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All Journal JURNAL FARMASIMED (JFM) Contagion: Scientific Periodical Journal of Public Health and Coastal Health Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Pharmaceutical and Clinical Research Journal of Functional Food and Nutraceutical Jurnal Penelitian Farmasi dan Herbal Journal of Pharmaceutical and Health Research Journal of Multidisciplinary Applied Natural Science Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal Journal of Pharmaceutical and Sciences. Journal of Innovative and Creativity Jurnal Bakti Nusantara
Vera Estefania Kaban
Program Studi Farmasi, Sekolah Tinggi Ilmu Kesehatan (STIKes) Senior Medan
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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Antihyperuricemia Effectiveness Test of Ethanol Extract of Kedondong Pagar Leaves (Lannea coromandelica (Houtt.) Merr.) Against Male White Rats (Ratus norvegicus) Nasution, Irma Suryani; Siregar, Anggie Patrisia; Br Ginting, Astriani Natalia; Kaban, Vera Estefania; Siagian, Roy Indrianto Bangar
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 03 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i03.137

Abstract

Hyperuricemia is a metabolic disorder caused by elevated serum uric acid levels that may progress to gout and other complications. Although synthetic drugs such as allopurinol are effective, their long-term use may cause adverse effects, thus alternative therapies derived from natural products are needed. This study aimed to evaluate the antihyperuricemic activity of the ethanol extract of kedondong pagar leaves (Lannea coromandelica (Houtt.) Merr.) in male white rats (Rattus norvegicus). An in vivo experimental study was conducted using potassium oxonate–induced hyperuricemic rats. The animals were divided into five groups: negative control (0.5% CMC), positive control (allopurinol 10 mg/kgBW), and three treatment groups receiving the ethanol extract at doses of 100, 200, and 300 mg/kgBW. Serum uric acid levels were measured before induction, after induction, and hourly up to six hours following treatment. Phytochemical screening revealed the presence of flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides in the extract. The results demonstrated that the ethanol extract of Lannea coromandelica leaves significantly reduced serum uric acid levels in a dose-dependent manner, with the 300 mg/kgBW dose showing the greatest effect and approaching the efficacy of allopurinol. In conclusion, the ethanol extract of kedondong pagar leaves has potential as a natural antihyperuricemic agent.
Sosialisasi Penggunaan Obat dengan Cara Khusus di Kecamatan Percut Sei Tuan, Deli Serdang, Sumatera Utara Rani, Zulmai; Dalimunthe, Gabena Indrayani; Nasution, Haris Munandar; Yuniarti, Rafita; Lubis, Minda Sari; Pulungan, Ainil Fithri; Kaban, Vera Estefania; Nasri, Nasri; Utami, Dinda Sari
Jurnal Bakti Nusantara Vol. 3 No. 1 (2025): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jutira.v3i1.107

Abstract

Seiring dengan kemajuan teknologi, semakin banyak sediaan farmasi yang dikembangkan. Ini termasuk inhaler, pen insulin, suppositoria, obat mata, telinga, dan lain-lain.  Tetes mata (oculoguttae), salep mata (oculenta), pencuci mata (colyria), dan bentuk lain dari obat mata dikenal sebagai optalmika. Penggunaan obat dengan alat khusus ini dapat menimbulkan efek samping dan hal yang tidak diiinginkan jika tidak digunakan secara benar. Hal ini disebabkan kurangnya informasi tentang penggunaan obat, cara penyimpanan dan lama penyimpanan obat pada masyarakat di Desa Kolam. Penyuluhan mengenai penggunaan obat dengan alat khusus ini untuk mencegah terjadinya efek samping atau hal yang tidak diinginkan. Kegiatan pengabdian dilakukan di Dusun I Desa Kolam, masyarakat dilibatkan dalam kegiatan yang dibantu oleh Kader Posyandu Kamboja dan pihak terkait lainnya.  Penyuluhan ini menggunakan ceramah, diskusi, dan pemutaran video. Selain itu, untuk mengetahui seberapa puas masyarakat dengan materi yang disampaikan, dan kuesioner. Pengabdian masyarakat yang dilakukan tim diharapkan dapat memberikan pemahaman yang baik kepada masyarakat, serta cara penggunaan obat dengan alat khusus secara tepat dan benar. Informasi akan pentingnya penggunaan obat, cara penyimpanan obat dan lama penyimpanan obat setelah kemasan dibuka. Hal ini akan berhubungan dengan efek terapi yang diharapkan serta untuk mencegah terjadinya efek samping obat.
ANTIOXIDANT ACTIVITY OF HYDROALCOHOLIC EXTRACT OF GREEN GEDI LEAVES (Abelmoschus manihot L.) USING CUPRAC (CUPRIC ION REDUCING ANTIOXIDANT CAPACITY) METHOD Kaban, Vera Estefania; Nasri, Nasri; Suci, Nurul; Lubis, Muhammad Fauzan; Rani, Zulmai; Nasution, Haris Munandar
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 02 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i02.20644

Abstract

Free radicals induce oxidative stress, which plays a pivotal role in the pathogenesis of various degenerative diseases. Abelmoschus manihot L., locally known as green gedi, is recognized for its rich secondary metabolite content with potential antioxidant properties. This study aimed to evaluate the antioxidant activity of the hydroalcoholic extract of green gedi leaves using the Cupric Ion Reducing Antioxidant Capacity (CUPRAC) method. Extraction was conducted via maceration using a 90% hydroalcoholic solvent, followed by comprehensive phytochemical screening and simplicia characterization. The antioxidant capacity was quantified by determining the IC50 value through linear regression analysis of inhibition percentage versus concentration. Phytochemical analysis confirmed the presence of alkaloids, flavonoids, glycosides, saponins, tannins, and triterpenoids/steroids. The hydroalcoholic extract exhibited "very strong" antioxidant activity, yielding an IC50 value of 41.65 ± 0.30 µg/mL. Although this potency was slightly lower than the pure quercetin standard, it demonstrates a significant capacity for free radical neutralization. These findings underscore the potential of Abelmoschus manihot L. as a robust natural antioxidant source, supporting its further development into phytopharmaceuticals or functional health supplements for the prevention of oxidative stress-related conditions.
Co-Authors Ahasyweroz T , Otniel Agung Aprilia, Hijjatun Bangar, Roy Indrianto Barus, Bunga Rimta Br Ginting, Astriani Natalia Br Sembiring, Novitaria Chiuman, Linda Chyntia Glori Tania Chyntia Glori Tania Denny Satria Dian Ika Perbina Meliala Dinda Sari Utami Ferendina, Imelda Firdaus Fahdi Fithri Pulungan, Ainil Friska Raulina Situmorang Gabena Indrayani Dalimunthe Ginting, Astriani Natalia Br Ginting, Chrismis Novalinda Ginting, Junius Gian Harahap, Daimah Wirdatus Sanaun Haris Munandar Nasution Hariyadi Dharmawan Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Henni Cintya Herviani Sari Iksen, Iksen Jansen Silalahi Jessi Octavia Aritonang Karo Sekali, Elva Swandi Kasta Gurning Khairunnisa, Lia Lubis, Minda Sari lubis, muhammad fauzan Lumban Gaol, Irma Yohana Mahatir Muhammad Muhammad Fauzan Lubis Muhammad Fauzan Lubis Nasri N Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri, Nasri Nasution, Irma Suryani Ningsih, Wulan Seppia Raissa Fitri Razoki, Razoki Ridwanto Ridwanto Sagala, Hasel Untung Bersinar Siagian, Roy Indrianto Bangar Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Anggie Patrisia Siregar, Nurhakiki Suci, Nurul Syahputra, Hariyadi Dharmawan Tania, Chyntia Glori Wahyudi Wahyudi Waruwu, Loice Desy Krisna Yanti Wijaya, Johanna Fransiska Yulia Citra Hasibuan Yuniarti, Rafita Yusmarlisa, Siti Ziza Putri Aisyia Fauzi Zulmai Rani