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All Journal Buletin Udayana Mengabdi E-Jurnal Medika Udayana WMJ (Warmadewa Medical Journal) Biology, Medicine, & Natural Product Chemistry JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Meditory : The Journal of Medical Laboratory WICAKSANA: Jurnal Lingkungan dan Pembangunan ISM (Intisari Sains Medis) : Jurnal Kedokteran Journal of Health Sciences PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Sewaka Bhakti Aesculapius Medical Journal Warmadewa Minesterium Medical Journal Indonesian Journal of Cancer Jurnal Sehat Indonesia (JUSINDO) Abdi Widya: Jurnal Pengabdian Masyarakat The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Community Services Journal (CSJ) Physical Therapy Journal of Indonesia Jambura Medical and Health Science Journal Jurnal Pelayanan Hubungan Masyarakat Jurnal Widya Medika Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Medical Community Dedication
Luh Gde Evayanti
Universitas Warmadewa
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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THE EFFECT OF FRANGIPANI FLOWER ETHANOL EXTRACT ON SUPEROXIDE DISMUTASE (SOD) LEVELS IN MALE RATS EXPOSED TO CIGARETTE SMOKE AND VAPE Austin Widyasari Wijaya Putu; Pharmawati Made; Evayanti Luh Gde; Sri Ekayanti Ni Wayan; Indah Kusumadewi Riandra Ni Putu; Hwee Ming Cheng
Meditory : The Journal of Medical Laboratory Vol. 13 No. 2 (2025): Meditory, Volume 13 No. 2 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i2.4826

Abstract

Abstract Background: Both types of cigarettes (traditional and electronic) have negative health effects, and public interest remains high. Based on several studies, antioxidants are known to counteract the effects of ROS caused by cigarettes. One of them is frangipani (Plumeria alba), which has phenols and flavonoids.Objective: To find out the antioxidant effects of frangipani flower extract on test animals exposed to cigarette and vape smoke.Methods: An experimental method with a randomized post-test control group design was used in this study. The sample consists of healthy male Wistar rats divided into five sample groups, which received intervention for a 3-week duration. Data were analyzed using one-way ANOVA followed by post hoc tests.Results: This study found that both cigarettes and vaping lowered SOD levels (P1 and P2 groups; 3.381 and 4.462 ng/mL). Meanwhile, the groups with frangipani flower extract, who were exposed to cigarettes and vaping, had a higher level of SOD (P3 and P4; 6.999 and 8.681 ng/mL).Conclusions: The administration of frangipani flower extract containing antioxidants has a positive effect on SOD levels.
Short-Chain Fatty Acids and Neurodegeneration in Alzheimer's Disease: A Narrative Review Komang Trisna Sumadewi; Dewa Ayu Agung Alit Suka Astini; Luh Gde Evayanti; Ida Ayu Laxmi Ananda Dewi Manuaba; Ni Made Gita Kusuma Dewi
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.498

Abstract

Background: Alzheimer Disease remains the most prevalent cause of dementia worldwide, representing a major and escalating global health challenge. Objective: This study aims to examine the role of short chain fatty acids in the pathogenesis and progression of Alzheimer Disease within the framework of the microbiota gut brain axis. Methods: The research employed a qualitative design with a descriptive approach through a narrative literature study. Data were collected through systematic searches of peer reviewed scientific articles published between 2015 and 2026, focusing on gut microbiota dysbiosis, short chain fatty acids, neuroinflammation, amyloid pathology, and cognitive decline in Alzheimer Disease. Document analysis was conducted using thematic identification, data reduction, conceptual categorization, and inductive interpretation to generate a comprehensive synthesis of the evidence. Results: The findings indicate that Alzheimer Disease is consistently associated with reduced abundance of short chain fatty acid producing bacteria and altered circulating and fecal short chain fatty acid profiles, which are linked to impaired blood brain barrier integrity, microglial activation, increased neuroinflammation, amyloid beta accumulation, and tau pathology. Mechanistic insights demonstrate that short chain fatty acids regulate inflammatory signaling pathways, epigenetic modulation, mitochondrial bioenergetics, and metabolic homeostasis. Conclusion: In conclusion, short chain fatty acids function as key metabolic mediators in Alzheimer Disease and represent promising targets for preventive and therapeutic strategies, contributing to a systems biology perspective and supporting microbiome based precision approaches in cognitive health management.
Pembinaan Perkembangan Batita dan Pemanfataan Tanaman Lahan Sempit pada Keluarga Binaan Come Luh Gde Evayanti; I Wayan Sudiarta; Anak Agung Ayu Asri Prima Dewi; Fransiscus Fiano Anthony Kerans; Komang Trisna Sumadewi; Dewa Ayu Agung Alit Suka Astini; Ida Kurniawati; Ni Putu Diah Witari
Abdi Widya: Jurnal Pengabdian Masyarakat Vol 5 No 1 (2026): Abdi Widya: Jurnal Pengabdian Masyarakat
Publisher : Pusat Penerbitan LP2MPP ISI Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59997/awjpm.v5i1.5535

Abstract

Periode emas dalam perkembangan otak manusia adalah 1000 hari pertama kehidupan (HAK). Perkembangan otak ini menunjangan perkembangan kognitif, motorik, dan berbahasa pada batita. Mitra pengabdian ini adalah keluarga binaan Community Oriented Medical Education (COME) 1000 HAK. Sebelumnya telah dilakukan wawancara dan pengamatan terkait perkembangan batita di keluarga tersebut. Sebanyak 10 keluarga binaan yang dilibatkan sebagai mitra. Kurangnya perhatian keluarga binaan terhadap pentingnya stimulasi perkembangan pada 1000 HAK bagi bayi akan berdampak pada penyimpangan perkembangan. Selain itu halaman rumah keluarga binaan tidak terdapat tanaman yang dapat dimanfaatkan untuk kebutuhan pangan sehari-hari. Tujuan pengabdian ini adalah meningkatkan pengetahuan keluarga binaan terkait pentingnya stimulasi perkembangan bagi batita dan pemanfaatan tanaman pekaranan rumah (lahan sempit). Metode yang digunakan adalah berdiskusi, praktek langsung, dan pemutaran video-video edukasi, serta penyediaan alat-alat stimulasi perkembangan dan hibah tanaman. Selanjutnya dilakukan follow up dan evaluasi kepada keluarga binaan. Kegiatan dilaksanakan dengan melalui kunjungan untuk melakukan survey kesehatan batita dan memberikan edukasi terkait perkembangan yang perlu dikuasai sesuai usia batita. Selanjutnya diberikan edukasi dan praktek yang melibatkan keluarga untuk memanfaatkan lahan sempit dengan menanam tanaman sayur-sayuran. Kegiatan dievaluasi menggunakan pre-test dan post-test. Berdasarkan follow up dan data analisis dari pre-test maupun post-test didapatkan peningkatan pengetahuan keluarga binaan setelah mengikuti kegiatan.
Female gender and time from injury to surgery as risk factors for decreased knee functions in ACL injury survivors Ida Kurniawati; Ni Putu Diah Witari; Anak Agung Ayu Asri Prima Dewi; Fransiscus Fiano Anthony Kerans; Komang Trisna Sumadewi; Dewa Ayu Agung Alit Suka Astini; Luh Gde Evayanti
Physical Therapy Journal of Indonesia Vol. 6 No. 1 (2025): January-June 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i1.247

Abstract

Background: Anterior cruciate ligament (ACL) injuries are serious orthopedic conditions that require long-term recovery and significant costs. This study aimed to assess the risk of decreased knee function among ACL injury survivors in the Indonesian ACL community. Methods: This study used a prospective observational cohort design with a population of all members of the Indonesian ACL community who experienced ACL injury. The primary outcome of this study was a decrease in knee function was measured using the Lysholm knee score. We calculated univariate and multivariate analyses using logistic regression for each variable. Results: The results showed that female gender and time from injury to surgery were significant factors that influenced poor knee function after ACL reconstruction. Women had a significantly higher risk (odd ratio (OR) = 15.28; adjusted OR (AOR) = 23.47; p-value < 0.010). In addition, the time between injury and surgery significantly affected postoperative knee function (AOR = 1.05; p-value = 0.049). Other factors such as age and body mass index did not show significant associations in either univariate or multivariate analyses. Conclusion: This study confirmed that female gender and time from injury to surgery were important factors influencing poor knee function after ACL reconstruction. Timely intervention and focused rehabilitation programs are key steps to improve patient functional outcomes.
Edukasi Kader Balita untuk Optimalisasi Tumbuh Kembang Anak Usia 0–5 Tahun Ni Made Gita Kusuma Dewi; Ida Ayu Laxmi Ananda Dewi Manuaba; Fransiscus Fiano Anthony Kerans; Ni Putu Diah Witari; Dewa Ayu Agung Alit Suka Astini; Luh Gde Evayanti; Komang Trisna Sumadewi
Medical Community Dedication Vol 2 No 1 (2026): Juni 2026
Publisher : Fakultas Kedokteran Universitas Islam Al-Azhar Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36679/jmcd.v2i1.15

Abstract

This community service activity aims to improve the knowledge and skills of health cadres in monitoring the growth and development of children aged 0–5 years in Banjar Mambang Gede, Mambang Village, Selemadeg Timur District, Tabanan Regency, Bali. The main problem faced by the partners is the limited understanding of cadres regarding child anatomy, cognitive development, and language stimulation through children's literature. The methods used include offline counseling with an interactive educational approach using PowerPoint presentations, anatomical videos, anatomy-based applications, and hands-on practice through storybooks, children's poetry, and educational games. The activity begins with a pre-test and ends with a post-test to evaluate the improvement of cadres' knowledge. The results of the activity show an increase in cadres’ understanding of anatomical, cognitive, and early childhood language stimulation aspects, with a minimum target of 80% of participants being able to understand and apply the provided materials. In addition, cadres demonstrated improved skills in educating parents and in conducting more optimal posyandu (integrated health service post) activities. The outputs of this activity include increased cadre capacity, scientific publications, and activity documentation.
Pemanfaatan Kakao Lokal melalui Pelatihan Pembuatan Yoghurt sebagai Upaya Edukasi Gizi Balita di Desa Gumbrih Fransiscus Kerans; Komang Trisna Sumadewi; Luh Gde Evayanti; Ni Putu Diah Witari; Dewa Ayu Agung Alit Suka Astini; Gede Agus Surya Pratama
Medical Community Dedication Vol 2 No 1 (2026): Juni 2026
Publisher : Fakultas Kedokteran Universitas Islam Al-Azhar Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36679/jmcd.v2i1.17

Abstract

The partners in this community service program were families with toddlers and Posyandu cadres in Gumbrih Village, Jembrana Regency, Bali. The main problems identified were the lack of knowledge regarding balanced nutrition for toddlers, the dangers of fast food, and the limited utilization of cocoa as a nutritious food source. This community service activity aimed to improve the knowledge of Posyandu cadres and families with toddlers regarding healthy eating patterns and skills in processing cocoa into nutritious yogurt. The methods included interactive education sessions, cocoa yogurt-making training, hands-on practice, and evaluation using pre-test and post-test assessments. The activity involved 10 participants, consisting of Posyandu cadres and families with toddlers. The results showed an increase in the participants’ average knowledge score from 60 to 86.7, representing a 44.40% improvement. In addition, participants were able to independently practice making cocoa yogurt during the mentoring process. This activity had a positive impact on improving community nutrition literacy, encouraging the utilization of local cocoa-based food products, and supporting healthy dietary patterns and local economic development.
Effect of Annona muricata Leaf Extract on Hepatic Histopathology and Hepatocyte Index in a Diabetic Rattus norvegicus Model Dewa Ayu Agung Alit Suka Astini; Desak Putu Oki Lestari; Luh Gde Evayanti; Ni Putu Diah Witari; Komang Trisna Sumadewi; Fransiscus Fiano Anthony Kerans; Ida Ayu Laxmi Ananda Dewi Manuaba; Ni Made Gita Kusuma Dewi; Syaifiyatul H
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 2 (2026): VOLUME 27, NUMBER 2, August, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2722026127-133

Abstract

Background: The oxidative stress caused by diabetes mellitus (DM) damages hepatocytes and reduces liver function. In this context, flavonoids and acetogenins found in soursop (Annona muricata L.) leaf have hepatoprotective and antioxidant qualities. Therefore, this study aimed to assess the effect of Annona muricata leaf extract on hepatocyte index and hepatic histopathology in diabetic Wistar rats.Methods: In a laboratory experiment, 16 male Wistar rats weighing 100–150 g and aged 2-3 months were given a high-fat diet and an injection of streptozotocin (27.5 mg/kg BW) to induce type 2 diabetes. Rats were placed in a randomized posttest-only control group. For 21 days, these experimental animals were split into two groups at random, namely control (n = 8) receiving aquadest, and treatment group (n = 8) receiving Annona muricata leaf extract at a dose of 100 mg/kg BW. Hematoxylin-eosin staining was used to analyze hepatic histopathology, and a quantitative evaluation of hepatocyte index was conducted. The independent t-test and Mann-Whitney U test were adopted to assess the data. Results: There was a significant difference (p=0.041) in hepatocyte index between treatment and control groups. Treatment group had less hepatocyte deterioration than the control, according to histopathological scoring (p=0.037).Conclusion: Diabetic Wistar rats treated with Annona muricata leaf extract showed better hepatocyte index and decreased hepatic degeneration, suggesting hepatoprotective potential
Prevalensi Kejadian Anemia pada Siswi SMP Negeri 1 Kintamani Ni Putu Diah Witari; Sri Ratna Dewi; Fransiscus Fiano Anthony Kerans; Aanak Agung Ayu Asri Prima Dewi; Ida Kurniawati; Komang Trisna Sumadewi; Luh Gde Evayanti; Dewa Ayu Agung Alit Suka Astini
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.7411

Abstract

Anemia is a condition characterized by low levels of hemoglobin or red blood cell counts in the bloodstream, resulting in a decreased ability of the blood to transport oxygen throughout the body. The prevalence of anemia is relatively high, especially in developing countries. In Indonesia, there has been an increase in the prevalence of anemia among adolescents aged 15-24 years, reaching 13.6%. In Bali, the recorded prevalence of anemia is 21.9%, with Bangli Regency ranking second. Kintamani is one of the sub-districts located in Bangli Regency, and SMP Negeri 1 Kintamani is one of the middle schools in the area. This study aims to identify the prevalence of anemia among female students of SMP Negeri 1 Kintamani. The method used is a cross-sectional study involving 147 respondents. Hemoglobin levels were measured using the Easy Touch GCHb device. The results indicate that the prevalence of anemia among female students at SMP Negeri 1 Kintamani is 18.37%, with mild anemia at 12.24% and moderate anemia at 6.12%. The majority of respondents are 12 years old.
Co-Authors A A I Ayesa Febrinia Adyasputri A. A. Ayu Asri Prima Dewi A.A.Ayu Asri Prima Dewi A.A.Made Semariyani Aanak Agung Ayu Asri Prima Dewi Adelia Putri Mas Adi Pratama Putra Agus Santosa Anak Agung Ayu Asri Prima Dewi Anak Agung Ayu Asri Prima Dewi Anak Agung Ayu Asri Prima Dewi Anak Agung Oka Lely Anak Agung Sri Agung Aryastuti Angga Priyana Asri Prima Dewi AA Ayu Astuti, Ni Luh Putu Vina Juni budiapsari, putu indah Cahyawati, Putu Nita Desak Putu Oki Lestari Dewa Ayu Ratna Juwita Dewi, A.A.Ayu Asri Prima Dewi, Anak Agung Ayu Asri Prima Ekayanti, Ni Wayan Sri Fransiscus Fiano Anthony Kerans Fransiscus Fiano Anthony Kerans Fransiscus Fiano Anthony Kerans Fransiscus Kerans Gede Agus Surya Pratama Gede Rizky Wismaya Pradipha Hwee Ming Cheng I Gde Suranaya Pandit I Gede Bagus Gita Pranata Putra I Gede Ngurah Bagus Arthayasa I Gusti Agung Istri Mas Dianti Pratiwi I Gusti Ayu Agung Wulan Cahyani I Gusti Lanang Agung Wiradinata I Wayan Sudiarta I Wayan Sudiarta Ida Ayu Diah Kencana Dewi Manuaba Suka Ida Ayu Laxmi Ananda Dewi Manuaba Ida Ayu Laxmi Ananda Dewi Manuaba Ida Ayu Laxmi Ananda Dewi Manuaba Ida Ayu Santi Purnamawati Ida Kurniawati Ida Kurniawati Ida Kurniawati, Ida IGNP Sana Kadek Ayu Alit Sintyawati Kadek Ayu Alit Sintyawati Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi KT Sumadewi Made Dharmesti Wijaya Marta Setiabudy Md Ayu Mirah Dewanti Murdhana Putere, Sagung Putri Permana Lestari Ni Gusti Agung Ayu Wulan Ananda Pratiwi Ni Kadek Elmy Saniathi Ni Luh Putu Indiani Ni Luh Putu Putri Setianingsih Ni Made Asthi Pramesti Kirana Ni Made Gita Kusuma Dewi Ni Made Gita Kusuma Dewi Ni Made Gita Kusuma Dewi Ni Made Meishanda Kusuma Divayanti Ni Putu Ayu Dian Maharani Ni Putu Diah Witari, Ni Putu Ni Putu Indah Kusumadewi Riandra Ni Wayan Armerinayanti, Ni Wayan Ni Wayan Diana Ekayani Ni Wayan Sri Ekayanti NPD Witari Pande Ayu Naya Kasih Permatananda Perdana, I Gede Sukma Okta Pharmawati Made Pratiwi, Anny Eka Prima Dewi, A.A.A Asri Putra, Adi Pratama Putu Austin Widyasari Wijaya Putu Ayu Kevin Komala Dewi Mahayuna Putri Putu Gde Hari Wangsa Putu Nadya Asti Utari Ratna Juwita Rima Kusuma Ningrum Sari, Ni Luh Putu Eka Kartika Sri Ekayanti Ni Wayan Sri Ratna Dewi Sueta, Made Agus Dwianthara Suka Astini, Dewa Ayu Agung Alit Sumadewi, Komang Trisna Syaifiyatul H Trisnia, Putu Ayunda