding Protein-2, 2-Methoxyestradiol.

High Level of Uterine Endocervical Interleukin-8, Matrix Metalloproteinase-8, and Interleukin 1Β as a Risk Factor for Preterm Labor Suwardewa TGA; Suwiyoga K K; Mantik Astawa N; Sutirta Yasa IWP
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
Publisher : Journal of Global Pharma Technology

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The preterm birth is a birth that takes place on a gestational age between 20–36 weeks and six days. The preterm birth is the leading cause of neonatal mortality and morbidity. Despite the current treatment procedures, the incidence of preterm birth has not changed in the last two decades. Incomplete understanding of the pathophysiological mechanisms underlying preterm labor is the major obstacle to prevent preterm birth. Recently, endocervical inflammation has been thought as a risk factor of a preterm labor. Several important substances such as endocervical IL-8, MMP-8, and IL-1β, has been considered to play a key role on preterm birth through cervical ripening. With those assumptions, the detection of a higher level of uterine endocervical IL-8, MMP-8, and IL-1β can be used to predict preterm labor. The design of this study is an observational case control study with a case group, which consisted of pregnant women with 20–36 weeks and six days of gestational age who had signs of labor, and the control group consisted of pregnant women with 20–36 weeks and six days of gestational age who had no signs of labor. The material used for this study is cervical mucous, and the enzyme-linked immunosorbent assay method was used to assess the level of IL-8, MMP-8, and IL-1β at laboratory of Veterinary Medicine of Udayana University Denpasar. In this study we used 48 samples, among which 24 were case group, and 24 as a control group. The mean age of the women, gestational age, and parity from both group are (27.04 vs 28.62 years old), (31.8 vs 29.50 weeks), and (0.96 vs 1.29) respectively, which are statistically homogenous (p > 0.05). Each level of interleukin-8, matrix metalloproteinase, and interleukin-1β suggests a risk factor of a preterm labor for: 35 times (OR = 35.00; CI 95% = 6.95–176.39; p = 0.001); 6.6 times (OR = 6.60; CI 95% = 1.25–34.95; p = 0.016), and 8.3 times (OR = 8.3; CI 95% = 2.15–32.3; p = 0.001), orderly. Among these cytokines, one that contributes most through a preterm birth is interleukin-8 (61%), followed by matrix metalloproteinase-8 (27%), and interleukin-1β (12%).Conclusion: Endocervical inflammation with high level of IL-8, MMP-8, and IL-1β is a risk factor for preterm labor. IL -8 gives the most contribution on preterm labor.Keywords: Preterm birth, Endocervical IL-8, MMP-8, and IL-1β.

Prevalence of Pregnant Women with Anemia in Sangkan Gunung Village, Karangasem Regency, Bali-Indonesia Luh Seri Ani; Ketut Suwiyoga
Journal of Global Pharma Technology Volume 09 Issue 03
Publisher : Journal of Global Pharma Technology

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Pregnant women are one of the groups with the risk of having anemia. Some factors that are correlated to anemia is an infectious disease, bleeding, and low iron daily intake.These factors were related to the knowledge level of pregnant women and iron supplementation compliance. This is a cross-sectional study with descriptive methods, where 34 pregnant women were chosen by consecutive sampling method. Anemia was then measured by sahli method, and hemoglobin level < 11 g/dl were categories as anemia. The results were analyzed with univariate and bivariate analysis using SPSS 23. Anemia in pregnant women at Sangkan Gunung village, Sidemen sub-district is20,6%. Most anemia incidents were found in 20-35 years old pregnant women, with low education level, work at the office, zero parity, and in afirst trimester. Anemia was not associated with chronic energy deficiency, knowledge level and iron supplementation compliance level (P>0,05). Anemia prevalence of pregnant women was relatively low, but the preventive effort must be taken to decrease therate of anemia prevalence.Keywords: Knowledge, Compliance, Iron tablets, Pregnant women, Anemia.

CHARACTERISTICS OF COVID-19 CASES IN PREGNANCY AT PROF DR I GUSTI NGOERAH GDE NGOERAH HOSPITAL IN 2021-2022 Gde Ari Putra, Orion Reffa; Gede Fajar Manuaba, Ida Bagus; Sastra Winata, I Gde; Ngurah Harry Wijaya Surya, I Gede
E-Jurnal Medika Udayana Vol 13 No 8 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i08.P16

COVID-19 is a respiratory virus that can cause mild to severe respiratory illnesses and complications. Pregnant women and new mothers are at high risk for infection. This study aims to understand COVID-19 cases during pregnancy. The objective of this study was to determine the characteristics of COVID-19 cases during pregnancy at RSUP Prof Dr I Gusti Ngoerah Gde Ngoerah in 2021-2022. This descriptive observational cross-sectional study analyzed events occurring in the population without intervening in the study subjects. The results indicate that pregnant women with COVID-19 at RSUP Prof Dr I Gusti Ngoerah Gde Ngoerah in 2021-2022 were mostly aged between 20-30 years (64,3%), had one pregnancy (74,4%), and were in the third trimester (79,9%). The study found that (44,7%) of participants had a BMI indicating overweight, (100%) had no COVID-19 risk, and (48,2%) did not know their COVID-19 risk. Additionally, (97,5%) had not received a COVID-19 vaccination, (49,2%) experienced mild clinical symptoms, and (41,2%) were treated with remdesivir as an antiviral medication. The majority of participants had a high leukocyte count (54,3%) and normal platelet values (77,9%), but (68,3%) did not undergo lymphocyte count examination. (47,2%) of the majority did not undergo radiological imaging. For those who did, it was done for pneumonia in (30,7%) of cases.

Karakteristik Pasien Kanker Serviks Stadium IIB Pasca Kemoterapi Neoadjuvant di RSUP Sanglah Denpasar Tahun 2020-2021 Satriawan, Nyoman Gede Dikawijaya; Winata, I Gde Sastra; Pangkahila, Evert Solomon; Manuaba, Ida Bagus Gede Fajar
E-Jurnal Medika Udayana Vol 11 No 4 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i04.P18

Kanker serviks adalah keganasan pada leher rahim akibat human papilloma virus. Terapi pada kasus kanker serviks stadium IIB adalah kemoterapi neoadjuvant. Tujuan dari penelitian ini untuk mengetahui karakteristik berdasarkan usia, tipe histopatologi, riwayat keluarga, paritas, riwayat kontrasepsi, respon kemoterapi, dan status operabilitas pada kasus kanker serviks stadium IIB pasca kemoterapi neoadjuvant di RSUP Sanglah Denpasar. Penelitian ini merupakan penelitian deskriptif retrospektif yang bersumber dari rekam medis pasien dengan teknik total sampling. Populasi dan sampel penelitian ini adalah pasien kanker serviks stadium IIB pasca kemoterapi neoadjuvant di RSUP Sanglah Denpasar periode 2020-2021 sesuai kriteria inklusi. Hasil penelitian menunjukkan terdapat 40 pasien kanker serviks stadium IIB dengan jumlah kasus tertinggi usia 40-49 tahun (45%). Tipe histopatologi tersering squamous cell carcinoma (85%). Pasien tanpa riwayat keluarga menderita kanker serviks sejumlah 92,5%. Pasien dengan jumlah paritas >2 sebanyak 52,5%. Pasien dengan riwayat penggunaan kontrasepsi sebanyak 65%. Respon kemoterapi baik lebih banyak ditemukan sebesar 70%. Status pasien operabel sebesar 57,5%. Kata kunci : karakteristik, kanker serviks stadium IIB, kemoterapi neoadjuvant.

Co-Authors Anak A. A. W. P. Dewi Anak Agung Gede Duwira Hadi Santosa Anak Agung Ngurah Jaya Kusuma Analysa, Analysa and I G. Alit-Artha Anom Suardika Anwar, Meirisa Afifah Nurmalia Arthawan Arthawan Aryana, Made Bagus Dwi Astawa, I Made Mulya Budiana, Nyoman Budiman, Ardelia Clara Candijaya, Gita Sirini Christyani, Fenyta Danny Aguswahyudi Darmayasa, Putu Bagus Desak Putu Oki Lestari Deviyanti, Gery Puspa Dewi, Anak A. A. W. P. E. Joewarini Evert Solomon Pangkahila Feliciano Pinto, Feliciano Ferry Santoso Fido Anggli, Fido Fransiskus C Raharja Gde Ari Putra, Orion Reffa Gede Fajar Manuaba, Ida Bagus Hadisubroto, Yona S. Hanny Aditanzil Hanny Aditanzil Harrista, Daniel Victor Heni Sunyoto I Dewa Made Sukrama I Gde Adnyana Sudibya I Gde Raka Widiana I Gde Sastra Winata I Gede Adnyana Sudibya, I Gede Adnyana I Gede M Putra I Gede Mahendra Adiguna Dira I Gede Mega Putra I Gede Putu Surya I Gusti Ayu Putri Kartika, I Gusti Ayu I Gusti Ayu Sri Mahendra Dewi I Gusti Putu Mayun Mayura I Ketut Labir I Ketut Labir I Ketut Surya Negara I Ketut Tunas I Made Darmayasa I Nyoman Gede Budiana I Nyoman H Sanjaya I NYOMAN MANTIK ASTAWA I Putu Kusuma Yudasmara, I Putu Kusuma I Wayan Artana Putra I Wayan Megadhana I Wayan Putu Sutirta Yasa I Wayan Suranadi I. F. W. Putra I. Lesmana I.W. Weta Ida Bagus Gde Fajar Manuaba Ida Bagus Putra Adnyana Ika Widi Astuti, Ika Widi Ines Kurniaty Hartono Intan Puspa Intizam, Marwa Humaira IPG Wardhiana IPG Wardhiana, IPG Janet Sumampouw Jessica Nathalia JOHANA SENSY LENI MANNA K Tangking Widarsa KADE YUDI SASPRIYANA Kadek Fajar Marta Kerans, Fransiscus Anthony Ketut S. Negara Kirana, Ni Wayan Prabasiwi Kusuma, I Komang Wira Ananta L.S. Ani Leonardo ., Leonardo Leony Lim Lidia Widianti, Lidia Luh Putu Iin Indrayani Maker Luh Seri Ani Made Bagus Dwi Aryana Mahendrata, Prayascita MANNA, JOHANA SENSY LENI Mantik AN Manuaba, Ida Bagus Gede Fajar Marta, Kadek Fajar Moestikaningsih . Mona Mariana Mona Mariana Muhammad Freddy Candra Sitepu Muliawan, Erlin Purnama N.W.A. Utami Nathalia, Jessica Negara, Ketut S. Ngurah Harry Wijaya Surya, I Gede Ni Ketut Karneli Ni Ketut Karneli Ni Ketut Supasti Dharmawan Ni Made Suciani Nyoman Bayu Mahendra Pramana, Bagus Andika Pratama, I Gede Bayu Adi Puspa, Intan Putra, I Gede M Putra, Ida Bagus Agung Widnyana Putri, Desak Agung Istri Padma Putu Adi Sujana Putra Putu Ayu Indrayathi Putu Doster Mahayasa R. Niruri Raharja, Fransiskus C Rasmaya Niruri Rasmaya Niruri Rasmaya Niruri Rastiti, Ni Putu Riasa, I Nyoman Putu Rini Noviyani Riza Firman Satria Sanjaya, I Nyoman H Santoso, Ferry Sari, Jayanti Purnama Satriawan, Nyoman Gede Dikawijaya Setiawan, William Alexander Stella Kawilarang Stella Kawilarang, Stella Sugianto Sugianto Sumampouw, Janet Tjokorda Gde Agung Suwardewa Wenas, Yongki Widia, Made Yudha Ganesa Wikantyas William Alexander Setiawan Wiraputri, Anak Agung Ratih Kusumadewi Yona S. Hadisubroto Yongki Wenas Yosevangelika Hutabarat

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