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Inovasi Diagnosis Meningitis Streptococcus Suis: Tantangan dan Solusi Komang Trisna Sumadewi; Saktivi Harkitasari; Dewa Ayu Agung Alit Suka Astini; Luh Gede Evayanti
Jurnal Biomedika dan Kesehatan Vol 9 No 1 (2026)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2026.v9.89-104

Abstract

Streptococcus suis (S. suis) is an important zoonotic pathogen that causes severe infections in humans, including meningitis, sepsis, and endocarditis. S. suis meningitis remains a public health concern, particularly in regions with high pork consumption, pig farming, or occupational exposure to pigs and pork products. This narrative review synthesizes current evidence on pathogenesis, diagnostic gaps, and emerging point-of-care strategies. The disease develops through sequential colonization, bloodstream invasion, disruption of the blood-brain barrier, entry into the central nervous system, and meningeal inflammation. Virulence factors, including capsular polysaccharide, suilysin, collagenase-like protease, and zinc metalloproteinase C, contribute to immune evasion, endothelial injury, and increased barrier permeability. Conventional cerebrospinal fluid culture enables bacterial isolation and antimicrobial susceptibility testing, but its diagnostic yield may decrease after prior antibiotic exposure, and its turnaround time is slow. PCR-based methods offer faster targeted detection, with reported diagnostic performance of approximately 92–100% and potential results within less than 4 hours in optimized workflows. Metagenomic next-generation sequencing improves detection in culture-negative or complex cases but remains limited by cost, infrastructure, and interpretation challenges. LAMP, RPA-lateral flow assays, biosensors, and CRISPR-based platforms are promising but require clinical validation using human cerebrospinal fluid. Future research should prioritize accuracy, affordability, accessibility, and implementation in endemic settings globally.
Co-Authors Aditya Yudistira Agus Eka Darwinata Agus Praktyasa Albert Salim Anak Agung Ayu Asri Prima Dewi Anak Agung Bagus Ngurah Nuartha Anak Agung Ngurah Agung Bayu Sutha Anak Agung Ngurah Agung Bayu Sutha Anny Pratiwi Asri Lestarin Audria, Intan Safira Citra Udiyani Cokorda Agung Pratiwi Cokorda Agung Wahyu Purnamasidhi Cokorda Agung Wahyu Purnamasidhi Cokorda Agung Wahyu Purnamasidhi Cokorda Agung Wahyu Purnamasidhi Darren Junior Darren Junior Darren Junior Desyanti Risky Putri Dewa Ayu Fony Prema Shanti Dewa Ayu Sri Shita Meliani Dewi Manuaba, Ida Ayu Laxmi Ananda Fransiscus Fiano Anthony Fransiscus Fiano Anthony Kerans Giovanca Verentzia Purnama Giovanca Verentzia Purnama Guptha, I Dewa Gede Agung Siwa Hiranandini Prawista, I Gusti Ayu Maha I Dewa Ayu Inten Dwi Primayanti, I Dewa Ayu Inten Dwi I Gde Nengah Adhilaksman Sunyamurthi Wirawan I Gede Purna Weisnawa I Gede Purna Weisnawa I Gusti Ngurah Agung Cahyadi Putra I Gusti Ngurah Ariestha Satya Diksha I Gusti Ngurah Ariestha Satya Diksha I Gusti Ngurah Dwija Putra I Komang Hotra Adiputra I Komang Hotra Adiputra I Made Susila Utama I Made Wandia I Nyoman Wande I Wayan Diki Wahyu Adinata I Wayan Sumardika I Wayan Sumardika Ida Ayu Laxmi Ananda Dewi Manuaba Ida Bagus Giri Sena Putra Ida Bagus Giri Sena Putra Ida Kurniawati Indra Wijaya Indratmo, Novea Irawan Sukma Jerry Jerry Junior, Darren Kadek Ayu Astuti Kadek Surya Atmaja KADEK SURYA ATMAJA Kartika Sari Ketut Tuti Parwati Merati Komang Aditya Yudistira Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Trisna Sumadewi Komang Triyani Kartinawati Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti MADE BAGUS MANIK SATRIA MAHOTTAMA MADE BAGUS MANIK SATRIA MAHOTTAMA Made Dharmesti Wijaya Made Ilora Hiranandasastri Ni Kadek Fitria Parahita Ni Made Gita Kusuma Dewi Ni Made Kharisma Praba Yuanika Ni Made Widya Apsari Cahyadewi Ni Putu Diah Witari Ni Putu Diah Witari Ni Putu Diah Witari Ni Putu Diah Witari, Ni Putu Ni Putu Dian Puspitha Maheswari Yasa Ni Putu Dina Pradnyani Ni Putu Sukarini Ni Wayan Diana Ekayani Ni Wayan Widhidewi Nia Calista Santoso Novitasari Novitasari Pande Ayu Naya Kasih Permatananda Pratiwi, Anny Eka Pratiwi, Cokorda Agung Pratyaksa, I Gusti Ngurah Dinda Primatanti, Putu Asih Putra Parwati, Tjok Istri Putu Asih Primatanti Putu Asih Primatanti Putu Kintan Wulandari Putu Kintan Wulandari R. A.T. Kuswardhani Richard Christian Suteja Richard Christian Suteja Richard Christian Suteja Rima Kusuma Ningrum Satya Diksha, I Gusti Ngurah Ariestha Sri Masyeni, Dewa Ayu Putri Sri Ratna Dewi Suka Astini, Dewa Ayu Agung Alit Sumadewi, Komang Trisna Suteja, Richard Christian Suyasning Hastiko Indonesia Tanjung Subrata Thomas Eko Purwata Tjok Istri Putra Parwati Toddy Hendrawan Yupardhi, Toddy Hendrawan Wayan Sayang Yupardhi Winianti, Ni Wayan Wiranatha, I Gede Wulandari, Putu Kintan