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All Journal HAYATI Journal of Biosciences Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Medical Journal of Indonesia Indonesian Journal of Cancer Chemoprevention Mutiara Medika: Jurnal Kedokteran dan Kesehatan The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan JFIOnline Jurnal Ilmu Kefarmasian Indonesia Majalah Patologi Indonesia Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Sciences of Pharmacy Ebers Papyrus Jurnal Kedokteran Meditek
Puspita Eka Wuyung
Departemen Patologi Anatomi FKUI
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Ekspresi Ki-67 pada Karsinoma Sebasea Palpebra dengan Penye-baran Pagetoid dan Diferensiasinya Effendi, Rina; Siregar, Nurjati Chairani; Wuyung, Puspita Eka
Majalah Patologi Indonesia Vol 27 No.3, September 2018
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

Latar belakangKarsinoma sebasea palpebra termasuk dalam karsinoma adneksa mata terbanyak dan memiliki prognosis buruk. Penyebaran pagetoid pada karsinoma sebasea palpebra merupakan salah satu faktor yang mempengaruhi prognosis buruk. Dalam penelitian ini akan dianalisis hubungan ekspresi Ki-67 dengan dan tanpa penyebaran pagetoid pada karsinoma sebasea palpebra.MetodePenelitian ini menggunakan desain potong-lintang, retrospektif, konsekutif pada 20 kasus karsinoma sebasea palpebra dengan penyebaran pagetoid dan 20 kasus tanpa penyebaran pagetoid di Departemen Patologi Anatomik FKUI/RSCM periode Januari 2009 sampai September 2016. Dilakukan pulasan imunohistokimia untuk Ki-67, kemudian dihitung persentase positivitasnya dari minimal 500 sel tumor menggunakan Image J, dan dilakukan analisis statistik menggunakan uji t test independent. Selain itu juga dihubungkan antara diferensiasi histologik dengan ekspresi Ki-67 menggunakan uji statistik Anova.HasilEkspresi Ki-67 pada semua kasus mempunyai rentang antara 2,8% sampai 88%, ekspresi Ki-67 tinggi sebanyak 30 kasus (75%). Ekspresi Ki-67 pada penyebaran pagetoid lebih tinggi dibanding tanpa penyebaran pagetoid (43,83±19,8: 34,10±21,26), walaupun tidak berbeda bermakna secara statistik (p=0,136). Ekspresi Ki-67 dibandingkan pada karsinoma sebasea berdiferensiasi baik, sedang dan buruk (34,07±28,79: 41,83%±19,96: 30,50±12,31), tidak berbeda bermakna (p=0,396).KesimpulanDitemukan ekspresi tinggi Ki-67 pada karsinoma sebasea palpebra. Tidak terdapat perbedaan bermakna ekspresi Ki-67 pada karsinoma sebasea palpebra dengan penyebaran pagetoid dibandingkan tanpa penyebaran pagetoid, maupun pada berbagai derajat diferensiasi histologik.
Ekspresi Bcl-2 pada Karsinoma Urotelial Kandung Kemih dan Hubungannya dengan Berbagai Faktor Prognosis Hendy Setyo Yudhanto; Budiana Tanurahardja; Puspita Eka Wuyung
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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BackgroundUrothelial carcinoma comprises of 90% of all cases in bladder. There are two groups which are non invasivedepend on whether the tumor has reached muscularis mucosa. 5-Years survival rate depend on grading andstaging. Low malignant grade and non invasive may reach 90% survival rate, with recurrence rate 40-60%. Highmalignant grade and invasive tumor has only10-17% survival rate. Mitosis and lymphovascular invasion arerelated with recurrency. However, there are some controvesi regarding Bcl-2 expression in bladder urothelialcarcinoma. This study was aimed to evaluate different expression of Bcl-2 with 4 related factors contributed tosurvival, which are degree of malignancy, stage, mitosis, and lymphovascular invasion.MethodsA retrospective cross sectional study on urothelial carcinoma of the bladder was conducted in the Departmentof Anatomical Pathology, Faculty of Medicine, University of Indonesia/RSCM. The cases were collected fromthe year of 2010 to 2014. In this study 21 cases of low grade and 21 cases of high high grade were found. Bcl-2immunohistochemistry staining performed in all cases and percentages are calculated to make 0-3 scoring.ResultsMost case is fifth decade as many as 27 cases. Obtained 4 cases found limfovaskuler invasion. This studyobtains the relationship between mitosis with grade of tumor (p: 0.000). the result suggests that there are nodifferences between the expression of Bcl-2 with the degree of malignancy stage, mitosis and lymphovascularinvasion.
Deteksi Mikrometastasis pada Bulky Kelenjar Getah Bening Karsinoma Serviks Stadium IA-IIB Menggunakan Sitokeratin AE1/AE3 Angeline, Reni; Tjahjadi, Hartono; Wuyung, Puspita Eka
Majalah Patologi Indonesia Vol. 29 No. 3, September 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i3.441

Abstract

BackgroundCervical uterine carcinoma is a primary malignant disease of the uterine cervix. The presence or absence of metastasis in lymphnodes does not alter the stage but affects recurrence, survival, and therapy. Immunohistochemistry stains of the AE1/AE3cytokeratin can assist in the diagnosis and determine the small focus of carcinoma metastasis. In this study, we analyzedimmunohistochemistry cytokeratin AE1/AE3 could determine micrometastasis in bulky lymph nodes negative.MethodsThis study used cross-sectional design. The sample consisted of 52 cases of stage IA-IIB cervical carcinoma performed by radicalhysterectomy and lymphadenectomy accompanied by negative bulky lymph nodes at the Department of Anatomical PathologyFaculty of Medicine University of Indonesia/Cipto Mangunkusumo Hospital (FKUI/RSCM) from January 2011 to June 2017. Allcases stained by immunohistochemistry cytokeratin AE1/AE3.ResultsBulky Lymph Nodes Cervical Carcinoma stage IA-IIB, histopathologic diagnose of non keratinized squamous cell carcinoma,moderate differentiation degree, no lymphovascular invasion and deepest invasion >5.0 mm. Immunohistochemistry staining ofAE1/AE3 cytokeratin showed no micrometastasis in all cases.ConclusionThe immunohistochemistry staining of AE1/AE3 cytokeratin used in Bulky Lymph Nodes Cervical Carcinoma stage IA-IIB could notdetected micrometastasis in all cases.
Hubungan antara Ekspresi P16 dengan Respon Histologik Kemoterapi Neoadjuvan pada Osteosarkoma Konvensional Vathonati, Dian Sari Oethia; Siregar, Nurjati Chairani; Wuyung, Puspita Eka
Majalah Patologi Indonesia Vol. 30 No. 2, Mei 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i2.469

Abstract

BackgroundOsteosarcoma is the most common primary malignant bone tumor in children and young adult. Its pathogenesis has been linked toalterations in several genes. The high percentage is found involving Retinoblatoma (RB) pathway. p16 plays as a tumor suppressorin RB pathway to controll proliferation of the tumor cell. The degree of neoadjuvan chemotherapy histological necrosis response isrelated to prognosis of patients with osteosarcoma. Chemotherapy and p16 both synergic in inhibit the cell tumor proliferation andsupport apoptotic. Loss of p16 function is related to progressiveness of the tumor. The aim of this study was to investigate therelationship of p16 expression in pretreatment osteosarcoma to pathologic necrotic histological response after neoadjuvanchomotherapy.MethodsThis is a cross sectional study p16 stainning was done and count the positive expression tumor cell in percentage. Positive wasdefined as strong and medium nuclear stainning in 30% or greater. The samples is catagorized into positive and negative expressionthen it is correlated into tumor necrotic area based on grade of Huvos.ResultsSamples consist of 33 cases. Positive stainning was found in 10 cases (30.3%), 6 of 10 cases had good chemotherapy response.Negative stainning was found in 23 cases and 21 of 23 cases had poor chemotherapy response. A significant association was notedbetween p16 expression and histological necrotic response to neoadjuvan chemotherapy (p=0.004).ConclusionThe result showed that p16 expression associate significantly with histological necrotic response to neoadjuvan chemotherapy inconventional osteosarcoma (p=0.004).
Co-Authors . Sriningsih Achmad Fauzi Kamal Agung Eru Wibowo Agung Eru Wibowo Ahmad Aulia Ahmad Sulaiman Alwahdy Angeline, Reni Anton Bahtiar Aprilya, Dina Aria Kekalih Arleni Bustami Asri Pratitis Berry Juliandi Budi Wiweko Budiana Tanurahardja Canintika, Anissa Feby Cicilia Febriani Hayuningrum Cicilia Febriyani Hayuningrum Deni Rahmat DEWI IRAWATI Dewi Jantika Dewi, Yulia Ratna Dian Sari Oethia Vathonati Effendi, Rina Elisabeth Indria Sari Ening Krisnuhoni Eziefule, Oluebube Magnificient Fanny Oktorina Ferdiana, Fita Firda Asma'ul Husna Fita Ferdiana Fitri Octaviana Hartono Tjahjadi Hendy Setyo Yudhanto Hening Pujasari Heri Suroto Heri Wibowo Hoemardani, Aida S.D. Irandi Putra Pratomo Irwina Eka Deraya Isabelle Deli Lestadi Ismail Hadisoebroto Dilogo Jantika, Dewi Kurniawan, Mohammad Lestari Rahayu Liem, Isabella Kurnia Melva Louisa Mila Maidarti Minarma Siagian Nabillah, Deya Adiby Nafrialdi Nafrialdi Ni Made Dwi Sandhiutami Niniek Hardini Nurjati Chaerani Siregar Nurjati Chairani Siregar Nurjati Chairani Siregar Nurjati Chairani Siregar Oentoeng Soeradi Raafqi Ranasasmita Raafqi Ranasasmita Raden Muharam Natadisastra Radiana Dhewayani Antarianto Radietya Alvarabie Ramli, Yetty Reni Angeline Reni Oktavina Ria Kodariah Rika Sari Dewi Rina Effendi Salinah Salinah Salinah Salinah Salinah Sari, Elisabeth Indria SEPTELIA INAWATI WANANDI Shintia Christina Shintia Christina Sinuraya, Evlina Suzanna Siti Nurkasanah Sriningsih Sriningsih Sudarto Pringgoutomo Sunarmi Sunarmi Suratih, Ni Made Desy Susy Olivia Syarifah Dewi Thamrin Wikanta Tjahjadi, Hartono Vathonati, Dian Sari Oethia Vita Fitria Handayani Wahyu Pangestuti Lestari Wahyu Widodo Wawaimuli Arozal Yayi Dwina Bilianti Susanto Zakiyah Zakiyah