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Muhammad Furqan, Muhammad
Pendidikan Biologi FKIP UNS, Surakarta
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Journal : SCRIPTA SCORE Scientific Medical Journal

 1 
Relationship of Histopathology Grading with Molecular Subtypes of Breast Cancer Patients in Haji Adam Malik General Hospital 2016-2018 Furqan, Muhammad; Pohan, Pimpin Utama
SCRIPTA SCORE Scientific Medical Journal Vol. 2 No. 1 (2020): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v2i1.3364

Abstract

Background: Breast cancer symptoms are often not felt clearly by patients, as a result many patients who come in an advanced stage. This will affect the prognosis and cure rate of the patient. There are several factors that influence the prognosis of breast cancer, including histopathological grade, and classic immunohistochemical markers such as estrogen receptors, progesterone receptors, and HER2. In addition, breast cancer can be 4 main molecular subtypes, namely Luminal A, Luminal B, HER2-Overexpression, and Triple Negative / Basal-Like. Objectives: This study aims to determine the relationship between histopathological grade with the molecular subtypes of breast cancer patients in Haji Adam Malik General Hospital in 2016-2018. Methods: This is analytical cross-sectional research using a consecutive-sampling technique. Data were obtained secondary from the medical records of breast cancer patients at Haji Adam Malik General Hospital in 2016-2018 and then analyzed with the chi-square test. From 1005 cases of breast cancer during the 2016-2018 period, 131 samples were taken in this study. Results: Of the 131 samples, the highest histopathological grade was grade 2 with 53 people  (40.5%), followed by 41 people (31.3%) with grade 3, and 37 people (28.2%) with grade 1. The most molecular subtypes were Luminal A with 38 people (29%), followed by 33 people (25.2%) with Luminal B, 31 people (23.7%) with HER-2 Overexpression, and 29 people (22.1%) with Triple Negative / Basal-like. From the analysis of the chi-square test obtained p value of 0.045. Conclusion: There is a relationship between histopathological grade with molecular subtypes of breast cancer patients. Keywords: breast cancer, histopathological grade, immunohistochemistry, molecular subtypes     Latar Belakang: Gejala-gejala kanker payudara sering tidak dirasakan dengan jelas oleh pasien, akibatnya banyak pasien yang datang dalam keadaan stadium lanjut. Hal ini akan mempengaruhi prognosis dan tingkat kesembuhan pasien. Terdapat beberapa faktor yang mempengaruhi prognosis dari kanker payudara, antara lain grading histopatologi, dan marker imunohistokimia klasik seperti reseptor estrogen, reseptor progesteron, dan HER2. Selain itu, kanker payudara dapat diklasifikasikan menjadi 4 subtipe molekuler utama, yaitu Luminal A, Luminal B, HER2-Overexpression, dan Triple Negative/Basal-Like. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara grading histopatologi dengan subtipe molekuler pasien kanker payudara di RSUP Haji Adam Malik Tahun 2016-2018. Metode: Penelitian ini merupakan penelitian analitik menggunakan desain cross-sectional dengan teknik pengambilan sampel consecutive-sampling. Data diperoleh secara sekunder dari rekam medis pasien kanker payudara di RSUP Haji Adam Malik pada tahun 2016-2018 dan kemudian dianalisis dengan uji chi-square. Dari 1005 kasus kanker payudara selama periode 2016-2018, diambil sampel pada penelitian ini sebanyak 131 buah rekam medis. Hasil: Dari 131 sampel, grading histopatologi terbanyak terdapat pada grade 2 dengan 53 orang (40,5%) , diikuti 41 orang (31,3%) dengan grade 3, dan 37 orang (28,2%) dengan grade 1. Subtipe molekuler terbanyak yaitu Luminal A dengan 38 orang (29%), diikuti 33 orang (25,2%) dengan Luminal B, 31 orang (23,7%) dengan HER-2 Overexpression, dan 29 orang (22,1%) dengan Triple Negative/Basal-like. Dari hasil uji chi-square diperoleh nilai p sebesar 0,045. Kesimpulan: Terdapat hubungan antara grading histopatologi dengan subtipe molekuler pasien kanker payudara. Kata kunci: grading histopatologi, imunohistokimia, kanker payudara, subtipe molekuler
Co-Authors Abda Abda Abdullah Abdullah Alfaiz, Alif Budi Amalia, Astrifidha Rahma Armidayanti, Armidayanti Arrafif, Caesar Rayhand Athifah, Syfa A’yun, Rizqah Qurrata Bambang Sutomo, Bambang Bedjo Santoso Kadri Chairul Chairul Chairullah, Muhammad Chentia, Rifani Dedi Gunawan Dedi Supriadi Dika Agung Bakhtiar Diyah Fatmasari Djakiman, Cilun Djamdjuri, Dewi Suriyani Dzulkifli, Dzulkifli Efriyanti, Liza Eka Srimulyani Endang Sawitri Fakhrul Rijal, Fakhrul fatimah Fatimah Fatmawati Fatmawati Fauzan, Muh . Furqan Furqan, Furqan Ghifrah, Ella Gusmirawati, Gusmirawati Haikal, M. Hajar, Ibnoel Halimatussakdiyah, Halimatussakdiyah Hamdani Hamdani Herawati, Cut Hery Widijanto Holifah, Muharani Humaira, Intan Ika Handayani Ilmiah, Nurul Inayatillah Inayatillah Irada Sinta Jariah Abu Bakar Khairisma, Khairisma Kusumawati, Andi Laila Wati Lestari, Eva Bunga Lestari, Indah Lestari M. Duskri Mahlil, Mahlil Maisyuri, Maisyuri Malem, Zaidan Zikri Martin Kustati Mashuri Maulidin, Maulidin Mellyan Muhammad Muhammad Muhammad Nasir Munazir, Munazir Munthasir, Sulthan Murni Murni Mustaqim, Mirja Mutia, Jarah Nafyla, Allyscra Nanik Retnowati Nasrullah Nasrullah Natsir, Andi Iqra Pradipta Noverika Windasari Nur, Akbar Nurbayani Nurbayani Nurdin Nurdin Nurmuntazlimah, Keisha Siti Nurwijayanti Patandean, Dewarawati Pertiwi, Shinta Pohan, Pimpin Utama Putri, Novi Amalia Putri, Novie Purnia Rahmalia, Tgk. Lina Rahmawati Nur, Maulidia Rasyad, Muhammad Ashadi Rezki Amelia Rizki Suwanda Rizkina, Fathi S Suranto Safitri, Dhiah Dwi Saiful Akmal Sain, Zohaib Hassan Sakdiah Sakdiah Sakdiah, Sakdiah Salahuddin, Nurfadhilah Salami Mahmud Salman Salman Samaniyah, Siti Sandra, Aria Shabir, Muhammad Sinai, Nadiva Kezia Siregar, Cahaya Indah Sugiyarto, S Swarjana, I Kadek Dwi Syabuddin Gade Syabuddin, Syabuddin SYAHRIAL SYAHRIAL Syelvia Putri Utami Tasnim Idris Teuku Multazam Teuku Zulfikar Thoyib, Mastur Yudabangsa, Adrian Yulianto, Fadly Yulis, Sari Z., Marwan Zakir, Supratman Zawira, Shafiqah Zulfani Sesmiarni