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All Journal International Journal of Public Health Science (IJPHS) Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Chemistry Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Gizi Kerja dan Produktivitas Jurnal Pengabdian Masyarakat (ABDIRA) Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan al Kimiya : Jurnal Ilmu Kimia dan Terapan Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Jurnal Riseta Naturafarm

Islamudin Ahmad

Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Mulawarman, Samarinda 75119, East Kalimantan, Indonesia Pharmaceutical Research And Development Laboratory Of FARMAKA TROPIS, Faculty Of Pharmacy, Universitas Mulawarman, Samarin

Author-ID : 4251452

Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Ekstraksi Polifenol Total dari Herba Suruhan (Peperomia pellucida [L.] KUNTH) Menggunakan Metode Citric Acid-Glucose Based Microwave Assisted Extraction Duwi Meiliyani; Sabaniah; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

This study aims to determine the effect of citric acid-glucose based microwave assited extraction (MAE) method on total polyphenols content from (Peperomia pellucida [L.] Kunth) herbs. Dried samples were extracted using green solvent glucose citric acid with a ratio of 1: 1 g/g, 3: 1 g/g, and 5: 1 g/g, respectively, 30% microwave power for 5 minutes, and 1:5 g /mL solid-liquid ratio. Then the obtained extract solution was performed determination total polyphenols content using Folin-Ciocalteu reagent, and the absorbance was measured using a UV-Vis spectrophotometer at 791 nm. Based on the results, obtained total polyphenols content according to the extraction condition namely 214.405 mg GAE/g sample (3: 1 g /g solvent), 84.833 mg GAE /g sample (1: 1 g /g solvent) and 53,9451 mg GAE/g sample (5: 1 g /g solvent), respectively. This study is a preliminary data about the use of citric acid-glucose based microwave assisted extraction method on total polyphenols content from this plant quickly, easily and efficiently.

Pengaruh Penggunaan Metode Lactic Acid-Sucrose dengan Microwave Assisted Extraction (MAE) terhadap Polifenol Total dari Herba Suruhan (Peperomia pellucida (L.) Kunth) Kharisma Ayu Tandi Datu; Nurul Fitriani; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

This study aim to determine the effect of use lactic acid and sucrose with assistance of Microwave Assisted Extraction (MAE) on Total Polyphenols from Herbs Suruhan (Peperomia pellucida (L.) Kunth). The dried sample of Herbs Suruhan was extracted using (green solvent) lactic acid-sucrose with a ratio of 1:1 g/g, 2:1 g/g and 3:1 g/g and the extraction conditions microwave strength was 50% for 10 minutes at a ratio sample and solvent 1:10 g/ml. Then the extract solution obtained to determine the total polyphenol level using the Folin Ciocalteu reagent and it absorbance was measured using a UV-VIS spectrophotometer at a wavelength of 791 nm. Based on the result of the study, obtained levels of polyphenols from each solvent condition used on the sample were 573,443 mg GAE/g (2:1), 472,479 mg GAE/g (1:1) and 420,14 mg GAE/g (3:1). It can be concluded that the lactic acid-sucrose method with microwave assisted extraction can be used to extract polyphenol compounds from Herbs Suruhan.

Ekstraksi Polifenol Total dari Umbi Bawang Dayak (Eleutherine bulbosa [Mill.] Urb.) menggunakan Metode Lactic Acid-Sucrose based Microwave Assisted Extraction Kurnya Kurnya; Hajrah Hajrah; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Dayak Onion (Eleutherine bulbosa [Mill.] Urb.) It is a plant that grows in Indonesia precisely in the Kalimantan area and has traditionally efficacious in curing various diseases such as diabetes mellitus, hypertension, breast cancer, cholesterol-lowering, and stroke. This study aims to determine the effect of using the lactic acid-sucrose based microwave-assisted extraction (MAE) method to extract total polyphenols from Dayak onion tubers (Eleutherine bulbosa [Mill.] Urb.). Dry samples were extracted using a lactic-sucrose acid (green solvent) solvent in the ratio of 1: 1, 2: 1, and 3: 1 g/g with 50% microwave strength for 10 minutes with a ratio of samples and solvents of 1:10 g /mL. Extracts that have been obtained then determined the total polyphenol levels using a UV-VIS spectrophotometer at a wavelength of 791 nm. Based on the results of the study, it was obtained the levels of polyphenols from each condition of the solvent used in the sample that is 28.73 mg GAE/g sample ( 1: 1 g/g solvent); 20.2 mg GAE/g sample ( 2:1 g/g solvent); 36.35 mg GAE/g sample ( 3:1 g/g solvent). From this study, it can be concluded that the MAE method can be used to extract polyphenol compounds from Dayak bulbs.

Ekstraksi Polifenol Total dari Daun Kadamba (Mitragyna speciosa Korth) Menggunakan Metode Choline Chloride-Sorbitol based Microwave Assisted Extraction Ramila Hidayati; Dewi Rahmawati; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

This research was conducted to determine the influence of the use of the choline chloride-sorbitol based microwave assisted extraction (MAE) method against the total extraction of polyphenols from the leaf Kadamba (Mitragyna speciosa Korth). Simplisia extracted using solvent (green solvent) choline chloride-sorbitol with a ratio of 1:1; 1:2 and 1:3 g/g with sample and solvent ratio of 1:10 g/mL, microwave strength is 50% watt and performed for 10 minutes, the extract solution has been obtained and then done determination of total levels of polyphenols by using folin ciocalteu reagents and further measured its absorption with the UV-VIS spectrophotometer device at a wavelength of 770 nm. Based on the results of the study, obtained the levels of polyphenols from each comparison of solvent used against the sample of 334 mg of GAE/g samples (1:1 g/g solvent); 372 mg GAE/g samples (1:2 g/g solvents) and 299 mg of GAE/g samples (1:3 g/g solvents). Based on the results of the study can be concluded that the method of choline chloride-sorbitol based microwave assisted extraction (MAE) can be used to extract the polyphenols from Kadamba leaves easily, quickly and efficiently.

Ekstraksi Polifenol Total dari Umbi Bawang Dayak (Eleutherine bulbosa [Mill.] Urb.) Menggunakan Metode Citric Acid-Glucose based Microwave Assisted Extraction Selvy Jumiatul Astati; Mirhansyah Ardana; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The use of environmentally friendly solvent-based expulsion methods today began to be widely used, one of which is a microwave-assisted extraction (MAE) using a citric acid-glucose acid solvent. The study aims to determine the influence of the use of citric acid-glucose based microwave-assisted extraction against the total extraction of polyphenols from Dayak onion bulbs (Eleutherine bulbosa [Mill.] Urb.).The dried samples were extracted using a solvent (green solvent) citric acid – glucose with a ratio of 4:1, 5:1 and 6:1 g/g with the extraction conditions in the form of microwave strength of 50% for 10 minutes with a sample and solvent ratio of 1:10 g/mL, then Extract solution obtained further determination of the total levels of polyphenols using Folin ciocalteu reagents, and its absorption was measured using a UV-vis spectrophotometer at a wavelength of 791 nm. Based on the results of the study, the total amount of polyphenols obtained from each of the solvent conditions used against the samples was 21.92 mgGAE/g samples, 13.86 mgGAE/g samples, and 14.38 mgGAE/g samples. From this study, it can be concluded that the concentration of citric acid in the microwave-based citric acid-glucose method is assisted by extraction according to the ability of the solvent in the competency of polyphenols from Dayak onion bulbs.

Ekstraksi Polifenol Total dari Daun Kadamba (Mitragyna Speciosa Korth.) Menggunakan Malic Acid-Glucose Based Microwave Assisted Extraction Andi Yusniah; Yuspian Nur; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

This study aims to determine the effect of the use of malic acid-glucose based microwave assited extraction (MAE) methods on total polyphenol extraction from kadamba leaves (Mitragyna Speciosa Korth). Samples that have been dried in the extraction using solvents (green solvent) Malic Acid-Glucose with a ratio of 1: 1 and 1: 3 g/g in several conditions including, microwave strength 50% for 10 minutes with a sample ratio and a solvent of 1:10 g/mL. Then the extract solution obtained was measured in total polyphenol levels using the folin ciocalteu (FC) reagent and the absorbance was measured at a wavelength of 791 nm using a UV-vis spectrophotometer. Based on the results of the study obtained levels of polyphenols from each condition of the solvent used is 258mg GAE/g sample (1:1 g/g solvent) and 292mg GAE /g sample (1: 3 g / g solvent). From this study it can be concluded that the method of malic acid-glucose based microwave assited extraction can be used to extract polyphenol compounds from Kadamba leaves quickly, easily and efficiently.

Penambatan Molekular Senyawa Metabolit Sekunder dari Daun Kelor sebagai Inhibitor Protease Utama dari SARS-CoV-2 Mayda Ariyati; Nur Masyithah; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) merupakan virus penyebab COVID-19. Salah satu kandidat target potensial dari SARS-CoV-2 ialah protease utama (Mpro). Penelitian ini bertujuan untuk mengetahui interaksi antara senyawa dari daun kelor dengan makromolekul Protease Utama SARS CoV-2 dan mengetahui senyawa yang berpotensi sebagai inhibitor Mpro secara in silico dengan studi penambatan molekuler. Struktur dari SARS CoV-2 sebagai molekul target diperoleh dari database PDB (ID: 5R84) 2-cyclohexyl-~{N}-pyridin-3-yl-ethanamidesebagai ligan alami. Analisis penambatan molekuler dilakukan dengan menggunakan AutoDockTools dengan jumlah runs 100 kali. Grid diletakkan pada ligan alami dengan ukuran kotak 40x30x34 dan center 9.812?x-0.257?x20.849? denganspacing 0.375?. Berdasarkan hasil docking dari 22 senyawa metabolit sekunder daun kelor diperoleh 17 senyawa yang memiliki nilai ikatan energy lebih rendah dari ligan alami. Senyawa Quercetin-3-o-glucoside memiliki nilai terendah sebesar -9.35 kkal/mol dibandingkan ligan alami yaitu sebesar -6.56 kkal/mol . Berdasarkan interaksi dari binding site M-pro SARS-CoV-2, senyawa niazimin memiliki interaksi yang mirip dengan ligan alami. Bentuk interaksi yang terjadi adalah adanya ikatan hydrogen dengan residu HIS41, MET49, MET165, CYS145, GLU166, HIS163. Hasil ini menunjukkan bahwa senyawa metabolit sekunder dari daun kelor memiliki aktivitas dalam menghambat protease utama SARS-CoV-2. Tetapi perlu dilakukan perbandingan dengan makromolekul lain.

Ekstraksi Polifenol Total dari Herba Suruhan (Pepperomia pellucida (L)Kunth.) menggunakan Malic Acid-Glucose Based Microwave Assisted Extraction Muhammad Safruddin; Nur Mita; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

This study aims to determine the effect of the use of malic acid-glucose based microwave assited extraction (MAE) methods on total polyphenol extraction from suruhan herbs (Pepperomia pellucida (L) Kunth.). Samples that have been dried in the extraction using solvents (green solvent) Malic Acid-Glucose with a ratio of 1: 2, 1:3 and 1: 4 g/g in several conditions including, microwave strength 30% for 5 minutes with a sample ratio and a solvent of 1:14 g/mL. Then the extract solution obtained was measured in total polyphenol levels using the folin ciocalteu (FC) reagent and the absorbance was measured at a wavelength of 658 nm using a UV-vis spectrophotometer. Based on the results of the study obtained levels of polyphenols from each condition of the solvent used is 85 mg GAE/g sample (1 : 2 g/g solvent), 696 mg GAE/ g sample (1:3 g / g solvent) and 317 mg GAE /g sample (1: 4 g / g solvent). From this study it can be concluded that the method of malic acid-glucose based microwave assited extraction can be used to extract polyphenol compounds from Suruhan herbs quickly, easily and efficiently.

Observasi Klinik Pemberian Jus Buah Naga Merah (Hylocereus polyrhizus) dan Jambu Biji (Psidium guajava) Terhadap Peningkatan Kadar Hemoglobin Wanita Menstruasi Suci Aprisilia Kartika; Risna Agustina; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Anemia is a condition when the blood hemoglobin level is less than normal because to iron deficiency. Red dragon fruit (Hylocereus polyrhizus) and guava (Psidium guajava) are sources of iron which can increase blood hemoglobin levels. The purpose of this study to determine the effect of dragon fruit juice and guava juice on increasing blood hemoglobin levels for menstruating women. The design of this research was Quasy Experimental Pre-Post Design which was conducted in two test groups. The first grup was given dragon fruit juice and the second group was given guava juice. Sampling was determined by purposive sampling based on inclusion and exclusion criteria. The hemoglobine level was using the Easy Touch GCHB tool and analyzed by the Paired Sample T-Test. The results showed that the effect of dragon fruit and guava juice on the hemoglobin level of menstruating women before the intervention in first group test was 11.5 g / dl, second group test was 10.5 g / dl and after the intervention the average was 13.6 g / dl and 13.5 g / dl. Based on the results of the Paired Sample T-Test statistical analysis which has a p value

Uji Toksisitas Ekstrak Berbasis Nades dari Daun Kadamba (Mitragyna Speciosa Korth) terhadap Mencit (Mus Musculus): Toxicity of Nades-Based Extract From Kadamba Leaf (Mitragyna Speciosa Korth) on Mice (Mus Musculus) Fauzan Afandi; Vita Olivia Siregar; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Traditionally, kadamba leaves have benefits for treating diarrhea, diabetes, pain, rheumatism, gout and have been scientifically proven to be antinociceptive and inhibit T47D breast cancer cells. This study aims to determine the toxicity of NADES-based extract from kadamba leaves by looking at the LD50 value and its effect on body weight and behavior of mice. The 15 mice used were divided into 5 groups with 3 mice in each group. The NADES-based extract from kadamba leaves was given orally with various doses of 4000 mg/KgBB, 8000 mg/KgBB, 16000 mg/KgBB, and 32000 mg/KgBB and one group was given a solvent. Each group was observed for 30, 60, 120, 180, and 240 minutes after administration of the extract and the observations were continued for 14 days to observe toxic symptoms, changes in body weight and death. Based on the results of the study, no deaths were found in the solvent group, 4000 mg/KgBB, and 8000 mg/KgBB. For the group with a dose of 16000 mg/KgBW, 2 mice died and the group with a dose of 32000 mg/KgBW found the death of 3 mice, so the LD50 value obtained was 14.256 g/KgBW which was included in the practically non-toxic category.

Co-Authors Abdul Mun'im Abdul Mun’im Abdul Mun’im Agus, Adhe Septa Ryant Ahmad Efendi Aji Ayatullah Alghifari, Muhammad Farhan Alyazahra, Restika Amarila Malik Andi Tenri Kawareng Andi Yusniah Angga Cipta Narsa Arifuddin, Muhammad Arsyik Ibrahim Azminah Azminah Baso Didik Hikmawan Berna Elya Bohari Yusuf Bone, Mahfuzun Dandy Zwageri Dewi Rahmawati Duwi Meiliyani Elisabeth James Randan Elly Kendali Larasati Elsa Edita Ervina Irmaya Sagita Erwin Samsul Erwin Samsul Faizatun Maulidha Fauzan Afandi Febrina, Lizma Ferry Semiawan Fika Aryati Firzan Nainu Firzan Nainu Gemini Alam Gemini Alam Hadi Kuncoro Hajrah Hajrah Hajrah Hanita Omar Hapizi, Amrullah Muhammad Helmi Heratris, Julieta Adillah Herman Herman Hifdzur Rashif Rija’i Himmatul Ulya I Putu Agus Yudiane Ibrahim, Arsyik Indriani, Gina Nabila Iswahyudi Iswahyudi Junaidin, Junaidin Karisman Karisman Kharisma Ayu Tandi Datu Kurnya Kurnya Laode Rijai Laode Rijai M Arifuddin M. Arifuddin M. Arifuddin M. Arifuddin M. Arifuddin Maghfiroh, Wasiul Mahfuzun Bone Maryono Maryono Mayda Ariyati Meilisa Athiyah Michael Rendy Yakubus Mirhansyah Ardana Mohd Azlan Nafiah, Mohd Azlan MUHAMMAD AMIR MASRUHIM Muhammad Faisal Muhammad Hanafi Muhammad Safruddin Neneng Siti Silfi Ambarwati Nia Fevniaty Rupa Ningrum, Indah Setiya Noor Linda Febrianie Novita Sari Noviyanty Indjar Gama Nur Masyitah Zamruddin Nur Masyithah Nur Mita Nurul Fauziah Nurul Fitriani Prabowo, Wisnu Cahyo Putri Diah Wulandari Putri Natasya Magdalena Ramila Hidayati Rifqi, Ahmad Nur Rija'i, Hifdzur Rashif Riki Risna Agustina Risna Agustina Risna Lestari Rolan Rusli Rusman, Arman Sabaniah Sabaniah Indjar Gama Salam, Supriatno Salsabila, Unik Hanifah Samsul, Erwin Selvi Jumiatul Astati Selvy Jumiatul Astati Siti Hasanah Suci Aprisilia Kartika Sulistiarini, Riski Suparningtyas, Juniza Firdha Susilowati, Kartika Indah Tanod, Brain Christian Severius Tanod Umi Khusnul Khotimah Vidia Prajna Lakhsita Vilca Veronica Hasiani Vita Olivia Siregar Wisnu Cahyo Prabowo Yuditya Artha Yurika Sastyarina Yurika Sastyarina Yuspian Nur Yuspian Nur

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