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All Journal JURNAL FARMASIMED (JFM) Contagion: Scientific Periodical Journal of Public Health and Coastal Health Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Pharmaceutical and Clinical Research Journal of Functional Food and Nutraceutical Jurnal Penelitian Farmasi dan Herbal Journal of Pharmaceutical and Health Research Indonesian Journal of Applied Research (IJAR) Jurnal Buana Farma Journal of Multidisciplinary Applied Natural Science Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Journal of Community Health Provision Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal Journal of Pharmaceutical and Sciences. Jurnal Bakti Nusantara
Vera Estefania Kaban
Program Studi Farmasi, Sekolah Tinggi Ilmu Kesehatan (STIKes) Senior Medan
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Transportation Veterinary Other

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Sosialisasi Penggunaan Obat dengan Cara Khusus di Kecamatan Percut Sei Tuan, Deli Serdang, Sumatera Utara Rani, Zulmai; Dalimunthe, Gabena Indrayani; Nasution, Haris Munandar; Yuniarti, Rafita; Lubis, Minda Sari; Pulungan, Ainil Fithri; Kaban, Vera Estefania; Nasri, Nasri; Utami, Dinda Sari
Jurnal Bakti Nusantara Vol. 3 No. 1 (2025): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jutira.v3i1.107

Abstract

Seiring dengan kemajuan teknologi, semakin banyak sediaan farmasi yang dikembangkan. Ini termasuk inhaler, pen insulin, suppositoria, obat mata, telinga, dan lain-lain.  Tetes mata (oculoguttae), salep mata (oculenta), pencuci mata (colyria), dan bentuk lain dari obat mata dikenal sebagai optalmika. Penggunaan obat dengan alat khusus ini dapat menimbulkan efek samping dan hal yang tidak diiinginkan jika tidak digunakan secara benar. Hal ini disebabkan kurangnya informasi tentang penggunaan obat, cara penyimpanan dan lama penyimpanan obat pada masyarakat di Desa Kolam. Penyuluhan mengenai penggunaan obat dengan alat khusus ini untuk mencegah terjadinya efek samping atau hal yang tidak diinginkan. Kegiatan pengabdian dilakukan di Dusun I Desa Kolam, masyarakat dilibatkan dalam kegiatan yang dibantu oleh Kader Posyandu Kamboja dan pihak terkait lainnya.  Penyuluhan ini menggunakan ceramah, diskusi, dan pemutaran video. Selain itu, untuk mengetahui seberapa puas masyarakat dengan materi yang disampaikan, dan kuesioner. Pengabdian masyarakat yang dilakukan tim diharapkan dapat memberikan pemahaman yang baik kepada masyarakat, serta cara penggunaan obat dengan alat khusus secara tepat dan benar. Informasi akan pentingnya penggunaan obat, cara penyimpanan obat dan lama penyimpanan obat setelah kemasan dibuka. Hal ini akan berhubungan dengan efek terapi yang diharapkan serta untuk mencegah terjadinya efek samping obat.
ANTIOXIDANT ACTIVITY OF HYDROALCOHOLIC EXTRACT OF GREEN GEDI LEAVES (Abelmoschus manihot L.) USING CUPRAC (CUPRIC ION REDUCING ANTIOXIDANT CAPACITY) METHOD Kaban, Vera Estefania; Nasri, Nasri; Suci, Nurul; Lubis, Muhammad Fauzan; Rani, Zulmai; Nasution, Haris Munandar
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 02 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i02.20644

Abstract

Free radicals induce oxidative stress, which plays a pivotal role in the pathogenesis of various degenerative diseases. Abelmoschus manihot L., locally known as green gedi, is recognized for its rich secondary metabolite content with potential antioxidant properties. This study aimed to evaluate the antioxidant activity of the hydroalcoholic extract of green gedi leaves using the Cupric Ion Reducing Antioxidant Capacity (CUPRAC) method. Extraction was conducted via maceration using a 90% hydroalcoholic solvent, followed by comprehensive phytochemical screening and simplicia characterization. The antioxidant capacity was quantified by determining the IC50 value through linear regression analysis of inhibition percentage versus concentration. Phytochemical analysis confirmed the presence of alkaloids, flavonoids, glycosides, saponins, tannins, and triterpenoids/steroids. The hydroalcoholic extract exhibited "very strong" antioxidant activity, yielding an IC50 value of 41.65 ± 0.30 µg/mL. Although this potency was slightly lower than the pure quercetin standard, it demonstrates a significant capacity for free radical neutralization. These findings underscore the potential of Abelmoschus manihot L. as a robust natural antioxidant source, supporting its further development into phytopharmaceuticals or functional health supplements for the prevention of oxidative stress-related conditions.
Optimizing Carrageenan-Based Moisturizers: From Kappaphycus alvarezii Extraction to Formulation Suci, Nurul; Rahmi, Alfia; Nasri, Nasri; Kaban, Vera Estefania
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 02 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i02.18124

Abstract

Carrageenan, a sulfated polysaccharide extracted from red seaweed (Kappaphycus alvarezii), possesses a high water-holding capacity and has been widely investigated for its potential application as a skin moisturizing agent. This study aimed to formulate isolated carrageenan into a topical cream and to evaluate its physicochemical characteristics and moisturizing efficacy. Carrageenan was isolated through sequential soaking, decantation, extraction, isolation, drying, and milling processes. The isolated material was characterized in terms of solubility, viscosity, loss on drying, and Fourier transform infrared (FTIR) spectroscopy. Cream formulations containing carrageenan at concentrations of 2.5%, 5%, 7.5%, and 10% (w/w) were prepared and compared with a 2% glycerin cream and a blank control. Physical quality evaluations included homogeneity, pH, emulsion type, stability testing for 12 weeks, skin irritation assessment, and in vivo moisturizing activity in 18 human volunteers. The isolated carrageenan complied with the requirements of USP XXX. All carrageenan-based creams exhibited acceptable homogeneity, skin-compatible pH, and satisfactory physical stability throughout the storage period. No signs of skin irritation were observed. Moisturizing efficacy increased proportionally with carrageenan concentration, with the 2.5% carrageenan cream demonstrating a moisturizing effect comparable to that of the 2% glycerin formulation. These findings support the potential of carrageenan derived from Kappaphycus alvarezii as an effective natural moisturizing agent in topical cream formulations.
FORMULASI DAN EVALUASI SEDIAAN LIPSTIK MENGGUNAKAN PEWARNA ALAMI DARI EKSTRAK ETANOL BUAH BIT (Beta vulgaris L.) Artanti, Elsan Fitri; Ginting, Astriani Natalia Br.; Kaban, Vera Estefania
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1665

Abstract

Lip color is a cosmetic preparation used to color the lips with an artistic touch, thereby enhancing facial aesthetics in makeup application. Long-term use of lipstick containing synthetic dyes such as Rhodamine B may cause cancer and impair liver and kidney function. One plant that can serve as a natural coloring source is beetroot (Beta vulgaris L.), which contains betalain pigments classified as antioxidants. This study aimed to determine whether ethanol extract of beetroot can be formulated into a lipstick preparation as a natural colorant. This experimental research was conducted through several stages, including plant identification, collection, simplicia preparation, characterization, extraction using 70% ethanol, thin-layer chromatography (TLC) analysis, formulation, and evaluation of product quality. The evaluation included organoleptic testing, homogeneity, pH, melting point, hardness, spreadability, irritation test, hedonic test, and stability test. The TLC results showed that ethanol extract of beetroot was positive for flavonoids, alkaloids, tannins, saponins, and steroids. Lipstick formulations containing 15%, 20%, and 25% ethanol extract of beetroot were semi-solid with brown and dark brown colors, homogeneous, and had pH values within the Indonesian National Standard (SNI) range of 4.5–7.0. The melting points ranged from 50–63°C. The spreadability was glossy and evenly distributed, the hardness met SNI requirements, and the formulations did not cause irritation. Formula F3 was most preferred by the panelists, and all formulations remained stable during storage at 4°C and 40°C. In conclusion, the ethanol extract of beetroot can be formulated into a lipstick preparation as a natural colorant and demonstrates good physical quality.
Docking-Based Evaluation of LC–HRMS Metabolites from Fermented Mustard Greens on DNA Gyrase B and Xanthine Oxidase Nasri; Cintya, Henni; Silalahi, Jansen; Haro, Ginda; Suci, Nurul; Kaban, Vera Estefania
Indonesian Journal of Applied Research (IJAR) Vol. 7 No. 1 (2026): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v7i1.866

Abstract

Fermented mustard greens (Brassica juncea L. Czern.) contain bioactive metabolites formed through lactic acid bacteria–driven biotransformation, yet their molecular targets related to antibacterial and antioxidant functions remain poorly understood. This study aimed to characterize key metabolites in fermented mustard greens and evaluated their potential inhibitory activity against DNA gyrase B and Xanthine Oxidase through an integrated LC–HRMS metabolomics and molecular docking approach. Untargeted LC–HRMS profiling identified 292 metabolite features, from which five compounds—gentisic acid, trans-cinnamic acid, xanthurenic acid, indole-3-lactic acid, and indole-3-acrylic acid—were structurally confirmed via MS/MS fragmentation. These metabolites were docked against DNA gyrase B (5D7R) and Xanthine Oxidase (3NVW) to predict binding affinity and interaction mechanisms. Xanthurenic acid exhibited the strongest interaction with DNA gyrase B (–7.6 kcal/mol), forming hydrogen bonds with key catalytic residues, such as Asp81 and Ile86, which suggested ATP-competitive inhibition. Meanwhile, gentisic acid and indole-3-acrylic acid exhibited the most favorable binding to Xanthine Oxidase (–7.2 kcal/mol), characterized by π–π stacking with Phe914 and Phe1009 and hydrogen bonding to Glu802, indicating dual antioxidant and anti-hyperuricemic potential. These findings highlighted fermented mustard greens as a promising functional food source containing metabolites with predicted antibacterial and XO-inhibitory activities. Further in vitro and in vivo validation is required to confirm these computational insights.
Formulation and Activity Testing of n-Hexane Fraction of Brotowali Leaves (Tinospora crispa L.) for a Diabetic Ulcer Treatment Tania, Kelly; Sembiring, Novitaria Br; Kaban, Vera Estefania
Journal of Community Health Provision Vol. 6 No. 1 (2026): Journal of Community Health Provision
Publisher : PSPP JOURNALS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55885/jchp.v6i1.299

Abstract

Diabetes mellitus is one of many degenerative illness with topmost number of cases in the world. One of the complications often created by diabetes mellitus is diabetic ulcer, which is susceptible to bacterial infection, obe of which is Staphylococcus aureus. This research wish to formulate an n-hexane fraction cream preparation from brotowali leaves (Tinospora crispa L.) and evaluate its antibacterial activity. Brotowali leaves were ectracted using 96% ethanol and the maceration method, then fractionates using n-hekxane. Then, antibacterial tests were implemented on the n-Hexane fraction using the disc method and formulates into a cream preparation with concentrations of 12,5%, 25% and 50%. The evaluation of the preparation was implemented by testing its spreadability, pH, homogeneity and organoleptic properties. Derived from the outcome of the study, it was shown that the n-Hexane fraction and Brotowali leaf cream formulation had inhibitory activity against Staphylococcus aureus, with the largest inhibition zone at a concentration of 50%. The n-Hexane fraction Brotowali leaf cream has the potential to be developed as a topical formulation for diabetic ulcers.
Co-Authors Aprilia, Hijjatun Artanti, Elsan Fitri Bangar, Roy Indrianto Barus, Bunga Rimta Br Ginting, Astriani Natalia Br Sembiring, Novitaria Chiuman, Linda Chyntia Glori Tania Chyntia Glori Tania Cintya, Henni Denny Satria Dian Ika Perbina Meliala Dinda Sari Utami FAHDI, FIRDAUS Ferendina, Imelda Fithri Pulungan, Ainil Friska Raulina Situmorang Gabena Indrayani Dalimunthe Ginting, Astriani Natalia Br. Ginting, Chrismis Novalinda Ginting, Junius Gian Harahap, Daimah Wirdatus Sanaun Haris Munandar Nasution Hariyadi Dharmawan Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Haro, Ginda Henni Cintya Herviani Sari Iksen, Iksen Jansen Silalahi Jessi Octavia Aritonang Karo Sekali, Elva Swandi Kasta Gurning Khairunnisa, Lia Lubis, Minda Sari lubis, muhammad fauzan Lumban Gaol, Irma Yohana Mahatir Muhammad Muhammad Fauzan Lubis Muhammad Fauzan Lubis Nasri Nasri N Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri, Nasri Nasution, Irma Suryani Ningsih, Wulan Seppia Rahmi, Alfia Raissa Fitri Razoki, Razoki Ridwanto Ridwanto Sagala, Hasel Untung Bersinar Sembiring, Novitaria Br Siagian, Roy Indrianto Bangar Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Anggie Patrisia Siregar, Nurhakiki Suci, Nurul Syahputra, Hariyadi Dharmawan Tania, Chyntia Glori Tania, Kelly Wahyudi Wahyudi Waruwu, Loice Desy Krisna Yanti Wijaya, Johanna Fransiska Yulia Citra Hasibuan Yuniarti, Rafita Yusmarlisa, Siti Ziza Putri Aisyia Fauzi Zulmai Rani