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All Journal The Journal of The Indonesian Medical Students´ Association Jurnal Berkala Epidemiologi Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Halaman Olahraga Nusantara : Jurnal Ilmu Keolahragaan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Heart Science Journal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Indonesian Andrology and Biomedical Journal Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Sewagati Buletin Pengabdian Folia Medica Indonesiana Buletin Pengabdian
Wungu, Citrawati Dyah Kencono
Department Of Physiology And Medical Biochemistry, Faculty Of Medicine, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Beyond solely estrogen: Sex-based differences in platelet biology and antithrombotic response Salma, Zaskia Nafisa; Susilo, Hendri; Wungu, Citrawati Dyah Kencono; Tandecxi, Gabriel; Nugrahani, Annisa Salsabilla Dwi
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.6

Abstract

Despite increased awareness of sex differences in cardiovascular disease (CVD), disparities in sex-specific platelet biology and antithrombotic studies are still underexplored. Moreover, women are frequently underrepresented in clinical trials, with numerous research initiatives primarily focusing on estrogen while neglecting non-hormonal influences that contribute variations in thrombotic risk and treatment outcomes. We conducted a literature review to examine sex-related differences in platelet biology, such as elevated platelet counts and reactivity in females, along with distinct expression of receptors and signaling molecules. These variations influence responses to antiplatelet medications—including aspirin, P2Y12 inhibitors, and glycoprotein IIb/IIIa inhibitors, and dual antiplatelet therapy—leading to altered effectiveness and a heightened bleeding risk in women. This review emphasizes the importance of non-hormonal factors, such as transcriptomic and proteomic variations, and highlights the growing potential of omics and systems biology in identifying therapeutic targets specific to sex. Incorporating sex as a biological factor in preclinical and clinical research is crucial for enhancing risk assessment and treatment results.
Distribution of Hepatitis B Virus Genotypes Among Patients at Internal Medicine Unit, Dr. Soetomo General Hospital, Surabaya Citrawati Dyah Kencono Wungu; Mochamad Amin; Ulfa Kholili; Gwenny Ichsan Prabowo; Poernomo Boedi Setiawan; Soetjipto Soetjipto; Retno Handajani
WMJ (Warmadewa Medical Journal) Vol 4 No 1 (2019): May 2019
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.4.1.1032.6-13

Abstract

Background: Hepatitis B virus (HBV) infection is a major health problem worldwide, especially in developing countries. The study of HBV genotypes is important to find out the diversity of HBV genotypes related to the severity of the disease, response to therapy, and clinical symptoms. Objective: This study was aimed to detect HBV genotypes in patients at Hepatology Outpatient Clinic, Dr. Soetomo Hospital Surabaya. Methods: This study was conducted on new patients at Hepatology Outpatient Clinic of Dr. Soetomo General Hospital, Surabaya in one month. Nested PCR was performed by targetting HBV surface genes. Samples with positive HBV DNA were sequenced and analysed further. Results: In this study, a total of 27 samples were obtained. The prevalence of HBV infection shown by positive HBsAg in patients with symptoms of liver disease was 55.55% (15/27 patients). Based on the results of electrophoresis from PCR products, positive HBV DNA was obtained in these 15 patients (100%). After sequencing samples with positive HBV DNA, genotype B of Indonesian strain was found to be predominant genotype (100%). Subgenotype analysis showed that 7/15 samples had B3 subgenotype (46.67%). Conclusion: In patients at Hepatology Outpatient Clinic of Dr. Soetomo General Hospital, Surabaya, the prevalence of HBV infection was high (55.55%) and genotype B was predominant. In Surabaya, HBV genotype infection still remained like the previous pattern, although in Indonesia there have been many inter-island and ethnic migration. Further similar studies are needed to obtain the diversity of other HBV genotypes.
Improving Posyandu Cadres knowledge through stunting education and training on sea fish–based MPASI and PMT preparation in Darungan Village Ira Humairah; Patmawati Patmawati; Ema Qurnianingsih; Lina Lukitasari; St. Khaerunnisa; Fithriyah Cholifatul Ummah; Langgeng Agung Waskito; Citrawati Dyah Kencono Wungu; Imanta Alifia Oktavira; Novita Nur Ramadhani; Dede Sayyidatunnisa; Muhammad Hidayat; Gwenny Ichsan Prabowo
Buletin Pengabdian Bulletin of Community Services Vol. 6 No. 1 (2026): Bull. Community. Serv.
Publisher : LPPM Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/bulpen.v6i1.2

Abstract

Background and Aim: Stunting remains a major public health problem that affects child growth and development. Community-based nutritional interventions utilizing local food resources are important strategies to support stunting prevention. This community service activity aimed to improve the knowledge and skills of Posyandu cadres regarding stunting prevention through education and training on the preparation of sea fish–based MPASI and PMT in Darungan Village. Methods: The program was conducted using educational counseling, practical training, and mentoring activities for Posyandu cadres. Participants received materials on stunting prevention, balanced nutrition, and practical demonstrations of preparing sea fish–based MPASI and PMT. Knowledge improvement was evaluated using pre-test and post-test assessments. Results: The results showed a significant increase in participants’ knowledge regarding stunting prevention and balanced nutrition, with a p-value of 0.025 (p < 0.05). In addition, participants demonstrated improved practical skills in preparing nutritious sea fish–based complementary and supplementary foods for children. Conclusion: Education and training using locally available sea fish as nutritional resources effectively improved Posyandu cadres’ knowledge and practical skills in stunting prevention. This program has the potential to support sustainable community-based nutrition interventions and contribute to achieving Sustainable Development Goal (SDG) 3, namely Good Health and Well-being.
Co-Authors . Kholik Achmad Firdaus Pamudya Wardhana Adi, Ginanjar Sasmito Amanda, Bella Amin, Indah Binti Mohd Amin, Mochammad Anggraeni, Zuhrotul Eka Yulis Arifa Mustika Awalia Ayesie Natasha Zulka Bakhtiar, Arief Bayu Satria Wiratama Berliana Hamidah Budi Susetyo Pikir Cennikon Pakpahan Darsini, Ninik David Setyo Budi Dede Sayyidatunnisa Dewi Ratna Sari Dharmawan, Mochamad Rangga Alif Edhi Rianto Eka Sri Handayani Elvaretta, Clarissa Ely Rahmatika Nugrahani Ely Rahmatika Nugrahani, Ely Rahmatika Faizah, Zakiyatul Fajar Syamsudin Fathimatuzzahroh Fepiosardi, Raihenette Amirasanti Fis Citra Ariyanto Fithriyah Cholifatul Ummah Fithriyah, Nathania Elma Ginanjar Sasmito Adi Hamzah, Arshq Mirza Harianto Notopuro Hendri Susilo HERAWATI, LILIK Humairah, Ira Imanta Alifia Oktavira Indri Safitri Indri Safitri Mukono, Indri Safitri Indri Safitri, Indri Jofan Viradella Kadek Rachmawati Khaerunnisa, Siti Kusuma Eko Purwantari Laurentius Andre Lucky Prasetiowati Lukitasari, Lina Maftuchah Maftuchah Maria Inge Lusida Maridsky, Aldilla Afifie Putri MOCHAMAD AMIN Mochamad Amin Mochamad Yusuf Alsagaff Mochammad Thaha MOCHAMMAD THAHA Muhammad Hidayat Muhammad Hidayat Novita Nur Ramadhani Nugrahani, Annisa Salsabilla Dwi NURUL AZIZAH Nyilo Purnami Palupi, Dian Eka Roro Parmanto, Christian Melka Patmawati Patmawati Poernomo Boedi Setiawan Poernomoboedi Setiawan Prabowo, Gwenny Ichsan Pradana, Munawer Pranawa Pranawa Priyo Budi Purwono Qurnianingsih, Ema Rahmadhani, Khafiyah Hikmah Rahmawati, Lita Diah Retno Asih Setyoningrum Retno Handajan Retno Handajani Rimbun, Rimbun Riwu, Katty Hendriana Priscilia Rochmanti, Maftuchah Rochmanti Ruslan, S. Eriaty N. Rusyda, Aqila sabila Salma, Zaskia Nafisa Setyawati, Dewi Siti Khaerunnisa SOETJIPTO SOETJIPTO . Soetjipto Soetjipto St. Khaerunnisa Sudibyo, Devi Ariani Suryantoro, Satriyo Dwi Susanti, Luthfiana Rofhani Susi Wahyuning Asih Susi Wahyuning Asih, Susi Wahyuning Susilo, Hendri Suwandito Suwandito Suwandito, Suwandito Syafa'ah, Irmi Syafa’ah, Irmi Tandecxi, Gabriel Tri Hartini Yuliawati Trisilya Mita Anggrek Ulfa Kholili Ummah, Fithriyah Cholifatul Ummah, Fithriyah Cholifatul Ummah Ummi Maimunah Waskito, Langgeng Agung Welliam, Yongki Yasan, Yanna Debby Restifanny Yongki Welliam Zuhrotul Eka Yulis Anggraeni Zulka, Ayesie Natasha