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Peningkatan pengetahuan untuk pencegahan stunting melalui sosialisasi dan demo pembuatan makanan balita berbahan dasar protein hewani bagi kelompok istri peternak sapi pedaging rumahan di Desa Lando, Lombok Timur, Nusa Tenggara Barat [Increasing knowledge for stunting prevention through socialization and demonstration for creating animal protein-based toddler food for a group of wives of home-based beef cattle farmers in Lando Village, East Lombok, West Nusa Tenggara] Qurnianingsih, Ema Ema; Rusyda, Aqila sabila; Hamzah, Arshq Mirza; Rachmawati, Kadek; Humairah, Ira Ira; Lukitasari, Lina; Khaerunnisa, St; Wungu, Citrawati Dyah Kencono; Ummah, Fithriyah Cholifatul Ummah; Kholik, Kholik; Riwu, Katty Hendriana Priscilia; Pradana, Munawer; Yansri, Alifianita Anake; Hidayat, Muhammad; Prabowo, Gwenny Ichsan
Buletin Pengabdian Vol 4, No 3 (2024): Bull. Community. Serv.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/bulpen.v4i3.40293

Abstract

Stunting is a condition of failure to thrive in children under five (toddlers) which can hinder the child's physical and mental development. Data from the 2023 Indonesian Health Survey (SKI) shows that the number of stunted toddlers in West Nusa Tenggara (NTB) Province is still quite high, namely 24.6%. Stunting cannot be cured but can be prevented. One of the prevention efforts is to increase the knowledge of mothers or prospective mothers regarding stunting and preventing it by providing food with high nutrition. This Community Service Activity (PKM) was carried out with the aim of educating mothers and wives of home-based beef cattle farmers in Lando Village, East Lombok, NTB about preventing stunting by providing highly nutritious supplementary food (PMT) and stunting detection. The methods used were socialization and demonstration of making toddler food. The results of this PKM activity were that there was a significant increase in participants' knowledge regarding the material being socialized (p0.0001). The conclusion that can be drawn is that There had been an increase in knowledge among PKM participants regarding stunting and preventing stunting through providing food with high protein content.
Osteopontin and Its Clinical Correlation to Type 1 Cardiorenal Syndrome: A Literature Review Yongki Welliam; Citrawati Dyah Kencono Wungu; Hendri Susilo
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.20878

Abstract

Cardiorenal syndrome (CRS) is a spectrum of disorders involving both the heart and the kidneys, either acutely or chronically, in one organ that can lead to dysfunction in the other. Type 1 CRS, the most common CRS, is when acute heart dysfunction impacts acute kidney dysfunction, commonly known as acute kidney injury. Comorbidities involving these two significant organs contribute to a high patient mortality rate that requires a new potential diagnostic method. Biomarkers are one of the diagnostic modalities widely used in various diseases. Osteopontin (OPN) is a phosphorylated glycoprotein found primarily in bones and teeth that regulates mineralization. Osteopontin is known to be involved in describing various pathological changes in the body, including cardiovascular diseases. This review aims to evaluate the clinical correlation of OPN level changes with the occurrence of Type 1 CRS. The results indicate that OPN also plays a role in detecting the progression of cardiovascular disease towards renal injury. The imbalance in the function of OPN as a pro-inflammatory and anti-inflammatory agent increases the progression of kidney disease in patients. Further findings suggest that, more specifically, urinary OPN describes renal injury events in type 1 CRS patients.
Systematic Review and Meta-Analysis of the Efficacy and Safety Profile of Belimumab in Combination with Standard Therapy for Adults with Systemic Lupus Erythematosus Dharmawan, Mochamad Rangga Alif; Rochmanti, Maftuchah; Awalia; Wungu, Citrawati Dyah Kencono
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 1 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i1.66383

Abstract

Introduction: Systemic lupus erythematosus (SLE) is a multi-system autoimmune disorder marked by pathogenic autoantibodies, resulting in considerable morbidity and mortality. Despite existing diverse treatment regimens, the need for more effective therapies persists. Recent advancements include monoclonal antibodies, such as belimumab, which can inhibit receptors tied to SLE’s pathogenesis. This meta-analysis aimed to evaluate the efficacy and safety of combining belimumab and standard therapy compared to placebo in SLE patients, utilizing as many indicators as possible to comprehensively assess the former's potential. Methods: This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the Cochrane Handbook for Systematic Reviews of Interventions. A thorough literature search was performed across various databases, including PubMed, ScienceDirect, ProQuest, and grey literature sources such as MedRxiv and BioRxiv. The data underwent statistical analysis, with I²<50% indicating low heterogeneity and p<0.05 denoting statistical significance. Results: The literature search yielded seven records for analysis in this study. All the selected studies were multicenter, phase III/IV, randomized clinical trials published between 2011 and 2019. The selected studies' risk of bias was assessed using Cochrane’s Risk of Bias (RoB) 2 tool. The results indicated that belimumab and standard therapy significantly improved disease activity, reduced flare occurrences—particularly severe flares, lowered corticosteroid dosage, and enhanced key biomarkers compared to placebo. The safety profile was favorable, with significantly minimal side effects, infections, and mortality risks. Conclusion: Belimumab combined with standard therapy demonstrates promising efficacy and safety for SLE treatment, suggesting its potential for broader adoption in clinical practice.   Highlights: 1. This systematic review and meta-analysis provide a thorough and complete analysis of multiple indicators regarding the efficacy and safety of belimumab in the treatment of systemic lupus erythematosus (SLE), which have never been reviewed before. 2. The findings of this study may lead to broader acceptance and adoption of belimumab as the standard treatment for SLE.
Efficacy of Ozoralizumab vs. Golimumab for Rheumatoid Arthritis: A Systematic Review Fithriyah, Nathania Elma; Rahmadhani, Khafiyah Hikmah; Susanti, Luthfiana Rofhani; Mustika, Arifa; Lita Diah Rahmawati; Wungu, Citrawati Dyah Kencono
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.66406

Abstract

Introduction: Rheumatoid arthritis, a systemic autoimmune disease, affects 13% of the world population. As a well-established therapy, golimumab provides a key benchmark for assessing novel biological treatments. In contrast, ozoralizumab represents an innovative therapeutic approach. This study aimed to comprehensively elucidate the efficacy of golimumab and ozoralizumab in reducing rheumatoid arthritis disease activity. Methods: Literature searches were conducted throughout PubMed, Cochrane, and Web of Science using Boolean operators, covering available records from database inception until October 2024. The literature search was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The included studies were randomized controlled trials (RCT) evaluating the efficacy of ozoralizumab or golimumab for rheumatoid arthritis. Five studies from 2015 to 2022 were obtained and assessed using the Cochrane Risk of Bias 2 (ROB2) tool. Results: The five studies consisted of two ozoralizumab trials and three golimumab trials conducted in Japan and the United States, involving 2,305 participants. All included studies exhibited a low risk of bias based on assessments undertaken using the ROB2 tool. The differences in Disease Activity Score-28 (DAS28) remission rates between ozoralizumab and placebo were 42.6% in one study and 6.3% in the other, whereas golimumab mainly showed smaller differences versus placebo across three studies (4.6%, 5.9%, and 10.4%). Conclusion: This study demonstrates DAS28 remission in rheumatoid arthritis patients receiving either ozoralizumab or golimumab therapy. Nonetheless, further direct statistical studies are essential to determine which therapy is superior and under what circumstances it should be administered.   Highlights: 1. This study provides robust evidence that establishes ozoralizumab as a novel tumor necrosis factor-alpha (TNF-α) inhibitor for rheumatoid arthritis. 2. According to the findings, ozoralizumab may be a clinician's choice due to its comparable efficacy and potential advantages over golimumab.
Osteopontin and Its Clinical Correlation to Type 1 Cardiorenal Syndrome: A Literature Review Welliam, Yongki; Wungu, Citrawati Dyah Kencono; Susilo, Hendri
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.20878

Abstract

Cardiorenal syndrome (CRS) is a spectrum of disorders involving both the heart and the kidneys, either acutely or chronically, in one organ that can lead to dysfunction in the other. Type 1 CRS, the most common CRS, is when acute heart dysfunction impacts acute kidney dysfunction, commonly known as acute kidney injury. Comorbidities involving these two significant organs contribute to a high patient mortality rate that requires a new potential diagnostic method. Biomarkers are one of the diagnostic modalities widely used in various diseases. Osteopontin (OPN) is a phosphorylated glycoprotein found primarily in bones and teeth that regulates mineralization. Osteopontin is known to be involved in describing various pathological changes in the body, including cardiovascular diseases. This review aims to evaluate the clinical correlation of OPN level changes with the occurrence of Type 1 CRS. The results indicate that OPN also plays a role in detecting the progression of cardiovascular disease towards renal injury. The imbalance in the function of OPN as a pro-inflammatory and anti-inflammatory agent increases the progression of kidney disease in patients. Further findings suggest that, more specifically, urinary OPN describes renal injury events in type 1 CRS patients.
PREVALENCE OF MENSTRUAL MIGRAINE AND THE EFFICACY OF SUMATRIPTAN ADMINISTRATION: Prevalensi Migrain Menstrual dan Efikasi dari Pemberian Sumatriptan Maridsky, Aldilla Afifie Putri; Sudibyo, Devi Ariani; Qurnianingsih, Ema; Dyah Kencono Wungu, Citrawati
Jurnal Berkala Epidemiologi Vol. 12 No. 1 (2024): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V12I12024.62-70

Abstract

Background: Menstrual migraine is a primary headache that often attacks women of reproductive age. This type of migraine has high severity and is resistant to treatment. Therefore, an effective treatment is needed to treat this menstrual migraine. Sumatriptan has been shown to have a better effect as an acute treatment for menstrual migraine patients. Purpose: This study aims to determine the prevalence and effectiveness of sumatriptan as a therapy for menstrual migraine. Methods: This research is based on a literature review following predetermined inclusion criteria. First, a literature search was carried out adhering to the PRISMA flow in 4 databases: Pubmed, Science Direct, ProQuest, and ClinicalTrial.co. Results: Based on keywords, 267 studies were found in the literature search. However, only three studies covering 845 participants met the predetermined inclusion criteria. The average age of menstrual migraine patients in the three studies was 37 years. These three studies of sumatriptan revealed a significant effect in providing a pain-free response in menstrual migraine patients. These three studies also showed that sumatriptan 100 mg has a higher level of effectiveness in providing a pain-free response in menstrual migraine sufferers and was preferably given during mild attacks. Conclusion: These three studies indicate that typically, women who suffer from menstrual migraines are of reproductive age. Additionally, this study shows that using sumatriptan as an acute therapy significantly helps provide a pain-free response in menstrual migraine patients.
The Improvement of Community Knowledge, Attitudes and Practices After Covid-19 Socialization Khaerunnisa, Siti; Syafa'ah, Irmi; Wungu, Citrawati Dyah Kencono; Prabowo, Gwenny Ichsan; Handajani, Retno; Safitri, Indri; Notopuro, Harianto; Qurnianingsih, Ema; Lukitasari, Lina; Humairah, Ira; Bakhtiar, Arief; Suwandito, Suwandito; Asih, Susi Wahyuning; Anggraeni, Zuhrotul Eka Yulis; Adi, Ginanjar Sasmito; Nugrahani, Ely Rahmatika; Zulka, Ayesie Natasha; Soetjipto, Soetjipto
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

This study determined community knowledge, attitudes, and practices after COVID-19 socialization in Rambipuji and Suci Village, Jember District, East Java, Indonesia. This study used the analytic observational design study. As many as 40 people were given socialization about COVID-19 by gathering and online. The questionnaires were completed in two parts included before-socialization and after-socialization. The questionnaire data were analyzed descriptively by calculating frequency, percentage, and inferential statistics by t-test, Spearman correlation, and chi-square test. The data analysis used IBM SPSS version 23 software. The mean and standard deviation of percentage of knowledge pre-test, knowledge post-test, high attitude, moderate attitude, low attitude, very high practice, high practice, sufficient practice, and low practice were 58.33 ± 30.97, 77.70 ± 22.52, 62.5±21.7, 31±22.2, 6.5±17.1, 65±13.8, 32.3±13.8, 1.25±2.4, 1.25±1.8, respectively. Knowledge pre-test and post-test correlated 0.819 (p=0.001) and a t-test with p=0.003. Attitudes and practices correlated with p=0.001. Socialization of COVID-19 was useful to improve the community knowledge, attitudes, and practices in Rambipuji and Suci Village, Jember District, East Java, Indonesia that could prevent the transmission and inhibit the spread of the COVID-19 pandemic in Indonesia. Furthermore, continuous encouragement of COVID-19 socialization in wide areas was recommended.
Efficacy and Safety of Ozoralizumab versus Moxibustion for Rheumatoid Arthritis Susanti, Luthfiana Rofhani; Mustika, Arifa; Rahmawati, Lita Diah; Kencono Wungu, Citrawati Dyah
Folia Medica Indonesiana Vol. 60, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Rheumatoid arthritis is a chronic inflammatory disease that symmetrically damages the synovial membrane, affecting approximately 13% of the global population. Systemic complications and substantial declines in quality of life may result from untreated rheumatoid arthritis. This study investigated the safety and efficacy of moxibustion and ozoralizumab in reducing disease activity scores in rheumatoid arthritis patients. Between July 2023 and February 2025, we conducted a thorough search on four online databases (PubMed, Cochrane, Scopus, and ProQuest) using keywords, reference searches, and other methods following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The obtained randomized controlled trials (RCTs) were assessed using the Cochrane Risk of Bias 2 (ROB2) tool. MetaInsight version 5.2.1 was utilized to perform the indirect network meta-analysis, using mean difference (MD) as the summary statistics. The measurement of the Disease Activity Score 28 (DAS28) indicated that ozoralizumab had a more significant effect on rheumatoid arthritis compared to placebo (MD=-1.88, 95% CI=-2.24-(-1.52)) and moxibustion (MD=-0.69, 95% CI=-1.07-0.31). Ozoralizumab demonstrated mild, moderate, and severe side effects, whereas moxibustion displayed modest side effects in comparison to placebo. In summary, both ozoralizumab and moxibustion reduced DAS28 in patients with rheumatoid arthritis, with ozoralizumab proving to be the more effective treatment. However, the adverse effects of ozoralizumab were more varied than those of moxibustion.
PRELIMINARY LABORATORY EVALUATION OF RAPID DIAGNOSTIC TEST PROTOTYPE TO DETECT HBsAg IN WHOLE BLOOD AND SERUM Qurnianingsih, Ema; Wungu, Citrawati Dyah Kencono; Amin, Mochammad; Setyawati, Dewi; Yasan, Yanna Debby Restifanny; Lukitasari, Lina; Lusida, Maria Inge; Soetjipto, Soetjipto
Folia Medica Indonesiana Vol. 61, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Chronic hepatitis B virus (HBV) remains a major global health issue,[-10pc]AU: Please provide ORCID ID for all authors.[-7pc]AU: Please provide affiliation’s for all authors. with over 250 million people affected worldwide. In Indonesia, HBV prevalence has declined from high to moderate endemicity, but challenges persist due to regional disparities, risk of mother-to-child transmission, and the predominance of B3 and C1 sub-genotype. Despite available preventive measures and diagnostic tools, approximately 90% of cases remain undiagnosed, particularly in low-resource settings, indicating the need for improved screening and control strategies. Therefore, this study aims to conduct preliminary performance tests of KODC hepatitis B surface antigen (HBsAg) (rapid diagnostic test (RDT) prototype) produced by Konimex on serum and whole blood samples. Performance was assessed through sensitivity, precision, specificity, and comparative testing against commercial RDT. The results obtained were visually interpreted by 2 independent readers. KODC HBsAg RDT demonstrated a detection limit of 50 IU/ml in serum and 400 IU/ml in whole blood. Precision testing showed high reproducibility (RSD <3.02%), with no cross-reactivity against other pathogens. Compared with a commercial RDT, it showed equivalent performance in serum and superior specificity in whole blood. In addition, predictive value analysis confirmed excellent accuracy, with Positive predictive value (PPV) and negative predictive value (NPV) >99% in both sample types. Therefore, KODC HBsAg RDT prototype showed comparable performance to commercial tests with good sensitivity, precision, and specificity, indicating its potential as a practical tool for HBV screening in resource-limited settings.
Upaya peningkatan pola pengasuhan guru dan orang tua penyandang disabilitas di Pendidikan Khusus dan Layanan Khusus (PK-LK) Shafa Mojokerto Rimbun, Rimbun; Yuliawati, Tri Hartini; Faizah, Zakiyatul; Hamidah, Berliana; Amanda, Bella; Prasetiowati, Lucky; Sari, Dewi Ratna; Purwantari, Kusuma Eko; Wungu, Citrawati Dyah Kencono; Darsini, Ninik; Fepiosardi, Raihenette Amirasanti; Fathimatuzzahroh; Parmanto, Christian Melka
Sewagati Vol 9 No 5 (2025)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j26139960.v9i5.8095

Abstract

Anak Berkebutuhan Khusus (ABK) adalah anak yang mengalami keterbatasan ataukeluarbiasaan, baik fisik, mental-intelektual, sosial, maupun emosional. Keberadaanpendamping bagi siswa ABK memiliki makna yang berarti bagi proses perlindungandan tumbuh kembangnya. Kegiatan pengabdian kepada masyarakat ini bertujuanuntuk meningkatkan pengetahuan guru dan orang tua mengenai pola asuh bagi siswapenyandang disabilitas di Sekolah Shafa Mojokerto. Sebanyak 23 siswa berkebutuhankhusus diberikan asesmen kognitif, sosioemosional dan psikomotor lengkapdengan saran bagi stimulasi tumbuh kembangnya, yang dilakukan oleh psikologklinis dari Layanan Psikologi Rumah Kumbang. Diantaranya, sebanyak 4 siswapenyandang tuna daksa (cerebral palsy) diberikan asesmen fisik yang dilakukan olehDokter Spesialis Kedokteran Fisik dan Rehabilitasi dari RSUD Dr. Soetomo. Selainitu juga diberikan penyuluhan mengenai cerebral palsy, pemeriksaan genetik danpola pengasuhan yang tepat bagi guru dan orang tua siswa. Luaran dari kegiatanPkM yang telah tercapai antara lain tersedianya laporan asesmen psikologis siswadan peningkatan pengetahuan guru dan orang tua yang dibuktikan dengan peningkatanrerata nilai posttest test (80, 63 ± 14, 36) dibanding pretest (61, 88 ± 20, 07)secara signifikan ( ? = 0, 010). Kesiapan dan kesiagaan guru dan orang tua siswaABK merupakan kunci sukses penanganan, ditambah dukungan dari masyarakat danpemerintah dalam menyediakan lingkungan dan fasilitas yang ramah terhadap ABK.
Co-Authors . Kholik Achmad Firdaus Pamudya Wardhana Adi, Ginanjar Sasmito Amanda, Bella Amin, Indah Binti Mohd Amin, Mochammad Anggraeni, Zuhrotul Eka Yulis Arifa Mustika Awalia Ayesie Natasha Zulka Bakhtiar, Arief Bayu Satria Wiratama Berliana Hamidah Budi Susetyo Pikir Cennikon Pakpahan Darsini, Ninik David Setyo Budi Dede Sayyidatunnisa Dewi Ratna Sari Dharmawan, Mochamad Rangga Alif Edhi Rianto Eka Sri Handayani Elvaretta, Clarissa Ely Rahmatika Nugrahani Ely Rahmatika Nugrahani, Ely Rahmatika Faizah, Zakiyatul Fajar Syamsudin Fathimatuzzahroh Fepiosardi, Raihenette Amirasanti Fis Citra Ariyanto Fithriyah Cholifatul Ummah Fithriyah, Nathania Elma Ginanjar Sasmito Adi Hamzah, Arshq Mirza Harianto Notopuro Hendri Susilo HERAWATI, LILIK Humairah, Ira Imanta Alifia Oktavira Indri Safitri Indri Safitri Mukono, Indri Safitri Indri Safitri, Indri Jofan Viradella Kadek Rachmawati Khaerunnisa, Siti Kusuma Eko Purwantari Laurentius Andre Lucky Prasetiowati Lukitasari, Lina Maftuchah Maftuchah Maria Inge Lusida Maridsky, Aldilla Afifie Putri MOCHAMAD AMIN Mochamad Amin Mochamad Yusuf Alsagaff Mochammad Thaha MOCHAMMAD THAHA Muhammad Hidayat Muhammad Hidayat Novita Nur Ramadhani Nugrahani, Annisa Salsabilla Dwi NURUL AZIZAH Nyilo Purnami Palupi, Dian Eka Roro Parmanto, Christian Melka Patmawati Patmawati Poernomo Boedi Setiawan Poernomoboedi Setiawan Prabowo, Gwenny Ichsan Pradana, Munawer Pranawa Pranawa Priyo Budi Purwono Qurnianingsih, Ema Rahmadhani, Khafiyah Hikmah Rahmawati, Lita Diah Retno Asih Setyoningrum Retno Handajan Retno Handajani Rimbun, Rimbun Riwu, Katty Hendriana Priscilia Rochmanti, Maftuchah Rochmanti Ruslan, S. Eriaty N. Rusyda, Aqila sabila Salma, Zaskia Nafisa Setyawati, Dewi Siti Khaerunnisa SOETJIPTO SOETJIPTO . Soetjipto Soetjipto St. Khaerunnisa Sudibyo, Devi Ariani Suryantoro, Satriyo Dwi Susanti, Luthfiana Rofhani Susi Wahyuning Asih Susi Wahyuning Asih, Susi Wahyuning Susilo, Hendri Suwandito Suwandito Suwandito, Suwandito Syafa'ah, Irmi Syafa’ah, Irmi Tandecxi, Gabriel Tri Hartini Yuliawati Trisilya Mita Anggrek Ulfa Kholili Ummah, Fithriyah Cholifatul Ummah, Fithriyah Cholifatul Ummah Ummi Maimunah Waskito, Langgeng Agung Welliam, Yongki Yasan, Yanna Debby Restifanny Yongki Welliam Zuhrotul Eka Yulis Anggraeni Zulka, Ayesie Natasha