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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan BALI MEDICAL JOURNAL (BMJ) Media Penelitian dan Pengembangan Kesehatan MPI (Media Pharmaceutica Indonesiana) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Jurnal Penelitian Kesehatan Suara Forikes Jurnal Wiyata : Penelitian Sains dan Kesehatan SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Serambi Engineering Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Humanism : Jurnal Pengabdian Masyarakat Berkala Ilmiah Kimia Farmasi Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Bakti Nusa Linggau Borneo Journal of Pharmacy Jurnal Pengabdian Farmasi dan Sains Jurnal Sains dan Kesehatan Jurnal Info Kesehatan
Retno Widyowati
Departemen Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
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Pembentukan pojok herbal dan produk herbal (teh dan sirup) untuk meningkatkan kualitas kesehatan masyarakat di Desa Bengkaung, Kecamatan Batulayar, NTB Aty Widyawaruyanti; Suciati Suciati; Tri Widiandani; Agriana Rosmalina Hidayati; Achmad Fuad Hafid; Djoko Agus Purwanto; Neny Purwitasari; Riesta Primaharinastiti; Sukardiman Sukardiman; Retno Widyowati; Devanus Lahardo; Hilkatul Ilmi; Maylisa Natalia Corry; Firman Wicaksana; Narendrani Sasmitaning Edhi; Muhammad Amir Hasan
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 3 (2025): May
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i3.30199

Abstract

Abstrak Desa Bengkaung adalah desa yang terletak di kecamatan Batu Layar, Lombok Barat, Nusa Tenggara Barat.  Banyak potensi pada desa Bengkaung yang masih bisa dikembangkan diantaranya adalah sumber daya alam yang berlimpah. Namun, pemanfaatan sumber daya alam ini belum maksimal, yang disebabkan oleh kurangnya pengetahuan masyarakat mengenai manfaat dan  pengolahannya. Maka dilakukan pengabdian masyarakat yang berlangsung 2 tahap yaitu seminar terkait pojok herbal dan pelatihan pembuatan teh dan sirup dengan bahan kayu manis, kunyit, temu lawak, asam jawa, kapulaga untuk sediaan sirup serta bangle pada sediaan teh herbal yang berfungsi untuk meningkatkan kesehatan masyarakat. Kegiatan tersebut dilaksanakan  pada 25 Oktober 2024 dengan mitra terdiri dari  anggota IAI  kota Mataram dan kader PKK desa Bengkaung. Adapun materi pelatihan diberikan dengan metode ceramah dan metode praktik. Evaluasi dilakukan dengan cara pemberian pre-test dan post-test, kemudian dianalisis secara kuantitatif. Berdasarkan hasil pre-test dan post-test, diperoleh nilai rata-rata sebesar 60,94 dan 79.37, yang menunjukkan adanya peningkatan pengetahuan mitra terhadap materi penyuluhan yang diberikan. Teh daun salam dan JKP-Bangle dievaluasi dengan pengukuran kadar antioksidan dengan DPPH dan FRAP assay. Hasil analisis menunjukkan bahwa kadar antioksidan the daun salam dan JKP-Bangle dengan FRAP assay memperoleh kadar tertinggi tertinggi nilai masing-masing sebesar 1359.84±13.47 mg GAE/g berat kering dan 396.73±16.79 mg GAE/g berat kering. Aktivitas antioksidan yang tinggi ini mengindikasikan potensi manfaat kesehatan dalam menangkal stres oksidatif yang berhubungan dengan penyakit neurodegeneratif, kardiovaskular, dan diabetes. Kata kunci: Desa Bengkaung; pojok herbal; tanaman obat; antioksidan. Abstract Bengkaung Village is a village located in Batu Layar sub-district, West Lombok, West Nusa Tenggara.  There is a lot of potential in Bengkaung Village that can still be developed, including abundant natural resources. However, the utilization of these natural resources has not been maximized, this is caused by a lack of public knowledge regarding their benefits and processing. So community service was carried out which took place in 2 stages, namely seminars related to the herbal corner and training in making tea and syrup using cinnamon, turmeric, ginger, tamarind, cardamom for syrup and bangle preparations, as well as bangles for herbal tea preparations which function to improve health. public. This activity was carried out on 24-26 October 2024 with partners consisting of IAI members from Mataram city and PKK cadres from Bengkaung village. The training material is provided using the lecture method and the Experimental Learning method (direct implementation learning). Evaluation is carried out by giving a pre-test and post-test, then analyzed quantitatively. Based on the results of the pre-test and post-test, an average score of 60.94 and 79.37 was obtained, which indicates an increase in partners' knowledge of the extension material providedrn how to make innovative products from mangosteen fruit so that they can be produced commercially. Thus, in the long term it is expected to increase the income of the Songgon Village residents. Antioxidant levels of bay leaf tea and JKP-Bangle were evaluated using DPPH and FRAP assays. Analysis results showed that the highest antioxidant levels measured by the FRAP assay were 1359.84±13.47 mg GAE/g dry weight for bay leaf tea and 396.73±16.79 mg GAE/g dry weight for JKP-Bangle. This high antioxidant activity indicates potential health benefits in combating oxidative stress associated with neurodegenerative, cardiovascular, and diabetes-related diseases. Keywords: Songgon Village; herbal corner; medicinal plants; antioxidants.
Pelatihan Peningkatan Kualitas Produk Ramuan Tradisional Kabupaten Bangli, Bali: Training for Improving the Quality of Traditional Herbal Products in Bangli Regency, Bali Wahyuni, Tutik Sri; Widyowati, Retno; Purwitasari, Neny; Widyawaruyanti, Aty; Fuad, Achmad; Poerwono, Hadi; Isadiartuti, Dewi; Sulistyowaty, Melanny Ika; Yusuf, Helmy; Rudyanto, Marcellino; Kusumawati, Idha; Widiandani, Tri; Retnowati, Dini
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 11 No. 2 (2026): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v11i2.11081

Abstract

Bali is renowned as a tourist island rich in local wisdom, one of which is the traditional herbal remedy loloh cemcem from Penglipuran Village, Bangli Regency. This herbal drink has long been used to maintain health and alleviate internal heat. However, the loloh cemcem products produced by the local community still fall short of the standards for quality traditional medicine preparations, particularly in terms of product quality, packaging, and labeling. Through a community service initiative, activities such as observation, education, training, and mentoring were conducted for local entrepreneurs, focusing on proper selection of raw materials, hygienic production processes, safe packaging practices, accurate labeling of composition, and the implementation of Standard Operating Procedures (SOPs). The training, attended by more than 20 participants from MSMEs and youth organizations (karang taruna), aimed to enhance public understanding of the benefits and importance of high-quality herbal products. It is hoped that loloh cemcem can evolve into a safe, high-quality, efficacious, and competitive traditional beverage. Furthermore, product innovation may serve as an alternative strategy for developing loloh cemcem preparations and expanding their recognition among the wider public.
Phytochemical Compounds of Ethanol Extract Kigelia africana (Lam.) Benth. from Pericarpium, Fructus, and Semen using LCMS/MS and in Silico Study (Potential of Phosphodiesterase-5 Inhibitor) Rizka Putra Samudra; Sukardiman Sukardiman; Retno Widyowati
JURNAL INFO KESEHATAN Vol 23 No 4 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss4.2261

Abstract

Erectile dysfunction can be treated by pharmacological therapy with phosphodiesterase-5 inhibitors (PDE5-I). One plant that has a function as a phosphodiesterase-5 inhibitor is Kigelia africana (Lam.) Benth. Research on Kigelia africana (Lam.) Benth. An extract as a Phosphodiesterase type 5 (PDE 5) inhibitor is still lacking. This research aims to determine the phytochemical compounds in the 70% ethanol extract of the pericarpium, fructus and semen of Kigelia africana (Lam.) Benth. with LC-MS/MS and to determine the ligand-protein interaction through in-silico studies. In previous studies, no one compared each part of the Kigelia africana (Lam.) Benth. as an aphrodisiac. The results of the identification of the 70% ethanol extract of Kigelia africana (Lam.) Benth. found several alkaloids, flavonoids, iridoids, phenolics, polyphenols, coumarins, steroids and fatty acids. Based on the results of molecular docking on 70% ethanol extract of pericarpium, fructus and semen of Kigelia africana (Lam.) Benth., 18 compounds, 20 compounds and 18 compounds were obtained sequentially, which were analyzed using LC-MS/MS. The sitosterol compound with (∆G = -8.90 kcal/mol) was identified in the three parts of the 70% ethanol extract sample of kunto bimo fruit, which showed the highest affinity for binding to the target protein compared to sildenafil with (∆G = -8.68 kcal/mol). Sitosterol compound has the same amino acid residues as the native ligand, namely ILE A:824, TYR A:664, ALA A:779, ILE A:768, ALA A:767, LEU A:765, ASN A:661, HIS A:613, PHE A:786, VAL A:782, LEU A:804, MET A:816, PHE A:820 in hydrophobic bonds. Phytochemical compounds from Kigelia africana (Lam.) Benth. It has the potential as an alternative additional therapy and a promising source for the discovery of new drugs as aphrodisiacs targeting PDE5.
Optimization of Self-Nanoemulsifying Drug Delivery System Combining Red Ginger and Aromatic Ginger Extracts to Improve Solubilization and Stability Linda Hindiana; Retno Widyowati; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.355-363

Abstract

Background: Red ginger (Zingiber officinale var. rubrum) and aromatic ginger (Kaempferia galanga L.) are traditional Indonesian medicinal plants with proven pharmacological activity, but their poor aqueous solubility requires formulation strategies to enhance solubilization and physical stability. Objective: This study aimed to optimize and evaluate a Self-Nanoemulsifying Drug Delivery System (SNEDDS) combining red ginger and aromatic ginger. Methods: The optimization was conducted by varying the oil-to-Smix ratio and extract concentration, while the internal Smix composition (Tween 80: PEG 400 = 1:2.8 w/w) remained constant to isolate the effect of oil–surfactant proportion. Virgin coconut oil (VCO), Tween 80, and PEG 400 were used as the oil phase, surfactant, and co-surfactant, respectively. Three formulas were prepared based on oil-to-Smix (w/w): Formula A (1:4.68, 500 mg extract), Formula B (1:10.6, 500 mg extract), and Formula C (1:10.6, 460 mg extract). Physical characterization included visual observation, centrifugation, particle size, polydispersity index (PDI), and transmittance before and after thermodynamic stability tests. Results: Formula A was unstable and exhibited precipitation. Before stability testing, Formula C showed improved dispersion, with a 41.5% reduction in droplet size and a 79.9% decrease in PDI relative to Formula B. After stability testing, Formula C demonstrated markedly better performance, including an 85.5% smaller droplet size, 81.4% lower PDI, and a 2.4% increase in transmittance compared with Formula B. These quantitative improvements indicated that Formula C exhibited more optimal solubilization capacity and physical stability. Conclusion: This study concludes that extract concentration and the oil-to-Smix ratio significantly influence SNEDDS characteristics, and Formula C represents the most favorable formulation for further development.
Co-Authors -, Rakhmawati - Abdul Rahem ACHMAD FUAD Achmad Fuad Hafid Akbar, Achmad Naufal Maulana Aly, M. Ainun Najib Amalia, Savira Rizky Meisya Andang Miatmoko Anggara Satria Putra, Anggara Satria Ario Imandiri, Ario Arum Widiyaningsih Aty Widyawaruyanti Bambang Prajogo Eko Wardojo Bobsaid, Jihan Burhan Ma'arif Devanus lahardo Devitri, Nabilah Apsari Dewi Isadiartuti Dewi Lestari Dewi Melani Hariyadi Dewi Melani Hariyati Dini Retnowati Djoko Agus Purwanto Ekapratista, Belinda Nabilah Fahmi Dimas Abdul Azis Farida Ifadotunnikmah Favian Rafif Firdaus Firdaus, Favian Rafif Firman Wicaksana Fridayanti S, Septia Indah Hadi Poerwono Haliza, Nabila Nur Handayani, Rosita Hani Plumeriastuti Haq, Nimas Rizqi Firdausy Hardiyanti, Andi Sry Hardiyanti, Merry Hening Laswati Putra Hidayati, Agriana Rosmalina Hilkatul Ilmi Idha Kusumawati Iis Wahyuningsih Imam Subadi Irawati Sholikhah Istiqamah, Farida J. A. Pangkahila Jaelani, Mochammad Iqbal Kholis Amalia Nofianti Laksmi, Farika Dyani Laksmi Linda Hindiana Luthfiatu Kanina Luthfiatu Kanina Ma'arif, Burhan Mabluhatus Solehah Mahalaksmi, Alika Sabrina Mangestuti Agil Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Marta Ika Riyana Maylisa Natalia Corry Melanny Ika Sulistyowaty Muhammad Amir Hasan Naima, Fathnin Ulya Najlaa, Fatimah Ahla Narendrani Sasmitaning Edhi Nareswari, Andwynanda Bhadra Neni Purwitasari Niluh Indrawati Noorma Rosita Novian, Farah Kusuma Wardhani Nur Irhamni Sabrina Nurina Febriyanti Ayuningtyas Pilipus Kopeuw Pradnyanantha, I Putu Bagus Pramesti, Ragil Putri Pratama, Edo Pratiwi Soesilawati Purwitasari, Neni Purwitasari, Neny Putri, Anisa Yustikka Putri, Yushalluuna Bekti Pasuka Rahman, Ave Rakhmawati - - Rania, Athaya Putri Rice Disi Oktarina Riesta Primaharinastiti Rizka Putra Samudra Rizkyah, Chaerini Sahu, Ram Kumar Salam, Anisa Rakhmania Sari, Trisiyana Sholika SETIAWAN, Catur Dian Shaffiqa, Nurul Subhan Rullyansyah Suciati - - Suciati Suciati Suciati Suciati Suciati Suciati Suciati Suciati Sudjarwo Sudjarwo Sukardiman Sukardiman Sukardiman Sukardiman Sukardiman Sulistiyono, Ilham Robbynoor Suryadi, A. Mu’thi Andy Syahrani, Achmad Syahrur Marta Dwi Susilo Taufikurrahman Taufikurrahman Taufikurrahman Tri Widiandani Tristiana Erawati Munandar Tutik Sri Wahyuni Ummah, Rokhmatul Wardhana, Brahma Wisnu Kusuma Widiyaningsih, Arum Windianto, Farhan Rizqi Wiwied Ekasari Wiwik Handayani Yakub, Nikolas Yusuf, Helmy Zulfah, Yasmin